Min Pa: Min Pa(max): Activity's type:

Ext Pa Pi Pmax Activity Other Results ID Pa_max
0.740.0050.745 Hydroxytryptamine release stimulant

0.686 0.008 CID_131769951

0.7210.0210.721Caspase 9 stimulant

0.648 0.03 CID_131769951

0.5490.0160.549Interleukin antagonist

0.397 0.031 CID_131769951

0.4580.0030.458Melatonin 1 agonist

0.154 0.004 CID_131769951

0.4820.0320.493Vasodilator, peripheral

0.493 0.029 CID_131769951

CID_131769951
0.4460.0030.446Melatonin 2 agonist

0.2 0.003 CID_131769951

0.4770.0370.477Calcium channel L-type activator

0.358 0.111 CID_131769951

0.4320.0030.432Melatonin agonist

0.203 0.004 CID_131769951

0.4430.0170.447Psychostimulant

0.447 0.016 CID_131769951

CID_131769951
0.4340.0090.626DNA methylase inhibitor

0.626 0.004 CID_131769951

CID_131769951
0.4260.0070.605DNA methyltransferase I inhibitor

0.605 0.004 CID_131769951

CID_131769951
0.4370.020.437Amyloid beta aggregation inhibitor

0.296 0.046 CID_131769951

0.3960.0050.3965 Hydroxytryptamine 1E antagonist
0.4110.020.411Insulysin inhibitor
0.3790.0030.379Myeloperoxidase inhibitor
0.3920.030.46Antiamyloidogenic

0.46 0.02 CID_131769951

CID_131769951
0.3710.0340.519Free radical scavenger

0.519 0.014 CID_131769951

CID_131769951
0.340.0050.34Nitric-oxide synthase stimulant

0.328 0.006 CID_131769951

0.3370.0040.337Toll-Like receptor 2 antagonist

0.177 0.035 CID_131769951

0.3530.0280.353Peroxidase inhibitor
0.3260.0030.326Melatonin antagonist

0.071 0.005 CID_131769951

0.3970.0760.39715-Lipoxygenase inhibitor
0.3940.0790.521Histamine release inhibitor

0.521 0.022 CID_131769951

CID_131769951
0.3770.0690.707Transcription factor NF kappa B inhibitor

0.707 0.02 CID_131769951

CID_131769951
0.3270.0530.545Antioxidant

0.545 0.015 CID_131769951

CID_131769951
0.2760.0020.276Melatonin receptor 1A agonist

0.033 0.024 CID_131769951

0.3180.0520.318Ca2+/calmodulin-dependent kinase II alpha inhibitor
0.2820.0160.282Neurotensin receptor agonist

0.159 0.081 CID_131769951

0.3260.0680.326Calcium channel activator
0.2570.0030.257Melatonin 1 antagonist

0.044 0.005 CID_131769951

0.3190.0730.485Vasodilator, coronary

0.485 0.018 CID_131769951

CID_131769951
0.2790.0330.386Peptidyltransferase inhibitor

0.386 0.008 CID_131769951

CID_131769951
0.3140.0720.31412-Lipoxygenase inhibitor
0.3120.0770.447Apoptosis antagonist

0.447 0.028 CID_131769951

CID_131769951
0.2930.060.293DNA damaging

0.293 0.06 CID_131769951

0.3040.0760.304Sodium/bile acid cotransporter inhibitor

0.241 0.138 CID_131769951

0.2740.0480.274Tyrosine 3 hydroxylase inhibitor
0.2380.0140.238Antibacterial (Helicobacter pylori)

0.146 0.049 CID_131769951

0.2810.0580.281Superoxide dismutase inhibitor
0.270.0480.27Calpain inhibitor
0.2240.0020.224Melatonin receptor 1A antagonist
0.2310.010.231Falcipain 3 inhibitor
0.3510.1380.509Apoptosis agonist

0.509 0.071 CID_131769951

CID_131769951
0.2350.0240.2355 Hydroxytryptamine 3E antagonist
0.2360.0280.236Tubulin antagonist
0.2510.0480.251Sigma receptor agonist
0.2120.010.2125 Hydroxytryptamine 1 agonist
0.210.010.21Adenylate cyclase stimulant

0.143 0.076 CID_131769951

0.2170.020.217Alpha 2b adrenoreceptor antagonist
0.1990.0040.199Beta 3 adrenoreceptor antagonist
0.2310.040.231Lipocortins synthesis antagonist

0.203 0.054 CID_131769951

0.2180.0290.218NADPH oxidase inhibitor

0.165 0.046 CID_131769951

0.2540.0680.609Angiogenesis stimulant

0.609 0.006 CID_131769951

CID_131769951
0.210.0240.21GABA C receptor rho-2 antagonist
0.2980.1170.298GABA C receptor rho-3 antagonist
0.1940.0170.194Carbonic anhydrase III inhibitor

0.099 0.063 CID_131769951

0.2130.0360.337Melanin inhibitor

0.337 0.017 CID_131769951

CID_131769951
0.1780.0090.178Adrenaline agonist
0.2650.10.278Caspase 3 stimulant

0.278 0.091 CID_131769951

CID_131769951
0.2450.0810.245Aryl hydrocarbon receptor agonist
0.1720.0080.175Acetylcholine release stimulant

0.175 0.007 CID_131769951

CID_131769951
0.2270.0650.227ErbB-1 antagonist
0.1730.0140.173Prolactin inhibitor
0.1810.0270.419Cyclooxygenase 3 inhibitor

0.419 0.004 CID_131769951

CID_131769951
0.1670.020.167Heat shock protein 70 antagonist

0.163 0.024 CID_131769951

0.1710.0240.171Alpha 2c adrenoreceptor antagonist
0.1890.0460.262Lipid peroxidase inhibitor

0.262 0.025 CID_131769951

CID_131769951
0.1460.0060.146Beta adrenoreceptor antagonist
0.1380.0050.138GABA B receptor agonist
0.1750.0420.175Histone deacetylase SIRT1 inhibitor
0.2080.0790.208Antimitotic
0.1910.0620.191Growth hormone agonist
0.2010.0720.201Insulin sensitizer

0.161 0.118 CID_131769951

0.3160.1910.316Ca2+/calmodulin-dependent protein kinase kinase A inhibitor
0.1530.030.153Bronchodilator

0.119 0.045 CID_131769951

0.130.0070.135 Hydroxytryptamine 2A agonist
0.1470.0250.147Breast cancer-resistant protein inhibitor
0.2260.1060.506Immunostimulant

0.506 0.028 CID_131769951

CID_131769951
0.1530.0340.153Chelator
0.2140.0970.473Tumour necrosis factor alpha release inhibitor

0.473 0.017 CID_131769951

CID_131769951
0.1230.0070.123Beta 1 adrenoreceptor antagonist
0.2320.1170.232Hypoxia-inducible factor 1 alpha inhibitor

0.212 0.138 CID_131769951

0.1640.0540.164CF transmembrane conductance regulator agonist
0.1540.0450.328Monophenol monooxygenase inhibitor

0.328 0.015 CID_131769951

CID_131769951
0.1450.0380.145Interleukin 8 antagonist
0.1320.0250.1325 Hydroxytryptamine agonist
0.1110.0070.111Beta 2 adrenoreceptor antagonist
0.1350.0320.135Antineoplastic alkaloid
0.1450.0440.145Vanilloid 1 agonist

0.121 0.086 CID_131769951

0.1370.040.153Mucolytic

0.153 0.03 CID_131769951

CID_131769951
0.1720.0750.172Tumour necrosis factor antagonist
0.1450.0490.145Proteasome inhibitor
0.1360.0410.2Photosensitizer

0.2 0.013 CID_131769951

CID_131769951
0.1010.0070.1015 Hydroxytryptamine 1B agonist
0.1150.0210.174Glycine receptor antagonist

0.174 0.004 CID_131769951

CID_131769951
0.1130.0190.113Beta tubulin antagonist
0.1310.0390.131Carbonic anhydrase XV inhibitor
0.1420.050.142Adenylate cyclase inhibitor
0.1330.0420.133Protein kinase C gamma inhibitor
0.1540.0640.154Vascular endothelial growth factor 3 antagonist
0.1340.0450.1345 Hydroxytryptamine 3A agonist
0.2650.1790.519Alpha-glucosidase inhibitor

0.519 0.075 CID_131769951

CID_131769951
0.1810.0970.181Platelet aggregation inhibitor
0.1050.0210.1055 Hydroxytryptamine 1D antagonist
0.1060.0230.106Phenylalanine 4-hydroxylase inhibitor
0.2120.130.2125 Hydroxytryptamine uptake stimulant
0.1230.0420.123DOPA decarboxylase inhibitor
0.1440.0650.144Neurotrophic factor

0.121 0.093 CID_131769951

0.1070.0290.107Somatostatin 1 agonist

0.073 0.06 CID_131769951

0.10.0250.1Estrogen-related receptor beta agonist
0.250.1770.635Antibacterial

0.635 0.015 CID_131769951

CID_131769951
0.1590.0860.159Death-associated protein kinase 2 inhibitor
0.0920.020.092Bombesin 1 receptor agonist
0.0830.0110.0835 Hydroxytryptamine 7 agonist
0.080.0090.08Beta 2 adrenoreceptor agonist
0.1030.0320.103Granulocyte macrophage colony stimulating factor agonist
0.0690.0020.069Melatonin 2 antagonist
0.1870.1210.187RNA-directed DNA polymerase inhibitor
0.1020.0380.102Carbonic anhydrase VI inhibitor
0.1910.1270.293Spasmolytic

0.293 0.073 CID_131769951

CID_131769951
0.1680.1050.168Growth factor agonist
0.0760.0130.076Cholecystokinin A antagonist
0.0670.0050.067Bombesin 1 receptor antagonist

0.037 0.026 CID_131769951

0.0970.0360.097Vanilloid agonist
0.1030.0430.1035 Hydroxytryptamine 2C antagonist
0.0960.0380.096Alpha 2a adrenoreceptor antagonist
0.1120.0540.273Beta glucuronidase inhibitor

0.273 0.007 CID_131769951

CID_131769951
0.1240.0660.124Histone deacetylase class III inhibitor
0.0870.030.087Sirtuin 1 inhibitor
0.0950.0380.095Macrophage migration inhibitory factor inhibitor
0.0770.0210.077Alpha tubulin antagonist
0.0770.0210.077Cyclin D1 inhibitor
0.1230.0680.123M18 aspartyl aminopeptidase inhibitor
0.110.0550.11Urease inhibitor
0.1110.0570.356Expectorant

0.356 0.006 CID_131769951

CID_131769951
0.0780.0250.0785 Hydroxytryptamine 5A antagonist
0.1070.0540.107GABA C receptor rho-1 antagonist
0.160.1070.16Pyruvate kinase inhibitor
0.1240.0720.124Papain-like protease (SARS coronavirus) inhibitor
0.0590.0080.059Beta adrenoreceptor agonist
0.0660.0160.066Cholecystokinin antagonist
0.2090.1590.253Angiogenesis inhibitor

0.253 0.121 CID_131769951

CID_131769951
0.1040.0540.104Antiadrenergic
0.0550.0060.055Melatonin 3 antagonist
0.1890.140.189Neuropeptide Y2 antagonist
0.150.1010.153C-like protease (Human coronavirus) inhibitor
0.1080.0590.108MAO A inhibitor
0.0810.0330.0815 Hydroxytryptamine 1B antagonist
0.1010.0530.101Adrenaline antagonist
0.0720.0250.0725 Hydroxytryptamine 5 antagonist
0.0650.0180.065Vanilloid 2 antagonist
0.1740.1280.302Vasodilator

0.302 0.047 CID_131769951

CID_131769951
0.1380.0920.302Thrombolytic

0.302 0.024 CID_131769951

CID_131769951
0.1250.0790.125Interleukin 4 antagonist

0.117 0.089 CID_131769951

0.0920.0460.092Platelet growth factor antagonist
0.050.0050.05Follicle-stimulating hormone agonist
0.110.0650.11EphA2 antagonist

0.096 0.079 CID_131769951

0.0630.0190.063Immunoglobulin Fc receptor antagonist
0.0840.040.0845 Hydroxytryptamine 1F antagonist
0.0590.0150.059Histone deacetylase 7 inhibitor
0.1030.060.103Butyrylcholinesterase inhibitor
0.1060.0630.287AMP-activated protein kinase stimulant

0.287 0.005 CID_131769951

CID_131769951
0.060.0180.06Bombesin antagonist

0.044 0.041 CID_131769951

0.0980.0560.119Falcipain inhibitor

0.119 0.045 CID_131769951

CID_131769951
0.1910.150.191Lipoxygenase inhibitor
0.0990.060.099Platelet activating factor alpha antagonist
0.060.0210.06Dopamine D2 agonist
0.1180.0790.118Acetylcholinesterase inhibitor
0.0610.0230.061Bombesin 2 receptor antagonist
0.1120.0750.125DNA polymerase I inhibitor

0.125 0.065 CID_131769951

CID_131769951
0.0640.0280.064Ryanodine receptor antagonist
0.1940.1590.194Gastrin inhibitor
0.0690.0340.091Neuraminidase inhibitor

0.091 0.019 CID_131769951

CID_131769951
0.140.1060.315Nitric oxide antagonist

0.315 0.038 CID_131769951

CID_131769951
0.0740.0410.074Dopamine agonist
0.0530.020.064Neuraminidase (Influenza A) inhibitor

0.064 0.01 CID_131769951

CID_131769951
0.0920.0580.113Falcipain 2 inhibitor

0.113 0.045 CID_131769951

CID_131769951
0.1020.0680.202Mediator release inhibitor

0.202 0.014 CID_131769951

CID_131769951
0.0650.0320.065Gonadotropin-releasing hormone receptor agonist
0.0490.0160.049Histone deacetylase 9 inhibitor
0.0930.0610.093Protein kinase C zeta inhibitor
0.0790.0470.079Alpha 1b adrenoreceptor antagonist
0.0770.0460.077Metalloproteinase-9 inhibitor
0.1020.0720.102Nav1.4 sodium channel blocker
0.0890.0590.117ATPase (Vacuolar H+) inhibitor

0.117 0.022 CID_131769951

CID_131769951
0.0680.0380.094Neuraminidase (influenza) inhibitor

0.094 0.018 CID_131769951

CID_131769951
0.0770.0490.0775 Hydroxytryptamine 1 antagonist
0.0790.050.079Keratolytic
0.1540.1270.154Proto-oncogene tyrosine-protein kinase Fyn inhibitor
0.1030.0760.103Electron transport complex I inhibitor
0.1420.1160.247ATPase inhibitor

0.247 0.014 CID_131769951

CID_131769951
0.1030.0790.1035 Hydroxytryptamine 2B antagonist
0.070.0460.075 Hydroxytryptamine 1A antagonist
0.0620.0390.062Carbonic anhydrase stimulant
0.0840.0610.084Alpha 2 adrenoreceptor antagonist
0.1570.1340.157Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase inhibitor
0.0610.0380.061Heat shock protein 90 beta antagonist
0.0780.0550.078Metalloproteinase-2 inhibitor
0.0470.0240.047Growth hormone release inhibitor
0.0940.0730.094Gastric antisecretory
0.0260.0050.026Follicle-stimulating hormone antagonist
0.030.0080.03Beta 1 adrenoreceptor agonist
0.0440.0230.044Somatostatin 1 antagonist
0.1820.1610.182Transcription factor STAT3 inhibitor
0.1430.1230.143Catenin beta inhibitor
0.0650.0450.065Neutrophil collagenase inhibitor
0.0440.0260.044Toll-Like receptor 2 agonist

0.041 0.029 CID_131769951

0.0640.0470.064Histone deacetylase inhibitor
0.0450.0270.045Histamine H2 receptor agonist
0.0350.0180.035GHS receptor antagonist
0.0930.0760.192Topoisomerase I inhibitor

0.192 0.029 CID_131769951

CID_131769951
0.040.0230.04Cholecystokinin B agonist
0.1570.1410.331Cyclic AMP phosphodiesterase inhibitor

0.331 0.031 CID_131769951

CID_131769951
0.0390.0230.039Somatostatin 4 agonist
0.0810.0650.081Factor XII inhibitor
0.0370.0210.037Somatostatin 5 agonist
0.0890.0740.121Interleukin 12 antagonist

0.121 0.028 CID_131769951

CID_131769951
0.1240.1110.124Phospholipase A2 inhibitor
0.0330.0190.033Cholecystokinin B antagonist
0.1090.0960.109Bone formation stimulant
0.0410.0280.041Histone deacetylase 8 inhibitor
0.1450.1340.145Ca2+/calmodulin-dependent kinase II beta inhibitor
0.1070.0960.107Ca2+/calmodulin-dependent kinase II delta inhibitor
0.030.0190.035 Hydroxytryptamine 1D agonist
0.080.0710.08Alpha adrenoreceptor antagonist
0.140.1320.14Succinate dehydrogenase inhibitor
0.0410.0330.041GHS receptor agonist
0.1110.1030.111Interleukin 1 antagonist
0.0360.0280.036Melanocortin 1 antagonist
0.1930.1860.614Antithrombotic

0.614 0.015 CID_131769951

CID_131769951
0.0440.0370.044Melanocortin antagonist
0.0910.0840.091Adenylate kinase inhibitor
0.080.0730.08Hematopoietic
0.0390.0320.039Melanocortin 4 antagonist
0.1470.1410.147Aldehyde oxidase inhibitor
0.0320.0260.032Gonadotropin-releasing hormone receptor antagonist
0.0190.0130.019Cholecystokinin agonist
0.0430.0370.043Adenylate cyclase 1 inhibitor
0.0640.0580.064Histidine decarboxylase inhibitor
0.0170.0110.017Cholecystokinin A agonist
0.0250.0190.025Thyroid hormone agonist
0.1260.120.229Interferon gamma antagonist

0.229 0.033 CID_131769951

CID_131769951
0.0520.0480.052Alpha 1 adrenoreceptor agonist
0.0670.0640.125Topoisomerase II alpha inhibitor

0.125 0.028 CID_131769951

CID_131769951
0.0180.0150.018Inosine monophosphate dehydrogenase 2 inhibitor
0.0580.0560.058Histone deacetylase SIRT3 inhibitor
0.040.0380.04Endothelin-converting enzyme inhibitor
0.0940.0920.179Topoisomerase II inhibitor

0.179 0.038 CID_131769951

CID_131769951
0.1940.20.368Interleukin 2 agonist

0.368 0.038 CID_131769951

CID_131769951
0.1250.1360.168Interleukin 6 antagonist

0.168 0.066 CID_131769951

CID_131769951
0.1260.1370.342Platelet adhesion inhibitor

0.342 0.022 CID_131769951

CID_131769951
0.0390.0510.053Carbonic anhydrase XIV inhibitor

0.053 0.03 CID_131769951

CID_131769951
0.0490.0620.306Selectin antagonist

0.306 0.005 CID_131769951

CID_131769951
0.090.1040.101Beta amyloid protein antagonist

0.101 0.089 CID_131769951

CID_131769951
0.0580.0720.074Carbonic anhydrase XIII inhibitor

0.074 0.055 CID_131769951

CID_131769951
0.0830.0990.121Phosphodiesterase 6D inhibitor

0.121 0.024 CID_131769951

CID_131769951
0.1010.1190.198Protein kinase stimulant

0.198 0.042 CID_131769951

CID_131769951
0.0930.1120.173Alpha-N-acetylglucosaminidase inhibitor

0.173 0.044 CID_131769951

CID_131769951
0.1240.1450.338Hepatoprotectant

0.338 0.021 CID_131769951

CID_131769951
0.0890.1130.111Microtubule formation inhibitor

0.111 0.072 CID_131769951

CID_131769951
0.0760.110.122DNA intercalator

0.122 0.056 CID_131769951

CID_131769951
0.020.0540.032Toll-Like receptor 4 agonist

0.032 0.009 CID_131769951

CID_131769951
0.0810.1160.179Alkylator

0.179 0.033 CID_131769951

CID_131769951
0.1080.1430.36Hemostatic

0.36 0.01 CID_131769951

CID_131769951
0.0740.1130.114Xanthine oxidase inhibitor

0.114 0.051 CID_131769951

CID_131769951
0.0380.0790.073Glucose-6-phosphate translocase inhibitor

0.073 0.014 CID_131769951

CID_131769951
0.0310.0740.09Protein 50S ribosomal subunit inhibitor

0.09 0.016 CID_131769951

CID_131769951
0.1360.1790.251Interleukin agonist

0.251 0.078 CID_131769951

CID_131769951
0.070.1190.091Protein-tyrosine phosphatase 1B inhibitor

0.091 0.088 CID_131769951

CID_131769951
0.0060.0590.017Ileal bile acid transport inhibitor

0.017 0.012 CID_131769951

CID_131769951
0.0670.1240.096Thioredoxin inhibitor

0.096 0.053 CID_131769951

CID_131769951
0.0370.1030.047Factor III inhibitor

0.047 0.042 CID_131769951

CID_131769951
0.0690.1530.096Multidrug resistance-associated protein 1 inhibitor

0.096 0.086 CID_131769951

CID_131769951
0.0430.1290.059Lipocortins synthesis agonist

0.059 0.039 CID_131769951

CID_131769951
0.1290.2190.484Hypoglycemic

0.484 0.017 CID_131769951

CID_131769951
0.0560.1550.117UDP-glucose 4-epimerase inhibitor

0.117 0.045 CID_131769951

CID_131769951
0.0280.1330.13Antineoplastic antibiotic

0.13 0.036 CID_131769951

CID_131769951
0.0280.1380.062Nitric oxide donor

0.062 0.044 CID_131769951

CID_131769951
0.0640.1740.136Toll-Like receptor 4 antagonist

0.136 0.03 CID_131769951

CID_131769951
0.1970.3130.2875 Hydroxytryptamine release inhibitor

0.287 0.18 CID_131769951

CID_131769951
0.0540.1920.115Transcription factor NF kappa B stimulant

0.115 0.028 CID_131769951

CID_131769951
0.0940.2340.255Non-steroidal antiinflammatory agent

0.255 0.041 CID_131769951

CID_131769951
0.1360.2760.403Immunosuppressant

0.403 0.062 CID_131769951

CID_131769951
0.0540.1950.229Amylase inhibitor

0.229 0.034 CID_131769951

CID_131769951
0.1240.2670.269DNA synthesis inhibitor

0.269 0.056 CID_131769951

CID_131769951
0.0830.2280.185Insulin secretagoues

0.185 0.045 CID_131769951

CID_131769951
0.0740.2210.192Cell wall synthesis inhibitor

0.192 0.033 CID_131769951

CID_131769951
0.010.1610.027Protein 30S ribosomal subunit inhibitor

0.027 0.014 CID_131769951

CID_131769951
0.080.2370.146DNA repair enzyme inhibitor

0.146 0.035 CID_131769951

CID_131769951
0.0470.2060.085Triose-phosphate isomerase inhibitor

0.085 0.068 CID_131769951

CID_131769951
0.0240.2020.081Heparanase inhibitor

0.081 0.006 CID_131769951

CID_131769951
0.0720.250.16Hexokinase inhibitor

0.16 0.067 CID_131769951

CID_131769951
0.0750.2540.163NOS3 expression enhancer

0.163 0.061 CID_131769951

CID_131769951
0.0830.2620.244Platelet antagonist

0.244 0.075 CID_131769951

CID_131769951
0.0180.20.058Antibiotic Aminoglycoside-like

0.058 0.009 CID_131769951

CID_131769951
0.0080.2010.03Sodium/glucose cotransporter inhibitor

0.03 0.011 CID_131769951

CID_131769951
0.0180.2120.053Alpha-mannosidase inhibitor

0.053 0.037 CID_131769951

CID_131769951
0.0050.2390.027Sodium/glucose cotransporter 2 inhibitor

0.027 0.017 CID_131769951

CID_131769951
0.0940.3520.203Cholesterol antagonist

0.203 0.162 CID_131769951

CID_131769951
0.0450.3220.16Cell adhesion inhibitor

0.16 0.041 CID_131769951

CID_131769951
0.0320.3190.084Cell adhesion molecule inhibitor

0.084 0.048 CID_131769951

CID_131769951
0.0430.3330.175Anticoagulant

0.175 0.064 CID_131769951

CID_131769951
0.0190.380.047Factor IXa inhibitor

0.047 0.041 CID_131769951

CID_131769951
0.0750.4560.295Immunomodulator

0.295 0.085 CID_131769951

CID_131769951
0.0850.4740.124CC chemokine 6 receptor antagonist

0.124 0.098 CID_131769951

CID_131769951
0.1060.5130.568Antiinflammatory

0.568 0.063 CID_131769951

CID_131769951
0.0720.5570.562Cyclophilin D inhibitor

0.562 0.035 CID_131769951

CID_131769951
Ext Pa Pi Pmax Activity Other Results ID Pa_max