Cells	Tissue of origin	Histology	AUC LOO CV*	Number of Synergistic Drug Pairs
BT-549	Breast	Carcinoma	0.713	110
HS_578T	Breast	Carcinosarcoma	0.774	113
SF-268	Brain	Glioblastoma	0.739	77
SF-539	Brain	Glioblastoma	0.723	164
SNB-75	Central nervous system	Glioblastoma	0.750	99
U251	Central nervous system	Glioblastoma	0.754	98
COLO 205	Colon	Adenocarcinoma	0.856	130
HCC-2998	Colon	Carcinoma	0.814	101
HCT-116	Colon	Carcinoma	0.727	107
HCT-15	Colon	Adenocarcinoma	0.826	84
HT29	Colon	Adenocarcinoma	0.781	108
KM12	Colon	Adenocarcinoma	0.768	73
SW-620	Colon	Adenocarcinoma	0.747	91
K-562	Erythroleukemia Haematopoietic and lymphoid tissue	Leukemia	0.799	165
RPMI-8226	Haematopoietic and lymphoid tissue	Myeloma	0.735	288
LOX IMVI	Melanoma	Malignant amelanotic melanoma	0.760	107
M14	Skin	Melanoma	0.757	105
MDA-MB-435	Breast	Melanoma	0.803	126
SK-MEL-5	Skin	Melanoma	0.726	191
UACC-257	Skin	Melanoma	0.767	92
UACC-62	Skin	Melanoma	0.701	117
EKVX	Lung	Carcinoma	0.741	81
NCI-H226	Lung	Carcinoma	0.741	78
H23	Lung	Carcinoma	0.703	119
H322M	Lung	Carcinoma	0.717	74
H522	Lung	Carcinoma	0.763	131
IGROV1	Ovarium	Cystoadenocarcinoma-pd	0.711	58
OVCAR-3	Ovarium	Adenocarcinoma	0.798	126
OVCAR-5	Ovarium	Adenocarcinoma	0.708	70
OVCAR-8	Ovarium	Adenocarcinoma	0.737	118
DU-145	Prostate	Carcinoma	0.731	142
PC-3	Prostate	Carcinoma	0.814	65
RXF 393	Renal	hypernephroma-pd	0.737	129
UO-31	Kidney	Carcinoma	0.713	75
Cells	Tissue of origin	Histology	AUC LOO CV*	Number of Synergistic Drug Pairs

AUC LOO CV* - the accuracy of prediction (AUC) calculated by leave-one-out compound out (excluded all drug pairs with any drug from the pair) cross validation.