Cells	Tissue of origin	Histology	Synergy model	Number of Synergistic Drug Pairs	AUC LOO CO CV*	Sens	Spec	Bal. Acc
786-0	Kidney	Adenocarcinoma	BLISS	146	0.704	0.708	0.711	0.710
786-0	Kidney	Adenocarcinoma	HSA	146	0.704	0.645	0.642	0.644
A498	Kidney	Adenocarcinoma	BLISS	140	0.782	0.664	0.665	0.664
A498	Kidney	Adenocarcinoma	HSA	120	0.864	0.671	0.671	0.671
A498	Kidney	Adenocarcinoma	LOEWE	48	0.864	0.758	0.761	0.760
A498	Kidney	Adenocarcinoma	ZIP	83	0.776	0.672	0.674	0.673
BT-549	Breast	Carcinoma	COMBOSCORE	140	0.763	0.692	0.694	0.693
BT-549	Breast	Carcinoma	HSA	160	0.735	0.679	0.680	0.680
BT-549	Breast	Carcinoma	ZIP	129	0.721	0.688	0.682	0.685
DU-145	Prostate	Carcinoma	COMBOSCORE	140	0.763	0.700	0.697	0.698
DU-145	Prostate	Carcinoma	HSA	148	0.711	0.723	0.720	0.722
HCC-2998	Colon	Carcinoma	BLISS	206	0.704	0.719	0.722	0.720
HCC-2998	Colon	Carcinoma	COMBOSCORE	115	0.776	0.675	0.675	0.675
HCC-2998	Colon	Carcinoma	HSA	106	0.810	0.729	0.734	0.731
HCC-2998	Colon	Carcinoma	ZIP	141	0.766	0.657	0.658	0.658
HCT116	Colon	Carcinoma	BLISS	198	0.702	0.713	0.711	0.712
HOP-92	Lung	Carcinoma	ZIP	44	0.739	0.680	0.682	0.681
HS 578T	Breast	Carcinosarcoma	COMBOSCORE	160	0.763	0.674	0.671	0.673
HT29	Colon	Adenocarcinoma	COMBOSCORE	104	0.743	0.702	0.701	0.702
HT29	Colon	Adenocarcinoma	HSA	188	0.732	0.667	0.676	0.672
HT29	Colon	Adenocarcinoma	ZIP	185	0.764	0.667	0.665	0.666
IGROV1	Ovarium	Cystoadenocarcinoma	COMBOSCORE	75	0.774	0.641	0.645	0.643
KM12	Colon	Adenocarcinoma	COMBOSCORE	67	0.763	0.694	0.692	0.693
LOX-IMVI	Skin	Malignant amelanotic melanoma	COMBOSCORE	77	0.738	0.683	0.685	0.684
M14	Skin	Melanotic melanoma	COMBOSCORE	124	0.802	0.676	0.678	0.677
M14	Skin	Melanotic melanoma	HSA	80	0.722	0.714	0.720	0.717
MALME-3M	Skin	Malignant melanotic melanoma	COMBOSCORE	108	0.708	0.681	0.683	0.682
MCF7	Breast	Adenocarcinoma	COMBOSCORE	77	0.729	0.702	0.699	0.700
MDA-MB-435	Skin	Melanoma	BLISS	242	0.754	0.705	0.705	0.705
MDA-MB-435	Skin	Melanoma	COMBOSCORE	122	0.815	0.651	0.649	0.650
MDA-MB-435	Skin	Melanoma	HSA	120	0.840	0.671	0.670	0.671
MDA-MB-435	Skin	Melanoma	LOEWE	37	0.717	0.792	0.787	0.790
MDA-MB-435	Skin	Melanoma	ZIP	137	0.765	0.676	0.673	0.674
MDA-MB-468	Breast	Adenocarcinoma	BLISS	206	0.700	0.724	0.725	0.725
MDA-MB-468	Breast	Adenocarcinoma	LOEWE	94	0.700	0.699	0.694	0.696
MDA-MB-468	Breast	Adenocarcinoma	ZIP	159	0.757	0.663	0.667	0.665
NCI-H23	Lung	Adenocarcinoma	BLISS	116	0.735	0.663	0.668	0.666
NCI-H23	Lung	Adenocarcinoma	COMBOSCORE	163	0.707	0.722	0.721	0.721
NCI-H23	Lung	Adenocarcinoma	HSA	79	0.801	0.716	0.718	0.717
NCI-H23	Lung	Adenocarcinoma	LOEWE	33	0.703	0.664	0.666	0.665
NCI-H23	Lung	Adenocarcinoma	ZIP	84	0.777	0.667	0.668	0.667
NCI-H322M	Lung	Carcinoma	COMBOSCORE	86	0.714	0.736	0.732	0.734
NCI-H460	Lung	Carcinoma	ZIP	238	0.704	0.710	0.714	0.712
NCI-H522	Lung	Adenocarcinoma	BLISS	159	0.793	0.706	0.710	0.708
NCI-H522	Lung	Adenocarcinoma	COMBOSCORE	149	0.804	0.695	0.692	0.694
NCI-H522	Lung	Adenocarcinoma	HSA	176	0.706	0.704	0.710	0.707
NCI-H522	Lung	Adenocarcinoma	ZIP	118	0.785	0.694	0.695	0.695
OVCAR-3	Ovarium	Adenocarcinoma	COMBOSCORE	140	0.767	0.657	0.659	0.658
OVCAR-3	Ovarium	Adenocarcinoma	HSA	138	0.703	0.660	0.660	0.660
OVCAR-3	Ovarium	Adenocarcinoma	ZIP	152	0.738	0.685	0.683	0.684
OVCAR-4	Ovarium	Adenocarcinoma	BLISS	47	0.781	0.667	0.670	0.668
OVCAR-4	Ovarium	Adenocarcinoma	COMBOSCORE	59	0.802	0.684	0.687	0.686
OVCAR-4	Ovarium	Adenocarcinoma	HSA	48	0.744	0.659	0.661	0.660
OVCAR-4	Ovarium	Adenocarcinoma	ZIP	21	0.785	0.694	0.695	0.695
OVCAR-5	Ovarium	Adenocarcinoma	COMBOSCORE	85	0.745	0.724	0.726	0.725
OVCAR-5	Ovarium	Adenocarcinoma	ZIP	74	0.768	0.738	0.734	0.736
OVCAR-8	Ovarium	Carcinoma	BLISS	182	0.724	0.674	0.674	0.674
OVCAR-8	Ovarium	Carcinoma	COMBOSCORE	97	0.789	0.710	0.707	0.708
OVCAR-8	Ovarium	Carcinoma	ZIP	130	0.737	0.758	0.762	0.760
PC-3	Prostate	Adenocarcinoma	COMBOSCORE	70	0.802	0.714	0.704	0.709
RXF-393	Kidney	Hypernephroma	BLISS	147	0.709	0.669	0.668	0.668
RXF-393	Kidney	Hypernephroma	COMBOSCORE	128	0.756	0.653	0.652	0.653
SF-268	Brain	Glioblastoma	COMBOSCORE	95	0.730	0.641	0.645	0.643
SF-268	Brain	Glioblastoma	ZIP	119	0.766	0.649	0.654	0.651
SF-295	Brain	Glioblastoma	COMBOSCORE	96	0.733	0.681	0.682	0.681
SF-539	Brain	Glial cell neoplasm	BLISS	143	0.764	0.730	0.729	0.729
SF-539	Brain	Glial cell neoplasm	COMBOSCORE	190	0.771	0.656	0.654	0.655
SF-539	Brain	Glial cell neoplasm	HSA	127	0.803	0.701	0.701	0.701
SK-MEL-2	Skin	Malignant melanotic melanoma	COMBOSCORE	125	0.726	0.734	0.740	0.737
SK-MEL-28	Skin	Malignant melanotic melanoma	BLISS	147	0.703	0.643	0.646	0.644
SK-MEL-28	Skin	Malignant melanotic melanoma	COMBOSCORE	71	0.720	0.697	0.683	0.690
SK-MEL-28	Skin	Malignant melanotic melanoma	ZIP	83	0.705	0.701	0.703	0.702
SK-MEL-5	Skin	Malignant melanotic melanoma	COMBOSCORE	186	0.720	0.702	0.708	0.705
SK-MEL-5	Skin	Malignant melanotic melanoma	HSA	93	0.783	0.677	0.680	0.679
SK-MEL-5	Skin	Malignant melanotic melanoma	LOEWE	36	0.721	0.670	0.666	0.668
SK-MEL-5	Skin	Malignant melanotic melanoma	ZIP	146	0.746	0.726	0.727	0.726
SK-OV-3	Ovarium	Adenocarcinoma	COMBOSCORE	71	0.764	0.717	0.718	0.718
SK-OV-3	Ovarium	Adenocarcinoma	HSA	106	0.730	0.707	0.706	0.707
SNB-19	Brain	Glioblastoma	BLISS	181	0.727	0.670	0.665	0.668
SNB-19	Brain	Glioblastoma	HSA	172	0.738	0.729	0.725	0.727
SNB-19	Brain	Glioblastoma	ZIP	148	0.803	0.675	0.671	0.673
SNB-75	Brain	Astrocytoma	BLISS	96	0.750	0.649	0.654	0.652
SNB-75	Brain	Astrocytoma	COMBOSCORE	104	0.718	0.738	0.736	0.737
SNB-75	Brain	Astrocytoma	ZIP	57	0.765	0.713	0.709	0.711
SR	Haematopoietic and lymphoid tissue	Lymphoma	LOEWE	39	0.713	0.692	0.693	0.693
SW-620	Colon	Carcinoma	BLISS	152	0.764	0.646	0.644	0.645
SW-620	Colon	Carcinoma	COMBOSCORE	58	0.798	0.648	0.648	0.648
SW-620	Colon	Carcinoma	HSA	93	0.774	0.700	0.697	0.698
SW-620	Colon	Carcinoma	LOEWE	28	0.750	0.705	0.697	0.701
SW-620	Colon	Carcinoma	ZIP	167	0.734	0.637	0.637	0.637
T-47D	Breast	Carcinoma	HSA	84	0.774	0.662	0.660	0.661
T-47D	Breast	Carcinoma	LOEWE	39	0.713	0.681	0.683	0.682
TK-10	Kidney	Carcinoma	BLISS	104	0.714	0.649	0.649	0.649
TK-10	Kidney	Carcinoma	HSA	100	0.729	0.658	0.656	0.657
TK-10	Kidney	Carcinoma	LOEWE	39	0.769	0.651	0.656	0.653
TK-10	Kidney	Carcinoma	ZIP	61	0.734	0.661	0.663	0.662
U251	Brain	Glioblastoma	COMBOSCORE	112	0.707	0.737	0.737	0.737
U251	Brain	Glioblastoma	HSA	91	0.739	0.658	0.656	0.657
UACC-257	Skin	Melanotic melanoma	COMBOSCORE	87	0.772	0.682	0.686	0.684
UACC-62	Skin	Melanotic melanoma	COMBOSCORE	135	0.701	0.674	0.674	0.674
UACC-62	Skin	Melanotic melanoma	HSA	118	0.719	0.707	0.705	0.706
UACC-62	Skin	Melanotic melanoma	ZIP	70	0.704	0.657	0.650	0.654
UO-31	Kidney	Carcinoma	COMBOSCORE	72	0.743	0.651	0.651	0.651
UO-31	Kidney	Carcinoma	LOEWE	83	0.702	0.646	0.647	0.647
Cells	Tissue of origin	Histology	Synergy model	Number of Synergistic Drug Pairs	AUC LOO CO CV*	Sens	Spec	Bal. Acc

AUC LOO CV* - the accuracy of prediction (AUC) calculated by leave-one-out compounds out (excluded all drug pairs with any drug from the pair) cross validation.