HGMMX

Metronidazole

Type: Approved drug
PubChem: 4173
DrugBank: DB00916
IUPAC: 2-(2-methyl-5-nitro-1-imidazolyl)ethanol
Standard InChI: InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
Standard InChIKey: VAOCPAMSLUNLGC-UHFFFAOYSA-N
SMILES: CC1=NC=C([N+](=O)[O-])N1CCO
Metabolism-related information: Correlating the systemic availability of metronidazole with the retardation of drug release the reduced bioavailability of the drug from some oral sustained release formulations has been attributed to the metabolic activity of the intestinal microflora. Probably increase its liver toxicity
Reference: 10.1016/0378-5173(93)90121-U

Metabolites

Chemical Structure Metablite's name Reaction name Genus Species Reference
N-(2-Hydroxyethyl)oxamic acidHydrolysisGut microbiotaGut microbiota10.1016/0378-5173(93)90121-U
AcetamideHydrolysisGut microbiotaGut microbiota10.1016/0378-5173(93)90121-U