Eupafolin

Representations & DB's id
ChEBI:	None
ChEMBL:	CHEMBL172350
PubChem:	5317284
IUPAC:	2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
Standard InChI:	InChI=1S/C16H12O7/c1-22-16-11(20)6-13-14(15(16)21)10(19)5-12(23-13)7-2-3-8(17)9(18)4-7/h2-6,17-18,20-21H,1H3
Standard InChI Key:	FHHSEFRSDKWJKJ-UHFFFAOYSA-N
SMILES:	COc1c(O)cc2c(c1O)c(=O)cc(o2)c1ccc(c(c1)O)O

Molecular propeties
AlogP:	2.29
Hydrogen bonds acceptors:	7
Hydrogen bonds donors:	4
Rotatable bonds:	2
Number of rings:	3
Molecular Weight:	316.06
Topological polar surface area:	116
Number of aromatic rings:	3
Fsp3:	0.062
Number of carbons:	16

Plant sources

Activity Type	Activity Value	Target Name	UniProt ID
IC50	48000 nM	Salivary alpha-amylase	P04745
Others	99.4 %	Salivary alpha-amylase	P04745
Potency	11220.2 nM	ATP-dependent DNA helicase Q1	P46063
Potency	8912.5 nM	ATP-dependent DNA helicase Q1	P46063
Potency	10000 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	6309.6 nM	DNA-(apurinic or apyrimidinic site) lyase	P27695
Potency	50118.7 nM	Thyroid hormone receptor beta-1	P10828
Potency	14125.4 nM	Microtubule-associated protein tau	P10636
Potency	5623.4 nM	Niemann-Pick C1 protein	O15118
Potency	44668.4 nM	Bloom syndrome protein	P54132
Potency	6309.6 nM	DNA polymerase beta	P06746
Potency	10000 nM	Lysosomal alpha-glucosidase	P10253
Potency	25118.9 nM	Beta-glucocerebrosidase	P04062
Potency	31622.8 nM	Lysine-specific demethylase 4A	O75164
Potency	50118.7 nM	Cellular tumor antigen p53	P04637
Potency	20587.8 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	50118.7 nM	Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8
Potency	12990 nM	ATPase family AAA domain-containing protein 5	Q96QE3
AC50	12728 nM	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q63470
Potency	8912.5 nM	Glutaminase kidney isoform, mitochondrial	O94925
Potency	19952.6 nM	Ataxin-2	Q99700
Potency	7943.3 nM	Glucagon-like peptide 1 receptor	P43220
Potency	25118.9 nM	Werner syndrome ATP-dependent helicase	Q14191