Phyto4Health

Gamolenic Acid

Representations & DB's id
ChEBI: CHEBI:28661
ChEMBL: CHEMBL464982
PubChem: 5280933
IUPAC: (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid
Standard InChI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12-
Standard InChI Key: VZCCETWTMQHEPK-QNEBEIHSSA-N
SMILES: CCCCC/C=CC/C=CC/C=CCCCCC(=O)O

Molecular propeties
AlogP: 5.66
Hydrogen bonds acceptors: 1
Hydrogen bonds donors: 1
Rotatable bonds: 13
Number of rings: 0
Molecular Weight: 278.22
Topological polar surface area: 37.3
Number of aromatic rings: 0
Fsp3: 0.611
Number of carbons: 18

Plant sources

Part of plant Plant name Ref.
PlantCannabis sativa
PlantCannabis sativa

In vitro data

Activity Type Activity Value Target Name UniProt ID Ref.
IC5030000 nMCoagulation factor IIIP13726
Potency35481.3 nMLethal(3)malignant brain tumor-like protein 1Q9Y468
Potency14125.4 nMHistone acetyltransferase GCN5Q92830
Potency35481.3 nMHistone-lysine N-methyltransferase, H3 lysine-9 specific 3Q96KQ7
Potency35481.3 nMGlutaminase kidney isoform, mitochondrialO94925
Potency35481.3 nMGlutaminase kidney isoform, mitochondrialO94925
Potency31622.8 nMGlucagon-like peptide 1 receptorP43220
Potency35481.3 nMWerner syndrome ATP-dependent helicaseQ14191
Others78 %Fatty acid synthaseP49327
Others41 %Fatty acid synthaseP49327
IC50270 nMPeroxisome proliferator-activated receptor alphaQ07869
IC50750 nMPeroxisome proliferator-activated receptor deltaQ03181
IC502200 nMPeroxisome proliferator-activated receptor gammaP37231
IC50270 nMPeroxisome proliferator-activated receptor alphaQ07869
EC504620 nMFree fatty acid receptor 1O14842