Progesterone

Representations & DB's id
ChEBI:	CHEBI:17026
ChEMBL:	CHEMBL103
PubChem:	5994
IUPAC:	(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Standard InChI:	InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
Standard InChI Key:	RJKFOVLPORLFTN-LEKSSAKUSA-N
SMILES:	O=C1CC[C@]2(C(=C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2C(=O)C)C)C

Molecular propeties
AlogP:	4.72
Hydrogen bonds acceptors:	2
Hydrogen bonds donors:	0
Rotatable bonds:	1
Number of rings:	4
Molecular Weight:	314.22
Topological polar surface area:	34.1
Number of aromatic rings:	0
Fsp3:	0.81
Number of carbons:	21

Plant sources

Part of plant	Plant name	Ref.
Semen	Linum usitatissimum

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID
Ki	8.5 nM	Androgen Receptor	P10275
Ki	30.5 nM	Glucocorticoid receptor	P04150
IC50	37 nM	Androgen Receptor	P10275
IC50	1000 nM	Glucocorticoid receptor	P04150
IC50	14 nM	Mineralocorticoid receptor	P08235
Ki	3.5 nM	Progesterone receptor	P06401
EC50	0.9 nM	Progesterone receptor	P06401
EC50	0.92 nM	Progesterone receptor	P06401
IC50	1000 nM	Glucocorticoid receptor	P04150
EC50	2.9 nM	Progesterone receptor	P06401
IC50	37 nM	Androgen Receptor	P10275
IC50	1000 nM	Glucocorticoid receptor	P04150
IC50	14 nM	Mineralocorticoid receptor	P08235
IC50	3.5 nM	Progesterone receptor	P06401
IC50	37 nM	Androgen Receptor	P10275
IC50	1000 nM	Glucocorticoid receptor	P04150
IC50	14 nM	Mineralocorticoid receptor	P08235
Ki	8.5 nM	Androgen Receptor	P10275
Ki	8.5 nM	Androgen Receptor	P10275
Ki	30.5 nM	Glucocorticoid receptor	P04150
EC50	2.89 nM	Progesterone receptor	P06401
Ki	3.5 nM	Progesterone receptor	P06401
IC50	5 nM	Progesterone receptor	P06401
EC50	1.5 nM	Progesterone receptor	P06401
Ki	3.8 nM	Progesterone receptor	P06401
EC50	2.9 nM	Progesterone receptor	P06401
Ki	30.5 nM	Glucocorticoid receptor	P04150
IC50	37 nM	Androgen Receptor	P10275
IC50	1000 nM	Glucocorticoid receptor	P04150
IC50	14 nM	Mineralocorticoid receptor	P08235
Kd	0.39 nM	Mineralocorticoid receptor	P08235
IC50	30 nM	Mineralocorticoid receptor	P08235
Ki	100000 nM	3-beta-hydroxysteroid-delta(8),delta(7)-isomerase	Q15125
IC50	1000 nM	Estrogen receptor alpha	P03372
IC50	1000 nM	Estrogen receptor alpha	P03372
IC50	1000000 nM	Estrogen receptor beta	Q92731
IC50	1000000 nM	Estrogen receptor beta	Q92731
Ki	3.467 nM	Progesterone receptor	P06401
IC50	48977.88 nM	P-glycoprotein 1	P08183
IC50	47863.01 nM	P-glycoprotein 1	P08183
IC50	20417379447 nM	P-glycoprotein 1	P08183
EC50	2770 nM	G-protein coupled bile acid receptor 1	Q8TDU6
IC50	200000 nM	Cytochrome P450 51	Q16850
Kd	114.82 nM	Testis-specific androgen-binding protein	P04278
IC50	125892.54 nM	ATP-binding cassette sub-family G member 2	Q9UNQ0
IC50	47863.01 nM	P-glycoprotein 1	P08183
Others	123 %	Canalicular multispecific organic anion transporter 1	Q92887
Others	55.7 %	Solute carrier family 22 member 1	O15245
EC50	0.9 nM	Progesterone receptor	P06401
EC50	0.5 nM	Progesterone receptor	P06401
EC50	2.2 nM	Progesterone receptor	P06401
Ki	3.4 nM	Progesterone receptor	P06401
Others	34 %	P-glycoprotein 1	P08183
Others	30 %	P-glycoprotein 1	P08183
EC50	0.1 nM	Progesterone receptor	P06401
Others	7.3 %	3-keto-steroid reductase	P56937
Others	19.1 %	3-keto-steroid reductase	P56937
Others	25 %	P-glycoprotein 1	P08183
Ki	5.1 nM	Progesterone receptor	P06401
Ki	35 nM	Androgen Receptor	P10275
IC50	10000 nM	Progesterone receptor	P06401
EC50	15.2 nM	Progesterone receptor	P06401
Potency	6309.6 nM	Prelamin-A/C	P02545
Potency	10000 nM	Prelamin-A/C	P02545
Potency	35481.3 nM	Prelamin-A/C	P02545
Potency	39810.7 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	115820.8 nM	Ras-related protein Rab-9A	P51151
Potency	14125.4 nM	Survival motor neuron protein	Q16637
Potency	15848.9 nM	Survival motor neuron protein	Q16637
Potency	1995.3 nM	Survival motor neuron protein	Q16637
Potency	25118.9 nM	Thyroid stimulating hormone receptor	P16473
Potency	10000 nM	Thyroid stimulating hormone receptor	P16473
Potency	39810.7 nM	Microtubule-associated protein tau	P10636
Potency	12589.3 nM	Hypoxia-inducible factor 1 alpha	Q16665
Potency	25118.9 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	28183.8 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	11220.2 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	84921.4 nM	Peripheral myelin protein 22	Q01453
Potency	35481.3 nM	Prelamin-A/C	P02545
Potency	12589.3 nM	Hypoxia-inducible factor 1 alpha	Q16665
Potency	39810.7 nM	MAP kinase ERK2	P28482
Potency	25118.9 nM	Thyroid stimulating hormone receptor	P16473
Potency	14125.4 nM	MAP kinase ERK2	P28482
Potency	10000 nM	Thyroid stimulating hormone receptor	P16473
Potency	10000 nM	Thrombopoietin	P40225
Potency	10000 nM	Neuropeptide S receptor	Q6W5P4
Potency	3981.1 nM	Cytochrome P450 3A4	P08684
Potency	3981.1 nM	Cytochrome P450 3A4	P08684
Potency	3981.1 nM	Cytochrome P450 3A4	P08684
Potency	10000 nM	Thrombopoietin	P40225
Potency	3981.1 nM	Cytochrome P450 3A4	P08684
Potency	10318.3 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	23109.3 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	14125.4 nM	Dopamine D1 receptor	P21728
Potency	1258.9 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	20596.2 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	35481.3 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	25918.5 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Others	0 pm/min/mg	UDP-glucuronosyltransferase 2B17	O75795
Others	0 pm/min/mg	UDP-glucuronosyltransferase 2B17	O75795
Potency	37578 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	37578 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	30637.9 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	39810.7 nM	Ataxin-2	Q99700
Potency	25118.9 nM	Glucagon-like peptide 1 receptor	P43220
Potency	39810.7 nM	Ataxin-2	Q99700
Potency	74978 nM	Interleukin-8	P10145
Potency	8412.7 nM	Nuclear receptor ROR-gamma	P51449
Potency	21131.7 nM	Nuclear receptor ROR-gamma	P51449
Others	-362.6 %	Solute carrier organic anion transporter family member 2B1	O94956
Others	33.4 %	Solute carrier organic anion transporter family member 1B3	Q9NPD5
Others	63.9 %	Solute carrier organic anion transporter family member 1B1	Q9Y6L6
EC50	2 nM	Progesterone receptor	P06401

Progesterone

Representations & DB's id

Molecular propeties

Plant sources

In vitro data