Phyto4Health

Hydroxyprogesterone

Representations & DB's id
ChEBI: CHEBI:17252
ChEMBL: CHEMBL1062
PubChem: 6238
IUPAC: (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Standard InChI: InChI=1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
Standard InChI Key: DBPWSSGDRRHUNT-CEGNMAFCSA-N
SMILES: O=C1CC[C@]2(C(=C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@]2(O)C(=O)C)C)C

Molecular propeties
AlogP: 3.84
Hydrogen bonds acceptors: 3
Hydrogen bonds donors: 1
Rotatable bonds: 1
Number of rings: 4
Molecular Weight: 330.22
Topological polar surface area: 54.4
Number of aromatic rings: 0
Fsp3: 0.81
Number of carbons: 21

Plant sources

Part of plant Plant name Ref.
SemenLinum usitatissimum

In vitro data

Activity Type Activity Value Target Name UniProt ID Ref.
Kd100 nMTestis-specific androgen-binding proteinP04278
Others20.8 %3-keto-steroid reductaseP56937
Potency5623.4 nMPrelamin-A/CP02545
Potency25118.9 nMPrelamin-A/CP02545
Potency2238.7 nMSurvival motor neuron proteinQ16637
Potency12589.3 nMMicrotubule-associated protein tauP10636
Potency12589.3 nMMicrotubule-associated protein tauP10636
Potency5011.9 nMBloom syndrome proteinP54132
Potency5011.9 nMBloom syndrome proteinP54132
Potency12995.3 nMNuclear factor erythroid 2-related factor 2Q16236
Potency35481.3 nMHistone acetyltransferase GCN5Q92830
Potency37.7 nMHistone-lysine N-methyltransferase, H3 lysine-9 specific 3Q96KQ7
Others0 pm/min/mgUDP-glucuronosyltransferase 1-10Q9HAW8
Others0 pm/min/mgUDP-glucuronosyltransferase 1-7Q9HAW7
Others0 pm/min/mgUDP-glucuronosyltransferase 1-10Q9HAW8
Others0 pm/min/mgUDP-glucuronosyltransferase 1-8Q9HAW9
Others0 pm/min/mgUDP-glucuronosyltransferase 2B7P16662
Others0 pm/min/mgUDP-glucuronosyltransferase 2B17O75795
Others0 pm/min/mgUDP-glucuronosyltransferase 2B17O75795
Potency68589.6 nMNuclear factor erythroid 2-related factor 2Q16236
Potency517.4 nMGemininO75496