1,2,9,10-Tetramethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline

Representations & DB's id
ChEBI:	None
ChEMBL:	CHEMBL36536
PubChem:	10145
IUPAC:	1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Standard InChI:	InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3
Standard InChI Key:	RUZIUYOSRDWYQF-UHFFFAOYSA-N
SMILES:	COc1cc2c(cc1OC)CC1c3c2c(OC)c(OC)cc3CCN1C

Molecular propeties
AlogP:	3.47
Hydrogen bonds acceptors:	5
Hydrogen bonds donors:	0
Rotatable bonds:	4
Number of rings:	4
Molecular Weight:	355.18
Topological polar surface area:	40.2
Number of aromatic rings:	2
Fsp3:	0.429
Number of carbons:	21

Plant sources

Part of plant	Plant name	Ref.
Plant	Papaver somniferum

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID	Ref.
Potency	25118.9 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	28183.8 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	14125.4 nM	Microtubule-associated protein tau	P10636
Potency	39810.7 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	39810.7 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
IC50	5000 nM	Sentrin-specific protease 8	Q96LD8
IC50	5470 nM	Sentrin-specific protease 8	Q96LD8
IC50	4630 nM	Sentrin-specific protease 7	Q9BQF6
IC50	1860 nM	Sentrin-specific protease 6	Q9GZR1
Potency	8199.5 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	1032.3 nM	Geminin	O75496