Phyto4Health

Tyramine

Representations & DB's id
ChEBI: CHEBI:15760
ChEMBL: CHEMBL11608
PubChem: 5610
IUPAC: 4-(2-aminoethyl)phenol
Standard InChI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
Standard InChI Key: DZGWFCGJZKJUFP-UHFFFAOYSA-N
SMILES: NCCc1ccc(cc1)O

Molecular propeties
AlogP: 0.89
Hydrogen bonds acceptors: 2
Hydrogen bonds donors: 2
Rotatable bonds: 2
Number of rings: 1
Molecular Weight: 137.08
Topological polar surface area: 46.2
Number of aromatic rings: 1
Fsp3: 0.25
Number of carbons: 8

Plant sources

Part of plant Plant name Ref.
ImmaturusCitrus unshiu
SeedSilybum marianum
PlantSilybum marianum
SeedSilybum marianum
PlantSilybum marianum
PlantChelidonium majus
Sprout SeedlingHordeum vulgare

In vitro data

Activity Type Activity Value Target Name UniProt ID Ref.
Ki17000 nMDopamine D2 receptorP14416
Others23 %TyrosinaseP14679
EC50731 nMTrace amine-associated receptor 1Q96RJ0
Potency35481.3 nMLysine-specific demethylase 4D-likeB2RXH2
Potency39810.7 nMCytochrome P450 2C19P33261
Potency39810.7 nMAldehyde dehydrogenase 1A1P00352
Potency12589.3 nMLethal(3)malignant brain tumor-like protein 1Q9Y468
Potency751.9 nMHistone-lysine N-methyltransferase, H3 lysine-9 specific 3Q96KQ7
Potency6513.1 nMGemininO75496
Potency10000 nMGlutaminase kidney isoform, mitochondrialO94925
Potency7943.3 nMGlutaminase kidney isoform, mitochondrialO94925
Potency8199.5 nMDopamine D1 receptorP21728