Daidzein

Representations & DB's id
ChEBI:	CHEBI:28197
ChEMBL:	CHEMBL8145
PubChem:	5281708
IUPAC:	7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one
Standard InChI:	InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
Standard InChI Key:	ZQSIJRDFPHDXIC-UHFFFAOYSA-N
SMILES:	Oc1ccc(cc1)c1coc2c(c1=O)ccc(c2)O

Molecular propeties
AlogP:	2.87
Hydrogen bonds acceptors:	4
Hydrogen bonds donors:	2
Rotatable bonds:	1
Number of rings:	3
Molecular Weight:	254.06
Topological polar surface area:	66.8
Number of aromatic rings:	3
Fsp3:	0
Number of carbons:	15

Plant sources

Part of plant	Plant name	Ref.
Plant	Trigonella foenum-graecum
Plant	Glycyrrhiza uralensis

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID
IC50	1000000 nM	Estrogen receptor alpha	P03372
IC50	1000000 nM	Estrogen receptor alpha	P03372
IC50	2800 nM	Estrogen receptor beta	Q92731
IC50	2800 nM	Estrogen receptor beta	Q92731
IC50	1200 nM	Estrogen receptor beta	Q92731
IC50	17000 nM	Estrogen receptor alpha	P03372
IC50	100 ug/ml	Epidermal growth factor receptor erbB1	P00533
Others	23.3 %	Salivary alpha-amylase	P04745
Others	35 %	Estradiol 17-beta-dehydrogenase 1	P14061
Others	58.3 %	Estradiol 17-beta-dehydrogenase 2	P37059
Ki	100000 nM	Cytochrome P450 19A1	P11511
Others	1.2	Peroxisome proliferator-activated receptor gamma	P37231
Others	9.6	Peroxisome proliferator-activated receptor gamma	P37231
Others	6.2	Peroxisome proliferator-activated receptor alpha	Q07869
Others	13.4	Peroxisome proliferator-activated receptor alpha	Q07869
Others	108.5 %	Estrogen receptor alpha	P03372
Others	17.2 %	Estrogen receptor alpha	P03372
Potency	5 nM	Prelamin-A/C	P02545
Potency	4466.8 nM	Nuclear factor NF-kappa-B p105 subunit	P19838
Potency	31622.8 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	35481.3 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	28183.8 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	31622.8 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	25118.9 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	19952.6 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	10000 nM	Ras-related protein Rab-9A	P51151
Potency	15848.9 nM	Survival motor neuron protein	Q16637
Potency	28183.8 nM	Survival motor neuron protein	Q16637
Potency	12589.3 nM	Survival motor neuron protein	Q16637
Potency	28183.8 nM	Survival motor neuron protein	Q16637
Potency	354.8 nM	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8
Potency	10000 nM	Cytochrome P450 2C19	P33261
Potency	7079.5 nM	Microtubule-associated protein tau	P10636
Potency	39810.7 nM	Microtubule-associated protein tau	P10636
Potency	39810.7 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	28183.8 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	39810.7 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	37650.5 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	35481.3 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	25118.9 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	35481.3 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	47754.8 nM	Peripheral myelin protein 22	Q01453
Potency	25118.9 nM	Pyruvate kinase isozymes M1/M2	P14618
Potency	25118.9 nM	Pyruvate kinase isozymes M1/M2	P14618
Potency	4466.8 nM	Nuclear factor NF-kappa-B p105 subunit	P19838
Potency	9200 nM	Niemann-Pick C1 protein	O15118
Potency	501.2 nM	Bloom syndrome protein	P54132
Potency	35481.3 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	31622.8 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	25118.9 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	14125.4 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	2511.9 nM	Thrombopoietin	P40225
Potency	12589.3 nM	Cellular tumor antigen p53	P04637
Potency	10000 nM	Cellular tumor antigen p53	P04637
Potency	10000 nM	Cellular tumor antigen p53	P04637
Potency	31622.8 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	39810.7 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	31622.8 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	501.2 nM	Bloom syndrome protein	P54132
Potency	15848.9 nM	Cytochrome P450 3A4	P08684
Potency	15848.9 nM	Cytochrome P450 2D6	P10635
Potency	25118.9 nM	Cytochrome P450 3A4	P08684
Potency	6309.6 nM	Cytochrome P450 2C9	P11712
Potency	15848.9 nM	Cytochrome P450 3A4	P08684
Potency	2511.9 nM	Thrombopoietin	P40225
Potency	25118.9 nM	Cytochrome P450 3A4	P08684
Potency	20587.8 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	18356.4 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	50118.7 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	9196.2 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	410.9 nM	Geminin	O75496
Potency	15848.9 nM	Aryl hydrocarbon receptor	P35869
Potency	6309.6 nM	Aryl hydrocarbon receptor	P35869
IC50	91260 nM	Rac GTPase-activating protein 1	Q9H0H5
Potency	42163.2 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	27306 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	1188.3 nM	Nuclear receptor ROR-gamma	P51449
Others	32 %	Solute carrier organic anion transporter family member 2B1	O94956
Others	0.7 %	Solute carrier organic anion transporter family member 1B3	Q9NPD5
Others	35 %	Solute carrier organic anion transporter family member 1B1	Q9Y6L6
Others	11	Peroxisome proliferator-activated receptor delta	Q03181
Others	6.7	Peroxisome proliferator-activated receptor delta	Q03181
Others	0.5 nmol/mg.min	UDP-glucuronosyltransferase 1-9	O60656
Others	0.5 nmol/mg.min	UDP-glucuronosyltransferase 1-10	Q9HAW8
Others	392 %	UDP-glucuronosyltransferase 1-1	P22309
IC50	120000 nM	UDP-glucuronosyltransferase 1-1	P22309
IC50	7300 nM	UDP-glucuronosyltransferase 1-1	P22309
Ki	10000 nM	Carbonic anhydrase I	P00915
Ki	10000 nM	Carbonic anhydrase II	P00918
Ki	718.7 nM	Carbonic anhydrase IV	P22748
Ki	4.2 nM	Carbonic anhydrase VII	P43166
Ki	56.4 nM	Carbonic anhydrase XII	O43570
IC50	161800 nM	Aldose reductase	P15121
IC50	32200 nM	Aldo-keto reductase family 1 member B10	O60218

Daidzein

Representations & DB's id

Molecular propeties

Plant sources

In vitro data