Formononetin

Representations & DB's id
ChEBI:	CHEBI:18088
ChEMBL:	CHEMBL242341
PubChem:	5280378
IUPAC:	7-hydroxy-3-(4-methoxyphenyl)chromen-4-one
Standard InChI:	InChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3
Standard InChI Key:	HKQYGTCOTHHOMP-UHFFFAOYSA-N
SMILES:	COc1ccc(cc1)c1coc2c(c1=O)ccc(c2)O

Molecular propeties
AlogP:	3.17
Hydrogen bonds acceptors:	4
Hydrogen bonds donors:	1
Rotatable bonds:	2
Number of rings:	3
Molecular Weight:	268.07
Topological polar surface area:	55.8
Number of aromatic rings:	3
Fsp3:	0.062
Number of carbons:	16

Plant sources

Part of plant	Plant name	Ref.
Plant	Trigonella foenum-graecum
Root	Glycyrrhiza glabra
Root	Glycyrrhiza glabra
Shoot	Glycyrrhiza uralensis
Root	Glycyrrhiza uralensis
Sprout Seedling	Glycyrrhiza uralensis
Shoot	Glycyrrhiza uralensis
Root	Glycyrrhiza uralensis
Sprout Seedling	Glycyrrhiza uralensis
Root	Ononis spinosa

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID
IC50	100000 nM	Cytochrome P450 1A1	P04798
Others	25 %	Sodium/glucose cotransporter 1	P13866
Others	75.4 %	Sodium/glucose cotransporter 2	P31639
Others	4.6	Peroxisome proliferator-activated receptor gamma	P37231
Others	12.8	Peroxisome proliferator-activated receptor gamma	P37231
Others	7.5	Peroxisome proliferator-activated receptor alpha	Q07869
Others	7.8	Peroxisome proliferator-activated receptor alpha	Q07869
Potency	39810.7 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	31622.8 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	31622.8 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	28183.8 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	11220.2 nM	Survival motor neuron protein	Q16637
Potency	7943.3 nM	Cytochrome P450 2C19	P33261
Potency	5011.9 nM	Microtubule-associated protein tau	P10636
Potency	39810.7 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	35481.3 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	25118.9 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	3981.1 nM	Cellular tumor antigen p53	P04637
Potency	39810.7 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	15848.9 nM	Cellular tumor antigen p53	P04637
Potency	15848.9 nM	Cellular tumor antigen p53	P04637
Potency	1584.9 nM	Cellular tumor antigen p53	P04637
Potency	15848.9 nM	Cytochrome P450 3A4	P08684
Potency	10000 nM	Cytochrome P450 2D6	P10635
Potency	10 nM	Cytochrome P450 2C9	P11712
Potency	15848.9 nM	Cytochrome P450 3A4	P08684
Potency	16360.1 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	31622.8 nM	Glutaminase kidney isoform, mitochondrial	O94925
Potency	2238.7 nM	Breast cancer type 1 susceptibility protein	P38398
Others	12.2	Peroxisome proliferator-activated receptor delta	Q03181
Others	7.4	Peroxisome proliferator-activated receptor delta	Q03181
Kd	5470 nM	Interleukin-2	P60568

Formononetin

Representations & DB's id

Molecular propeties

Plant sources

In vitro data