5-Hydroxyflavone

Representations & DB's id
ChEBI:	None
ChEMBL:	CHEMBL16807
PubChem:	68112
IUPAC:	5-hydroxy-2-phenylchromen-4-one
Standard InChI:	InChI=1S/C15H10O3/c16-11-7-4-8-13-15(11)12(17)9-14(18-13)10-5-2-1-3-6-10/h1-9,16H
Standard InChI Key:	IYBLVRRCNVHZQJ-UHFFFAOYSA-N
SMILES:	Oc1cccc2c1c(=O)cc(o2)c1ccccc1

Molecular propeties
AlogP:	3.17
Hydrogen bonds acceptors:	3
Hydrogen bonds donors:	1
Rotatable bonds:	1
Number of rings:	3
Molecular Weight:	238.06
Topological polar surface area:	46.5
Number of aromatic rings:	3
Fsp3:	0
Number of carbons:	15

Plant sources

Part of plant	Plant name	Ref.
Plant	Chamaemelum nobile

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID	Ref.
Others	50 %	DNA topoisomerase II alpha	P11388
IC50	300 nM	Androgen Receptor	P10275
IC50	1000000 nM	Sialidase 2	Q9Y3R4
Potency	31622.8 nM	Survival motor neuron protein	Q16637
Potency	39810.7 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	19952.6 nM	Arachidonate 15-lipoxygenase	P16050
Potency	15848.9 nM	Microtubule-associated protein tau	P10636
Potency	6309.6 nM	Cytochrome P450 3A4	P08684
Potency	19952.6 nM	Cytochrome P450 3A4	P08684
Potency	6309.6 nM	Cytochrome P450 3A4	P08684
Potency	19952.6 nM	Cytochrome P450 3A4	P08684
Potency	11220.2 nM	Beta-glucocerebrosidase	P04062
Potency	2310.9 nM	Geminin	O75496
Potency	35481.3 nM	Nuclear factor erythroid 2-related factor 2	Q16236
IC50	310 nM	Cytochrome P450 1A2	P05177
IC50	4030 nM	Cytochrome P450 1A1	P04798
IC50	831.76 nM	Androgen Receptor	P10275
IC50	840 nM	Androgen Receptor	P10275