Flavone

Representations & DB's id
ChEBI:	CHEBI:42491
ChEMBL:	CHEMBL275638
PubChem:	10680
IUPAC:	2-phenylchromen-4-one
Standard InChI:	InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H
Standard InChI Key:	VHBFFQKBGNRLFZ-UHFFFAOYSA-N
SMILES:	O=c1cc(oc2c1cccc2)c1ccccc1

Molecular propeties
AlogP:	3.46
Hydrogen bonds acceptors:	2
Hydrogen bonds donors:	0
Rotatable bonds:	1
Number of rings:	3
Molecular Weight:	222.07
Topological polar surface area:	26.3
Number of aromatic rings:	3
Fsp3:	0
Number of carbons:	15

Plant sources

Part of plant	Plant name	Ref.
Plant	Chamaemelum nobile

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID
Ki	16900 nM	Adenosine A3 receptor	P0DMS8
IC50	10000 nM	DNA-dependent protein kinase	P78527
IC50	50 ug/ml	Epidermal growth factor receptor erbB1	P00533
Others	94 %	Estradiol 17-beta-dehydrogenase 1	P14061
Others	63.9 %	Estradiol 17-beta-dehydrogenase 2	P37059
IC50	5900 nM	Androgen Receptor	P10275
IC50	5900 nM	Androgen Receptor	P10275
Others	6.5	Androgen Receptor	P10275
Others	40 %	Monoamine oxidase A	P21397
IC50	8 nM	Cytochrome P450 19A1	P11511
Others	16 %	11-beta-hydroxysteroid dehydrogenase 1	P28845
Potency	3162.3 nM	Ras-related protein Rab-9A	P51151
Potency	14125.4 nM	Survival motor neuron protein	Q16637
Potency	5623.4 nM	Niemann-Pick C1 protein	O15118
Potency	8912.5 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	5 nM	Cellular tumor antigen p53	P04637
Potency	12589.3 nM	Cytochrome P450 3A4	P08684
Potency	12589.3 nM	Cytochrome P450 3A4	P08684
IC50	102280 nM	Calmodulin	P62158
Others	0.34	Calmodulin	P62158
Potency	20587.8 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	14575 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Ki	1890 nM	Carbonic anhydrase I	P00915
Ki	1880 nM	Carbonic anhydrase I	P00915
Ki	8710 nM	Carbonic anhydrase II	P00918
Ki	8800 nM	Carbonic anhydrase II	P00918
Ki	4130 nM	Carbonic anhydrase IX	Q16790
Ki	4220 nM	Carbonic anhydrase IX	Q16790
Ki	7220 nM	Carbonic anhydrase XII	O43570
Ki	7330 nM	Carbonic anhydrase XII	O43570
Potency	103.2 nM	Geminin	O75496
Potency	50118.7 nM	Aryl hydrocarbon receptor	P35869
Potency	44668.4 nM	Aryl hydrocarbon receptor	P35869
Potency	4609 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	5448.3 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	730.8 nM	Geminin	O75496
Potency	12589.3 nM	Glucagon-like peptide 1 receptor	P43220
Potency	74978 nM	Interleukin-8	P10145
Potency	31622.8 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	1496 nM	Nuclear receptor ROR-gamma	P51449
Potency	19952.6 nM	Glucagon-like peptide 1 receptor	P43220
IC50	1380.38 nM	Poly [ADP-ribose] polymerase-1	P09874
IC50	1400 nM	Poly [ADP-ribose] polymerase-1	P09874
IC50	147.91 nM	Tankyrase-2	Q9H2K2
IC50	140 nM	Tankyrase-2	Q9H2K2
IC50	323.59 nM	Tankyrase-1	O95271
IC50	320 nM	Tankyrase-1	O95271
IC50	323.59 nM	Tankyrase-1	O95271
IC50	330 nM	Tankyrase-1	O95271
Others	50 %	Arachidonate 5-lipoxygenase	P09917
IC50	10000 nM	Cytochrome P450 19A1	P11511
IC50	8000 nM	Cytochrome P450 19A1	P11511

Flavone

Representations & DB's id

Molecular propeties

Plant sources

In vitro data