Phyto4Health

Honokiol

Representations & DB's id
ChEBI: CHEBI:5759
ChEMBL: CHEMBL16901
PubChem: 72303
IUPAC: 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
Standard InChI: InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
Standard InChI Key: FVYXIJYOAGAUQK-UHFFFAOYSA-N
SMILES: C=CCc1ccc(c(c1)c1ccc(c(c1)CC=C)O)O

Molecular propeties
AlogP: 4.22
Hydrogen bonds acceptors: 2
Hydrogen bonds donors: 2
Rotatable bonds: 5
Number of rings: 2
Molecular Weight: 266.13
Topological polar surface area: 40.5
Number of aromatic rings: 2
Fsp3: 0.111
Number of carbons: 18

Plant sources

Part of plant Plant name Ref.
RhizomaRheum palmatum

In vitro data

Activity Type Activity Value Target Name UniProt ID Ref.
Others94 %Arachidonate 5-lipoxygenaseP09917
IC504200 nMArachidonate 5-lipoxygenaseP09917
EC5011800 nMRetinoid X receptor alphaP19793
Potency35481.3 nMDNA polymerase betaP06746
Potency35481.3 nMLysosomal alpha-glucosidaseP10253
Potency63095.7 nMLysine-specific demethylase 4AO75164
Potency29092.9 nMGemininO75496
Potency206 nMGemininO75496
Potency28183.8 nMAtaxin-2Q99700
Potency14125.4 nMGlucagon-like peptide 1 receptorP43220
Others42 %G-protein coupled receptor 55Q9Y2T6
EC5010000 nMCannabinoid CB1 receptorP21554
Ki5610 nMCannabinoid CB2 receptorP34972
Ki6460 nMCannabinoid CB1 receptorP21554
ED5011.8 nMRetinoid X receptor alphaP19793
Ki5.61 nMCannabinoid CB2 receptorP34972
Ki6.46 nMCannabinoid CB1 receptorP21554