Resveratrol

Representations & DB's id
ChEBI:	CHEBI:45713
ChEMBL:	CHEMBL165
PubChem:	445154
IUPAC:	5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
Standard InChI:	InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
Standard InChI Key:	LUKBXSAWLPMMSZ-OWOJBTEDSA-N
SMILES:	Oc1ccc(cc1)/C=C/c1cc(O)cc(c1)O

Molecular propeties
AlogP:	2.97
Hydrogen bonds acceptors:	3
Hydrogen bonds donors:	3
Rotatable bonds:	2
Number of rings:	2
Molecular Weight:	228.08
Topological polar surface area:	60.7
Number of aromatic rings:	2
Fsp3:	0
Number of carbons:	14

Plant sources

Part of plant	Plant name	Ref.
Fruit Juice	Vitis vinifera
Fruit	Vitis vinifera
Leaf	Vitis vinifera
Shoot	Vitis vinifera
Plant	Panax ginseng
Plant	Arachis hypogaea
Plant	Lavandula vera
Plant	Rheum palmatum
Plant	Humulus lupulus
Fruit Juice	Vitis vinifera
Fruit	Vitis vinifera
Leaf	Vitis vinifera
Shoot	Vitis vinifera

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID
Ki	785 nM	Estrogen receptor alpha	P03372
IC50	195500 nM	Cyclooxygenase-1	P23219
IC50	60000 nM	P-glycoprotein 1	P08183
AC50	100000 nM	P-glycoprotein 1	P08183
IC50	28000 nM	Bcr/Abl fusion protein	P11274
AC50	100000 nM	Bcr/Abl fusion protein	P11274
IC50	2840 nM	Cyclooxygenase-1	P23219
IC50	33150 nM	Cyclooxygenase-2	P35354
IC50	996 nM	Cyclooxygenase-2	P35354
IC50	4120 nM	Cyclooxygenase-1	P23219
IC50	34610 nM	Cyclooxygenase-2	P35354
EC50	46200 nM	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	201 %	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	1.8	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	1.7	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	1.9	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	1.3	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	1.3	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	1.1	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	1.2	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	1.2	NAD-dependent deacetylase sirtuin 1	Q96EB6
IC50	40 ug/ml	Cytochrome P450 19A1	P11511
IC50	960 nM	Quinone reductase 2	P16083
Others	75 %	Canalicular multispecific organic anion transporter 1	Q92887
Others	0.048 nM	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	250 %	NAD-dependent deacetylase sirtuin 1	Q96EB6
IC50	19000 nM	Ornithine decarboxylase	P11926
IC50	212000 nM	Leukotriene A4 hydrolase	P09960
IC50	366000 nM	Leukotriene A4 hydrolase	P09960
IC50	450 nM	Quinone reductase 2	P16083
IC50	450 nM	Quinone reductase 2	P16083
IC50	190000 nM	Apoptosis regulator Bcl-X	Q07817
IC50	750 nM	Cyclooxygenase-2	P35354
Others	72.2 %	Cyclooxygenase-2	P35354
Ki	2210 nM	Carbonic anhydrase I	P00915
Ki	2770 nM	Carbonic anhydrase II	P00918
Ki	9090 nM	Carbonic anhydrase III	P07451
Ki	4470 nM	Carbonic anhydrase IV	P22748
Ki	4750 nM	Carbonic anhydrase VA	P35218
Ki	4640 nM	Carbonic anhydrase VB	Q9Y2D0
Ki	8070 nM	Carbonic anhydrase VI	P23280
Ki	4350 nM	Carbonic anhydrase VII	P43166
Ki	810 nM	Carbonic anhydrase IX	Q16790
Ki	950 nM	Carbonic anhydrase XII	O43570
Ki	4090 nM	Carbonic anhydrase XIII	Q8N1Q1
Ki	830 nM	Carbonic anhydrase XIV	Q9ULX7
Potency	5 nM	Prelamin-A/C	P02545
Potency	35481.3 nM	Prelamin-A/C	P02545
Potency	31622.8 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	39810.7 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	39810.7 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	22387.2 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	31622.8 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	25118.9 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	3981.1 nM	Ras-related protein Rab-9A	P51151
Potency	14125.4 nM	Survival motor neuron protein	Q16637
Potency	29092.9 nM	Ras-related protein Rab-9A	P51151
Potency	12589.3 nM	Survival motor neuron protein	Q16637
Potency	8912.5 nM	Survival motor neuron protein	Q16637
Potency	35481.3 nM	Survival motor neuron protein	Q16637
Potency	3689.8 nM	Serine/threonine-protein kinase mTOR	P42345
Potency	112201.8 nM	Thyroid hormone receptor beta-1	P10828
Potency	7079.5 nM	Microtubule-associated protein tau	P10636
Potency	8912.5 nM	Microtubule-associated protein tau	P10636
Potency	5623.4 nM	Microtubule-associated protein tau	P10636
Potency	17782.8 nM	Microtubule-associated protein tau	P10636
Potency	10000 nM	Microtubule-associated protein tau	P10636
Potency	10000 nM	Hypoxia-inducible factor 1 alpha	Q16665
Potency	35481.3 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	39810.7 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	39810.7 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	22387.2 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	31622.8 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	42561.5 nM	Peripheral myelin protein 22	Q01453
Potency	12589.3 nM	Prelamin-A/C	P02545
Potency	7079.5 nM	Microtubule-associated protein tau	P10636
Potency	22387.2 nM	Microtubule-associated protein tau	P10636
Potency	10000 nM	Hypoxia-inducible factor 1 alpha	Q16665
Potency	18492.7 nM	Serine/threonine-protein kinase mTOR	P42345
Potency	5623.4 nM	Niemann-Pick C1 protein	O15118
Potency	18356.4 nM	Niemann-Pick C1 protein	O15118
Potency	50118.7 nM	Bloom syndrome protein	P54132
Potency	25118.9 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	31622.8 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	14125.4 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	10000 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	25118.9 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	6309.6 nM	Cellular tumor antigen p53	P04637
Potency	2238.7 nM	Huntingtin	P42858
Potency	10000 nM	Cellular tumor antigen p53	P04637
Potency	10000 nM	Cellular tumor antigen p53	P04637
Potency	31622.8 nM	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714
Potency	44668.4 nM	DNA polymerase beta	P06746
Potency	50118.7 nM	Bloom syndrome protein	P54132
Potency	39506.8 nM	Lysosomal alpha-glucosidase	P10253
Potency	3981.1 nM	Cytochrome P450 3A4	P08684
Potency	3981.1 nM	Cytochrome P450 3A4	P08684
IC50	59642 nM	Cathepsin L	P07711
Potency	3981.1 nM	Cytochrome P450 3A4	P08684
Potency	3981.1 nM	Cytochrome P450 3A4	P08684
Others	27 %	Estrogen receptor beta	Q92731
IC50	960 nM	Quinone reductase 2	P16083
Potency	2908.1 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	5804.8 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	50118.7 nM	Cellular tumor antigen p53	P04637
Potency	158.5 nM	M-phase phosphoprotein 8	Q99549
Potency	14581 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	7943.3 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	0.04228 nM	Chromobox protein homolog 1	P83916
Potency	19952.6 nM	Arachidonate 15-lipoxygenase, type II	O15296
Potency	4109.5 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	6510.4 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Ki	20000 nM	Cytochrome P450 3A4	P08684
IC50	100000 nM	Lymphocyte differentiation antigen CD38	P28907
IC50	25000 nM	Cytochrome P450 19A1	P11511
IC50	25000 nM	Cytochrome P450 19A1	P11511
Ki	41670 nM	Cytochrome P450 19A1	P11511
Potency	29092.9 nM	Geminin	O75496
Potency	25118.9 nM	Aryl hydrocarbon receptor	P35869
Potency	17782.8 nM	Aryl hydrocarbon receptor	P35869
Potency	19331.2 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	37578 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	35481.3 nM	Ataxin-2	Q99700
Potency	28183.8 nM	Glucagon-like peptide 1 receptor	P43220
Potency	12589.3 nM	Breast cancer type 1 susceptibility protein	P38398
Potency	2371 nM	Nuclear receptor ROR-gamma	P51449
IC50	25400 nM	Cytochrome P450 19A1	P11511
Others	63.2 %	Cytochrome P450 19A1	P11511
Others	2	NAD-dependent deacetylase sirtuin 1	Q96EB6
EC50	87200 nM	NAD-dependent deacetylase sirtuin 1	Q96EB6
EC50	23600 nM	NAD-dependent deacetylase sirtuin 1	Q96EB6
Others	40 %	Forkhead box protein O1	Q12778
IC50	60000 nM	Myc proto-oncogene protein	P01106
Others	86.43 %	Beta amyloid A4 protein	P05067
Others	61 %	Beta amyloid A4 protein	P05067
Others	78.92 %	Beta amyloid A4 protein	P05067
IC50	15110 nM	Beta amyloid A4 protein	P05067
Others	69.73 %	Beta amyloid A4 protein	P05067
IC50	15900 nM	Beta amyloid A4 protein	P05067
Others	61.1 %	Beta amyloid A4 protein	P05067
Kd	54 nM	Quinone reductase 2	P16083
IC50	6900 nM	Quinone reductase 2	P16083
Ki	88 nM	Quinone reductase 2	P16083
Others	63.4 %	Beta amyloid A4 protein	P05067
Others	64.2 %	Beta amyloid A4 protein	P05067
Others	68.51 %	Beta amyloid A4 protein	P05067
IC50	29370 nM	Monoamine oxidase B	P27338
IC50	17410 nM	Monoamine oxidase A	P21397
IC50	250 nM	PI3-kinase p110-alpha subunit	P42336
IC50	500 nM	PI3-kinase p110-beta subunit	P42338
Others	61.5 %	Beta amyloid A4 protein	P05067
IC50	85000 nM	Telomerase reverse transcriptase	O14746
Others	64.2 %	Beta amyloid A4 protein	P05067
Others	0.1	Estrogen receptor alpha	P03372
Others	0 %	Estrogen receptor alpha	P03372
Others	1.54	Estrogen receptor beta	Q92731
Others	0 %	Estrogen receptor beta	Q92731
Others	39.1 %	Beta amyloid A4 protein	P05067
IC50	996 nM	Cyclooxygenase-2	P35354
IC50	1400 nM	Quinone reductase 2	P16083
IC50	913 nM	Quinone reductase 2	P16083
Others	49.8 %	Beta amyloid A4 protein	P05067
IC50	4100 nM	Beta amyloid A4 protein	P05067
IC50	2600 nM	Beta amyloid A4 protein	P05067
Others	11 %	Cytochrome P450 1A1	P04798
IC50	34000 nM	Cytochrome P450 1A1	P04798
Others	56 %	Cytochrome P450 1B1	Q16678
IC50	55000 nM	Cytochrome P450 1B1	Q16678
Others	7.48 %	Beta amyloid A4 protein	P05067
Others	4.25 %	Beta amyloid A4 protein	P05067
Others	100.07 %	Beta amyloid A4 protein	P05067
Others	24.09 %	Beta amyloid A4 protein	P05067
Others	45.2 %	Beta amyloid A4 protein	P05067

Resveratrol

Representations & DB's id

Molecular propeties

Plant sources

In vitro data