Phyto4Health

Isoliquiritigenin

Representations & DB's id

ChEBI: CHEBI:310312
ChEMBL: CHEMBL129795
PubChem: 638278
IUPAC: (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Standard InChI: InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
Standard InChI Key: DXDRHHKMWQZJHT-FPYGCLRLSA-N
SMILES: Oc1ccc(cc1)/C=C/C(=O)c1ccc(cc1O)O

Molecular propeties

AlogP: 2.7
Hydrogen bonds acceptors: 4
Hydrogen bonds donors: 3
Rotatable bonds: 3
Number of rings: 2
Molecular Weight: 256.07
Topological polar surface area: 77.8
Number of aromatic rings: 2
Fsp3: 0
Number of carbons: 15

Plant sources

Part of plant Plant name Ref.
RootGlycyrrhiza glabra
RhizomeGlycyrrhiza glabra
RootGlycyrrhiza glabra
RhizomeGlycyrrhiza glabra
RootGlycyrrhiza glabra
RhizomeGlycyrrhiza glabra
RootGlycyrrhiza uralensis
Sprout SeedlingGlycyrrhiza uralensis
RhizomeGlycyrrhiza uralensis
RootGlycyrrhiza uralensis
Sprout SeedlingGlycyrrhiza uralensis
RhizomeGlycyrrhiza uralensis
RootGlycyrrhiza uralensis
Sprout SeedlingGlycyrrhiza uralensis
RhizomeGlycyrrhiza uralensis
RootGlycyrrhiza uralensis
Sprout SeedlingGlycyrrhiza uralensis
RhizomeGlycyrrhiza uralensis
PlantEucalyptus australiana

In vitro data

Activity Type Activity Value Target Name UniProt ID Ref.
IC5060000 nMProtein-tyrosine phosphatase 1BP18031
Others1.25 Peroxisome proliferator-activated receptor gammaP37231
Others1.3 Peroxisome proliferator-activated receptor gammaP37231
IC5050000 nMProtein-tyrosine phosphatase 1BP18031
Potency12589.3 nMPrelamin-A/CP02545
Potency3981.1 nMBeta-glucocerebrosidaseP04062
Potency6309.6 nMPrelamin-A/CP02545
Potency31622.8 nMHistone-lysine N-methyltransferase MLLQ03164
Potency3981.1 nMCytochrome P450 2C19P33261
Potency11220.2 nMMicrotubule-associated protein tauP10636
Potency10000 nMMicrotubule-associated protein tauP10636
Potency7943.3 nMMicrotubule-associated protein tauP10636
Potency15848.9 nMMicrotubule-associated protein tauP10636
Potency3548.1 nMMicrotubule-associated protein tauP10636
Potency15101.4 nMPeripheral myelin protein 22Q01453
Potency19952.6 nMBeta-glucocerebrosidaseP04062
Potency4466.8 nMBeta-glucocerebrosidaseP04062
Potency26121.6 nMSerine/threonine-protein kinase mTORP42345
Potency11220.2 nMBeta-glucocerebrosidaseP04062
Potency50118.7 nMBloom syndrome proteinP54132
Potency11220.2 nMBeta-glucocerebrosidaseP04062
Potency28183.8 nM15-hydroxyprostaglandin dehydrogenase [NAD+]P15428
Potency31622.8 nMNeuropeptide S receptorQ6W5P4
Potency50118.7 nMBloom syndrome proteinP54132
Potency10000 nMCytochrome P450 3A4P08684
Potency3981.1 nMCytochrome P450 3A4P08684
Potency7943.3 nMCytochrome P450 2C9P11712
Potency10000 nMCytochrome P450 3A4P08684
Potency15848.9 nMGemininO75496
Potency3981.1 nMCytochrome P450 3A4P08684
Potency1000 nMBeta-glucocerebrosidaseP04062
Potency8196.1 nMATPase family AAA domain-containing protein 5Q96QE3
Potency1778.3 nMBeta-glucocerebrosidaseP04062
Potency7943.3 nMBeta-glucocerebrosidaseP04062
Potency39810.7 nMBeta-glucocerebrosidaseP04062
Potency50118.7 nMCellular tumor antigen p53P04637
Potency35481.3 nMM-phase phosphoprotein 8Q99549
Potency23109.3 nMATPase family AAA domain-containing protein 5Q96QE3
Potency89125.1 nMHistone-lysine N-methyltransferase, H3 lysine-9 specific 3Q96KQ7
Potency3768.6 nMHistone-lysine N-methyltransferase, H3 lysine-9 specific 3Q96KQ7
Potency39810.7 nMHistone-lysine N-methyltransferase, H3 lysine-9 specific 3Q96KQ7
Potency35481.3 nMChromobox protein homolog 1P83916
Potency10322.5 nMATPase family AAA domain-containing protein 5Q96QE3
Potency21331.3 nMPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1Q13526
Potency2310 nMATPase family AAA domain-containing protein 5Q96QE3
Potency15848.9 nMDopamine D1 receptorP21728
Potency20596.2 nMGemininO75496
Others67 %Matrix metalloproteinase 9P14780
Others91 %Matrix metalloproteinase 9P14780
Others97 %Matrix metalloproteinase 9P14780
IC50320 nMAldose reductaseP15121
Potency14581 nMGemininO75496
Potency1122 nMGemininO75496
Potency10000 nMAtaxin-2Q99700
Potency28183.8 nMGlucagon-like peptide 1 receptorP43220
Potency12589.3 nMNuclear factor erythroid 2-related factor 2Q16236
IC5033000 nMBeta-secretase 1P56817
IC5019700 nMBeta amyloid A4 proteinP05067
EC5011600 nMNeuronal acetylcholine receptor protein alpha-7 subunitP36544
Others6.5 Neuronal acetylcholine receptor protein alpha-7 subunitP36544
Others98.1 %Isocitrate dehydrogenase [NADP] cytoplasmicO75874
Others94.6 %Isocitrate dehydrogenase [NADP] cytoplasmicO75874
Others5.88 Nuclear factor erythroid 2-related factor 2Q16236