Phyto4Health

7-Hydroxy-2-(4-Hydroxyphenyl)Chromen-4-One

Representations & DB's id
ChEBI: CHEBI:29503
ChEMBL: CHEMBL294878
PubChem: 5282073
IUPAC: 7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
Standard InChI: InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-8,16-17H
Standard InChI Key: LCAWNFIFMLXZPQ-UHFFFAOYSA-N
SMILES: Oc1ccc(cc1)c1cc(=O)c2c(o1)cc(cc2)O

Molecular propeties
AlogP: 2.87
Hydrogen bonds acceptors: 4
Hydrogen bonds donors: 2
Rotatable bonds: 1
Number of rings: 3
Molecular Weight: 254.06
Topological polar surface area: 66.8
Number of aromatic rings: 3
Fsp3: 0
Number of carbons: 15

Plant sources

Part of plant Plant name Ref.
PlantGlycyrrhiza glabra
PlantGlycyrrhiza uralensis
PlantGlycyrrhiza uralensis

In vitro data

Activity Type Activity Value Target Name UniProt ID Ref.
Others1.3 Peroxisome proliferator-activated receptor gammaP37231
Others5 Peroxisome proliferator-activated receptor gammaP37231
Others1.5 Peroxisome proliferator-activated receptor alphaQ07869
Others2.6 Peroxisome proliferator-activated receptor alphaQ07869
IC50470000 nMSialidase 2Q9Y3R4
IC502 nMCytochrome P450 19A1P11511
Potency7943.3 nMEndoplasmic reticulum-associated amyloid beta-peptide-binding proteinQ99714
Potency794.3 nMLysine-specific demethylase 4D-likeB2RXH2
Potency35481.3 nMSurvival motor neuron proteinQ16637
Potency8912.5 nMAldehyde dehydrogenase 1A1P00352
Potency10000 nMMAP kinase ERK2P28482
Potency10000 nM15-hydroxyprostaglandin dehydrogenase [NAD+]P15428
Potency7943.3 nMCytochrome P450 3A4P08684
Potency7943.3 nMCytochrome P450 3A4P08684
Potency39810.7 nMAlpha-galactosidase AP06280
Others5.9 Peroxisome proliferator-activated receptor deltaQ03181
Others3.5 Peroxisome proliferator-activated receptor deltaQ03181
Others50 %Protein-tyrosine phosphatase 1BP18031
Others50 %Arachidonate 5-lipoxygenaseP09917
Others71.8 %Glutaminyl-peptide cyclotransferaseQ16769
IC5045200 nMGlutaminyl-peptide cyclotransferaseQ16769