Morphine

Representations & DB's id
ChEBI:	CHEBI:17303
ChEMBL:	CHEMBL70
PubChem:	5288826
IUPAC:	(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Standard InChI:	InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
Standard InChI Key:	BQJCRHHNABKAKU-KBQPJGBKSA-N
SMILES:	O[C@H]1C=C[C@@H]2[C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)ccc1O

Molecular propeties
AlogP:	1.2
Hydrogen bonds acceptors:	4
Hydrogen bonds donors:	2
Rotatable bonds:	0
Number of rings:	5
Molecular Weight:	285.14
Topological polar surface area:	52.9
Number of aromatic rings:	1
Fsp3:	0.529
Number of carbons:	17

Plant sources

Part of plant	Plant name	Ref.
Plant	Papaver somniferum
Shoot	Papaver somniferum
Latex Exudate	Papaver somniferum
Seed	Papaver somniferum
Leaf	Papaver somniferum
Resin, Exudate, Sap	Papaver somniferum
Fruit	Papaver somniferum
Gum	Papaver somniferum
Stem	Papaver somniferum
Inflorescence	Papaver somniferum
Root	Papaver somniferum
Hypocotyl	Papaver somniferum
Plant	Papaver somniferum
Shoot	Papaver somniferum
Latex Exudate	Papaver somniferum
Seed	Papaver somniferum
Leaf	Papaver somniferum
Resin, Exudate, Sap	Papaver somniferum
Fruit	Papaver somniferum
Gum	Papaver somniferum
Stem	Papaver somniferum
Inflorescence	Papaver somniferum
Root	Papaver somniferum
Hypocotyl	Papaver somniferum
Plant	Papaver somniferum
Shoot	Papaver somniferum
Latex Exudate	Papaver somniferum
Seed	Papaver somniferum
Leaf	Papaver somniferum
Resin, Exudate, Sap	Papaver somniferum
Fruit	Papaver somniferum
Gum	Papaver somniferum
Stem	Papaver somniferum
Inflorescence	Papaver somniferum
Root	Papaver somniferum
Hypocotyl	Papaver somniferum
Plant	Papaver somniferum
Shoot	Papaver somniferum
Latex Exudate	Papaver somniferum
Seed	Papaver somniferum
Leaf	Papaver somniferum
Resin, Exudate, Sap	Papaver somniferum
Fruit	Papaver somniferum
Gum	Papaver somniferum
Stem	Papaver somniferum
Inflorescence	Papaver somniferum
Root	Papaver somniferum
Hypocotyl	Papaver somniferum
Plant	Rhaponticum carthamoides

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID
Ki	3.96 nM	Mu opioid receptor	P35372
Others	1	P-glycoprotein 3	P21447
Others	1.5	P-glycoprotein 3	P21447
Others	2.4	P-glycoprotein 3	P21447
Ki	0.88 nM	Mu opioid receptor	P35372
Ki	140 nM	Delta opioid receptor	P41143
Ki	24 nM	Kappa opioid receptor	P41145
Others	62 %	Kappa opioid receptor	P41145
EC50	484 nM	Kappa opioid receptor	P41145
Others	103 %	Delta opioid receptor	P41143
EC50	316 nM	Delta opioid receptor	P41143
Others	93 %	Mu opioid receptor	P35372
EC50	15.6 nM	Mu opioid receptor	P35372
Ki	140 nM	Delta opioid receptor	P41143
Ki	46.9 nM	Kappa opioid receptor	P41145
Ki	1.1 nM	Mu opioid receptor	P35372
ED50	37 nM	Mu opioid receptor	P35372
Ki	1.1 nM	Mu opioid receptor	P35372
Ki	46.9 nM	Kappa opioid receptor	P41145
Ki	140 nM	Delta opioid receptor	P41143
EC50	15.6 nM	Mu opioid receptor	P35372
EC50	484 nM	Kappa opioid receptor	P41145
EC50	316 nM	Mu opioid receptor	P35372
Others	93 %	Mu opioid receptor	P35372
Others	62 %	Kappa opioid receptor	P41145
Others	103 %	Delta opioid receptor	P41143
EC50	6 nM	Mu opioid receptor	P35372
Ki	4 nM	Mu opioid receptor	P35372
EC50	6.4 nM	Mu opioid receptor	P35372
EC50	7 nM	Mu opioid receptor	P35372
IC50	28000 nM	Solute carrier family 22 member 1	O15245
Others	67.9 %	Solute carrier family 22 member 1	O15245
EC50	15.6 nM	Mu opioid receptor	P35372
EC50	316 nM	Delta opioid receptor	P41143
EC50	484 nM	Kappa opioid receptor	P41145
Others	93 %	Mu opioid receptor	P35372
Others	103 %	Delta opioid receptor	P41143
Others	62 %	Kappa opioid receptor	P41145
Ki	2.55 nM	Mu opioid receptor	P35372
ED50	37 nM	Mu opioid receptor	P35372
ED50	316 nM	Delta opioid receptor	P41143
ED50	1140 nM	Kappa opioid receptor	P41145
Ki	6.9 nM	Kappa opioid receptor	P41145
Others	93 %	Delta opioid receptor	P41143
Others	103 %	Mu opioid receptor	P35372
Others	62 %	Kappa opioid receptor	P41145
EC50	15.6 nM	Delta opioid receptor	P41143
EC50	316 nM	Mu opioid receptor	P35372
EC50	484 nM	Kappa opioid receptor	P41145
Ki	2.55 nM	Mu opioid receptor	P35372
Ki	2.6 nM	Mu opioid receptor	P35372
Others	0 pm/min/mg	UDP-glucuronosyltransferase 1-1	P22309
Others	0 pm/min/mg	UDP-glucuronosyltransferase 1-6	P19224
Others	0 pm/min/mg	UDP-glucuronosyltransferase 1-6	P19224
Others	0 pm/min/mg	UDP-glucuronosyltransferase 1-9	O60656
Others	2536 pm/min/mg	UDP-glucuronosyltransferase 2B7	P16662
Others	2968 pm/min/mg	UDP-glucuronosyltransferase 2B7	P16662
Others	3719 pm/min/mg	UDP-glucuronosyltransferase 2B7	P16662
Others	0 pm/min/mg	UDP-glucuronosyltransferase 2B15	P54855
Others	0 pm/min/mg	UDP-glucuronosyltransferase 1A4	P22310
Others	0 pm/min/mg	UDP-glucuronosyltransferase 1-6	P19224
Others	0 pm/min/mg	UDP-glucuronosyltransferase 1-9	O60656
Others	0 pm/min/mg	UDP-glucuronosyltransferase 1-10	Q9HAW8
Others	35 pm/min/mg	UDP-glucuronosyltransferase 1-8	Q9HAW9
Others	0 pm/min/mg	UDP-glucuronosyltransferase 2B15	P54855
Others	21 pm/min/mg	UDP-glucuronosyltransferase 1-3	P35503
Others	0 pm/min/mg	UDP-glucuronosyltransferase 1A4	P22310
Others	15 pm/min/mg	UDP-glucuronosyltransferase 1-8	Q9HAW9
Others	73 pm/min/mg	UDP-glucuronosyltransferase 2A1	Q9Y4X1
Others	0 pm/min/mg	UDP-glucuronosyltransferase 2B10	P36537
Others	0 pm/min/mg	UDP-glucuronosyltransferase 2B4	P06133
Others	0 pm/min/mg	UDP-glucuronosyltransferase 2B7	P16662
Others	160 pm/min/mg	UDP-glucuronosyltransferase 2B7	P16662
Ki	2.6 nM	Mu opioid receptor	P35372
Ki	605 nM	Delta opioid receptor	P41143
Ki	299 nM	Kappa opioid receptor	P41145
Ki	2.2 nM	Mu opioid receptor	P35372
EC50	3.7 nM	Mu opioid receptor	P35372
Ki	140 nM	Delta opioid receptor	P41143
Ki	24 nM	Kappa opioid receptor	P41145
Ki	0.88 nM	Mu opioid receptor	P35372
IC50	4.3 nM	Mu opioid receptor	P35372
Ki	60.9 nM	Kappa opioid receptor	P41145
Ki	299 nM	Kappa opioid receptor	P41145
Ki	605 nM	Delta opioid receptor	P41143
Ki	2.6 nM	Mu opioid receptor	P35372
Ki	605 nM	Delta opioid receptor	P41143
Ki	299 nM	Kappa opioid receptor	P41145
Ki	2.6 nM	Mu opioid receptor	P35372
Others	91 %	Mu opioid receptor	P35372
Others	90 %	Kappa opioid receptor	P41145
Others	69 %	Delta opioid receptor	P41143
EC50	500 nM	Delta opioid receptor	P41143
EC50	400 nM	Kappa opioid receptor	P41145
EC50	50 nM	Mu opioid receptor	P35372
EC50	501.19 nM	Mu opioid receptor	P35372
EC50	39.81 nM	Mu opioid receptor	P35372
IC50	2.5 nM	Mu opioid receptor	P35372
Others	98 %	Mu opioid receptor	P35372
Others	81 %	Mu opioid receptor	P35372
EC50	10 nM	Mu opioid receptor	P35372
Ki	5.2 nM	Mu opioid receptor	P35372
Ki	2.6 nM	Mu opioid receptor	P35372
Ki	605 nM	Delta opioid receptor	P41143
Ki	299 nM	Kappa opioid receptor	P41145
Ki	22 nM	Mu opioid receptor	P35372
IC50	6.3 nM	Mu opioid receptor	P35372
Ki	120 nM	Kappa opioid receptor	P41145
Ki	0.53 nM	Mu opioid receptor	P35372
Ki	5.2 nM	Mu opioid receptor	P35372

Morphine

Representations & DB's id

Molecular propeties

Plant sources

In vitro data