Phyto4Health

Kaempferol

Representations & DB's id

ChEBI: CHEBI:28499
ChEMBL: CHEMBL150
PubChem: 5280863
IUPAC: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
Standard InChI: InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
Standard InChI Key: IYRMWMYZSQPJKC-UHFFFAOYSA-N
SMILES: Oc1ccc(cc1)c1oc2cc(O)cc(c2c(=O)c1O)O

Molecular propeties

AlogP: 2.28
Hydrogen bonds acceptors: 6
Hydrogen bonds donors: 4
Rotatable bonds: 1
Number of rings: 3
Molecular Weight: 286.05
Topological polar surface area: 107
Number of aromatic rings: 3
Fsp3: 0
Number of carbons: 15

Plant sources

Part of plant Plant name Ref.
HerbaPolygonum aviculare
PlantBrassica juncea
FructusPunica granatum
FructusPunica granatum
FructusPunica granatum
FructusPunica granatum
RadixPanax ginseng
RadixPanax ginseng
RadixPanax ginseng
RadixPanax ginseng
RadixPanax ginseng
RadixPanax ginseng
HerbaHypericum perforatum
InflorescenceUrtica dioica
PlantUrtica dioica
FlosTussilago farfara
PlantVinca minor
PlantArtemisia cina
PlantRhodiola rosea
PlantBeta vulgaris
FoliumCassia acutifolia
FruitRibes nigrum
Fruit JuiceRibes nigrum
PlantGlycyrrhiza uralensis
FruitVaccinium vitis-idaea
PlantThymus vulgaris
FruitPrunus armeniaca
LeafPrunus armeniaca
FructusFoeniculum vulgare
FructusFoeniculum vulgare
StrobilusHumulus lupulus
StrobilusHumulus lupulus
FlowerCrocus sativus
FlowerCrocus sativus
PlantEucalyptus australiana

In vitro data

Activity Type Activity Value Target Name UniProt ID Ref.
IC5022000 nMCyclin-dependent kinase 6Q00534
Others0 %Serine/threonine-protein kinase PIM1P11309
Others0 %Serine/threonine-protein kinase PIM1P11309
IC502700 nMArachidonate 5-lipoxygenaseP09917
IC50100000 nMCyclooxygenase-2P35354
IC50100000 nMCyclooxygenase-1P23219
IC5020600 nMGlyoxalase IQ04760
Others60 %Glyoxalase IQ04760
IC503 ug/mlEpidermal growth factor receptor erbB1P00533
Others34.5 %Salivary alpha-amylaseP04745
Others8.3 %DNA topoisomerase II alphaP11388
Others1.6 DNA topoisomerase II alphaP11388
Others60 %DNA topoisomerase II alphaP11388
Others13 %Estradiol 17-beta-dehydrogenase 1P14061
Others4.83 %Estradiol 17-beta-dehydrogenase 2P37059
IC501050 nMEstradiol 17-beta-dehydrogenase 1P14061
IC50360 nMEstradiol 17-beta-dehydrogenase 2P37059
IC50200000 nMProlyl endopeptidaseP48147
IC509700 nMAndrogen ReceptorP10275
Ki43100 nMButyrylcholinesteraseP06276
Ki92800 nMAcetylcholinesteraseP22303
Others3.5 Peroxisome proliferator-activated receptor gammaP37231
Others1.8 Peroxisome proliferator-activated receptor alphaQ07869
Others2.6 Peroxisome proliferator-activated receptor alphaQ07869
IC50230000 nMSialidase 2Q9Y3R4
IC50716 nMCytochrome P450 1A2P05177
IC50632 nMCytochrome P450 1A1P04798
IC5047 nMCytochrome P450 1B1Q16678
Potency3548.1 nMPrelamin-A/CP02545
Potency15848.9 nMLysine-specific demethylase 4D-likeB2RXH2
Potency39810.7 nMLysine-specific demethylase 4D-likeB2RXH2
Potency1995.3 nMTyrosyl-DNA phosphodiesterase 1Q9NUW8
Potency10000 nMCytochrome P450 2C19P33261
Potency6309.6 nMCytochrome P450 2C19P33261
Potency12589.3 nMMicrotubule-associated protein tauP10636
Potency1584.9 nMHypoxia-inducible factor 1 alphaQ16665
Potency39810.7 nMAldehyde dehydrogenase 1A1P00352
Potency31622.8 nMAldehyde dehydrogenase 1A1P00352
Potency10000 nMArachidonate 15-lipoxygenaseP16050
Potency7943.3 nMArachidonate 15-lipoxygenaseP16050
Potency1584.9 nMHypoxia-inducible factor 1 alphaQ16665
Potency28183.8 nM15-hydroxyprostaglandin dehydrogenase [NAD+]P15428
Potency5011.9 nMCellular tumor antigen p53P04637
Potency15848.9 nMEndoplasmic reticulum-associated amyloid beta-peptide-binding proteinQ99714
Potency3981.1 nMCellular tumor antigen p53P04637
Potency10000 nMCellular tumor antigen p53P04637
Potency7943.3 nMCellular tumor antigen p53P04637
Potency15848.9 nMEndoplasmic reticulum-associated amyloid beta-peptide-binding proteinQ99714
Potency15848.9 nMCytochrome P450 2D6P10635
Potency7943.3 nMCytochrome P450 3A4P08684
Potency15848.9 nMCytochrome P450 3A4P08684
Potency10000 nMCytochrome P450 2D6P10635
Potency1.3 nMCytochrome P450 2C9P11712
Potency7943.3 nMCytochrome P450 3A4P08684
Potency15848.9 nMCytochrome P450 3A4P08684
Potency15848.9 nMCytochrome P450 2C9P11712
Potency11220.2 nMBeta-glucocerebrosidaseP04062
Potency11220.2 nMBeta-glucocerebrosidaseP04062
Potency35481.3 nMBeta-glucocerebrosidaseP04062
Potency79432.8 nMLysine-specific demethylase 4AO75164
Potency25118.9 nMArachidonate 15-lipoxygenase, type IIO15296
AC501259 nMDual specificity tyrosine-phosphorylation-regulated kinase 1AQ63470
IC5010000 nMAldose reductaseP15121
Others38.56 %Estrogen receptor alphaP03372
Others45.15 %Estrogen receptor alphaP03372
Potency44668.4 nMAryl hydrocarbon receptorP35869
Potency56234.1 nMAryl hydrocarbon receptorP35869
Potency21689.9 nMNuclear factor erythroid 2-related factor 2Q16236
IC5044490 nMRac GTPase-activating protein 1Q9H0H5
Potency29849.3 nMNuclear factor erythroid 2-related factor 2Q16236
Potency15848.9 nMAtaxin-2Q99700
Potency74978 nMNuclear receptor ROR-gammaP51449
IC5022000 nMCyclin-dependent kinase 6Q00534
IC5014700 nMBeta-secretase 1P56817
Others7.3 Peroxisome proliferator-activated receptor deltaQ03181
Others4.2 Peroxisome proliferator-activated receptor deltaQ03181
IC502320 nMTyrosine-protein kinase receptor FLT3P36888
IC509640 nMEstrogen-related receptor alphaP11474
Others25 %DNA-3-methyladenine glycosylaseP29372
Others50 %Xanthine dehydrogenaseP47989
IC5010000 nMDeath-associated protein kinase 1P53355
Ki9525.7 nMCarbonic anhydrase IIP00918
Ki10000 nMCarbonic anhydrase IP00915
Ki10000 nMCarbonic anhydrase IVP22748
Ki25 nMCarbonic anhydrase VIIP43166
Ki145.9 nMCarbonic anhydrase XIIO43570
Others112.3 %Isocitrate dehydrogenase [NADP] cytoplasmicO75874
Others103.6 %Isocitrate dehydrogenase [NADP] cytoplasmicO75874
Others22.4 %Receptor-type tyrosine-protein phosphatase SQ13332
IC5075100 nMBeta amyloid A4 proteinP05067
Others95.48 %CatalaseP04040
Others95 %TyrosinaseP14679
IC501000 nMTyrosinaseP14679