Piceatannol

Representations & DB's id
ChEBI:	CHEBI:28814
ChEMBL:	CHEMBL69863
PubChem:	667639
IUPAC:	4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
Standard InChI:	InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
Standard InChI Key:	CDRPUGZCRXZLFL-OWOJBTEDSA-N
SMILES:	Oc1cc(/C=C/c2ccc(c(c2)O)O)cc(c1)O

Molecular propeties
AlogP:	2.68
Hydrogen bonds acceptors:	4
Hydrogen bonds donors:	4
Rotatable bonds:	2
Number of rings:	2
Molecular Weight:	244.07
Topological polar surface area:	80.9
Number of aromatic rings:	2
Fsp3:	0
Number of carbons:	14

Plant sources

Part of plant	Plant name	Ref.
Plant	Vitis vinifera
Plant	Picea abies
Plant	Panax ginseng
Rhizoma	Rheum palmatum

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID
Others	41 %	Tyrosine-protein kinase SRC	P12931
IC50	5 ug/ml	Tyrosine-protein kinase SYK	P43405
Others	60 %	NAD-dependent deacetylase sirtuin 2	Q8IXJ6
Potency	56.2 nM	Prelamin-A/C	P02545
Potency	70794.6 nM	Thyroid hormone receptor beta-1	P10828
Potency	22387.2 nM	Lysine-specific demethylase 4D-like	B2RXH2
Potency	58047.9 nM	Ras-related protein Rab-9A	P51151
Potency	31622.8 nM	Survival motor neuron protein	Q16637
Potency	25118.9 nM	Survival motor neuron protein	Q16637
Potency	15848.9 nM	Survival motor neuron protein	Q16637
Potency	23280.9 nM	Serine/threonine-protein kinase mTOR	P42345
Potency	2818.4 nM	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8
Potency	50118.7 nM	Thyroid hormone receptor beta-1	P10828
Potency	6309.6 nM	Microtubule-associated protein tau	P10636
Potency	1778.3 nM	Microtubule-associated protein tau	P10636
Potency	7079.5 nM	Microtubule-associated protein tau	P10636
Potency	5011.9 nM	Microtubule-associated protein tau	P10636
Potency	10000 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	28183.8 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	28183.8 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	28183.8 nM	Aldehyde dehydrogenase 1A1	P00352
Potency	30131.3 nM	Peripheral myelin protein 22	Q01453
Potency	14125.4 nM	Prelamin-A/C	P02545
Potency	23280.9 nM	Serine/threonine-protein kinase mTOR	P42345
Potency	4466.8 nM	Arachidonate 12-lipoxygenase	P18054
Potency	31622.8 nM	Lethal(3)malignant brain tumor-like protein 1	Q9Y468
Potency	6513.1 nM	Niemann-Pick C1 protein	O15118
Potency	25118.9 nM	Bloom syndrome protein	P54132
Potency	28183.8 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	3162.3 nM	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428
Potency	25118.9 nM	Bloom syndrome protein	P54132
Potency	7943.3 nM	DNA polymerase beta	P06746
Potency	3162.3 nM	Geminin	O75496
Potency	19952.6 nM	Beta-glucocerebrosidase	P04062
Potency	3661.1 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	16360.1 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	44668.4 nM	Lysine-specific demethylase 4A	O75164
Potency	32642.7 nM	Nuclear factor erythroid 2-related factor 2	Q16236
Potency	39810.7 nM	Histone acetyltransferase GCN5	Q92830
Potency	25118.9 nM	Histone acetyltransferase GCN5	Q92830
Potency	10000 nM	Cellular tumor antigen p53	P04637
Potency	39810.7 nM	M-phase phosphoprotein 8	Q99549
Potency	580.4 nM	Dopamine D1 receptor	P21728
Potency	21192.3 nM	M-phase phosphoprotein 8	Q99549
Potency	5171.4 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	2818.4 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	316.2 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	1584.9 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	1778.3 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	1412.5 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	670.2 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	44668.4 nM	Chromobox protein homolog 1	P83916
Potency	50118.7 nM	Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8
Potency	4466.8 nM	Arachidonate 15-lipoxygenase, type II	O15296
Potency	12589.3 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	1157.7 nM	ATPase family AAA domain-containing protein 5	Q96QE3
Potency	843.7 nM	Flap endonuclease 1	P39748
IC50	100000 nM	Lymphocyte differentiation antigen CD38	P28907
AC50	7534 nM	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q63470
Potency	29092.9 nM	Geminin	O75496
Potency	35481.3 nM	Glutaminase kidney isoform, mitochondrial	O94925
Potency	31622.8 nM	Ataxin-2	Q99700
Potency	22387.2 nM	Ataxin-2	Q99700
Potency	17782.8 nM	Breast cancer type 1 susceptibility protein	P38398
EC50	25000 nM	Tyrosine-protein kinase SYK	P43405
EC50	5000 nM	Tyrosine-protein kinase SYK	P43405
IC50	10000 nM	Tyrosine-protein kinase SYK	P43405

Piceatannol

Representations & DB's id

Molecular propeties

Plant sources

In vitro data