Phyto4Health

Taxifolin

Representations & DB's id

ChEBI: CHEBI:38747
ChEMBL: CHEMBL337309
PubChem: 471
IUPAC: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
Standard InChI: InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H
Standard InChI Key: CXQWRCVTCMQVQX-UHFFFAOYSA-N
SMILES: Oc1cc2OC(c3ccc(c(c3)O)O)C(C(=O)c2c(c1)O)O

Molecular propeties

AlogP: 1.19
Hydrogen bonds acceptors: 7
Hydrogen bonds donors: 5
Rotatable bonds: 1
Number of rings: 3
Molecular Weight: 304.06
Topological polar surface area: 127
Number of aromatic rings: 2
Fsp3: 0.133
Number of carbons: 15

Plant sources

Part of plant Plant name Ref.
PlantPolygonum aviculare
PlantThymus vulgaris
PlantHumulus lupulus

In vitro data

Activity Type Activity Value Target Name UniProt ID Ref.
Ki34100 nMAdenosine A3 receptorP0DMS8
Others108 %Canalicular multispecific organic anion transporter 1Q92887
Potency35481.3 nMATP-dependent DNA helicase Q1P46063
Potency8912.5 nMLysine-specific demethylase 4D-likeB2RXH2
Potency10000 nMLysine-specific demethylase 4D-likeB2RXH2
Potency35481.3 nMSurvival motor neuron proteinQ16637
Potency15848.9 nMMicrotubule-associated protein tauP10636
Potency75686.3 nMPeripheral myelin protein 22Q01453
Potency4466.8 nMBloom syndrome proteinP54132
Potency3548.1 nM15-hydroxyprostaglandin dehydrogenase [NAD+]P15428
Potency4466.8 nMBloom syndrome proteinP54132
Potency1888.8 nMDNA polymerase betaP06746
Potency25118.9 nMCytochrome P450 3A4P08684
Potency25118.9 nMCytochrome P450 3A4P08684
Potency31622.8 nMGemininO75496
Potency36.6 nMDopamine D1 receptorP21728
Potency1000 nMHistone-lysine N-methyltransferase, H3 lysine-9 specific 3Q96KQ7
Potency8.4 nMChromobox protein homolog 1P83916
Potency6012 nMPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1Q13526
Potency2667.9 nMFlap endonuclease 1P39748
IC50100000 nMLymphocyte differentiation antigen CD38P28907
IC5022620 nMMatrix metalloproteinase-2P08253
IC5033910 nMMatrix metalloproteinase 3P08254
IC5032020 nMMatrix metalloproteinase 9P14780
IC505750 nMMatrix metalloproteinase 12P39900
IC5034600 nMMatrix metalloproteinase 13P45452
Others30 %Matrix metalloproteinase-2P08253
Others30 %Matrix metalloproteinase 3P08254
Others30 %Matrix metalloproteinase 9P14780
Others30 %Matrix metalloproteinase 12P39900
Others30 %Matrix metalloproteinase 13P45452
IC5010000 nMTyrosine-protein kinase receptor FLT3P36888
Others40 %MyeloperoxidaseP05164
Others19.9 %Arachidonate 5-lipoxygenaseP09917
Others90.7 %Cytochrome P450 19A1P11511
Ki10000 nMCarbonic anhydrase IP00915
Ki10000 nMCarbonic anhydrase IIP00918
Ki9098.2 nMCarbonic anhydrase IVP22748
Ki493.1 nMCarbonic anhydrase VIIP43166
Ki32.5 nMCarbonic anhydrase XIIO43570