Phyto4Health

(+)-Taxifolin

Representations & DB's id
ChEBI: CHEBI:17948
ChEMBL: CHEMBL66
PubChem: 439533
IUPAC: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
Standard InChI: InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
Standard InChI Key: CXQWRCVTCMQVQX-LSDHHAIUSA-N
SMILES: Oc1cc2O[C@H](c3ccc(c(c3)O)O)[C@H](C(=O)c2c(c1)O)O

Molecular propeties
AlogP: 1.19
Hydrogen bonds acceptors: 7
Hydrogen bonds donors: 5
Rotatable bonds: 1
Number of rings: 3
Molecular Weight: 304.06
Topological polar surface area: 127
Number of aromatic rings: 2
Fsp3: 0.133
Number of carbons: 15

Plant sources

Part of plant Plant name Ref.
PlantPolygonum aviculare
PlantPinus sylvestris
PlantOnonis spinosa
PlantThymus vulgaris
PlantHumulus lupulus

In vitro data

Activity Type Activity Value Target Name UniProt ID Ref.
IC5035000 nMBeta-secretase 1P56817
IC5030000 nMBeta-secretase 1P56817
Potency28183.8 nMATP-dependent DNA helicase Q1P46063
Potency19952.6 nMLysine-specific demethylase 4D-likeB2RXH2
Potency15848.9 nMMicrotubule-associated protein tauP10636
Potency3162.3 nMDNA polymerase betaP06746
Potency3548.1 nMLysosomal alpha-glucosidaseP10253
Potency10000 nMHistone-lysine N-methyltransferase, H3 lysine-9 specific 3Q96KQ7
Potency89125.1 nMBromodomain adjacent to zinc finger domain protein 2BQ9UIF8
Potency631 nMGemininO75496
IC5033000 nMBeta amyloid A4 proteinP05067
Others15 %Stem cell growth factor receptorP10721
Others12 %Stem cell growth factor receptorP10721
IC5015700 nMStem cell growth factor receptorP10721
IC5021900 nMStem cell growth factor receptorP10721