L-Glutamate

Representations & DB's id
ChEBI:	CHEBI:16015
ChEMBL:	CHEMBL575060
PubChem:	33032
IUPAC:	(2S)-2-azaniumyl-5-hydroxy-5-oxopentanoate
Standard InChI:	InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
Standard InChI Key:	WHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES:	OC(=O)CC[C@@H](C(=O)O)N

Molecular propeties
AlogP:	-0.74
Hydrogen bonds acceptors:	3
Hydrogen bonds donors:	3
Rotatable bonds:	4
Number of rings:	0
Molecular Weight:	147.05
Topological polar surface area:	101
Number of aromatic rings:	0
Fsp3:	0.6
Number of carbons:	5

Plant sources

Part of plant	Plant name	Ref.
Plant	Brassica juncea
Plant	Tussilago farfara
Plant	Silybum marianum

In vitro data

Activity Type	Activity Value	Target Name	UniProt ID
EC50	75000 nM	Glutamate receptor ionotropic kainate 1	P39086
Ki	1106 nM	Glutamate receptor ionotropic kainate 2	Q13002
EC50	25000 nM	Glutamate receptor ionotropic kainate 2	Q13002
Others	1000 nM	Metabotropic glutamate receptor 1	Q13255
Others	4000 nM	Metabotropic glutamate receptor 5	P41594
Others	4000 nM	Metabotropic glutamate receptor 2	Q14416
Others	9000 nM	Metabotropic glutamate receptor 3	Q14832
Others	12000 nM	Metabotropic glutamate receptor 4	Q14833
Others	20000 nM	Metabotropic glutamate receptor 6	O15303
Others	5400000 nM	Metabotropic glutamate receptor 7	Q14831
Ki	1360 nM	Glutamate receptor ionotropic, AMPA 1	P42261
Ki	940 nM	Glutamate receptor ionotropic, AMPA 2	P42262
Ki	868 nM	Glutamate receptor ionotropic, AMPA 4	P48058
Ki	701 nM	Glutamate receptor ionotropic kainate 5	Q16478
IC50	5.7 nM	Metabotropic glutamate receptor 8	O00222
IC50	613 nM	Adenosine A3 receptor	P0DMS8
EC50	26000 nM	Metabotropic glutamate receptor 2	Q14416
EC50	1000000 nM	Metabotropic glutamate receptor 7	Q14831
EC50	22000 nM	Glutamate receptor ionotropic kainate 1	P39086
IC50	428000 nM	Glutamate carboxypeptidase II	Q04609
Ki	250 nM	Metabotropic glutamate receptor 1	Q13255
Ki	390 nM	Metabotropic glutamate receptor 5	P41594
Ki	11000 nM	Metabotropic glutamate receptor 2	Q14416
Ki	2400 nM	Metabotropic glutamate receptor 4	Q14833
EC50	26000 nM	Metabotropic glutamate receptor 2	Q14416
EC50	1000000 nM	Metabotropic glutamate receptor 7	Q14831
Ki	1160 nM	Metabotropic glutamate receptor 5	P41594
Ki	570 nM	Metabotropic glutamate receptor 1	Q13255
Ki	1400 nM	Metabotropic glutamate receptor 4	Q14833
Ki	6400 nM	Metabotropic glutamate receptor 2	Q14416
Ki	35000 nM	Excitatory amino acid transporter 1	P43003
Ki	62000 nM	Excitatory amino acid transporter 2	P43004
Ki	51 nM	Excitatory amino acid transporter 3	P43005
EC50	12589.25 nM	Metabotropic glutamate receptor 2	Q14416
Potency	10621.3 nM	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Q96KQ7
Potency	8492.1 nM	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Q13526
Potency	20596.2 nM	Beta-2 adrenergic receptor	P07550
IC50	53700 nM	Glutathione reductase	P00390
Ki	42700 nM	Glutathione reductase	P00390
Potency	12589.3 nM	Glutaminase kidney isoform, mitochondrial	O94925
IC50	1000000 nM	Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1
EC50	1800 nM	Metabotropic glutamate receptor 2	Q14416
EC50	1600 nM	Metabotropic glutamate receptor 1	Q13255
Ki	1174897.55 nM	Metabotropic glutamate receptor 7	Q14831
Ki	4677.35 nM	Metabotropic glutamate receptor 5	P41594
Ki	3235.94 nM	Metabotropic glutamate receptor 4	Q14833
Ki	57.54 nM	Metabotropic glutamate receptor 3	Q14832
Ki	1819.7 nM	Metabotropic glutamate receptor 2	Q14416
Ki	1584.89 nM	Metabotropic glutamate receptor 1	Q13255
EC50	1180000 nM	Metabotropic glutamate receptor 7	Q14831
EC50	4700 nM	Metabotropic glutamate receptor 5	P41594
EC50	3200 nM	Metabotropic glutamate receptor 4	Q14833
EC50	60 nM	Metabotropic glutamate receptor 3	Q14832
EC50	1827 nM	Metabotropic glutamate receptor 2	Q14416
EC50	2351 nM	Metabotropic glutamate receptor 2	Q14416
EC50	1767 nM	Metabotropic glutamate receptor 2	Q14416
EC50	2575 nM	Metabotropic glutamate receptor 2	Q14416
EC50	1002 nM	Metabotropic glutamate receptor 3	Q14832
EC50	4182 nM	Metabotropic glutamate receptor 3	Q14832
EC50	1484 nM	Metabotropic glutamate receptor 3	Q14832
EC50	5118 nM	Metabotropic glutamate receptor 3	Q14832
EC50	1180 nM	Metabotropic glutamate receptor 7	Q14831

L-Glutamate

Representations & DB's id

Molecular propeties

Plant sources

In vitro data