Download the full list of predicted values of DDIs for VEDs (*.xls 24 mB)
| Drug1 | Drug2 | DDI count | The severity of DDIs | Adverse effects on the cardiovascular system | Cytochromes P450 that mediate DDI |
|---|---|---|---|---|---|
| Mebeverine | Trifluoperazine | 9 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Imipramine | 9 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Sotalol | 9 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Trifluoperazine | 9 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Perphenazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Haloperidol | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Procainamide | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Trifluoperazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Bupivacaine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Chlorpromazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Clomifene | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Levobupivacaine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nintedanib | Terizidone | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Trifluoperazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Benzyl benzoate | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Carvedilol | Dopamine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Fluphenazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Perphenazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Haloperidol | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Methotrimeprazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Procainamide | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Trifluoperazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Chlorpromazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Clomipramine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Imipramine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Sulpiride | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Methotrimeprazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Chlorpromazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Clomifene | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Clomipramine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Thioridazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Benzyl benzoate | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Dobutamine | Imipramine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Haloperidol | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Procainamide | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Fluphenazine | Oxybuprocaine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Metoprolol | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Norepinephrine | Procainamide | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Trifluoperazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Trifluoperazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Oxybuprocaine | Imipramine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Propafenone | Chlorpromazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Perampanel | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Procainamide | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Bupivacaine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Chlorpromazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Clomipramine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Imipramine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Levobupivacaine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Ropivacaine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Pirfenidone | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dopamine | Trifluoperazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Dopamine | Chlorpromazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Haloperidol | Phenylephrine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Procainamide | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Procarbazine | Benzyl benzoate | 8 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Propranolol | Trifluoperazine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Propranolol | Clomifene | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Clomifene | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Chlorpromazine | Clomifene | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Clomifene | Imipramine | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Benzyl benzoate | Mitotane | 8 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C9 mediated DDI |
| Cromoglicic acid | Dobutamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carfilzomib | Mebeverine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Hexoprenaline | Verapamil | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Bedaquiline | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Fluphenazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Ivacaftor | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Mebendazole | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hexoprenaline | Periciazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Vismodegib | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Amiodarone | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Procarbazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Teriflunomide | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Imipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hexoprenaline | Ropivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Imatinib | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Lisinopril | Halothane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Acalabrutinib | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Ivabradine | Dobutamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nimodipine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Nintedanib | Dobutamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Nintedanib | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Tamsulosin | Dobutamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Terizidone | Mebeverine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Terizidone | Procaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Chlorpromazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Halothane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Verapamil | Mebeverine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Epinephrine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Bupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Verapamil | Chlorpromazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Clomipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Imipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Levobupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Verapamil | Ropivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Verapamil | Thioridazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Mitotane | 7 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cetirizine | Fenoterol | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cetirizine | Dobutamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | |
| Chloramphenicol | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Drotaverine | Dobutamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Drotaverine | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Fenoterol | Hydroxyzine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Procarbazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Bupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Levobupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Thioridazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Dobutamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Levodopa | Halothane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Mebeverine | Dobutamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Mebeverine | Fluphenazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Metoclopramide | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebeverine | Oxybuprocaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Perphenazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Mebeverine | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Dopamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Mebeverine | Haloperidol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Procainamide | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Mebeverine | Tropicamide | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Bupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Levobupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Ropivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Tamoxifen | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nifedipine | Droperidol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Teriflunomide | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Atenolol | Fluphenazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Dopamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Chlorpromazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Imipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bedaquiline | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Fluphenazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Oxybuprocaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Propafenone | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Droperidol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Haloperidol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Methotrimeprazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Procainamide | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Procaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Procarbazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Propranolol | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Agomelatine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Bupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Chlorpromazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Clomipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Levobupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Ropivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Sertindole | 7 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Imipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fluphenazine | Metoprolol | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Norepinephrine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fluphenazine | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fluphenazine | Dopamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoclopramide | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoclopramide | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Metoprolol | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Imipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Norepinephrine | Perphenazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | |
| Norepinephrine | Haloperidol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Norepinephrine | Procarbazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Bupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Chlorpromazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Norepinephrine | Imipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Norepinephrine | Levobupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Thioridazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Norepinephrine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Oxybuprocaine | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Methotrimeprazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Bupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Oxybuprocaine | Chlorpromazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | |
| Oxybuprocaine | Clomipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Oxybuprocaine | Levobupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Oxybuprocaine | Tamoxifen | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Periciazine | Sotalol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Perphenazine | Dopamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | |
| Perphenazine | Phenylephrine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Perphenazine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Propafenone | Dopamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Mitotane | 7 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Sotalol | Vismodegib | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Atropine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Bisacodyl | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Dopamine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Fingolimod | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Haloperidol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Ketorolac | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Methotrimeprazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Procaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Tropicamide | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Agomelatine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Fentanyl | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Levamisole | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Lidocaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Nicotinamide | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Sotalol | Sertindole | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Tapentadol | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Thioridazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Cinacalcet | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atropine | Phenylephrine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atropine | Imipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dopamine | Mefloquine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dopamine | Methotrimeprazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Dopamine | Procainamide | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Dopamine | Procarbazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Propranolol | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dopamine | Bupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Dopamine | Levobupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Dopamine | Ropivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Dopamine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Methotrimeprazine | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Phenylephrine | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Bupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Clomipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Imipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Levobupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Procaine | Trifluoperazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Procaine | Imipramine | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI |
| Procaine | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Procaine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Propranolol | Imipramine | 7 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Propranolol | Thioridazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Trifluoperazine | Agomelatine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Trifluoperazine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tropicamide | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Bupivacaine | Clomifene | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bupivacaine | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Bupivacaine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Chlorpromazine | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Chlorpromazine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomifene | Levobupivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Clomifene | Ropivacaine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Clomifene | Thioridazine | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Clomifene | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Levobupivacaine | Benzyl benzoate | 7 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Levobupivacaine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Lidocaine | Mitotane | 7 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Ganirelix | Sotalol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Cromoglicic acid | Mebeverine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Oxybuprocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Cromoglicic acid | Sotalol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Cromoglicic acid | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Chlorhexidine | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Chlorhexidine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carfilzomib | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Carfilzomib | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP2D6 mediated DDI |
| Carfilzomib | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hexoprenaline | Carbidopa | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Nimodipine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Terizidone | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Alectinib | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Avibactam | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI |
| Hexoprenaline | Carvedilol | 6 | Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Chloramphenicol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Glyburide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Mebeverine | 6 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Hexoprenaline | Nifedipine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Nitisinone | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Hexoprenaline | Metoclopramide | 6 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Atropine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Hexoprenaline | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Droperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Fingolimod | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Loperamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Perampanel | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Propranolol | 6 | Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Clomipramine | 6 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Fentanyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Levamisole | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Lidocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Amitriptyline | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Pirfenidone | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ertugliflozin | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Lisinopril | Sotalol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Selexipag | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Carbidopa | Terizidone | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Mebeverine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Carbidopa | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Carbidopa | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Carbidopa | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ivabradine | Terizidone | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Ivabradine | Nifedipine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ivabradine | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Ivabradine | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | |
| Ivabradine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | |
| Ivabradine | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nimodipine | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nimodipine | Clomipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nimodipine | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nimodipine | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nintedanib | Fenoterol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nintedanib | Sotalol | 6 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Nintedanib | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Nintedanib | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Nintedanib | Phenylephrine | 6 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Nintedanib | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nintedanib | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nintedanib | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Piribedil | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | |
| Tamsulosin | Fenoterol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Mebeverine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Norepinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Tamsulosin | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Verapamil | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Fenoterol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Methyldopa | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Epinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Norepinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Propafenone | 6 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Atropine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Methotrimeprazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Terizidone | Clomipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Urapidil | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Verapamil | Salmeterol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Verapamil | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Ivacaftor | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Metoclopramide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Verapamil | Oxybuprocaine | 6 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Verapamil | Fingolimod | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Verapamil | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Loperamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Methotrimeprazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Verapamil | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Procainamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Verapamil | Salicylic acid | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Verapamil | Tramadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Verapamil | Fluoxetine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Tamoxifen | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Amitriptyline | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Verapamil | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Vilanterol | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Amlodipine | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Avibactam | Epinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI |
| Avibactam | Oxybuprocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI |
| Avibactam | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Bisoprolol | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Fenoterol | 6 | Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Fluphenazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Norepinephrine | 6 | Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Procarbazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Chlorpromazine | 6 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | |
| Cetirizine | Norepinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Cetirizine | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Cetirizine | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Mebendazole | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Chloramphenicol | Sotalol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Fingolimod | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Chloramphenicol | Clomipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | |
| Chloramphenicol | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Chloramphenicol | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | |
| Drotaverine | Mebeverine | 6 | CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Drotaverine | Fluphenazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Oxybuprocaine | 6 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Drotaverine | Periciazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Drotaverine | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Drotaverine | Procaine | 6 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Drotaverine | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Drotaverine | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Enalapril | Sotalol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Fenoterol | Glyburide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Mebeverine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Nifedipine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Bedaquiline | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Ivacaftor | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Mebendazole | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fenoterol | Periciazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Propafenone | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Sotalol | 6 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Vismodegib | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Amiodarone | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Atropine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Bisacodyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Droperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Fingolimod | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Mefloquine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Procaine | 6 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Propranolol | 6 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Umifenovir | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Fentanyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Lidocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Rivastigmine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Amitriptyline | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fenoterol | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Oxybuprocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Sotalol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Formoterol | Atropine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Procainamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Procaine | 6 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Glyburide | Norepinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Glyburide | Sotalol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Glyburide | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Glyburide | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | |
| Levodopa | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C8 mediated DDI |
| Levodopa | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C8 mediated DDI |
| Mebeverine | Methyldopa | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Mebeverine | Mebendazole | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Norepinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Mebeverine | Oseltamivir | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebeverine | Periciazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Mebeverine | Vismodegib | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Amiodarone | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Bisacodyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Flupentixol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Flutamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebeverine | Mefloquine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Procarbazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebeverine | Agomelatine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Fentanyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Mebeverine | Fluoxetine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebeverine | Amitriptyline | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Cinacalcet | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Methyldopa | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Sotalol | 6 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Procainamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Agomelatine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Methyldopa | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Methyldopa | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Nifedipine | Salmeterol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Epinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Nifedipine | Metoclopramide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Norepinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Periciazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Nifedipine | Cariprazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Nifedipine | Procainamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Nifedipine | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP3A4 mediated DDI |
| Nifedipine | Clomipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Nifedipine | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nifedipine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Nicotinamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Cinacalcet | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nitisinone | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nitisinone | Epinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nitisinone | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Repaglinide | Dobutamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Repaglinide | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Salmeterol | Sotalol | 6 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Salmeterol | Atropine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Salmeterol | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salmeterol | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salmeterol | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Sulpiride | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Atenolol | Dobutamine | 6 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Atenolol | Oxybuprocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Tramadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Agomelatine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Fluoxetine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bedaquiline | Norepinephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Ivacaftor | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Mebendazole | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Dobutamine | Metoprolol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Oseltamivir | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Dobutamine | Periciazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Perphenazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Vismodegib | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Acetylsalicylic acid | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dobutamine | Amiodarone | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Bisacodyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dobutamine | Cariprazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Fingolimod | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Flutamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Dobutamine | Ketorolac | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dobutamine | Mefloquine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Umifenovir | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Fentanyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Fluoxetine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Levamisole | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Lidocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Rivastigmine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Tamoxifen | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Amitriptyline | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Epinephrine | Fluphenazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Atropine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Droperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Fingolimod | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Perampanel | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Procarbazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Epinephrine | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Clomipramine | 6 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Lidocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fluphenazine | Procaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Fluphenazine | Propranolol | 6 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fluphenazine | Nicotinamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Indacaterol | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Ivacaftor | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Mebendazole | Sotalol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Metoclopramide | Oxybuprocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Metoclopramide | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Metoclopramide | Flutamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoclopramide | Agomelatine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Metoclopramide | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Metoprolol | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Norepinephrine | Periciazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Vismodegib | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Amiodarone | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Norepinephrine | Atropine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Bisacodyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Norepinephrine | Droperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Umifenovir | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Norepinephrine | Clomipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Norepinephrine | Levamisole | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Lidocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Norepinephrine | Tamoxifen | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Norepinephrine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Periciazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | |
| Oxybuprocaine | Amiodarone | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Oxybuprocaine | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Flupentixol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Oxybuprocaine | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Oxybuprocaine | Procarbazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Agomelatine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Oxybuprocaine | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Oxybuprocaine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Periciazine | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Periciazine | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Propranolol | 6 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Perphenazine | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Propafenone | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Umifenovir | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Agomelatine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Clomifene | 6 | CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Salbutamol | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salbutamol | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salbutamol | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Sotalol | Chloropyramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Flupentixol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Flutamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Sotalol | Loperamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Procarbazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Sotalol | Propranolol | 6 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Salicylic acid | 6 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Teriflunomide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Sotalol | Tramadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Umifenovir | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Betahistine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Sotalol | Fluoxetine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Piracetam | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Tamoxifen | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Amitriptyline | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Carbamazepine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Sotalol | Propofol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Sotalol | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Vismodegib | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Acetylsalicylic acid | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Amiodarone | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Amiodarone | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Amiodarone | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Atropine | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Atropine | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Atropine | Amitriptyline | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Atropine | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Dopamine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Clonidine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | |
| Dopamine | Fingolimod | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dopamine | Ketorolac | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dopamine | Procaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Dopamine | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Umifenovir | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Agomelatine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dopamine | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dopamine | Clomipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Dopamine | Fentanyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Dopamine | Levamisole | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Lidocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Dopamine | Rivastigmine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Dopamine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dopamine | Amitriptyline | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Dopamine | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Ethanol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dopamine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Droperidol | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fingolimod | Loperamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fingolimod | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Lidocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Flutamide | Haloperidol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Flutamide | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Flutamide | Procaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Flutamide | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Haloperidol | Methotrimeprazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Procaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Haloperidol | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Lidocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Haloperidol | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Methotrimeprazine | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perampanel | Phenylephrine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Perampanel | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Phenobarbital | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Phenylephrine | Procarbazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Phenylephrine | Teriflunomide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Phenylephrine | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Lidocaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Phenylephrine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Procainamide | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Procainamide | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Procainamide | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | |
| Procainamide | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Procaine | Procarbazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Procaine | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | |
| Procaine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | |
| Procaine | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | |
| Procaine | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Procaine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Procarbazine | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Procarbazine | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Procarbazine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | |
| Propranolol | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Chlorpromazine | 6 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Clomipramine | 6 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salicylic acid | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salicylic acid | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Sunitinib | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Teriflunomide | Trifluoperazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Teriflunomide | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Tropicamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Fluoxetine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Trifluoperazine | Nicotinamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Trifluoperazine | Cinacalcet | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Tropicamide | Bupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Tropicamide | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tropicamide | Clomipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tropicamide | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tropicamide | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Tropicamide | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Tropicamide | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Umifenovir | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Umifenovir | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Agomelatine | Clomifene | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Agomelatine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Betahistine | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | |
| Bupivacaine | Chlorpromazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Bupivacaine | Imipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bupivacaine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Bupivacaine | Nicotinamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI |
| Bupivacaine | Piracetam | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Bupivacaine | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Bupivacaine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Chlorpromazine | Fentanyl | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | |
| Chlorpromazine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Chlorpromazine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Clomifene | Clomipramine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomifene | Tapentadol | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Clomifene | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Clomipramine | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hydroxyurea | Leflunomide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Imipramine | Levobupivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Imipramine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Imipramine | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Levobupivacaine | Nicotinamide | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI |
| Levobupivacaine | Piracetam | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Levobupivacaine | Ropivacaine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Levobupivacaine | Thioridazine | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Nicotinamide | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | |
| Nicotinamide | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Ropivacaine | Benzyl benzoate | 6 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Tapentadol | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Tapentadol | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Thioridazine | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clotrimazole | Halothane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Halothane | Mitotane | 6 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Etelcalcetide | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Micafungin | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Cetrorelix | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Triptorelin | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | |
| Leuprolide | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Leuprolide | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | |
| Lanreotide | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Lanreotide | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Lanreotide | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Lanreotide | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Lanreotide | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Lanreotide | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Lanreotide | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Octreotide | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Octreotide | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Octreotide | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Octreotide | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Octreotide | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2B6 mediated DDI |
| Cromoglicic acid | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Methotrimeprazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cromoglicic acid | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Cromoglicic acid | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Benzyl benzoate | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Chlorhexidine | Sotalol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Chlorhexidine | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Glecaprevir | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Pasireotide | Terizidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Pasireotide | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Pasireotide | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Pasireotide | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Pasireotide | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Iohexol | Verapamil | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ioversol | Verapamil | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ioversol | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Ioversol | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Bosutinib | Hexoprenaline | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Bosutinib | Fenoterol | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bosutinib | Atenolol | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Dobutamine | 5 | Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Bosutinib | Epinephrine | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bosutinib | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Norepinephrine | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Bosutinib | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Bosutinib | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Phenylephrine | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Propranolol | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bosutinib | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Bosutinib | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Bosutinib | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Bosutinib | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Carfilzomib | Hexoprenaline | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Carfilzomib | Nimodipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Carfilzomib | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Carfilzomib | Formoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Carfilzomib | Levodopa | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carfilzomib | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Carfilzomib | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | CYP2D6 mediated DDI |
| Carfilzomib | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Carfilzomib | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP2D6 mediated DDI |
| Carfilzomib | Salbutamol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Carfilzomib | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Carfilzomib | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Carfilzomib | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Carfilzomib | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Carfilzomib | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Carfilzomib | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Carfilzomib | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Delamanid | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Hexoprenaline | Atazanavir | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hexoprenaline | Imatinib | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Acalabrutinib | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Alogliptin | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Hexoprenaline | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Miglustat | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Salmeterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Ethambutol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Oseltamivir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Hexoprenaline | Paroxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Sotalol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Chloropyramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Hexoprenaline | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Mefloquine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Methotrimeprazine | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hexoprenaline | Methylergometrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Hexoprenaline | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Regorafenib | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Umifenovir | 5 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Diphenhydramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Solifenacin | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Hexoprenaline | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Propofol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Iomeprol | Verapamil | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iomeprol | Fenoterol | 5 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Dobutamine | 5 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Oxybuprocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Iomeprol | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iomeprol | Levetiracetam | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Iopromide | Verapamil | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Glyburide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Iopromide | Oxybuprocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iopromide | Vismodegib | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Iopromide | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iopromide | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iopromide | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Iopromide | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iopromide | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Iopromide | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Iopromide | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iopromide | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Iopromide | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Iopromide | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Iopromide | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Sulfasalazine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Apremilast | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Apremilast | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Apremilast | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atazanavir | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Benserazide | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Darunavir | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Empagliflozin | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Ertugliflozin | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Ertugliflozin | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Gefitinib | Terizidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Verapamil | 5 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Dobutamine | 5 | CLASS 1 (from 3); Major DDI | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Gefitinib | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Gefitinib | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Gefitinib | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Gefitinib | Procaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Gefitinib | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI |
| Imatinib | Fenoterol | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Imatinib | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Imatinib | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP3A4 mediated DDI |
| Imatinib | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Imatinib | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Imatinib | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Imatinib | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Imatinib | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Imatinib | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Lapatinib | Metoprolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Lapatinib | Propranolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Lisinopril | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Ombitasvir | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Osimertinib | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Saquinavir | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2B6 mediated DDI |
| Saquinavir | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Saquinavir | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2B6 mediated DDI |
| Selexipag | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Selexipag | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Selexipag | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Selexipag | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Selexipag | Procaine | 5 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Acalabrutinib | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Acalabrutinib | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Acalabrutinib | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Acalabrutinib | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Acalabrutinib | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Acalabrutinib | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Nimodipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Amlodipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Carbidopa | Linezolid | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Carbidopa | Nifedipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Bedaquiline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Carbidopa | Oxybuprocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Carbidopa | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Carbidopa | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Carbidopa | Bisacodyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Carbidopa | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI |
| Carbidopa | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | |
| Carbidopa | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Carbidopa | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Carbidopa | Ethanol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Dapagliflozin | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dapagliflozin | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Deferasirox | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Ivabradine | Nimodipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Mebeverine | 5 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Clomifene | 5 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Lumacaftor | Nifedipine | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Lumacaftor | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Lumacaftor | Sotalol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Lumacaftor | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Nimodipine | Terizidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Nimodipine | Urapidil | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Nimodipine | Formoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nimodipine | Glyburide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Nimodipine | Levodopa | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Nimodipine | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Methyldopa | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Nimodipine | Salmeterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Nimodipine | Metoclopramide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Oseltamivir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nimodipine | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Nimodipine | Salbutamol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Cariprazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Nimodipine | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Nimodipine | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Nimodipine | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nimodipine | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nimodipine | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Nimodipine | Zuclopenthixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Nimodipine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Nimodipine | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Propofol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nimodipine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nintedanib | Verapamil | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Nintedanib | Drotaverine | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nintedanib | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nintedanib | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Nintedanib | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nintedanib | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nintedanib | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nintedanib | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Nintedanib | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Nintedanib | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nintedanib | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nintedanib | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Nintedanib | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Olodaterol | Terizidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Olodaterol | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Sotalol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Atropine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Olodaterol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Olodaterol | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Piribedil | Terizidone | 5 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Piribedil | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C9 mediated DDI |
| Piribedil | Propranolol | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Piribedil | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Piribedil | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Rilpivirine | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C8 mediated DDI |
| Rilpivirine | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Tamsulosin | Epinephrine | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Sotalol | 5 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Tamsulosin | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Tamsulosin | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Terizidone | Vilanterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Carvedilol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Dasabuvir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Drotaverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Levodopa | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Nifedipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Salmeterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Oxybuprocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Salbutamol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Tetrabenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Terizidone | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Lacosamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Mefloquine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Propranolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Umifenovir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Acetaminophen | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Terizidone | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Rivastigmine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Terizidone | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Sevoflurane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI |
| Terizidone | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Urapidil | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Nifedipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Urapidil | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Urapidil | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Urapidil | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Urapidil | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Verapamil | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Formoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Levodopa | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Verapamil | Methyldopa | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Verapamil | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Verapamil | Indacaterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Verapamil | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Verapamil | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Verapamil | Sotalol | 5 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Vismodegib | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Verapamil | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Atropine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Verapamil | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Verapamil | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Verapamil | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Verapamil | Mefloquine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Perampanel | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Verapamil | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Propranolol | 5 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Verapamil | Zuclopenthixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Verapamil | Diphenhydramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Verapamil | Rivastigmine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Sertindole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Verapamil | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Trihexyphenidyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Verapamil | Pirfenidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Vilanterol | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Vilanterol | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vilanterol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Vilanterol | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vilanterol | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Vilanterol | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Vilanterol | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Vilanterol | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Alectinib | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Alectinib | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Alectinib | Nifedipine | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Alectinib | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Alectinib | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alectinib | Fosfomycin | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Alectinib | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alectinib | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Alectinib | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Alectinib | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Amlodipine | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Amlodipine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Amlodipine | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Amlodipine | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Amlodipine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Amlodipine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Apixaban | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Avibactam | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | |
| Avibactam | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Avibactam | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | |
| Avibactam | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Avibactam | Propranolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Avibactam | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Avibactam | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Bicalutamide | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Bicalutamide | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Bicalutamide | Procaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Bicalutamide | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Bisoprolol | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bisoprolol | Fingolimod | 5 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bisoprolol | Trifluoperazine | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisoprolol | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bisoprolol | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cabozantinib | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Cabozantinib | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cabozantinib | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Cabozantinib | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carvedilol | Salmeterol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Bedaquiline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Epinephrine | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Perphenazine | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Sotalol | 5 | Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Haloperidol | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Mefloquine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Methotrimeprazine | 5 | CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Phenylephrine | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Clomifene | 5 | CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Imipramine | 5 | CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Trihexyphenidyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cetirizine | Nifedipine | 5 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Cetirizine | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Cetirizine | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Cetirizine | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Cetirizine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Chloramphenicol | Fenoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Formoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | |
| Chloramphenicol | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | |
| Chloramphenicol | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Atropine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Chloramphenicol | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Chloramphenicol | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Drotaverine | Fenoterol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Sulpiride | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Drotaverine | Perphenazine | 5 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Lacosamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Drotaverine | Methotrimeprazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Drotaverine | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Drotaverine | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Drotaverine | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Benzyl benzoate | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Enalapril | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Enalapril | Atropine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Enalapril | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | |
| Enalapril | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Fenoterol | Formoterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Methyldopa | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Nitisinone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Salmeterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Siponimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Apalutamide | 5 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Indacaterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Metoclopramide | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Oseltamivir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Fenoterol | Oxybuprocaine | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Paroxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fenoterol | Tetrabenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Chloropyramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Fenoterol | Dexketoprofen | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Fenoterol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Fluorescein | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Ketoprofen | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Fenoterol | Ketorolac | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Methylergometrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Fenoterol | Perampanel | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Tramadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Zuclopenthixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fenoterol | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Sertindole | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Solifenacin | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Fenoterol | Tamoxifen | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Pirfenidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Propofol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Sertraline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Methyldopa | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Formoterol | Nifedipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Salmeterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Formoterol | Bedaquiline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Formoterol | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Metoclopramide | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Formoterol | Oseltamivir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Formoterol | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Vismodegib | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Bisacodyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Formoterol | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Formoterol | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Methotrimeprazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Perampanel | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Formoterol | Propranolol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Zuclopenthixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Mebeverine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Nifedipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Glyburide | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Glyburide | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Rivastigmine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Ibrutinib | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Levodopa | Mebeverine | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Levodopa | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Levodopa | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Levodopa | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Levodopa | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Levodopa | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Levodopa | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Levodopa | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | CYP2C8 mediated DDI |
| Levodopa | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Levodopa | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Linezolid | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Losartan | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI |
| Losartan | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | CYP2C9 mediated DDI |
| Mebeverine | Nifedipine | 5 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Salmeterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Siponimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Mebeverine | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebeverine | Ketorolac | 5 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Mebeverine | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Propranolol | 5 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Mebeverine | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Tramadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Zuclopenthixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Mebeverine | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Nicotinamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Mebeverine | Sertindole | 5 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Methyldopa | Nifedipine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Salmeterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Bedaquiline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Methyldopa | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Propafenone | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Atropine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C8 mediated DDI |
| Methyldopa | Bisacodyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Procaine | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Methyldopa | Propranolol | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Umifenovir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Chlorpromazine | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Methyldopa | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Miglustat | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Nifedipine | Bedaquiline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Nifedipine | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Nifedipine | Indacaterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Nifedipine | Tetrabenazine | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nifedipine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nifedipine | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Tropicamide | 5 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Zuclopenthixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nifedipine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nifedipine | Loratadine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Nifedipine | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nifedipine | Benzyl benzoate | 5 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Propofol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Nitisinone | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Nitisinone | Salbutamol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Nitisinone | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Nitisinone | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nitisinone | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Paliperidone | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Paliperidone | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Paliperidone | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Quetiapine | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2D6 mediated DDI |
| Quetiapine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Salmeterol | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salmeterol | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salmeterol | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Ivacaftor | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salmeterol | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salmeterol | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Salmeterol | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salmeterol | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Salmeterol | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Propranolol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salmeterol | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salmeterol | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salmeterol | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salmeterol | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Salmeterol | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Siponimod | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Siponimod | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Sulpiride | Fluphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Sulpiride | Oxybuprocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Sulpiride | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Sulpiride | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Sulpiride | Methotrimeprazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Sulpiride | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Sulpiride | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Sulpiride | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Sulpiride | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sulpiride | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Sulpiride | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Sulpiride | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Trametinib | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Aminosalicylic acid | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Aminosalicylic acid | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Aminosalicylic acid | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Aminosalicylic acid | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Apalutamide | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Apalutamide | Sotalol | 5 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Apalutamide | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Atenolol | Bedaquiline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Paroxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Tetrabenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Fingolimod | 5 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Mefloquine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Cinacalcet | 5 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bedaquiline | Dobutamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Bedaquiline | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Bedaquiline | Oxybuprocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Bedaquiline | Propafenone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bedaquiline | Salbutamol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Bedaquiline | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Bedaquiline | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Bedaquiline | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Bedaquiline | Propranolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bedaquiline | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Bedaquiline | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Dapsone | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | |
| Dobutamine | Epinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Ethambutol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Hydroxyzine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Dobutamine | Indacaterol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Metoclopramide | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Paroxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Salbutamol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Tetrabenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Atropine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Chloropyramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dobutamine | Enzalutamide | 5 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dobutamine | Fluorescein | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Lacosamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | |
| Dobutamine | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Dobutamine | Methylergometrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Dobutamine | Perampanel | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dobutamine | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Tramadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Zuclopenthixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Loratadine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Dobutamine | Nicotinamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dobutamine | Praziquantel | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Dobutamine | Ethanol | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dobutamine | Pirfenidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Propofol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dobutamine | Sertraline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Epinephrine | Ivacaftor | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Mebendazole | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Epinephrine | Metoclopramide | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Oseltamivir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Epinephrine | Periciazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Perphenazine | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Sotalol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Vismodegib | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Epinephrine | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Bisacodyl | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Epinephrine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Epinephrine | Mefloquine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Methylergometrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Propranolol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Umifenovir | 5 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Epinephrine | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Pirfenidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Ethambutol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Ethambutol | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Favipiravir | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Favipiravir | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Favipiravir | Propranolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Fluphenazine | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Fluphenazine | Propafenone | 5 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fluphenazine | Salbutamol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fluphenazine | Tetrabenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Fluphenazine | Vismodegib | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Fluphenazine | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Fluphenazine | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Fluphenazine | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Perampanel | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Fluphenazine | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Fluphenazine | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Fluphenazine | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Fluphenazine | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Fluphenazine | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Fluphenazine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Fosfomycin | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Fosfomycin | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Fosfomycin | Trihexyphenidyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Fosfomycin | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Hydroxychloroquine | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hydroxychloroquine | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Hydroxyzine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Hydroxyzine | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Hydroxyzine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Indacaterol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Indacaterol | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Indacaterol | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Indacaterol | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Ivacaftor | Norepinephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Ivacaftor | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Ivacaftor | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Ivacaftor | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Mebendazole | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mesalazine | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Mesalazine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Metoclopramide | Norepinephrine | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Metoclopramide | Sotalol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Metoclopramide | Vismodegib | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Metoclopramide | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Metoclopramide | Phenylephrine | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoclopramide | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Metoclopramide | Procaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Metoclopramide | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Metoclopramide | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Metoclopramide | Imipramine | 5 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Metoclopramide | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Metoclopramide | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Metoclopramide | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Metoclopramide | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | |
| Metoclopramide | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Metoprolol | Oseltamivir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Metoprolol | Tetrabenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Fingolimod | 5 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Phenylephrine | 5 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Biperiden | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Clomifene | 5 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Trihexyphenidyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Midostaurin | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Norepinephrine | Oseltamivir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Norepinephrine | Propafenone | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Norepinephrine | Sotalol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Norepinephrine | Ketorolac | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Norepinephrine | Mefloquine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Norepinephrine | Methotrimeprazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Norepinephrine | Methylergometrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Norepinephrine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Propranolol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Norepinephrine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Norepinephrine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Norepinephrine | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Norepinephrine | Pirfenidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Olaparib | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Oseltamivir | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Oseltamivir | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Oxybuprocaine | Perphenazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Oxybuprocaine | Propafenone | 5 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Oxybuprocaine | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Oxybuprocaine | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Mefloquine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Oxybuprocaine | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Tramadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Oxybuprocaine | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Oxybuprocaine | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Oxybuprocaine | Nicotinamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Sertindole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Oxybuprocaine | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI |
| Oxybuprocaine | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Paroxetine | Sotalol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Paroxetine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Pentoxifylline | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI |
| Periciazine | Propafenone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Periciazine | Salbutamol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Periciazine | Cycloserine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Periciazine | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Periciazine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Periciazine | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Periciazine | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Periciazine | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Periciazine | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Periciazine | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Periciazine | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Periciazine | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Perphenazine | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Perphenazine | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Perphenazine | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Perphenazine | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Propafenone | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Atropine | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Fingolimod | 5 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Methotrimeprazine | 5 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Propafenone | Phenylephrine | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Tramadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Nicotinamide | 5 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Propafenone | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salbutamol | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salbutamol | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Salbutamol | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Salbutamol | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salbutamol | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Salbutamol | Propranolol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Salbutamol | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salbutamol | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salbutamol | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Salbutamol | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salbutamol | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salbutamol | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Salbutamol | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Salbutamol | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Salbutamol | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Sotalol | Acetylsalicylic acid | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Amiodarone | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Axitinib | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Droperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Fenofibrate | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Mefloquine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Methylergometrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Sotalol | Phenylephrine | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Sotalol | Zuclopenthixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Sotalol | Biperiden | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Solifenacin | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Sotalol | Trihexyphenidyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Sertraline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Tetrabenazine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Tetrabenazine | Propranolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tetrabenazine | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Tetrabenazine | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Vismodegib | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Vismodegib | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI |
| Vismodegib | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI |
| Vismodegib | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Vismodegib | Sunitinib | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Vismodegib | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Vismodegib | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Vismodegib | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Vismodegib | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vismodegib | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Vismodegib | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Vismodegib | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2D6 mediated DDI |
| Vismodegib | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Vismodegib | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Acetylsalicylic acid | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Aminocaproic acid | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Amiodarone | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Amiodarone | Haloperidol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Amiodarone | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Amiodarone | Propranolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Amiodarone | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Amiodarone | Acetaminophen | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Amiodarone | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Amiodarone | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Amiodarone | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Amiodarone | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Amiodarone | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Amiodarone | Tamoxifen | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Amiodarone | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atropine | Fingolimod | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Atropine | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Atropine | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Atropine | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | |
| Atropine | Tramadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atropine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atropine | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Atropine | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atropine | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atropine | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Atropine | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Atropine | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | |
| Atropine | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atropine | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Bisacodyl | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Bisacodyl | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bisacodyl | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Caffeine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI |
| Captopril | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | |
| Captopril | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Captopril | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | |
| Chloropyramine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Chloropyramine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Clonidine | Dopamine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Cycloserine | Procaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Cycloserine | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Diclofenac | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Dopamine | Flupentixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Dopamine | Flutamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Dopamine | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dopamine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Sunitinib | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Zuclopenthixol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI |
| Dopamine | Acetaminophen | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Dopamine | Levetiracetam | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Sertindole | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Dopamine | Tamoxifen | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Dopamine | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Droperidol | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Droperidol | Procaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Droperidol | Propranolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Droperidol | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Droperidol | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fingolimod | Methotrimeprazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fingolimod | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Procaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Propranolol | 5 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fingolimod | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Tramadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Umifenovir | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fingolimod | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fingolimod | Levetiracetam | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Fingolimod | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Rivastigmine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Flupentixol | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Flupentixol | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Flutamide | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Flutamide | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Flutamide | Procarbazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Flutamide | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Flutamide | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Flutamide | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Flutamide | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Flutamide | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Flutamide | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Flutamide | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Flutamide | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Flutamide | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Glycine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Haloperidol | Loperamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Haloperidol | Sorafenib | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Haloperidol | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Haloperidol | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Piracetam | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Haloperidol | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Sertindole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Haloperidol | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ketorolac | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Lacosamide | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Lacosamide | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Lacosamide | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Lacosamide | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Lacosamide | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Loperamide | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Mefloquine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mefloquine | Procaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | |
| Mefloquine | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Mefloquine | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Mefloquine | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Mefloquine | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Procainamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Methotrimeprazine | Propranolol | 5 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Methotrimeprazine | Chlorpromazine | 5 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methylergometrine | Phenylephrine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Perampanel | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Phenylephrine | Propranolol | 5 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Umifenovir | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Phenylephrine | Levamisole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Phenylephrine | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Tamoxifen | 5 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Phenylephrine | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Pirfenidone | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Procainamide | Sunitinib | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Procainamide | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Procainamide | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Procainamide | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Procainamide | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Procainamide | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Sertindole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Tamoxifen | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Procaine | Teriflunomide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Procaine | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Procaine | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Procaine | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Procaine | Clomifene | 5 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Procaine | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Procaine | Nicotinamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI |
| Procaine | Tamoxifen | 5 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Procaine | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procarbazine | Propranolol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Procarbazine | Salicylic acid | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Procarbazine | Trifluoperazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Procarbazine | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Procarbazine | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Procarbazine | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Procarbazine | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procarbazine | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Procarbazine | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Procarbazine | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Propranolol | Agomelatine | 5 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Trihexyphenidyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | |
| Salicylic acid | Chlorpromazine | 5 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salicylic acid | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salicylic acid | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Sunitinib | Tropicamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Sunitinib | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Sunitinib | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Sunitinib | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Sunitinib | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Teriflunomide | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Teriflunomide | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Tramadol | Agomelatine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tramadol | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Tramadol | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Tramadol | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Acetaminophen | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Trifluoperazine | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Trifluoperazine | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Trifluoperazine | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Trifluoperazine | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Trifluoperazine | Praziquantel | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Trifluoperazine | Vinpocetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Trifluoperazine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Clotrimazole | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Tropicamide | Chlorpromazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Umifenovir | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Umifenovir | Clomifene | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Umifenovir | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Umifenovir | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Umifenovir | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Zuclopenthixol | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Acetaminophen | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Agomelatine | Bupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Agomelatine | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Agomelatine | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Agomelatine | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Agomelatine | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Agomelatine | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bupivacaine | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Bupivacaine | Rivastigmine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Chlorpromazine | Clomipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Chlorpromazine | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Chlorpromazine | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Chlorpromazine | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Chlorpromazine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Chlorpromazine | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Chlorpromazine | Clotrimazole | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Clomifene | Fentanyl | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Clomifene | Fluoxetine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomifene | Lidocaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Clomifene | Nicotinamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Clomifene | Piracetam | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Clomifene | Sertindole | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Clomifene | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Clomifene | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomipramine | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomipramine | Levobupivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Clomipramine | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Clomipramine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Clomipramine | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fentanyl | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fentanyl | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | |
| Fluoxetine | Imipramine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fluoxetine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Fluoxetine | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Nicotinamide | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Amitriptyline | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Imipramine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Levobupivacaine | Rivastigmine | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Lidocaine | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Lidocaine | Thioridazine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Lidocaine | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Lidocaine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nicotinamide | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Piracetam | Ropivacaine | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing arrhythmia | |
| Piracetam | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Rivastigmine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Rivastigmine | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Ropivacaine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Ropivacaine | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Sertindole | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Solifenacin | Tapentadol | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Solifenacin | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | |
| Tamoxifen | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Tapentadol | Benzyl benzoate | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Thioridazine | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Vinpocetine | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Amitriptyline | Mitotane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Benzyl benzoate | Cinacalcet | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Benzyl benzoate | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Carbamazepine | Sevoflurane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing arrhythmia | |
| Cinacalcet | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Pirfenidone | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Propofol | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Protionamide | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Sevelamer | Halothane | 5 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Daptomycin | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Micafungin | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Ganirelix | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Ganirelix | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Ganirelix | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Ganirelix | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Ganirelix | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Ganirelix | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ganirelix | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Ganirelix | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ganirelix | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Sennosides | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI |
| Cetrorelix | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Cetrorelix | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Degarelix | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Degarelix | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Degarelix | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Degarelix | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Degarelix | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Degarelix | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Goserelin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Polymyxin B | Iopromide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Polymyxin B | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Polymyxin B | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Polymyxin B | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Terlipressin | Iohexol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Terlipressin | Iomeprol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Terlipressin | Iopromide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Terlipressin | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Terlipressin | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Terlipressin | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Terlipressin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Terlipressin | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Terlipressin | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Triptorelin | Fenoterol | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Triptorelin | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Triptorelin | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Triptorelin | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Triptorelin | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI |
| Triptorelin | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Triptorelin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Leuprolide | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Leuprolide | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Leuprolide | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Leuprolide | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C19 mediated DDI |
| Leuprolide | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Leuprolide | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Leuprolide | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Leuprolide | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C19 mediated DDI |
| Leuprolide | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI |
| Leuprolide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Leuprolide | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Desmopressin | Iomeprol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Desmopressin | Iopromide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Desmopressin | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Desmopressin | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Desmopressin | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Desmopressin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Desmopressin | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Desmopressin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Atosiban | Iopromide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Atosiban | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Atosiban | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Atosiban | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Atosiban | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Azithromycin | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Azithromycin | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Azithromycin | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Azithromycin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Azithromycin | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Azithromycin | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Azithromycin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Azithromycin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Azithromycin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Azithromycin | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Azithromycin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Alectinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Clarithromycin | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Clarithromycin | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Clarithromycin | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Clarithromycin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Clarithromycin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Clarithromycin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Clarithromycin | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Clarithromycin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Clarithromycin | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Clarithromycin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Carbetocin | Iopromide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Carbetocin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Carbetocin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Lanreotide | Iohexol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Lanreotide | Ioversol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Lanreotide | Hexoprenaline | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Lanreotide | Iomeprol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Lanreotide | Iopromide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI |
| Lanreotide | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Lanreotide | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Lanreotide | Formoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Lanreotide | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Lanreotide | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Lanreotide | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Lanreotide | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI |
| Lanreotide | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Lanreotide | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Lanreotide | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lanreotide | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Lanreotide | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lanreotide | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI |
| Lanreotide | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Lanreotide | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lanreotide | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lanreotide | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lanreotide | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lanreotide | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lanreotide | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Lanreotide | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Octreotide | Iohexol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Octreotide | Ioversol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Octreotide | Hexoprenaline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Octreotide | Iomeprol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Octreotide | Iopromide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Octreotide | Nintedanib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Octreotide | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Octreotide | Formoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Octreotide | Mebeverine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Octreotide | Paliperidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Octreotide | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Octreotide | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Octreotide | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Octreotide | Risperidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Octreotide | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Octreotide | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Octreotide | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Octreotide | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Octreotide | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Octreotide | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Octreotide | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Octreotide | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Octreotide | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Octreotide | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Octreotide | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Octreotide | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Octreotide | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Octreotide | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Cromoglicic acid | Gefitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Carbidopa | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | |
| Cromoglicic acid | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Cromoglicic acid | Glyburide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Sulpiride | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Metoclopramide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Cromoglicic acid | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Cromoglicic acid | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Piracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Cromoglicic acid | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Lactulose | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Ademetionine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Chlorhexidine | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Chlorhexidine | Procarbazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Chlorhexidine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Chlorhexidine | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Chlorhexidine | Mitotane | 4 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Glecaprevir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Grazoprevir | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI |
| Grazoprevir | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Pasireotide | Iohexol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI |
| Pasireotide | Ioversol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Pasireotide | Iomeprol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Pasireotide | Iopromide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Pasireotide | Nintedanib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI |
| Pasireotide | Carvedilol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Pasireotide | Chloramphenicol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Pasireotide | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Pasireotide | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Pasireotide | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Pasireotide | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Pasireotide | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Pasireotide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Pasireotide | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI |
| Pibrentasvir | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Pibrentasvir | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Pibrentasvir | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Pibrentasvir | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Pibrentasvir | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Pibrentasvir | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Venetoclax | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Doxazosin | Avibactam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Fluphenazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Doxazosin | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Trifluoperazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Doxazosin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Doxazosin | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Doxazosin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iohexol | Oxybuprocaine | 4 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Iohexol | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iohexol | Procaine | 4 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iohexol | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Ioversol | Hexoprenaline | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Ioversol | Fenoterol | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Ioversol | Nifedipine | 4 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Ioversol | Epinephrine | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ioversol | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Ioversol | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Ioversol | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Ioversol | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Ioversol | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Ioversol | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ioversol | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Ioversol | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Macitentan | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Nelarabine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Posaconazole | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Posaconazole | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Remdesivir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Alendronic acid | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Alfuzosin | Fluphenazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Haloperidol | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Trifluoperazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Bupivacaine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Chlorpromazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Alfuzosin | Clomifene | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Imipramine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Alfuzosin | Levobupivacaine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Ropivacaine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Alfuzosin | Mitotane | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Bosutinib | Terizidone | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Bosutinib | Verapamil | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Bosutinib | Carvedilol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bosutinib | Formoterol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Mebeverine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Oxybuprocaine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bosutinib | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C8 mediated DDI |
| Bosutinib | Dopamine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bosutinib | Procainamide | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Bosutinib | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Bosutinib | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Carfilzomib | Verapamil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Carfilzomib | Carvedilol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carfilzomib | Drotaverine | 4 | CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carfilzomib | Nifedipine | 4 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Carfilzomib | Salmeterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carfilzomib | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Carfilzomib | Oxybuprocaine | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Carfilzomib | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Carfilzomib | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Carfilzomib | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Carfilzomib | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carfilzomib | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Carfilzomib | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carfilzomib | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carfilzomib | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Carfilzomib | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Carfilzomib | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Carfilzomib | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Carfilzomib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Carfilzomib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Ceritinib | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ceritinib | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Ceritinib | Formoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Ceritinib | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Ceritinib | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Delamanid | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Delamanid | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Ertapenem | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Fosamprenavir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Hexoprenaline | Iomeprol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Hexoprenaline | Iopromide | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Gefitinib | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Saquinavir | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Lumacaftor | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Nilotinib | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Urapidil | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Hexoprenaline | Bicalutamide | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Cabozantinib | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Hexoprenaline | Dasabuvir | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia | CYP2C9 mediated DDI |
| Hexoprenaline | Enalapril | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Hexoprenaline | Formoterol | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Ipragliflozin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Losartan | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Methyldopa | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Nelfinavir | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Siponimod | 4 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Apalutamide | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Diatrizoate | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Hexoprenaline | Favipiravir | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Hexoprenaline | Hydroxychloroquine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Nitrazepam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Norepinephrine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Tetrabenazine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Cariprazine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Chlorambucil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Hexoprenaline | Fluorescein | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Hexoprenaline | Isoniazid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Hexoprenaline | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Leflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C9 mediated DDI |
| Hexoprenaline | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Tamoxifen | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Carbamazepine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Hexoprenaline | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C9 mediated DDI |
| Hexoprenaline | Sertraline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C9 mediated DDI |
| Inosine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iomeprol | Carvedilol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iomeprol | Chloramphenicol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Glyburide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Iomeprol | Nifedipine | 4 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Iomeprol | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iomeprol | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Iomeprol | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Iomeprol | Phenylephrine | 4 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing arrhythmia | |
| Iomeprol | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Iomeprol | Procaine | 4 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Iomeprol | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Iomeprol | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iomeprol | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Iomeprol | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Iomeprol | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Iomeprol | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Iomeprol | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Iomeprol | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Iopromide | Saquinavir | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iopromide | Alectinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iopromide | Bicalutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Iopromide | Chloramphenicol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Iopromide | Fenoterol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Mebeverine | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iopromide | Nifedipine | 4 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Iopromide | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Epinephrine | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iopromide | Norepinephrine | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iopromide | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Iopromide | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Iopromide | Phenylephrine | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Procaine | 4 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Iopromide | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iopromide | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Iopromide | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iopromide | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Iopromide | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iopromide | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Iopromide | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Iopromide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Isosorbide dinitrate | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Palbociclib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Palbociclib | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C8 mediated DDI |
| Palbociclib | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C8 mediated DDI |
| Palbociclib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Palbociclib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Riociguat | Sotalol | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Tenofovir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Abemaciclib | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Abemaciclib | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Abemaciclib | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Abemaciclib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Abemaciclib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Abemaciclib | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Abemaciclib | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Abemaciclib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Abemaciclib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Afatinib | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Afatinib | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Afatinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Afatinib | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Afatinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Apremilast | Oxybuprocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Apremilast | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Apremilast | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Apremilast | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Apremilast | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Apremilast | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Apremilast | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Apremilast | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Apremilast | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Apremilast | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Atazanavir | Mebeverine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Atazanavir | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Atazanavir | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Atazanavir | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atazanavir | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Atazanavir | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atazanavir | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atazanavir | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Atazanavir | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atazanavir | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Atazanavir | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Atazanavir | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atazanavir | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Atazanavir | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Atazanavir | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Atazanavir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Atazanavir | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Benserazide | Verapamil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Benserazide | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Benserazide | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Benserazide | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Benserazide | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Benserazide | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Cladribine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Cobicistat | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP3A4 mediated DDI |
| Cobicistat | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Cobicistat | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Cobicistat | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Cobicistat | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Cobicistat | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Darunavir | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Empagliflozin | Dobutamine | 4 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Empagliflozin | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Erlotinib | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Erlotinib | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Erlotinib | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Erlotinib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Erlotinib | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Erlotinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Erlotinib | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Erlotinib | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Erlotinib | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Erlotinib | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Erlotinib | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Erlotinib | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Erlotinib | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Erlotinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Erlotinib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Ertugliflozin | Fenoterol | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ertugliflozin | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Ertugliflozin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Carvedilol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Gefitinib | Salmeterol | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | |
| Gefitinib | Atenolol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Hydroxychloroquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Gefitinib | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Metoclopramide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Gefitinib | Oxybuprocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gefitinib | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gefitinib | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Gefitinib | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Gefitinib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Phenylephrine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Gefitinib | Propranolol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Gefitinib | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gefitinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gefitinib | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Gefitinib | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Gefitinib | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gefitinib | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Gefitinib | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gefitinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gefitinib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Imatinib | Alectinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C8 mediated DDI |
| Imatinib | Formoterol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Imatinib | Mebeverine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Imatinib | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Imatinib | Salmeterol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Imatinib | Atenolol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Imatinib | Dobutamine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Imatinib | Epinephrine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Imatinib | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Imatinib | Metoprolol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Imatinib | Norepinephrine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Imatinib | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Imatinib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Imatinib | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Imatinib | Phenylephrine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Imatinib | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Imatinib | Propranolol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Imatinib | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Imatinib | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Imatinib | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Imatinib | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Imatinib | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Imatinib | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Imatinib | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Imatinib | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Imatinib | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Imatinib | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Imatinib | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Imatinib | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Imatinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Imatinib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Lapatinib | Verapamil | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Mebeverine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Atenolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Lapatinib | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Ivacaftor | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Lapatinib | Oxybuprocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C9 mediated DDI |
| Lapatinib | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Propafenone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Lapatinib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Lapatinib | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Lapatinib | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Lapatinib | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C9 mediated DDI |
| Lapatinib | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Lapatinib | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Lapatinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Lapatinib | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Lapatinib | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C8 mediated DDI |
| Lapatinib | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Lapatinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lapatinib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Levofloxacin | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Alectinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Levofloxacin | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Levofloxacin | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Leflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lisinopril | Carbidopa | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Lisinopril | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Lisinopril | Verapamil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Lisinopril | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Lisinopril | Mebeverine | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Lisinopril | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Lisinopril | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Lisinopril | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Lisinopril | Atropine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Lisinopril | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Lisinopril | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Lisinopril | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Lisinopril | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Lisinopril | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Lisinopril | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C8 mediated DDI |
| Lisinopril | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lisinopril | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mitomycin | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Moxifloxacin | Alectinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Bicalutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Moxifloxacin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Moxifloxacin | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Alectinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ofloxacin | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ofloxacin | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Leflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ombitasvir | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ombitasvir | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ombitasvir | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Ombitasvir | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Ombitasvir | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Ombitasvir | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Ombitasvir | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ombitasvir | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Ombitasvir | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Ombitasvir | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Ombitasvir | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Osimertinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Osimertinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Raltegravir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ribociclib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Saquinavir | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2B6 mediated DDI |
| Saquinavir | Epinephrine | 4 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Saquinavir | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Saquinavir | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Saquinavir | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Saquinavir | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Saquinavir | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Saquinavir | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Saquinavir | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Saquinavir | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Saquinavir | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Saquinavir | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Saquinavir | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Saquinavir | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Saquinavir | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Saquinavir | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Saquinavir | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Saquinavir | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Selexipag | Norepinephrine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Selexipag | Oxybuprocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Selexipag | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Selexipag | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Selexipag | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Selexipag | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Selexipag | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Selexipag | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Tenofovir alafenamide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Timolol | Dobutamine | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Timolol | Dopamine | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Timolol | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Timolol | Fingolimod | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | |
| Timolol | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Trimethoprim | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Acalabrutinib | Formoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Acalabrutinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Baricitinib | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Bictegravir | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Bictegravir | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Bictegravir | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Bromocriptine | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Bromocriptine | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Bromocriptine | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Bromocriptine | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Bromocriptine | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Bromocriptine | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Capecitabine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Carbidopa | Nintedanib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Carbidopa | Piribedil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Carbidopa | Tamsulosin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Carbidopa | Vilanterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Carvedilol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | |
| Carbidopa | Enalapril | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Carbidopa | Formoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Salmeterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Indacaterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Carbidopa | Metoprolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | |
| Carbidopa | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Carbidopa | Propafenone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | |
| Carbidopa | Atropine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Carbidopa | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Carbidopa | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Isoniazid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2C8 mediated DDI |
| Carbidopa | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | |
| Carbidopa | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI |
| Carbidopa | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Carbidopa | Propranolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | |
| Carbidopa | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Carbidopa | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Carbidopa | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Carbidopa | Betahistine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Carbidopa | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2C8 mediated DDI |
| Carbidopa | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Carbidopa | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Carbidopa | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Carbidopa | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2C8 mediated DDI |
| Carbidopa | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Carbidopa | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Carbidopa | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Carbidopa | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Cilastatin | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Cilastatin | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Cilastatin | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Cilastatin | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Ciprofloxacin | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Alectinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Fluconazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Ciprofloxacin | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ciprofloxacin | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ciprofloxacin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Leflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ciprofloxacin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Dapagliflozin | Fenoterol | 4 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dapagliflozin | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C9 mediated DDI |
| Dapagliflozin | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Deferasirox | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Deferasirox | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Deferasirox | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Deferasirox | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Deferasirox | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Deferasirox | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Deferasirox | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Elvitegravir | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Elvitegravir | Sotalol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | |
| Elvitegravir | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Elvitegravir | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Elvitegravir | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Elvitegravir | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Elvitegravir | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Elvitegravir | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Elvitegravir | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Elvitegravir | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Elvitegravir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Etravirine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Gosogliptin | Periciazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Haloperidol | 4 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Trifluoperazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Clomifene | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Imipenem | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Irinotecan | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ivabradine | Verapamil | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Ivabradine | Carvedilol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Fenoterol | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Favipiravir | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Ivabradine | Fluphenazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Ivabradine | Propafenone | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Ivabradine | Haloperidol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Methotrimeprazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Ivabradine | Phenylephrine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Procainamide | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Ivabradine | Propranolol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Trifluoperazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Ivabradine | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Ivabradine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Ivabradine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Lomefloxacin | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lomefloxacin | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lomefloxacin | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lomefloxacin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lomefloxacin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lomefloxacin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lomefloxacin | Leflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lomefloxacin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lumacaftor | Fenoterol | 4 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Lumacaftor | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Mannitol | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Meropenem | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Moxonidine | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Nilotinib | Fluconazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Nilotinib | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nilotinib | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nilotinib | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Nilotinib | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Nilotinib | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Nilotinib | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nilotinib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Nilotinib | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Nilotinib | Phenylephrine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Nilotinib | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Nilotinib | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nilotinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nilotinib | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Nilotinib | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Nilotinib | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Nilotinib | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nilotinib | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Nilotinib | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Nilotinib | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Nilotinib | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Nilotinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Nilotinib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Nimodipine | Olodaterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Alectinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Nimodipine | Avibactam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Nimodipine | Cetirizine | 4 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nimodipine | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nimodipine | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nimodipine | Favipiravir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Indacaterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Tetrabenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Nimodipine | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Atropine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Fluorescein | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Nimodipine | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Nimodipine | Propranolol | 4 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nimodipine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nimodipine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nimodipine | Lomustine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Nimodipine | Loratadine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nimodipine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nimodipine | Sertindole | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Nimodipine | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nintedanib | Alectinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nintedanib | Chloramphenicol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Nintedanib | Methyldopa | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Nintedanib | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Nintedanib | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Nintedanib | Flutamide | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Nintedanib | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Nintedanib | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Nintedanib | Procainamide | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Nintedanib | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nintedanib | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nintedanib | Clomifene | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nintedanib | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Nintedanib | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nintedanib | Amitriptyline | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nintedanib | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Olodaterol | Verapamil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Olodaterol | Carvedilol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Olodaterol | Fenoterol | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI |
| Olodaterol | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Olodaterol | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Olodaterol | Propranolol | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Olodaterol | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Olodaterol | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Olodaterol | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Olodaterol | Lidocaine | 4 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Olodaterol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Piribedil | Avibactam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Piribedil | Bisoprolol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Piribedil | Atenolol | 4 | Major DDI | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Piribedil | Propafenone | 4 | Major DDI | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Piribedil | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI |
| Piribedil | Trifluoperazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Piribedil | Bupivacaine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Piribedil | Levobupivacaine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Piribedil | Ropivacaine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Rilpivirine | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Rilpivirine | Trifluoperazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP3A4 mediated DDI |
| Rilpivirine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ritonavir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Tamsulosin | Terizidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Tamsulosin | Verapamil | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Tamsulosin | Methyldopa | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Tamsulosin | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Tamsulosin | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Tamsulosin | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Tamsulosin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Tamsulosin | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Tamsulosin | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Tamsulosin | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Terizidone | Urapidil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Chloramphenicol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Terizidone | Enalapril | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2C8 mediated DDI |
| Terizidone | Formoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Terizidone | Losartan | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Siponimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Atenolol | 4 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Fosfomycin | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Indacaterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Metoprolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Terizidone | Acetylsalicylic acid | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Aminophylline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Terizidone | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Dexketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Fluorescein | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Terizidone | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Ketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Tranexamic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Terizidone | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Pyrantel | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Terizidone | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP3A4 mediated DDI |
| Terizidone | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Terizidone | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Verapamil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP3A4 mediated DDI |
| Urapidil | Carvedilol | 4 | CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Salmeterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP1A2 mediated DDI |
| Urapidil | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Urapidil | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vandetanib | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Vandetanib | Metoclopramide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Vandetanib | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI |
| Vandetanib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vandetanib | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Vandetanib | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Vandetanib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Vandetanib | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Vandetanib | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Vandetanib | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vandetanib | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Vandetanib | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Vandetanib | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Vandetanib | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Vandetanib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Vandetanib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Verapamil | Avibactam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP3A4 mediated DDI |
| Verapamil | Bicalutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Verapamil | Cabozantinib | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Verapamil | Chloramphenicol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Verapamil | Drotaverine | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Enalapril | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Verapamil | Glyburide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Verapamil | Siponimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Verapamil | Sulpiride | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Verapamil | Ethambutol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Verapamil | Indapamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Verapamil | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Midostaurin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Verapamil | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Verapamil | Tetrabenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Verapamil | Cariprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Verapamil | Chlorambucil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Verapamil | Dexketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Verapamil | Ketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Verapamil | Ketorolac | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Verapamil | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Sunitinib | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Verapamil | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Verapamil | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Verapamil | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Verapamil | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Loratadine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Verapamil | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Vilanterol | Fenoterol | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Vilanterol | Norepinephrine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Vilanterol | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Vilanterol | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI |
| Vilanterol | Sotalol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Vilanterol | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI |
| Vilanterol | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Vilanterol | Propranolol | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Vilanterol | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Vilanterol | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | |
| Vilanterol | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Vilanterol | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | |
| Vilanterol | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI |
| Vilanterol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vilanterol | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C9 mediated DDI |
| Alectinib | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Alectinib | Oxybuprocaine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C8 mediated DDI |
| Alectinib | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Alectinib | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Alectinib | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Alectinib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Alectinib | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Alectinib | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Alectinib | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Alectinib | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Alectinib | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Alectinib | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Alectinib | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Alectinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Alectinib | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Alogliptin | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Alogliptin | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Alogliptin | Sotalol | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Alogliptin | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Amlodipine | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Amlodipine | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Amlodipine | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Amlodipine | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Amlodipine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Amlodipine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Amlodipine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Amlodipine | Mitotane | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Apixaban | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Apixaban | Sotalol | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Apixaban | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Avibactam | Carvedilol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Chloramphenicol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia | |
| Avibactam | Enalapril | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Avibactam | Formoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Avibactam | Nifedipine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Avibactam | Salmeterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Avibactam | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Dexketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Avibactam | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Ketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Avibactam | Ketorolac | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Avibactam | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI |
| Avibactam | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Betahistine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Avibactam | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Avibactam | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Avibactam | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Avibactam | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Avibactam | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Avibactam | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Avibactam | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Bicalutamide | Chloramphenicol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Bicalutamide | Mebeverine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Bicalutamide | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Bicalutamide | Hydroxychloroquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Bicalutamide | Oxybuprocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Bicalutamide | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Bicalutamide | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C8 mediated DDI |
| Bicalutamide | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Bicalutamide | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Bicalutamide | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Bicalutamide | Phenylephrine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Bicalutamide | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Bicalutamide | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Bicalutamide | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bicalutamide | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bicalutamide | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Bisoprolol | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Bisoprolol | Sotalol | 4 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bisoprolol | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bisoprolol | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bisoprolol | Tropicamide | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bisoprolol | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Bisoprolol | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bisoprolol | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Bisoprolol | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bisoprolol | Mitotane | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cabozantinib | Epinephrine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Cabozantinib | Sotalol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cabozantinib | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cabozantinib | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cabozantinib | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Cabozantinib | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cabozantinib | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Cabozantinib | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Carvedilol | Drotaverine | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Formoterol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Quetiapine | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Sulpiride | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Tizanidine | 4 | Major DDI | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Carvedilol | Ethambutol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Carvedilol | Favipiravir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Carvedilol | Mebendazole | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Metoclopramide | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Pentoxifylline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP1A2 mediated DDI |
| Carvedilol | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Salbutamol | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Carvedilol | Caffeine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP1A2 mediated DDI |
| Carvedilol | Procainamide | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Tropicamide | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Agomelatine | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Biperiden | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Clomipramine | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Piracetam | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Tapentadol | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Cinacalcet | 4 | Major DDI | DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cetirizine | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cetirizine | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cetirizine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Chloramphenicol | Glyburide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Methyldopa | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Chloramphenicol | Salmeterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Chloramphenicol | Atenolol | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Favipiravir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Fosfomycin | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Hydroxyzine | 4 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Ivacaftor | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Chloramphenicol | Metoclopramide | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Metoprolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Chloramphenicol | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Chloramphenicol | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Chloramphenicol | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Chloramphenicol | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Chloramphenicol | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Chloramphenicol | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Chloramphenicol | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Chloramphenicol | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Chloramphenicol | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Chloramphenicol | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Chloramphenicol | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Chloramphenicol | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Chloramphenicol | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Chloramphenicol | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Dasabuvir | Atenolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Dasabuvir | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Dasabuvir | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Dasabuvir | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Dasabuvir | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Dasabuvir | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Dasabuvir | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Dasabuvir | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Dasabuvir | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Dasabuvir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Dasabuvir | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C9 mediated DDI |
| Doravirine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Drotaverine | Methyldopa | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Drotaverine | Epinephrine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Propafenone | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Sotalol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Drotaverine | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Flutamide | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Phenylephrine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Propranolol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Zuclopenthixol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Amitriptyline | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Elsulfavirine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Emtricitabine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Enalapril | Fenoterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Enalapril | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Enalapril | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Enalapril | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Enalapril | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Enalapril | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Enalapril | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Enalapril | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Enalapril | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Enalapril | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Enalapril | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Enalapril | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Enalapril | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Enalapril | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Enalapril | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2D6 mediated DDI |
| Enalapril | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Enalapril | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2D6 mediated DDI |
| Fenoterol | Levodopa | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Fenoterol | Losartan | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI |
| Fenoterol | Miglustat | 4 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Nelfinavir | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2B6 mediated DDI |
| Fenoterol | Rivaroxaban | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Fenoterol | Clonazepam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Ethambutol | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Favipiravir | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Fenoterol | Fosfomycin | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Fenoterol | Nitrazepam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Fenoterol | Acetylsalicylic acid | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Fenoterol | Axitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Fenoterol | Cariprazine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Chlorambucil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Fenoterol | Enzalutamide | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fenoterol | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Sunitinib | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fenoterol | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fenoterol | Praziquantel | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Fenoterol | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Fenoterol | Carbamazepine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Fenoterol | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Cariprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Formoterol | Levodopa | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Formoterol | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Siponimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Epinephrine | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Formoterol | Hydroxyzine | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Ivacaftor | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Formoterol | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Chloropyramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Ketorolac | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Methylergometrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Formoterol | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Formoterol | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Formoterol | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Formoterol | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Rivastigmine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Formoterol | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Formoterol | Carbamazepine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Formoterol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Formoterol | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Formoterol | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Glyburide | Methyldopa | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Salmeterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C9 mediated DDI |
| Glyburide | Metoclopramide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Glyburide | Oxybuprocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Salbutamol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Glyburide | Atropine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C9 mediated DDI |
| Glyburide | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI |
| Glyburide | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Glyburide | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Glyburide | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Glyburide | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Ibrutinib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Ipragliflozin | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Lamivudine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Levodopa | Nifedipine | 4 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Levodopa | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Levodopa | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Levodopa | Atropine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Levodopa | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Levodopa | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C9 mediated DDI |
| Levodopa | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Levodopa | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Levodopa | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C8 mediated DDI |
| Levodopa | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Levodopa | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Levodopa | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Levodopa | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Levodopa | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Levodopa | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Levodopa | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Levodopa | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Levodopa | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Levodopa | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Linezolid | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Linezolid | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Linezolid | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Linezolid | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Linezolid | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2B6 mediated DDI |
| Lopinavir | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Lopinavir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Lopinavir | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Losartan | Mebeverine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI |
| Losartan | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Oxybuprocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Losartan | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Losartan | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Lurasidone | Sotalol | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Mebeverine | Miglustat | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Mebeverine | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Tizanidine | 4 | Major DDI | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | |
| Mebeverine | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Epinephrine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mebeverine | Favipiravir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Mebeverine | Indacaterol | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Mebeverine | Ivacaftor | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Mebeverine | Paroxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Mebeverine | Axitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Mebeverine | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Mebeverine | Fenofibrate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Mebeverine | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Sunitinib | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebeverine | Umifenovir | 4 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Mebeverine | Rivastigmine | 4 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebeverine | Solifenacin | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Mebeverine | Vinpocetine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Mebeverine | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Mebeverine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Mebeverine | Sertraline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Methyldopa | Siponimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C8 mediated DDI |
| Methyldopa | Atenolol | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia | |
| Methyldopa | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Methyldopa | Indapamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Methyldopa | Norepinephrine | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Oxybuprocaine | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Paroxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Methyldopa | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Methyldopa | Perphenazine | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Methyldopa | Acetylsalicylic acid | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Chloropyramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Fluorescein | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Methyldopa | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Methyldopa | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Methotrimeprazine | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Methyldopa | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Methyldopa | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Methyldopa | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Methyldopa | Ketamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Methyldopa | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Methyldopa | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Methyldopa | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Methyldopa | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Methyldopa | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Methyldopa | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Methyldopa | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Miglustat | Nifedipine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Miglustat | Atenolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Miglustat | Dobutamine | 4 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Miglustat | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Miglustat | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Miglustat | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Nelfinavir | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Nelfinavir | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Nelfinavir | Sotalol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Nelfinavir | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2B6 mediated DDI |
| Nelfinavir | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Nelfinavir | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Nelfinavir | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Nelfinavir | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Nelfinavir | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Nelfinavir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Nelfinavir | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Nitisinone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Favipiravir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Perphenazine | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia | |
| Nifedipine | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Nifedipine | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Lacosamide | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Nifedipine | Methylergometrine | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Propranolol | 4 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nifedipine | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Salmeterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Nitisinone | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Nitisinone | Fosfomycin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Nitisinone | Hydroxychloroquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nitisinone | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Nitisinone | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Nitisinone | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Nitisinone | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Nitisinone | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nitisinone | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Nitisinone | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Nitisinone | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Nitisinone | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Nitisinone | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Oxycodone | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Paliperidone | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Paliperidone | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Paliperidone | Trifluoperazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Perindopril | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Perindopril | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Pomalidomide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Quetiapine | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Quetiapine | Phenylephrine | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Quetiapine | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Quetiapine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Quetiapine | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Repaglinide | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C8 mediated DDI |
| Repaglinide | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Repaglinide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Repaglinide | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Rivaroxaban | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Rivaroxaban | Epinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Rivaroxaban | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Rivaroxaban | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Rivaroxaban | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Salmeterol | Bedaquiline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Salmeterol | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Salmeterol | Metoclopramide | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Salmeterol | Pentoxifylline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Salmeterol | Salbutamol | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Salmeterol | Tetrabenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Salmeterol | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salmeterol | Chloropyramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Salmeterol | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Salmeterol | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Methotrimeprazine | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Methylergometrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Salmeterol | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Zuclopenthixol | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Salmeterol | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Salmeterol | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Salmeterol | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Salmeterol | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Salmeterol | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Siponimod | Indacaterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Siponimod | Norepinephrine | 4 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Siponimod | Oxybuprocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Siponimod | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C8 mediated DDI |
| Siponimod | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI |
| Siponimod | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI |
| Siponimod | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Siponimod | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Siponimod | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C8 mediated DDI |
| Siponimod | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Siponimod | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Siponimod | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI |
| Siponimod | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI |
| Siponimod | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Siponimod | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Sulpiride | Hydroxychloroquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sulpiride | Metoclopramide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Sulpiride | Sotalol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sulpiride | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sulpiride | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sulpiride | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Sulpiride | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sulpiride | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sulpiride | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sulpiride | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Sulpiride | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Sulpiride | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Sulpiride | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sulpiride | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Sulpiride | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Talazoparib | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Tizanidine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Tofacitinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Trametinib | Fosfomycin | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Trametinib | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Trametinib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Trametinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Voriconazole | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Voriconazole | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Voriconazole | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Voriconazole | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Voriconazole | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Voriconazole | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Voriconazole | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Aminosalicylic acid | Sotalol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing bradycardia | |
| Aminosalicylic acid | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Aminosalicylic acid | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Aminosalicylic acid | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Aminosalicylic acid | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Apalutamide | Phenylephrine | 4 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Atenolol | Cobimetinib | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Indacaterol | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Atenolol | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Dexketoprofen | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Ketoprofen | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Ketorolac | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Loperamide | 4 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Methylergometrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Atenolol | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Atenolol | Biperiden | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Levamisole | 4 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Atenolol | Lidocaine | 4 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Sertindole | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Atenolol | Sertraline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Bedaquiline | Fluphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Bedaquiline | Indacaterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Bedaquiline | Metoprolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bedaquiline | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C9 mediated DDI |
| Bedaquiline | Atropine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Bedaquiline | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Bedaquiline | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Bedaquiline | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Bedaquiline | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Bedaquiline | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Bedaquiline | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bedaquiline | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Bedaquiline | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Bedaquiline | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI |
| Bedaquiline | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Bedaquiline | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Bedaquiline | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Clonazepam | Dobutamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Clonazepam | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Clonazepam | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Clonazepam | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Cobimetinib | Metoprolol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cobimetinib | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Cobimetinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Dapsone | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Diatrizoate | Norepinephrine | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Dobutamine | Indapamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Dobutamine | Nitrazepam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Dobutamine | Axitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dobutamine | Chlorambucil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Dobutamine | Fenofibrate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Dobutamine | Isoniazid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Dobutamine | Betahistine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Dobutamine | Leflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Dobutamine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Dobutamine | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Dobutamine | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Dobutamine | Carbamazepine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Dobutamine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Epinephrine | Fosfomycin | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Epinephrine | Olaparib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Paroxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Chloropyramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Epinephrine | Dexketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Epinephrine | Enzalutamide | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Epinephrine | Fluorescein | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Flutamide | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Epinephrine | Ketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Epinephrine | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Pyrazinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Epinephrine | Sunitinib | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Teriflunomide | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Epinephrine | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Leflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Epinephrine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Praziquantel | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Tamoxifen | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Carbamazepine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Epinephrine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Sertraline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Ethambutol | Norepinephrine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Ethambutol | Sotalol | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | |
| Ethambutol | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Ethambutol | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Ethambutol | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Ethambutol | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Favipiravir | Metoprolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Favipiravir | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Favipiravir | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Favipiravir | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Favipiravir | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Favipiravir | Ketorolac | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Favipiravir | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Favipiravir | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Favipiravir | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Favipiravir | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Fluphenazine | Fosfomycin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Fluphenazine | Hydroxychloroquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Indacaterol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Fluphenazine | Ivacaftor | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Fluphenazine | Lenvatinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Fluphenazine | Metoclopramide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Fluphenazine | Olaparib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Fluphenazine | Oseltamivir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Fluphenazine | Paroxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Fluphenazine | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Fluphenazine | Risperidone | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Fluphenazine | Bisacodyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Fluphenazine | Cariprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Fluphenazine | Dexketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Fluphenazine | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Fluphenazine | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Ketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Fluphenazine | Ketorolac | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Fluphenazine | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Fluphenazine | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Fluphenazine | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Fluphenazine | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2D6 mediated DDI |
| Fluphenazine | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Fluphenazine | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Acetaminophen | 4 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Fluphenazine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Fluphenazine | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Fluphenazine | Loratadine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Praziquantel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Fluphenazine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Fluphenazine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Fluphenazine | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fluphenazine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fluphenazine | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Fosfomycin | Norepinephrine | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Fosfomycin | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Fosfomycin | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Fosfomycin | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Fosfomycin | Phenylephrine | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Fosfomycin | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Fosfomycin | Warfarin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Fosfomycin | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Fosfomycin | Biperiden | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Fosfomycin | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Fosfomycin | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Fosfomycin | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI |
| Fosfomycin | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Fosfomycin | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Gliclazide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Hydroxychloroquine | Mebendazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Hydroxychloroquine | Oxybuprocaine | 4 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Hydroxychloroquine | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Hydroxychloroquine | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Hydroxychloroquine | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Hydroxychloroquine | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Hydroxychloroquine | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Hydroxychloroquine | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hydroxychloroquine | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Hydroxychloroquine | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Hydroxychloroquine | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Hydroxychloroquine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Hydroxychloroquine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Hydroxychloroquine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Hydroxychloroquine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Hydroxyzine | Phenylephrine | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Hydroxyzine | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hydroxyzine | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Hydroxyzine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Hydroxyzine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Hydroxyzine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Indacaterol | Norepinephrine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Indacaterol | Sotalol | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Indacaterol | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Indacaterol | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Indacaterol | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Indacaterol | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Indacaterol | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Indacaterol | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Indacaterol | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Indacaterol | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Indacaterol | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Indacaterol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Indacaterol | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Indapamide | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Indapamide | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Indapamide | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Indapamide | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Ivacaftor | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ivacaftor | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ivacaftor | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Ivacaftor | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Ivacaftor | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ivacaftor | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ivacaftor | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ivacaftor | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ivacaftor | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ivacaftor | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ivacaftor | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ivacaftor | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ivacaftor | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ivacaftor | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ivacaftor | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP1A2 mediated DDI |
| Ivacaftor | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP3A4 mediated DDI |
| Ixazomib | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Ixazomib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Lenalidomide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Lenvatinib | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Lenvatinib | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Lenvatinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lenvatinib | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C8 mediated DDI |
| Lenvatinib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lenvatinib | Mitotane | 4 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Norepinephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Mebendazole | Oxybuprocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Mebendazole | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Mebendazole | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Propranolol | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Piracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Mebendazole | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Mebendazole | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Mesalazine | Sotalol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Mesalazine | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Mesalazine | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Mesalazine | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C9 mediated DDI |
| Mesalazine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C9 mediated DDI |
| Metoclopramide | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Metoclopramide | Propafenone | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoclopramide | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Metoclopramide | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Metoclopramide | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Metoclopramide | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Metoclopramide | Propranolol | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoclopramide | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Metoclopramide | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Metoclopramide | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Metoclopramide | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Metoclopramide | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoclopramide | Tapentadol | 4 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Metoprolol | Paroxetine | 4 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Haloperidol | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Ketorolac | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Tramadol | 4 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Diphenhydramine | 4 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Sertindole | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Amitriptyline | 4 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nevirapine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Nitrazepam | Sotalol | 4 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Nitrazepam | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Norepinephrine | Paroxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Norepinephrine | Tetrabenazine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Cariprazine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Chlorambucil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Norepinephrine | Chloropyramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Norepinephrine | Enzalutamide | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Norepinephrine | Fluorescein | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Norepinephrine | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Norepinephrine | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Norepinephrine | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Norepinephrine | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Norepinephrine | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Norepinephrine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Norepinephrine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Norepinephrine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Norepinephrine | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Norepinephrine | Carbamazepine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Norepinephrine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Norepinephrine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Norepinephrine | Sertraline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Olaparib | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Olaparib | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Olaparib | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Olaparib | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Oseltamivir | Salbutamol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Oseltamivir | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Oseltamivir | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Oseltamivir | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Oseltamivir | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Oseltamivir | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Oseltamivir | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Oseltamivir | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Oseltamivir | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Oseltamivir | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Oseltamivir | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Oseltamivir | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Oxybuprocaine | Paroxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Oxybuprocaine | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Bisacodyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Oxybuprocaine | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Oxybuprocaine | Lacosamide | 4 | CLASS 1 (from 5); Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Oxybuprocaine | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C8 mediated DDI |
| Oxybuprocaine | Betahistine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Oxybuprocaine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Oxybuprocaine | Piracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Paroxetine | Periciazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Paroxetine | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Paroxetine | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Paroxetine | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Paroxetine | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Paroxetine | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Paroxetine | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Paroxetine | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Paroxetine | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Paroxetine | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Paroxetine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Paroxetine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Paroxetine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Paroxetine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Pentoxifylline | Sotalol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Periciazine | Perphenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Periciazine | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Periciazine | Amiodarone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Periciazine | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Periciazine | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Periciazine | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Periciazine | Ketorolac | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Periciazine | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Periciazine | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Periciazine | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Periciazine | Propranolol | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Periciazine | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Periciazine | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Periciazine | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Periciazine | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Periciazine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Periciazine | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Periciazine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Periciazine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Periciazine | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Tetrabenazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Perphenazine | Vismodegib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Perphenazine | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Perphenazine | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Perphenazine | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Perphenazine | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Perphenazine | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Perphenazine | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Perphenazine | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Perphenazine | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Perphenazine | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Perphenazine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Perphenazine | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Perphenazine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Perphenazine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Perphenazine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Perphenazine | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Tapentadol | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Perphenazine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2D6 mediated DDI |
| Propafenone | Sotalol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Tetrabenazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Procainamide | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Fluoxetine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Benzyl benzoate | 4 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Pyridoxine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Risperidone | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Risperidone | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Risperidone | Trifluoperazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Risperidone | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Risperidone | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Risperidone | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Risperidone | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C19 mediated DDI |
| Salbutamol | Sotalol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia | |
| Salbutamol | Loperamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Salbutamol | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salbutamol | Methylergometrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salbutamol | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Salbutamol | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salbutamol | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salbutamol | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salbutamol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salbutamol | Pirfenidone | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia | |
| Salbutamol | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Sotalol | Tetrabenazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Sotalol | Cariprazine | 4 | CLASS 1 (from 5); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Sotalol | Chlorambucil | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Sotalol | Enzalutamide | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Sotalol | Fluorescein | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Isoniazid | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Sotalol | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Sunitinib | 4 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Sotalol | Acetaminophen | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | |
| Sotalol | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Sotalol | Ketamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Sotalol | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Sotalol | Lipoic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia | |
| Sulfamethoxazole | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Tetrabenazine | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Tetrabenazine | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Tetrabenazine | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Tetrabenazine | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Tetrabenazine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Tetrabenazine | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Vemurafenib | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Vemurafenib | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP3A4 mediated DDI |
| Vemurafenib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Vismodegib | Atropine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Vismodegib | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Vismodegib | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Vismodegib | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Vismodegib | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vismodegib | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C9 mediated DDI |
| Vismodegib | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Vismodegib | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Vismodegib | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Vismodegib | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vismodegib | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vismodegib | Piracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Vismodegib | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Vismodegib | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Vismodegib | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Vismodegib | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Acetylsalicylic acid | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Acetylsalicylic acid | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Acetylsalicylic acid | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Acetylsalicylic acid | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Acetylsalicylic acid | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Acetylsalicylic acid | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Acetylsalicylic acid | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Acetylsalicylic acid | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ambroxol | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Aminocaproic acid | Cycloserine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Aminophylline | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Amiodarone | Bisacodyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Amiodarone | Captopril | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Amiodarone | Clonidine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Amiodarone | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Amiodarone | Ketorolac | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Amiodarone | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Amiodarone | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Amiodarone | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Amiodarone | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Amiodarone | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Amiodarone | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Amiodarone | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Amiodarone | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Amiodarone | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Amiodarone | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Amiodarone | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Amiodarone | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Amiodarone | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Amiodarone | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Amiodarone | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Atropine | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Atropine | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Atropine | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Atropine | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Atropine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Atropine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI |
| Atropine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Atropine | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Atropine | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Atropine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Atropine | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI |
| Atropine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Baclofen | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bisacodyl | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C8 mediated DDI |
| Bisacodyl | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Bisacodyl | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Bisacodyl | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Captopril | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Captopril | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Captopril | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Captopril | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Captopril | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Captopril | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Captopril | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | |
| Captopril | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Cariprazine | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Cariprazine | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI |
| Cariprazine | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Cariprazine | Phenylephrine | 4 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cariprazine | Procainamide | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Cariprazine | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Cariprazine | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI |
| Cariprazine | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Cariprazine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI |
| Cariprazine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI |
| Cariprazine | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Cariprazine | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Chlorambucil | Dopamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Chloropyramine | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Chloropyramine | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Clonidine | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Clonidine | Clomifene | 4 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia | |
| Clonidine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Cycloserine | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Cycloserine | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Cycloserine | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Cycloserine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Cycloserine | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI |
| Cycloserine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Cycloserine | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Dexketoprofen | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dexketoprofen | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Dexketoprofen | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Dexketoprofen | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C8 mediated DDI |
| Dexketoprofen | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Dexketoprofen | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Dopamine | Droperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Dopamine | Enzalutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C8 mediated DDI |
| Dopamine | Fluorescein | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Dopamine | Isoniazid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Dopamine | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Dopamine | Methylergometrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Dopamine | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Dopamine | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Dopamine | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Dopamine | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Dopamine | Tranexamic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Dopamine | Betahistine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Dopamine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Dopamine | Ketamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C9 mediated DDI |
| Dopamine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Dopamine | Pyrantel | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Dopamine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Dopamine | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Dopamine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Dopamine | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Dopamine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Dopamine | Sertraline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Droperidol | Fingolimod | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Droperidol | Flupentixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Droperidol | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Droperidol | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Droperidol | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Droperidol | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Droperidol | Acetaminophen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Droperidol | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Droperidol | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Droperidol | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Droperidol | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Droperidol | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Droperidol | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Droperidol | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Droperidol | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Droperidol | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Droperidol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Enzalutamide | Phenylephrine | 4 | Major DDI | DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Fenofibrate | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C8 mediated DDI |
| Fingolimod | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Ketoprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Fingolimod | Ketorolac | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fingolimod | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Fingolimod | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Fingolimod | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fingolimod | Betahistine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Fingolimod | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fingolimod | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fingolimod | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Fingolimod | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Fingolimod | Piracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Fingolimod | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fingolimod | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Fingolimod | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Fingolimod | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Fingolimod | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Fingolimod | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fingolimod | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI |
| Fingolimod | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Fingolimod | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Fluorescein | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Fluorescein | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Flupentixol | Flutamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Haloperidol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Flupentixol | Ketorolac | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Flupentixol | Methotrimeprazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Flupentixol | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Flupentixol | Propranolol | 4 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Flupentixol | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Flupentixol | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Flupentixol | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Flupentixol | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Flupentixol | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Flupentixol | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Flupentixol | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Flupentixol | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Flupentixol | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Flupentixol | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Flupentixol | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Flutamide | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Flutamide | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Flutamide | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Flutamide | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Flutamide | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Flutamide | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Flutamide | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flutamide | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Flutamide | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Flutamide | Lomustine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Flutamide | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flutamide | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Flutamide | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Lacosamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Haloperidol | Perampanel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Propranolol | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Haloperidol | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI |
| Haloperidol | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI |
| Haloperidol | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Haloperidol | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Haloperidol | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Haloperidol | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Haloperidol | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Isoniazid | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Isoniazid | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Isoniazid | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Ketoprofen | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Ketoprofen | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Ketoprofen | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C8 mediated DDI |
| Ketoprofen | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Ketoprofen | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI |
| Ketorolac | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Ketorolac | Propranolol | 4 | Major DDI | DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ketorolac | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Ketorolac | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Ketorolac | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Ketorolac | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Ketorolac | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Ketorolac | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Ketorolac | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Lacosamide | Phenylephrine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Lacosamide | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Lacosamide | Propranolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Lacosamide | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Lacosamide | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Mefloquine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Loperamide | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Loperamide | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Loperamide | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Loperamide | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Loperamide | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Loperamide | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Loperamide | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Loperamide | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Loperamide | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Loperamide | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Loperamide | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Loperamide | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Loperamide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Lorazepam | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Mefloquine | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Mefloquine | Propranolol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Mefloquine | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Mefloquine | Acetaminophen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Mefloquine | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mefloquine | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Mefloquine | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Mefloquine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Mefloquine | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Mefloquine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mefloquine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mefloquine | Piracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Mefloquine | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Mefloquine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mefloquine | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Mefloquine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Meldonium | Desflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Methotrimeprazine | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Clomipramine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Imipramine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Amitriptyline | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Methotrimeprazine | Benzyl benzoate | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methylergometrine | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Methylergometrine | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Methylergometrine | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Methylergometrine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Methylergometrine | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Methylergometrine | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Methylergometrine | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Methylergometrine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Oxazepam | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Penicillamine | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Perampanel | Procainamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Perampanel | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Perampanel | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Perampanel | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Perampanel | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perampanel | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Perampanel | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perampanel | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perampanel | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perampanel | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Perampanel | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Perampanel | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Perampanel | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Perampanel | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perampanel | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Perampanel | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Perampanel | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Perampanel | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Phenobarbital | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Phenylephrine | Pyrazinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Phenylephrine | Salicylic acid | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Phenylephrine | Sunitinib | 4 | Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Phenylephrine | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Ketamine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Phenylephrine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Phenylephrine | Ondansetron | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Phenylephrine | Praziquantel | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Phenylephrine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Phenylephrine | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Phenylephrine | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Carbamazepine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Phenylephrine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Phenylephrine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Phenylephrine | Sertraline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Procainamide | Procaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Procarbazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Procainamide | Propranolol | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Procainamide | Teriflunomide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Procainamide | Tramadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Procainamide | Tropicamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procainamide | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Procainamide | Betahistine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI |
| Procainamide | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Procainamide | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Procainamide | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Procainamide | Piracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Procainamide | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Procainamide | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Procainamide | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Procainamide | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Procaine | Lidocaine | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Procaine | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Procaine | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI |
| Procarbazine | Sunitinib | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Procarbazine | Betahistine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI |
| Procarbazine | Clomipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Procarbazine | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Procarbazine | Ibuprofen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Procarbazine | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Procarbazine | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Procarbazine | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Procarbazine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Procarbazine | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Procarbazine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Procarbazine | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Procarbazine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Procarbazine | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Procarbazine | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Procarbazine | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Procarbazine | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Procarbazine | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Propranolol | Tramadol | 4 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Levamisole | 4 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Propranolol | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Propranolol | Piracetam | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Propranolol | Sertindole | 4 | Major DDI | DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Propranolol | Amitriptyline | 4 | Major DDI | DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Propranolol | Sertraline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Regorafenib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Salicylic acid | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Salicylic acid | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Salicylic acid | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salicylic acid | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Salicylic acid | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Salicylic acid | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salicylic acid | Mitotane | 4 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Sorafenib | Bupivacaine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Sorafenib | Levobupivacaine | 4 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Sorafenib | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Sorafenib | Mitotane | 4 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Sunitinib | Trifluoperazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Sunitinib | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Sunitinib | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Sunitinib | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Sunitinib | Mitotane | 4 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Teriflunomide | Agomelatine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Teriflunomide | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Teriflunomide | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Teriflunomide | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Teriflunomide | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Teriflunomide | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Teriflunomide | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Teriflunomide | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Teriflunomide | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Teriflunomide | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Teriflunomide | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Teriflunomide | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Tramadol | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Tramadol | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tramadol | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Tramadol | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Tramadol | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tramadol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Trifluoperazine | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Trifluoperazine | Zuclopenthixol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Trifluoperazine | Loratadine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Trifluoperazine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Trifluoperazine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Trifluoperazine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Trifluoperazine | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Tropicamide | Umifenovir | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Tropicamide | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tropicamide | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Tropicamide | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Tropicamide | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Tropicamide | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tropicamide | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Tropicamide | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Tropicamide | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Tropicamide | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tropicamide | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Tropicamide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Umifenovir | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Zuclopenthixol | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Zuclopenthixol | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Zuclopenthixol | Clomifene | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Zuclopenthixol | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Zuclopenthixol | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Zuclopenthixol | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Zuclopenthixol | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Zuclopenthixol | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Zuclopenthixol | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Acetaminophen | Bupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Acetaminophen | Clomifene | 4 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Acetaminophen | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Acetaminophen | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Acetaminophen | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Acetaminophen | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Acetaminophen | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Agomelatine | Chlorpromazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Agomelatine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Agomelatine | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Agomelatine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Agomelatine | Rivastigmine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Agomelatine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Agomelatine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Agomelatine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Agomelatine | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Agomelatine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Agomelatine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Betahistine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Betahistine | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Biperiden | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bupivacaine | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Bupivacaine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Bupivacaine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bupivacaine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Bupivacaine | Loratadine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Bupivacaine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Bupivacaine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Bupivacaine | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Bupivacaine | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Bupivacaine | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Bupivacaine | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Bupivacaine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Bupivacaine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bupivacaine | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Chlorpromazine | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Chlorpromazine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Chlorpromazine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Chlorpromazine | Piracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Chlorpromazine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Chlorpromazine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Chlorpromazine | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Chlorpromazine | Tapentadol | 4 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Chlorpromazine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Chlorpromazine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Clomifene | Diphenhydramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Clomifene | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Clomifene | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Clomifene | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Clomipramine | Fentanyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Clomipramine | Fluoxetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomipramine | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Clomipramine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Clomipramine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomipramine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomipramine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomipramine | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomipramine | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Clomipramine | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Diazepam | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Diphenhydramine | Imipramine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Diphenhydramine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Diphenhydramine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Diphenhydramine | Nicotinamide | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Diphenhydramine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Diphenhydramine | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Diphenhydramine | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Diphenhydramine | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Diphenhydramine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Diphenhydramine | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Efavirenz | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Fentanyl | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fentanyl | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fentanyl | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Fentanyl | Piracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fentanyl | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fentanyl | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fentanyl | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fentanyl | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Fentanyl | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Fentanyl | Pirfenidone | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fentanyl | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI |
| Fluorouracil | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Fluoxetine | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Fluoxetine | Levobupivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Fluoxetine | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Fluoxetine | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Levamisole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Imipramine | Levetiracetam | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Imipramine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Imipramine | Praziquantel | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Imipramine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Imipramine | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Imipramine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Imipramine | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Imipramine | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ketamine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Leflunomide | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Leflunomide | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Levamisole | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Levamisole | Benzyl benzoate | 4 | CLASS 1 (from 3); Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Levetiracetam | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Levetiracetam | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Levobupivacaine | Lidocaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Levobupivacaine | Loratadine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Levobupivacaine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Levobupivacaine | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Levobupivacaine | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Levobupivacaine | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP2C19 mediated DDI |
| Levobupivacaine | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Levobupivacaine | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Levobupivacaine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Levobupivacaine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Levobupivacaine | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lidocaine | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Lidocaine | Trihexyphenidyl | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | CYP1A2 mediated DDI |
| Lomustine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Lomustine | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Loratadine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Loratadine | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Midazolam | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Nicotinamide | Tapentadol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Nicotinamide | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nicotinamide | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Oxcarbazepine | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Oxcarbazepine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Praziquantel | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Pyrantel | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Rivastigmine | Ropivacaine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Rivastigmine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Rivastigmine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Rivastigmine | Propofol | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Ropivacaine | Sertindole | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ropivacaine | Tamoxifen | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Ropivacaine | Thioridazine | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ropivacaine | Vinpocetine | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Ropivacaine | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Ropivacaine | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Sertindole | Solifenacin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Sertindole | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Sertindole | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Solifenacin | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Tamoxifen | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Tamoxifen | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tamoxifen | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Tapentadol | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Tapentadol | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Tapentadol | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Thiopental | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Thioridazine | Amitriptyline | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Thioridazine | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | |
| Thioridazine | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Trihexyphenidyl | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Trihexyphenidyl | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Trihexyphenidyl | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI |
| Valproic acid | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vinpocetine | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Amitriptyline | Benzyl benzoate | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Amitriptyline | Cinacalcet | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Amitriptyline | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Carbamazepine | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Cinacalcet | Clotrimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Cinacalcet | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Pirfenidone | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Propofol | Mitotane | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C9 mediated DDI |
| Sertraline | Halothane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Sevelamer | Sevoflurane | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Sevoflurane | Methimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension; DDI causing arrhythmia | |
| Halothane | Methimazole | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Halothane | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Mitotane | Oxaliplatin | 4 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Lixisenatide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lixisenatide | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Lixisenatide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lixisenatide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lixisenatide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lixisenatide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lixisenatide | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lixisenatide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lixisenatide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Semaglutide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Semaglutide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Semaglutide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Semaglutide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Semaglutide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Semaglutide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Telavancin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Telavancin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Telavancin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Daptomycin | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Daptomycin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Daptomycin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Daptomycin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daptomycin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Vancomycin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vancomycin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vancomycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vancomycin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Etelcalcetide | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Etelcalcetide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Etelcalcetide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Etelcalcetide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Etelcalcetide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Micafungin | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Pibrentasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Micafungin | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Iopromide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Verapamil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Micafungin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Micafungin | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Micafungin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Micafungin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Micafungin | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Micafungin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Micafungin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Micafungin | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Micafungin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ganirelix | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Ticagrelor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ganirelix | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Ganirelix | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ganirelix | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Ganirelix | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Ganirelix | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ganirelix | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ganirelix | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ganirelix | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Ganirelix | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ganirelix | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ganirelix | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Ganirelix | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ganirelix | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ganirelix | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Ganirelix | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Sennosides | Dobutamine | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia | |
| Sennosides | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sennosides | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Sennosides | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sennosides | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Sennosides | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Sennosides | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Streptomycin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Streptomycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Caspofungin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Caspofungin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Caspofungin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Caspofungin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Caspofungin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Caspofungin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Cetrorelix | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cetrorelix | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Cetrorelix | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Cetrorelix | Sotalol | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Cetrorelix | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cetrorelix | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cetrorelix | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Cetrorelix | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cetrorelix | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cetrorelix | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cetrorelix | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cetrorelix | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetrorelix | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cetrorelix | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Cetrorelix | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cetrorelix | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cetrorelix | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Cetrorelix | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Cyanocobalamin | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyanocobalamin | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyanocobalamin | Fosfomycin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyanocobalamin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyanocobalamin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyanocobalamin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cyanocobalamin | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyanocobalamin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cyanocobalamin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Degarelix | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Degarelix | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Degarelix | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Degarelix | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Degarelix | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Degarelix | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Degarelix | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Degarelix | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Degarelix | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Degarelix | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Degarelix | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Degarelix | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Degarelix | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Degarelix | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Degarelix | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Degarelix | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Degarelix | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Degarelix | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Degarelix | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Degarelix | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Degarelix | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Goserelin | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Ticagrelor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Fenoterol | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Goserelin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Goserelin | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Goserelin | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Goserelin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Goserelin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Goserelin | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Goserelin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Goserelin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Clomifene | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | |
| Goserelin | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Goserelin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Goserelin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Goserelin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Goserelin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Goserelin | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Goserelin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Goserelin | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Polymyxin B | Pibrentasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Ioversol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Sotalol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Polymyxin B | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Polymyxin B | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Polymyxin B | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Polymyxin B | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Polymyxin B | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Polymyxin B | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Amikacin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amikacin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amikacin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amikacin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amphotericin B | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Amphotericin B | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nystatin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nystatin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Pibrentasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Terlipressin | Ioversol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Terlipressin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Terlipressin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Terlipressin | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Phenylephrine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Terlipressin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Terlipressin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Terlipressin | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Terlipressin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Terlipressin | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Terlipressin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Terlipressin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terlipressin | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Triptorelin | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Pibrentasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Triptorelin | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Iopromide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Triptorelin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Triptorelin | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Norepinephrine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing bradycardia | |
| Triptorelin | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Triptorelin | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Triptorelin | Sotalol | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Triptorelin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Triptorelin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Triptorelin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Triptorelin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Triptorelin | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Triptorelin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Triptorelin | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Triptorelin | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Triptorelin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Triptorelin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Triptorelin | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Triptorelin | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Triptorelin | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Triptorelin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Triptorelin | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Triptorelin | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Triptorelin | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Glycyrrhizic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Glycyrrhizic acid | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Leuprolide | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Pibrentasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Leuprolide | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Iopromide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Leuprolide | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Leuprolide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Leuprolide | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Norepinephrine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing bradycardia | |
| Leuprolide | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Leuprolide | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Leuprolide | Sotalol | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Leuprolide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Leuprolide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Leuprolide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Leuprolide | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Leuprolide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Leuprolide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Leuprolide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Leuprolide | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Leuprolide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Leuprolide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Leuprolide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leuprolide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Leuprolide | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Leuprolide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Desmopressin | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Ioversol | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Desmopressin | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Desmopressin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Desmopressin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Desmopressin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Desmopressin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Desmopressin | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Desmopressin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Desmopressin | Levamisole | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | |
| Desmopressin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Desmopressin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Kanamycin | Hexoprenaline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Kanamycin | Epinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Kanamycin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Kanamycin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Kanamycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Kanamycin | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Iohexol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Ioversol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Iopromide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Ribociclib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Sparfloxacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Acalabrutinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Bictegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Deferasirox | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Capreomycin | Nilotinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Trametinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Apalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Metoprolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Capreomycin | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Propranolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Capreomycin | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Capreomycin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Rifampicin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Rifampicin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Tobramycin | Iopromide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tobramycin | Bictegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tobramycin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tobramycin | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tobramycin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tobramycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tobramycin | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Iohexol | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Atosiban | Ioversol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Atosiban | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Atosiban | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Atosiban | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Atosiban | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Atosiban | Acetaminophen | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Atosiban | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Atosiban | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Atosiban | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Atosiban | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atosiban | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Atosiban | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atosiban | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Azithromycin | Ioversol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Azithromycin | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Azithromycin | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Azithromycin | Atorvastatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Azithromycin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Azithromycin | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Azithromycin | Paliperidone | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Azithromycin | Mebendazole | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Azithromycin | Paroxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Azithromycin | Risperidone | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Azithromycin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Azithromycin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Procarbazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Azithromycin | Sunitinib | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Azithromycin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Azithromycin | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Azithromycin | Imipramine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Azithromycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Azithromycin | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Azithromycin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Azithromycin | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Azithromycin | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Azithromycin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ceftaroline fosamil | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Clarithromycin | Ivabradine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Clarithromycin | Atorvastatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Clarithromycin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clarithromycin | Drotaverine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Paliperidone | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Clarithromycin | Mebendazole | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Paroxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Risperidone | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Clarithromycin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Clarithromycin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clarithromycin | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Clarithromycin | Sunitinib | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Clarithromycin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Clarithromycin | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clarithromycin | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Clarithromycin | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Clarithromycin | Imipramine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Clarithromycin | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clarithromycin | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Clarithromycin | Sertindole | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Clarithromycin | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Clarithromycin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Digoxin | Iohexol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Digoxin | Ioversol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Digoxin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Digoxin | Teriflunomide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Digoxin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Everolimus | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Everolimus | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Everolimus | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Josamycin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Josamycin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Josamycin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Josamycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Josamycin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Josamycin | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Natamycin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Natamycin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Natamycin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Natamycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rifabutin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Rifabutin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Carbetocin | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Ioversol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Carbetocin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carbetocin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carbetocin | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Carbetocin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Carbetocin | Acetaminophen | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Carbetocin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Carbetocin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Carbetocin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carbetocin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbetocin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Cyclosporine | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Cyclosporine | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Cyclosporine | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Cyclosporine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyclosporine | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyclosporine | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyclosporine | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyclosporine | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Cyclosporine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cyclosporine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Cyclosporine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Cyclosporine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Doxorubicin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Doxorubicin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doxorubicin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Doxorubicin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doxorubicin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doxorubicin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doxorubicin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doxorubicin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Epirubicin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Epirubicin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Epirubicin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Epirubicin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Epirubicin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Epirubicin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Epirubicin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Epirubicin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Eribulin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Eribulin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Eribulin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Etoposide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Folic acid | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Folic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gentamicin | Octreotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gentamicin | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gentamicin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gentamicin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Grazoprevir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lanreotide | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Pibrentasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lanreotide | Posaconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Tenofovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lanreotide | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Ombitasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Ribociclib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Acalabrutinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Bictegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Nintedanib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Lanreotide | Verapamil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Lanreotide | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lanreotide | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Carvedilol | 3 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing bradycardia | |
| Lanreotide | Chloramphenicol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Lanreotide | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Lanreotide | Mebeverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Lanreotide | Salmeterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Lanreotide | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Trametinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lanreotide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Ethambutol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Lanreotide | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lanreotide | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lanreotide | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Lanreotide | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Lanreotide | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Lanreotide | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Lanreotide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Lanreotide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lanreotide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lanreotide | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Lanreotide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lanreotide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Lanreotide | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Lanreotide | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lanreotide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Lanreotide | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Lanreotide | Ethanol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Lanreotide | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Lanreotide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Lanreotide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lanreotide | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methotrexate | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Methotrexate | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Grazoprevir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Pibrentasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Posaconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Ertugliflozin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Ombitasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Ribociclib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Acalabrutinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Bictegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Mannitol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Octreotide | Verapamil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Apixaban | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Octreotide | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Carvedilol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Chloramphenicol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Salmeterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Octreotide | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Trametinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Octreotide | Apalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Ethambutol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Octreotide | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Octreotide | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Flutamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI |
| Octreotide | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Octreotide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Octreotide | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Octreotide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Octreotide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Octreotide | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Octreotide | Ethanol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Octreotide | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Octreotide | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Octreotide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Octreotide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Octreotide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Octreotide | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cromoglicic acid | Macitentan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Cromoglicic acid | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Cromoglicic acid | Iomeprol | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Isosorbide dinitrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Cromoglicic acid | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Cromoglicic acid | Selexipag | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Cromoglicic acid | Methyldopa | 3 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing bradycardia | |
| Cromoglicic acid | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Cromoglicic acid | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Cromoglicic acid | Siponimod | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Cromoglicic acid | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cromoglicic acid | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Cromoglicic acid | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Cromoglicic acid | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Cromoglicic acid | Lacosamide | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | |
| Cromoglicic acid | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Cromoglicic acid | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Cromoglicic acid | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cromoglicic acid | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Cromoglicic acid | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Cromoglicic acid | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Cromoglicic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Cromoglicic acid | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Cromoglicic acid | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Daunorubicin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Daunorubicin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daunorubicin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Daunorubicin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daunorubicin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daunorubicin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daunorubicin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daunorubicin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lactulose | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Leucovorin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Rifamycin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Tacrolimus | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tacrolimus | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tacrolimus | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ademetionine | Procarbazine | 3 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia | |
| Ademetionine | Bupivacaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia | |
| Ademetionine | Levobupivacaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia | |
| Ademetionine | Mitotane | 3 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI |
| Ceftazidime | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Chlorhexidine | Iopromide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Chlorhexidine | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Chlorhexidine | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Chlorhexidine | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Chlorhexidine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Chlorhexidine | Fingolimod | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Chlorhexidine | Flutamide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Chlorhexidine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Chlorhexidine | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Chlorhexidine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Chlorhexidine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Chlorhexidine | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Chlorhexidine | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Chlorhexidine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Chlorhexidine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Citicoline | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Glecaprevir | Verapamil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Glecaprevir | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Glecaprevir | Metoprolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Glecaprevir | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Glecaprevir | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Glecaprevir | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Glecaprevir | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Glecaprevir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Glecaprevir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Glecaprevir | Propranolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Glecaprevir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Glecaprevir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Glecaprevir | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Glecaprevir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Glecaprevir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Glecaprevir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Glecaprevir | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Glecaprevir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Glecaprevir | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Glecaprevir | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Glecaprevir | Methimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Glecaprevir | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Grazoprevir | Hexoprenaline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Grazoprevir | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Grazoprevir | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Grazoprevir | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Grazoprevir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Grazoprevir | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Grazoprevir | Epinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Grazoprevir | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Grazoprevir | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Grazoprevir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Grazoprevir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Grazoprevir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Grazoprevir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Grazoprevir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Grazoprevir | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Grazoprevir | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Grazoprevir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Grazoprevir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Grazoprevir | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Grazoprevir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Grazoprevir | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Grazoprevir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Grazoprevir | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Grazoprevir | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Grazoprevir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Grazoprevir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Grazoprevir | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Grazoprevir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Grazoprevir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Grazoprevir | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Grazoprevir | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Grazoprevir | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Grazoprevir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Grazoprevir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Grazoprevir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Grazoprevir | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Grazoprevir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Grazoprevir | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Idarubicin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Idarubicin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Idarubicin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Idarubicin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Idarubicin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Idarubicin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Idarubicin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mitoxantrone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mitoxantrone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Mitoxantrone | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Paritaprevir | Pasireotide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Posaconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Paritaprevir | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Fenoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Paritaprevir | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Paritaprevir | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Paritaprevir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paritaprevir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paritaprevir | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paritaprevir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Paritaprevir | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Pasireotide | Pibrentasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Ertapenem | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Ombitasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Acalabrutinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Bictegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Irinotecan | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Mannitol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Pasireotide | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pasireotide | Verapamil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pasireotide | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Enalapril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Pasireotide | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Pasireotide | Formoterol | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Pasireotide | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Talazoparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Trametinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pasireotide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pasireotide | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pasireotide | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Norepinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Pasireotide | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pasireotide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pasireotide | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pasireotide | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pasireotide | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Pasireotide | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pasireotide | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Pasireotide | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pasireotide | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pasireotide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Pasireotide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Carfilzomib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Dolutegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Irinotecan | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Verapamil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pibrentasvir | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Chloramphenicol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Pibrentasvir | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Mebeverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Pibrentasvir | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Pibrentasvir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pibrentasvir | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pibrentasvir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Pibrentasvir | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pibrentasvir | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Pibrentasvir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Pibrentasvir | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pimecrolimus | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pimecrolimus | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pimecrolimus | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Venetoclax | Hexoprenaline | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C9 mediated DDI |
| Venetoclax | Amlodipine | 3 | Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Venetoclax | Carvedilol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Venetoclax | Nifedipine | 3 | Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Venetoclax | Epinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Venetoclax | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Venetoclax | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Venetoclax | Phenylephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Venetoclax | Propranolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Venetoclax | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Venetoclax | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bosentan | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bosentan | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Doxazosin | Ioversol | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C19 mediated DDI |
| Doxazosin | Iomeprol | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Iopromide | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Isosorbide dinitrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Doxazosin | Gefitinib | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C19 mediated DDI |
| Doxazosin | Ivabradine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Doxazosin | Cabozantinib | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Drotaverine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Doxazosin | Sulpiride | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Doxazosin | Mebendazole | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C19 mediated DDI |
| Doxazosin | Metoclopramide | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Periciazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Doxazosin | Tetrabenazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Doxazosin | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Doxazosin | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Doxazosin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doxazosin | Fingolimod | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Haloperidol | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Doxazosin | Procainamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Chlorpromazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Doxazosin | Clomifene | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doxazosin | Ropivacaine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Doxazosin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Doxycycline | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doxycycline | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Alendronic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Hexoprenaline | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Imipenem | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Iohexol | Carvedilol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iohexol | Fenoterol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Iohexol | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Nifedipine | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Iohexol | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Dobutamine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Epinephrine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Fosfomycin | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Norepinephrine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iohexol | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Sotalol | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iohexol | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Fingolimod | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Iohexol | Haloperidol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Iohexol | Loperamide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iohexol | Procainamide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Propranolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Iohexol | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iohexol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iohexol | Clomifene | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Iohexol | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iohexol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iohexol | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Lidocaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iohexol | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Iohexol | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iohexol | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iohexol | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Ioversol | Posaconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ioversol | Alendronic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Ertapenem | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Atazanavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Darunavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Gefitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ioversol | Imatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Ombitasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ioversol | Saquinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Ciprofloxacin | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | |
| Ioversol | Imipenem | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Irinotecan | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Meropenem | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ioversol | Carvedilol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ioversol | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Ioversol | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ioversol | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ioversol | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ioversol | Dapsone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Dobutamine | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Ioversol | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ioversol | Norepinephrine | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Ioversol | Oxybuprocaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Ioversol | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ioversol | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Sotalol | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ioversol | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ioversol | Captopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Clonidine | 3 | Major DDI | DDI causing hypotension; DDI causing tachycardia | |
| Ioversol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ioversol | Fingolimod | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Ioversol | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ioversol | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ioversol | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Phenylephrine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Ioversol | Procainamide | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | |
| Ioversol | Procaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Ioversol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ioversol | Clomifene | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Ioversol | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ioversol | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ioversol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ioversol | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Lidocaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Ioversol | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Ioversol | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ioversol | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ioversol | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Ioversol | Mitotane | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Macitentan | Gefitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Macitentan | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Macitentan | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Macitentan | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Macitentan | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Macitentan | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Macitentan | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Macitentan | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Macitentan | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pemetrexed | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pemetrexed | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pemetrexed | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pemetrexed | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pemetrexed | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pemetrexed | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pemetrexed | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Posaconazole | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Posaconazole | Iopromide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Posaconazole | Bictegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Bromocriptine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Posaconazole | Irinotecan | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Atorvastatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Posaconazole | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Posaconazole | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Sotalol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Posaconazole | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Posaconazole | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Posaconazole | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Posaconazole | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Posaconazole | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Posaconazole | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Posaconazole | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Posaconazole | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Posaconazole | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Posaconazole | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Posaconazole | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Posaconazole | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Posaconazole | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP3A4 mediated DDI | |
| Posaconazole | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Posaconazole | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Raltitrexed | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Raltitrexed | Fenoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Raltitrexed | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Raltitrexed | Epinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Raltitrexed | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Raltitrexed | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Raltitrexed | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Raltitrexed | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Raltitrexed | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltitrexed | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Raltitrexed | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Raltitrexed | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Remdesivir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Remdesivir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Riboflavin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Tetracycline | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetracycline | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Deferasirox | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ticagrelor | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ticagrelor | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ticagrelor | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ticagrelor | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ticagrelor | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ticagrelor | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ticagrelor | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ticagrelor | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Valganciclovir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vinblastine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Vinblastine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alendronic acid | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alendronic acid | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alendronic acid | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alfuzosin | Bosutinib | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Alfuzosin | Piribedil | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Cetirizine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Drotaverine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Alfuzosin | Hydroxyzine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Alfuzosin | Oxybuprocaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Perphenazine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alfuzosin | Cariprazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Alfuzosin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Alfuzosin | Fingolimod | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Alfuzosin | Flutamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Alfuzosin | Procainamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Alfuzosin | Teriflunomide | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | |
| Alfuzosin | Tropicamide | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Alfuzosin | Agomelatine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2C19 mediated DDI |
| Alfuzosin | Clomipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Alfuzosin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alfuzosin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alfuzosin | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Azacitidine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bosutinib | Ceritinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bosutinib | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bosutinib | Nintedanib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Bosutinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bosutinib | Chloramphenicol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Bosutinib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bosutinib | Paliperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Bosutinib | Aminosalicylic acid | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Bosutinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bosutinib | Mebendazole | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Bosutinib | Mesalazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Bosutinib | Perphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Bosutinib | Propafenone | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bosutinib | Risperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Bosutinib | Sotalol | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Bosutinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bosutinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bosutinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bosutinib | Flupentixol | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bosutinib | Methotrimeprazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Procaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Bosutinib | Salicylic acid | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bosutinib | Agomelatine | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Chlorpromazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Clomipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bosutinib | Imipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bosutinib | Lidocaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Bosutinib | Cinacalcet | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bosutinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Ertapenem | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Lisinopril | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | |
| Carfilzomib | Piribedil | 3 | Major DDI | DDI causing hypotension; DDI causing tachycardia | |
| Carfilzomib | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carfilzomib | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Carfilzomib | Chloramphenicol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Carfilzomib | Enalapril | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | |
| Carfilzomib | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2B6 mediated DDI |
| Carfilzomib | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Carfilzomib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carfilzomib | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carfilzomib | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Aminocaproic acid | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carfilzomib | Atropine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Carfilzomib | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2B6 mediated DDI |
| Carfilzomib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carfilzomib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Carfilzomib | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Carfilzomib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Carfilzomib | Salicylic acid | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Carfilzomib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carfilzomib | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Carfilzomib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carfilzomib | Acetaminophen | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Carfilzomib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carfilzomib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Carfilzomib | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Carfilzomib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carfilzomib | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carfilzomib | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carfilzomib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Carfilzomib | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Carfilzomib | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Carfilzomib | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Delamanid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Hexoprenaline | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C9 mediated DDI |
| Ceritinib | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Iopromide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Riociguat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Ceritinib | Apremilast | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Gefitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Linagliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ceritinib | Raltegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Saquinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Selexipag | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Acalabrutinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Bromocriptine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Irinotecan | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Ivabradine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Nilotinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Tamsulosin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ceritinib | Verapamil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ceritinib | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ceritinib | Atorvastatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Ceritinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Bisoprolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Cabozantinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Carvedilol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Ceritinib | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Dorzolamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Mebeverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Ceritinib | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Paliperidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Phenoxymethylpenicillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Trametinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Atenolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Ethambutol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Lenvatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Metoclopramide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Metoprolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Nevirapine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Oxybuprocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ceritinib | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Propafenone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Ceritinib | Risperidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Ceritinib | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Ceritinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ceritinib | Bisacodyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Ceritinib | Caffeine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ceritinib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ceritinib | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Ceritinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Fluorescein | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ceritinib | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Ceritinib | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ceritinib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ceritinib | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Ceritinib | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Procaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Propranolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Betahistine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Ceritinib | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Brivaracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ceritinib | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ceritinib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ceritinib | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ceritinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Loratadine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Ceritinib | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ceritinib | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ceritinib | Protionamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Ceritinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ceritinib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Dabigatran etexilate | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Dabigatran etexilate | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Dasatinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasatinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasatinib | Procarbazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Dasatinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Dasatinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasatinib | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Delamanid | Hexoprenaline | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Delamanid | Verapamil | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Delamanid | Fenoterol | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Delamanid | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Delamanid | Norepinephrine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Delamanid | Sotalol | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Delamanid | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Delamanid | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Delamanid | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Delamanid | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Delamanid | Procainamide | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | |
| Delamanid | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Delamanid | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Delamanid | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI |
| Delamanid | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Delamanid | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Delamanid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Delamanid | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Delamanid | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ertapenem | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Verapamil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP3A4 mediated DDI |
| Ertapenem | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ertapenem | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ertapenem | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Ertapenem | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ertapenem | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ertapenem | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Ertapenem | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertapenem | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Ertapenem | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Fludarabine | Halothane | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Fosamprenavir | Iomeprol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fosamprenavir | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Fosamprenavir | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Fosamprenavir | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Phenylephrine | 3 | CLASS 1 (from 3); Major DDI | DDI causing tachycardia | |
| Fosamprenavir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Fosamprenavir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Fosamprenavir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fosamprenavir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Fosamprenavir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Fosamprenavir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fosamprenavir | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Hexoprenaline | Palbociclib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Hexoprenaline | Abemaciclib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2C9 mediated DDI |
| Hexoprenaline | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Hexoprenaline | Lisinopril | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Hexoprenaline | Ombitasvir | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Hexoprenaline | Osimertinib | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Hexoprenaline | Timolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Hexoprenaline | Bortezomib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Bromocriptine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Hexoprenaline | Vandetanib | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Ibrutinib | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Hexoprenaline | Trametinib | 3 | Major DDI | DDI causing hypertension; DDI causing arrhythmia | |
| Hexoprenaline | Indapamide | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Hexoprenaline | Lenvatinib | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Hexoprenaline | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Hexoprenaline | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Hexoprenaline | Sulfamethoxazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Hexoprenaline | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Hexoprenaline | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Hexoprenaline | Dexketoprofen | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Ketoprofen | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Tramadol | 3 | CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Hexoprenaline | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Hexoprenaline | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C9 mediated DDI |
| Hexoprenaline | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Iomeprol | Afatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Atazanavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Cobicistat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Darunavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Gefitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Imatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Lisinopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Moxifloxacin | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | |
| Iomeprol | Ombitasvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Raltegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Saquinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Bictegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iomeprol | Ciprofloxacin | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | |
| Iomeprol | Dolutegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iomeprol | Imipenem | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Irinotecan | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Ivabradine | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iomeprol | Meropenem | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Nilotinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Vandetanib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Iomeprol | Formoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Iomeprol | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Iomeprol | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Epinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Iomeprol | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Iomeprol | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iomeprol | Metoclopramide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iomeprol | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Bisacodyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iomeprol | Captopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iomeprol | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Lacosamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iomeprol | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Iomeprol | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iomeprol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Lidocaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | |
| Iomeprol | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Iomeprol | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iomeprol | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Benzyl benzoate | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Iomeprol | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iomeprol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iomeprol | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Iopromide | Atazanavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iopromide | Gefitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Iopromide | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Carbidopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iopromide | Imipenem | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Nimodipine | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Iopromide | Nintedanib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Iopromide | Olodaterol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Iopromide | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Iopromide | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Iopromide | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Iopromide | Formoterol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Iopromide | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iopromide | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Salmeterol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Sulpiride | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Iopromide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Iopromide | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Iopromide | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iopromide | Indacaterol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iopromide | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Iopromide | Metoclopramide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Iopromide | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iopromide | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Iopromide | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iopromide | Caffeine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Iopromide | Captopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iopromide | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Iopromide | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iopromide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iopromide | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Iopromide | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iopromide | Tramadol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Iopromide | Umifenovir | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Iopromide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Iopromide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iopromide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Iopromide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Iopromide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iopromide | Benzyl benzoate | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Iopromide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Iopromide | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Iopromide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Isosorbide dinitrate | Lisinopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Drotaverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Enalapril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Fenoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Isosorbide dinitrate | Atenolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Ethambutol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Metoprolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Propafenone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Captopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Propranolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide dinitrate | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Isosorbide dinitrate | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Palbociclib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Palbociclib | Carvedilol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Palbociclib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Palbociclib | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Palbociclib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Palbociclib | Procarbazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Palbociclib | Propranolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Palbociclib | Trifluoperazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Palbociclib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Palbociclib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Palbociclib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Riociguat | Fenoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Riociguat | Telbivudine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Riociguat | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Riociguat | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Riociguat | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Riociguat | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Riociguat | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Riociguat | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Riociguat | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Riociguat | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Riociguat | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Riociguat | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Riociguat | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Riociguat | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Riociguat | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Riociguat | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Riociguat | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Riociguat | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Riociguat | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Sulfasalazine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Sulfasalazine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sulfasalazine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sulfasalazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Sulfasalazine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Sulfasalazine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Tenofovir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tenofovir | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tenofovir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Tenofovir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Tenofovir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tenofovir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Tenofovir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tenofovir | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Tenofovir | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Velpatasvir | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Velpatasvir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Velpatasvir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Velpatasvir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Velpatasvir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Velpatasvir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Velpatasvir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Velpatasvir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Velpatasvir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Velpatasvir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Velpatasvir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Velpatasvir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Velpatasvir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Velpatasvir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Velpatasvir | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Vinorelbine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Zoledronic acid | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Abemaciclib | Bisoprolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Abemaciclib | Carvedilol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Abemaciclib | Fenoterol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Abemaciclib | Atenolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Abemaciclib | Epinephrine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Abemaciclib | Metoprolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Abemaciclib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Abemaciclib | Phenylephrine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Abemaciclib | Propranolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Abemaciclib | Teriflunomide | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Abemaciclib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Abemaciclib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Abemaciclib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Abemaciclib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acyclovir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Afatinib | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Afatinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Afatinib | Metoclopramide | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Afatinib | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Afatinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Afatinib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Afatinib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Afatinib | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Afatinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Afatinib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Afatinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Afatinib | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Tamoxifen | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Afatinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Afatinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Afatinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Afatinib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apremilast | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apremilast | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apremilast | Mebeverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Apremilast | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apremilast | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Fosfomycin | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Apremilast | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Metoclopramide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apremilast | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Apremilast | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apremilast | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Apremilast | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Apremilast | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apremilast | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apremilast | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apremilast | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Apremilast | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apremilast | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Apremilast | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apremilast | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Irinotecan | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Atazanavir | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Atazanavir | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Atazanavir | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP3A4 mediated DDI | |
| Atazanavir | Atorvastatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Atazanavir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Atazanavir | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Atazanavir | Formoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Atazanavir | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Atazanavir | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atazanavir | Salmeterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atazanavir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Atazanavir | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atazanavir | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Atazanavir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Atropine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP3A4 mediated DDI | |
| Atazanavir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Atazanavir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atazanavir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Atazanavir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Atazanavir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Methotrimeprazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Atazanavir | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atazanavir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atazanavir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atazanavir | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atazanavir | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Atazanavir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Atazanavir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Atazanavir | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Atazanavir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atazanavir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Atazanavir | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atazanavir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Atazanavir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Atazanavir | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Benserazide | Nimodipine | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Benserazide | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Benserazide | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Benserazide | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Benserazide | Atropine | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing tachycardia | |
| Benserazide | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Benserazide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Benserazide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Benserazide | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Benserazide | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Benserazide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Benserazide | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Benserazide | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Benserazide | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Benserazide | Clomipramine | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Benserazide | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Benserazide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Benserazide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Benserazide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Benserazide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Benserazide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Benserazide | Amitriptyline | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Benserazide | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Benserazide | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Cladribine | Oxybuprocaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI |
| Cladribine | Dopamine | 3 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2C9 mediated DDI |
| Cladribine | Propranolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia | |
| Cobicistat | Irinotecan | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Cobicistat | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Cobicistat | Atorvastatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Fenoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Cobicistat | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Cobicistat | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cobicistat | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cobicistat | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobicistat | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cobicistat | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cobicistat | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Cobicistat | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cobicistat | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Cobicistat | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Cobicistat | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cobicistat | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Cobicistat | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cobicistat | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cobicistat | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cobicistat | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Cobicistat | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Cobicistat | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cobicistat | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobicistat | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Cobicistat | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Cobicistat | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cobicistat | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cobicistat | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Cobicistat | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Cytarabine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Darunavir | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Darunavir | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Darunavir | Atorvastatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Darunavir | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Darunavir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Darunavir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Darunavir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Darunavir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Darunavir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Darunavir | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Darunavir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Darunavir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Darunavir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Darunavir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Darunavir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Elbasvir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Elbasvir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elbasvir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Elbasvir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Elbasvir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Elbasvir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Elbasvir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elbasvir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Elbasvir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elbasvir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Elbasvir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elbasvir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Elbasvir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Elbasvir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Elbasvir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Elbasvir | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Empagliflozin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Empagliflozin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Empagliflozin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Empagliflozin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Empagliflozin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Empagliflozin | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Empagliflozin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Empagliflozin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Erlotinib | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Erlotinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Erlotinib | Metoclopramide | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Erlotinib | Oxybuprocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Erlotinib | Periciazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Erlotinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Erlotinib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Erlotinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Erlotinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Erlotinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Erlotinib | Methotrimeprazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Erlotinib | Procaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Erlotinib | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Erlotinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Erlotinib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Erlotinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Erlotinib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Erlotinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Erlotinib | Ropivacaine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Erlotinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Erlotinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ertugliflozin | Methyldopa | 3 | CLASS 1 (from 3) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI |
| Ertugliflozin | Ethambutol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Ertugliflozin | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ertugliflozin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Ertugliflozin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Ertugliflozin | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ertugliflozin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ertugliflozin | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Ertugliflozin | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Ertugliflozin | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ertugliflozin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Ertugliflozin | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ertugliflozin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ertugliflozin | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Ertugliflozin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Lapatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Gefitinib | Vandetanib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Gefitinib | Alectinib | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C8 mediated DDI |
| Gefitinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gefitinib | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gefitinib | Drotaverine | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Gefitinib | Fenoterol | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Gefitinib | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Gefitinib | Formoterol | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI |
| Gefitinib | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Gefitinib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gefitinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gefitinib | Sulpiride | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gefitinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Gefitinib | Epinephrine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Gefitinib | Norepinephrine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Gefitinib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Gefitinib | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gefitinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gefitinib | Cariprazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Gefitinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gefitinib | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Gefitinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gefitinib | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gefitinib | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gefitinib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gefitinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Gefitinib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gefitinib | Sunitinib | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gefitinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gefitinib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Gefitinib | Zuclopenthixol | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Gefitinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gefitinib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Gefitinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gefitinib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gefitinib | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gefitinib | Benzyl benzoate | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Gefitinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Gefitinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imatinib | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Imatinib | Verapamil | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Imatinib | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Imatinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imatinib | Bisoprolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Imatinib | Carvedilol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Imatinib | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Imatinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Imatinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Imatinib | Oxybuprocaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Imatinib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Imatinib | Propafenone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Imatinib | Risperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Imatinib | Salbutamol | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Imatinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imatinib | Cariprazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Imatinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Imatinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Imatinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imatinib | Procaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C9 mediated DDI |
| Imatinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imatinib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Imatinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imatinib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Imatinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imatinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Imatinib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imatinib | Lidocaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Imatinib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Imatinib | Benzyl benzoate | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Imatinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Imatinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Deferasirox | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Irinotecan | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Ivabradine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Nilotinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Tamsulosin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lapatinib | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Lapatinib | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Lapatinib | Vandetanib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Lapatinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Cabozantinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Carvedilol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lapatinib | Crizotinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Drotaverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lapatinib | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Lapatinib | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Salmeterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Lapatinib | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Trametinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Epinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Lapatinib | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Lenvatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Metoclopramide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Lapatinib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lapatinib | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lapatinib | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Lapatinib | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Lapatinib | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Aminocaproic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Lapatinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Lapatinib | Chlorambucil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Lapatinib | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP3A4 mediated DDI | |
| Lapatinib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Lapatinib | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lapatinib | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP3A4 mediated DDI | |
| Lapatinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Lapatinib | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Salicylic acid | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Lapatinib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Lapatinib | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Lapatinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lapatinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Lapatinib | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Lapatinib | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lapatinib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lapatinib | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C9 mediated DDI |
| Lapatinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lapatinib | Pirfenidone | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Lapatinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Levofloxacin | Raltegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Levofloxacin | Urapidil | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Levofloxacin | Atenolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Levofloxacin | Mebendazole | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Levofloxacin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Levofloxacin | Fluoxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Ropivacaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Levofloxacin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Linagliptin | Ribociclib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Linagliptin | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Linagliptin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Linagliptin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Linagliptin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Lisinopril | Isosorbide mononitrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Lisinopril | Chloramphenicol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Lisinopril | Formoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Lisinopril | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Lisinopril | Methyldopa | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | |
| Lisinopril | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Lisinopril | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lisinopril | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Lisinopril | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Lisinopril | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Lisinopril | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Lisinopril | Caffeine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Lisinopril | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Lisinopril | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lisinopril | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lisinopril | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Lisinopril | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Lisinopril | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Lisinopril | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Lisinopril | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Lisinopril | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Lisinopril | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Lisinopril | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Lisinopril | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lisinopril | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lisinopril | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Lisinopril | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Lisinopril | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lisinopril | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Lisinopril | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Lisinopril | Nicotinamide | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Lisinopril | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Lisinopril | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Lisinopril | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Lisinopril | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Lisinopril | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Lisinopril | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Lisinopril | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Mitomycin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mitomycin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Mitomycin | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Moxifloxacin | Raltegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Moxifloxacin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxifloxacin | Fluconazole | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Moxifloxacin | Glyburide | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Moxifloxacin | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxifloxacin | Paroxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Moxifloxacin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxifloxacin | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxifloxacin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxifloxacin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxifloxacin | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Moxifloxacin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxifloxacin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxifloxacin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ofloxacin | Raltegravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ofloxacin | Urapidil | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ofloxacin | Atenolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Ofloxacin | Mebendazole | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ofloxacin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ofloxacin | Fluoxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Ropivacaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ofloxacin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ombitasvir | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ombitasvir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ombitasvir | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ombitasvir | Fenoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Ombitasvir | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Ombitasvir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ombitasvir | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ombitasvir | Epinephrine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Ombitasvir | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ombitasvir | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ombitasvir | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Ombitasvir | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Ombitasvir | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ombitasvir | Sotalol | 3 | Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ombitasvir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ombitasvir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Ombitasvir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ombitasvir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ombitasvir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Ombitasvir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ombitasvir | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ombitasvir | Perampanel | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Ombitasvir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ombitasvir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ombitasvir | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ombitasvir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ombitasvir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ombitasvir | Chlorpromazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Ombitasvir | Clomipramine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Ombitasvir | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Ombitasvir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ombitasvir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ombitasvir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Ombitasvir | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Ombitasvir | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Ombitasvir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Ombitasvir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ombitasvir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ombitasvir | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Ombitasvir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Osimertinib | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Osimertinib | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Fenoterol | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Osimertinib | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Osimertinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Osimertinib | Dobutamine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Osimertinib | Epinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Osimertinib | Ethambutol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Fluphenazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Osimertinib | Norepinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Osimertinib | Salbutamol | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Osimertinib | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Osimertinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Osimertinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Osimertinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Osimertinib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Phenylephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Osimertinib | Procainamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Osimertinib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Osimertinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Osimertinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Osimertinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Osimertinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Osimertinib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Pazopanib | Atenolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Pazopanib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pazopanib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Pazopanib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pazopanib | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Raltegravir | Ribociclib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltegravir | Ciprofloxacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Raltegravir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Raltegravir | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Raltegravir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Raltegravir | Epinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Raltegravir | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Raltegravir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Raltegravir | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Raltegravir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Raltegravir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Raltegravir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ribociclib | Carbidopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Ribociclib | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ribociclib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ribociclib | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Ribociclib | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ribociclib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ribociclib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ribociclib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ribociclib | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ribociclib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Ribociclib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Ribociclib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ribociclib | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Ribociclib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ribociclib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Sapropterin | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Saquinavir | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Saquinavir | Verapamil | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Saquinavir | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Atorvastatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Saquinavir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Saquinavir | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Saquinavir | Carvedilol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP3A4 mediated DDI |
| Saquinavir | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Saquinavir | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Saquinavir | Salmeterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Saquinavir | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Saquinavir | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Saquinavir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Saquinavir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Saquinavir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Saquinavir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Saquinavir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Saquinavir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Saquinavir | Propranolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2B6 mediated DDI |
| Saquinavir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Saquinavir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Zuclopenthixol | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Saquinavir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Saquinavir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Saquinavir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Saquinavir | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Saquinavir | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Saquinavir | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Saquinavir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Saquinavir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Saquinavir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Saquinavir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Selexipag | Formoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Selexipag | Salmeterol | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Selexipag | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Selexipag | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Selexipag | Epinephrine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Selexipag | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Selexipag | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Selexipag | Flutamide | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Selexipag | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Selexipag | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Selexipag | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Selexipag | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Selexipag | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Selexipag | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Selexipag | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Selexipag | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Selexipag | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Selexipag | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Selexipag | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Selexipag | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Selexipag | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Selexipag | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Selexipag | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Sparfloxacin | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sparfloxacin | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Sparfloxacin | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sparfloxacin | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sparfloxacin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sparfloxacin | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sparfloxacin | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sparfloxacin | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sparfloxacin | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sparfloxacin | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sparfloxacin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sparfloxacin | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Tazobactam | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tedizolid | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tedizolid | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tedizolid | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Tedizolid | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tedizolid | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Tedizolid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tedizolid | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tedizolid | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tenofovir alafenamide | Sotalol | 3 | CLASS 1 (from 3); Major DDI | DDI causing tachycardia | |
| Tenofovir alafenamide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tenofovir alafenamide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir alafenamide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir alafenamide | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir alafenamide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tenofovir alafenamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Tenofovir alafenamide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Timolol | Carbidopa | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | |
| Timolol | Vilanterol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Timolol | Fenoterol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Timolol | Methyldopa | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | |
| Timolol | Epinephrine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Timolol | Phenylephrine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Timolol | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Trimethoprim | Fluphenazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Trimethoprim | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Trimethoprim | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Trimethoprim | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Trimethoprim | Trifluoperazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Trimethoprim | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Trimethoprim | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Trimethoprim | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Trimethoprim | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Trimethoprim | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Carbidopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Acalabrutinib | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Acalabrutinib | Verapamil | 3 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Acalabrutinib | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Acalabrutinib | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Carvedilol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Acalabrutinib | Chloramphenicol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Acalabrutinib | Mebeverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Methyldopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Acalabrutinib | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Acalabrutinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Acalabrutinib | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Acalabrutinib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Acalabrutinib | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Acalabrutinib | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Acalabrutinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Acalabrutinib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Acalabrutinib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Acalabrutinib | Propranolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Acalabrutinib | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Acalabrutinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Acalabrutinib | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Acalabrutinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Acalabrutinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Lidocaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | |
| Acalabrutinib | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Acalabrutinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Acalabrutinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acalabrutinib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Acalabrutinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Acalabrutinib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Ambrisentan | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Ambrisentan | Mebeverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ambrisentan | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Ambrisentan | Oseltamivir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ambrisentan | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ambrisentan | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Ambrisentan | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Ambrisentan | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Ambrisentan | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ambrisentan | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ambrisentan | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Ambrisentan | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Ambrisentan | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ambrisentan | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Azathioprine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Azathioprine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Baricitinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Baricitinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Baricitinib | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Baricitinib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bictegravir | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Bictegravir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bictegravir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bictegravir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bictegravir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bictegravir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Bictegravir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bictegravir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bictegravir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Bictegravir | Chlorpromazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Bictegravir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bictegravir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bictegravir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Bictegravir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Bictegravir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bictegravir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Bortezomib | Fenoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Bortezomib | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Bortezomib | Epinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Bortezomib | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Bortezomib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bortezomib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bortezomib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Bortezomib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bortezomib | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Bortezomib | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bortezomib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bortezomib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bortezomib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bortezomib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bortezomib | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Bortezomib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Bromocriptine | Levodopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Bromocriptine | Linezolid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bromocriptine | Rivaroxaban | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bromocriptine | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bromocriptine | Atenolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Bromocriptine | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bromocriptine | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Bromocriptine | Metoprolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Bromocriptine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bromocriptine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bromocriptine | Efavirenz | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Bromocriptine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bromocriptine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bromocriptine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Bromocriptine | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bromocriptine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bromocriptine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Bromocriptine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Bromocriptine | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Capecitabine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Capecitabine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Carbidopa | Ivabradine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Carbidopa | Lumacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Carbidopa | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Verapamil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Carbidopa | Cetirizine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Drotaverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C8 mediated DDI |
| Carbidopa | Levodopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Carbidopa | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Carbidopa | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Carbidopa | Rivaroxaban | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbidopa | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Carbidopa | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Carbidopa | Atenolol | 3 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing bradycardia | CYP2C8 mediated DDI |
| Carbidopa | Ethambutol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Carbidopa | Hydroxyzine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Carbidopa | Metoclopramide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Carbidopa | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Carbidopa | Salbutamol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Carbidopa | Acetylsalicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Carbidopa | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Carbidopa | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Clonidine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Carbidopa | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Carbidopa | Diclofenac | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Carbidopa | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Carbidopa | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Carbidopa | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Carbidopa | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Carbidopa | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Carbidopa | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Carbidopa | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Carbidopa | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Carbidopa | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Carbidopa | Tranexamic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbidopa | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Carbidopa | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carbidopa | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Carbidopa | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carbidopa | Efavirenz | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Carbidopa | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Carbidopa | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Carbidopa | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Carbidopa | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Carbidopa | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Carbidopa | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Carbidopa | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Carbidopa | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Carbidopa | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cilastatin | Formoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cilastatin | Salmeterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cilastatin | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cilastatin | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cilastatin | Atropine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Cilastatin | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cilastatin | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Cilastatin | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cilastatin | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Cilastatin | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cilastatin | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cilastatin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Cilastatin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Cilastatin | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Ciprofloxacin | Urapidil | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Alogliptin | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ciprofloxacin | Bicalutamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ciprofloxacin | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ciprofloxacin | Mebendazole | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Ciprofloxacin | Paroxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Ciprofloxacin | Dopamine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Procainamide | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Procarbazine | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | |
| Ciprofloxacin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ciprofloxacin | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Ropivacaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Ciprofloxacin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Dabrafenib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dabrafenib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Daclatasvir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Daclatasvir | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Daclatasvir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Daclatasvir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Daclatasvir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Daclatasvir | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Daclatasvir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Daclatasvir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Daclatasvir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Daclatasvir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Daclatasvir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Daclatasvir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Daclatasvir | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Dapagliflozin | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Dapagliflozin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Dapagliflozin | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Dapagliflozin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dapagliflozin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Dapagliflozin | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Dapagliflozin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Deferasirox | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Deferasirox | Fenoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Deferasirox | Formoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Deferasirox | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Deferasirox | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Deferasirox | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Deferasirox | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Deferasirox | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Deferasirox | Sulfamethoxazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Deferasirox | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Deferasirox | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Deferasirox | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Deferasirox | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Deferasirox | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Deferasirox | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Deferasirox | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Deferasirox | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Deferasirox | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Deferasirox | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Deferasirox | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Deferasirox | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Deferasirox | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Deferasirox | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Deferasirox | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Deferasirox | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Dolutegravir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Dolutegravir | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dolutegravir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dolutegravir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Dolutegravir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dolutegravir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dolutegravir | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dolutegravir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Dolutegravir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Dolutegravir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dolutegravir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dolutegravir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Elvitegravir | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Elvitegravir | Verapamil | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Elvitegravir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Elvitegravir | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Elvitegravir | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elvitegravir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Elvitegravir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Elvitegravir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Elvitegravir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elvitegravir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Elvitegravir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elvitegravir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Elvitegravir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elvitegravir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Elvitegravir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elvitegravir | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Elvitegravir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Elvitegravir | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Elvitegravir | Mitotane | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Etravirine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Etravirine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Etravirine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Etravirine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gemcitabine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Gosogliptin | Nintedanib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Quetiapine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Atenolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | |
| Gosogliptin | Fluphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Metoclopramide | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Gosogliptin | Oxybuprocaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Perphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gosogliptin | Procainamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Gosogliptin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gosogliptin | Chlorpromazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Clomipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Imipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Gosogliptin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Gosogliptin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gosogliptin | Mitotane | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP3A4 mediated DDI |
| Imipenem | Rivaroxaban | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imipenem | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imipenem | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Imipenem | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Irinotecan | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Irinotecan | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Irinotecan | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Irinotecan | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Irinotecan | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Irinotecan | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Irinotecan | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Irinotecan | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Isosorbide mononitrate | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide mononitrate | Drotaverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide mononitrate | Enalapril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide mononitrate | Fenoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Isosorbide mononitrate | Atenolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide mononitrate | Metoprolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide mononitrate | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide mononitrate | Propranolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Isosorbide mononitrate | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Ivabradine | Nintedanib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Alogliptin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Cabozantinib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Chloramphenicol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Ivabradine | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ivabradine | Atenolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Oseltamivir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Ivabradine | Oxybuprocaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia | |
| Ivabradine | Periciazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Ivabradine | Perphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Ivabradine | Sotalol | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Flutamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Ivabradine | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ivabradine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ivabradine | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Chlorpromazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Ivabradine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Ivabradine | Lidocaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Ivabradine | Tamoxifen | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivabradine | Benzyl benzoate | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Ivabradine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Ivabradine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ixabepilone | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Levosimendan | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Levosimendan | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Levosimendan | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Levosimendan | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Levosimendan | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Levosimendan | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Levosimendan | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Levosimendan | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Levosimendan | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Levosimendan | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Lomefloxacin | Atenolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Lomefloxacin | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lomefloxacin | Dopamine | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Lomefloxacin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lomefloxacin | Loperamide | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lomefloxacin | Propranolol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP1A2 mediated DDI |
| Lomefloxacin | Teriflunomide | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | |
| Lomefloxacin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lomefloxacin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lomefloxacin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lomefloxacin | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lomefloxacin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Lomefloxacin | Mitotane | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Lumacaftor | Nimodipine | 3 | Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP2C9 mediated DDI |
| Lumacaftor | Amlodipine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Lumacaftor | Carvedilol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Lumacaftor | Formoterol | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Lumacaftor | Methyldopa | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Lumacaftor | Epinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Lumacaftor | Fluphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Lumacaftor | Norepinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Lumacaftor | Perphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Lumacaftor | Propafenone | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Lumacaftor | Clonidine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Lumacaftor | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lumacaftor | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lumacaftor | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Lumacaftor | Phenylephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Lumacaftor | Propranolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Lumacaftor | Trifluoperazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Lumacaftor | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Lumacaftor | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Mannitol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Mannitol | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Mannitol | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Mannitol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Mannitol | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Meropenem | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Meropenem | Rivaroxaban | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Meropenem | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Meropenem | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Meropenem | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Meropenem | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Meropenem | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Meropenem | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Meropenem | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Meropenem | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Moxonidine | Tizanidine | 3 | Major DDI | DDI causing hypotension; DDI causing tachycardia | |
| Moxonidine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxonidine | Clomifene | 3 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing tachycardia | |
| Moxonidine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Moxonidine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Moxonidine | Mitotane | 3 | Major DDI | DDI causing hypotension; DDI causing tachycardia | |
| Mycophenolate mofetil | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mycophenolate mofetil | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nilotinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Nilotinib | Fenoterol | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Nilotinib | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nilotinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nilotinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nilotinib | Epinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Nilotinib | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Nilotinib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Nilotinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nilotinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nilotinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nilotinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nilotinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nilotinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Nilotinib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Nilotinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nilotinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Nilotinib | Nicotinamide | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Nilotinib | Tapentadol | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Nilotinib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C8 mediated DDI |
| Nilotinib | Amitriptyline | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Nilotinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Nilotinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nimodipine | Bicalutamide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nimodipine | Chloramphenicol | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | |
| Nimodipine | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nimodipine | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nimodipine | Siponimod | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Nimodipine | Risperidone | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Nimodipine | Vemurafenib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Nimodipine | Axitinib | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Chlorambucil | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nimodipine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Nimodipine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nimodipine | Fulvestrant | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Nimodipine | Lacosamide | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Regorafenib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nimodipine | Umifenovir | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nimodipine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nimodipine | Betahistine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nimodipine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nimodipine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Nimodipine | Pyrantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Nimodipine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nintedanib | Rilpivirine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Nintedanib | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Nintedanib | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C9 mediated DDI |
| Nintedanib | Paliperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Nintedanib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nintedanib | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Nintedanib | Indacaterol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI |
| Nintedanib | Ivacaftor | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nintedanib | Mebendazole | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nintedanib | Metoclopramide | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Nintedanib | Oseltamivir | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | |
| Nintedanib | Perphenazine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Nintedanib | Risperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Nintedanib | Vismodegib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP3A4 mediated DDI |
| Nintedanib | Caffeine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Nintedanib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nintedanib | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Nintedanib | Sunitinib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Nintedanib | Teriflunomide | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nintedanib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Nintedanib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Nintedanib | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Nintedanib | Clomipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Nintedanib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Nintedanib | Levamisole | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | |
| Nintedanib | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Nintedanib | Piracetam | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Nintedanib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Nintedanib | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nintedanib | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Nintedanib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olodaterol | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olodaterol | Chloramphenicol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Olodaterol | Mebeverine | 3 | CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Methyldopa | 3 | CLASS 1 (from 3) | DDI causing tachycardia; DDI causing bradycardia | |
| Olodaterol | Salmeterol | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Olodaterol | Siponimod | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C8 mediated DDI |
| Olodaterol | Oseltamivir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Olodaterol | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Olodaterol | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Olodaterol | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Olodaterol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olodaterol | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Olodaterol | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Olodaterol | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Olodaterol | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Olodaterol | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olodaterol | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Olodaterol | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Olodaterol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Olodaterol | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Olodaterol | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Olodaterol | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Olodaterol | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Olodaterol | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Olodaterol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olodaterol | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Olodaterol | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Olodaterol | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Olodaterol | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Olodaterol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Olodaterol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Olodaterol | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Olodaterol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Piribedil | Verapamil | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Piribedil | Carvedilol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Piribedil | Sulpiride | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Piribedil | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Piribedil | Fluphenazine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Piribedil | Periciazine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Piribedil | Sotalol | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Piribedil | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Piribedil | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Piribedil | Flupentixol | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Piribedil | Haloperidol | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Piribedil | Perampanel | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP3A4 mediated DDI |
| Piribedil | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Piribedil | Acetaminophen | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Piribedil | Agomelatine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Piribedil | Clomifene | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Piribedil | Clomipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Piribedil | Fluoxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Piribedil | Imipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Piribedil | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Piribedil | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Piribedil | Amitriptyline | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Piribedil | Cinacalcet | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Rilpivirine | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rilpivirine | Fluphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP3A4 mediated DDI |
| Rilpivirine | Oxybuprocaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Rilpivirine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rilpivirine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Rilpivirine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Rilpivirine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Rilpivirine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Rilpivirine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Rilpivirine | Benzyl benzoate | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Rilpivirine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Rilpivirine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Risdiplam | Fosfomycin | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Risdiplam | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Risdiplam | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Ritonavir | Terizidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Urapidil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Ritonavir | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ritonavir | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ritonavir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Ritonavir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ritonavir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Ritonavir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ritonavir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Procainamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP3A4 mediated DDI |
| Ritonavir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ritonavir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Ritonavir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Ritonavir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ritonavir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ritonavir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Ritonavir | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Sofosbuvir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sofosbuvir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sofosbuvir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sofosbuvir | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Tamsulosin | Chloramphenicol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Tamsulosin | Levodopa | 3 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Tamsulosin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tamsulosin | Oseltamivir | 3 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tamsulosin | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Tamsulosin | Atropine | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Tamsulosin | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Tamsulosin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tamsulosin | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Tamsulosin | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Tamsulosin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Tamsulosin | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Tamsulosin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tamsulosin | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Tamsulosin | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Tamsulosin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Tamsulosin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Tamsulosin | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Tamsulosin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Tamsulosin | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Tamsulosin | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Tamsulosin | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Terizidone | Vandetanib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Terizidone | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Terizidone | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI | |
| Terizidone | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Terizidone | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Linezolid | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Terizidone | Lopinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Terizidone | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Lenvatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Metoclopramide | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Terizidone | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Terizidone | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Terizidone | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Tafluprost | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C8 mediated DDI |
| Terizidone | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Terizidone | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Terizidone | Caffeine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Captopril | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | |
| Terizidone | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Terizidone | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Terizidone | Betahistine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Terizidone | Dimethyl fumarate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Terizidone | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Terizidone | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Terizidone | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Terizidone | Desflurane | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Ethanol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Terizidone | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Terizidone | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Terizidone | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Urapidil | Alectinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Bisoprolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Urapidil | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Enalapril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Urapidil | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Urapidil | Formoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Urapidil | Mebeverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Methyldopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Urapidil | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Urapidil | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Urapidil | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Urapidil | Atenolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Epinephrine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Urapidil | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Lenvatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Urapidil | Metoprolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Urapidil | Oxybuprocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Urapidil | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Urapidil | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Urapidil | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Urapidil | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Urapidil | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Urapidil | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Urapidil | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Urapidil | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Urapidil | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Urapidil | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Phenylephrine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Urapidil | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Propranolol | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Urapidil | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Urapidil | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Urapidil | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Urapidil | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Urapidil | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Urapidil | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Urapidil | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Urapidil | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Urapidil | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Urapidil | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Urapidil | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Urapidil | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Urapidil | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Urapidil | Oxaliplatin | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Vandetanib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Vandetanib | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Fenoterol | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Vandetanib | Mebeverine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Vandetanib | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Vandetanib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vandetanib | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Vandetanib | Norepinephrine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Vandetanib | Oxybuprocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Vandetanib | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Vandetanib | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vandetanib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vandetanib | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vandetanib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Vandetanib | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vandetanib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vandetanib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Vandetanib | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Vandetanib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Vandetanib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Vandetanib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vandetanib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Vandetanib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Vandetanib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Verapamil | Apixaban | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | CYP3A4 mediated DDI |
| Verapamil | Atorvastatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP3A4 mediated DDI |
| Verapamil | Lopinavir | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Verapamil | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C9 mediated DDI |
| Verapamil | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP3A4 mediated DDI |
| Verapamil | Nelfinavir | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Verapamil | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Verapamil | Hydroxychloroquine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Verapamil | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Verapamil | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Verapamil | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Verapamil | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI |
| Verapamil | Fenofibrate | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Verapamil | Fluorescein | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Verapamil | Fulvestrant | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Verapamil | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Verapamil | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Verapamil | Regorafenib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Verapamil | Sorafenib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Verapamil | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Verapamil | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Verapamil | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C9 mediated DDI |
| Verapamil | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Verapamil | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Verapamil | Lipoic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Verapamil | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Verapamil | Piracetam | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Verapamil | Pyrantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Verapamil | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Verapamil | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP3A4 mediated DDI |
| Verapamil | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Verapamil | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vilanterol | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Vilanterol | Carvedilol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Vilanterol | Chloramphenicol | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing bradycardia | |
| Vilanterol | Methyldopa | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Vilanterol | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Vilanterol | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Vilanterol | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Vilanterol | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vilanterol | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Vilanterol | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Vilanterol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Vilanterol | Diphenhydramine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vilanterol | Fluoxetine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Vilanterol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vilanterol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Vilanterol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Vilanterol | Amitriptyline | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Zidovudine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Zidovudine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Zopiclone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Zopiclone | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Zopiclone | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Alectinib | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alectinib | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Carvedilol | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Alectinib | Chloramphenicol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Doravirine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Alectinib | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Alectinib | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Alectinib | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Alectinib | Talazoparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Alectinib | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Alectinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Alectinib | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alectinib | Lenalidomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alectinib | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Alectinib | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alectinib | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP3A4 mediated DDI | |
| Alectinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Alectinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Alectinib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Alectinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Alectinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Alectinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Alectinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Alectinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Alectinib | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Alectinib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C8 mediated DDI |
| Alectinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alectinib | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Alectinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Alectinib | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alogliptin | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alogliptin | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Alogliptin | Salmeterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Alogliptin | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alogliptin | Apalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Alogliptin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Alogliptin | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Alogliptin | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Alogliptin | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Alogliptin | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Alogliptin | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Alogliptin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alogliptin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Alogliptin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alogliptin | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alogliptin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alogliptin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alogliptin | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alogliptin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alogliptin | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Alogliptin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alogliptin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Alogliptin | Efavirenz | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Alogliptin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Alogliptin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Alogliptin | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Alogliptin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Alogliptin | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Alprostadil | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Alprostadil | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amlodipine | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Amlodipine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Amlodipine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Amlodipine | Isoniazid | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Amlodipine | Teriflunomide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Amlodipine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amlodipine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Amlodipine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Amlodipine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Amlodipine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Amlodipine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Amlodipine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Apixaban | Avibactam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Apixaban | Fluphenazine | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Apixaban | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apixaban | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apixaban | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apixaban | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apixaban | Phenylephrine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Apixaban | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apixaban | Trifluoperazine | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Apixaban | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Apixaban | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apixaban | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apixaban | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apixaban | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apixaban | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Apixaban | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apixaban | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apixaban | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apixaban | Cinacalcet | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Apixaban | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Apixaban | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Ascorbic acid | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ascorbic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atorvastatin | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Atorvastatin | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Atorvastatin | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atorvastatin | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Atorvastatin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Atorvastatin | Fosfomycin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Atorvastatin | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Atorvastatin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Atorvastatin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Atorvastatin | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Atorvastatin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Atorvastatin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atorvastatin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atorvastatin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atorvastatin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Avibactam | Bicalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Cabozantinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Drotaverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Elsulfavirine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Avibactam | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Ibrutinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Linezolid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Avibactam | Methyldopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Avibactam | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Perindopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Avibactam | Pomalidomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Rivaroxaban | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Telbivudine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Trametinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Avibactam | Apalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Atenolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Lenalidomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Lenvatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Metoclopramide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Metoprolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Avibactam | Propafenone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Risperidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Avibactam | Salbutamol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Avibactam | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Acetylsalicylic acid | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Avibactam | Atropine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Avibactam | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Bisacodyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Avibactam | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Enzalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Avibactam | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Phenobarbital | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Avibactam | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Avibactam | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Clopidogrel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Avibactam | Dimethyl fumarate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Avibactam | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Avibactam | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Avibactam | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Avibactam | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Avibactam | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Avibactam | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Avibactam | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Avibactam | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Avibactam | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Avibactam | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Avibactam | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Beclomethasone dipropionate | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Betamethasone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Dasabuvir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Bicalutamide | Fenoterol | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Bicalutamide | Fluconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Bicalutamide | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Talazoparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Telbivudine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Bicalutamide | Trametinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Bicalutamide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Fosfomycin | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Bicalutamide | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Lenalidomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Bicalutamide | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Norepinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Bicalutamide | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Oseltamivir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Bicalutamide | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bicalutamide | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bicalutamide | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Stavudine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Bicalutamide | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bicalutamide | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bicalutamide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bicalutamide | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Bicalutamide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Bicalutamide | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Bicalutamide | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bicalutamide | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Bicalutamide | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bicalutamide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bicalutamide | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bicalutamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bicalutamide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bicalutamide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bicalutamide | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Bicalutamide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bicalutamide | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI | |
| Bicalutamide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Bicalutamide | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Bicalutamide | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bisoprolol | Miglustat | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | |
| Bisoprolol | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisoprolol | Favipiravir | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Bisoprolol | Teriflunomide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisoprolol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bisoprolol | Fluoxetine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisoprolol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Buprenorphine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Buprenorphine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Buprenorphine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Buprenorphine | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Buprenorphine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Buprenorphine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Buprenorphine | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Cabozantinib | Carvedilol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Fenoterol | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cabozantinib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Cabozantinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cabozantinib | Atenolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cabozantinib | Metoprolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Norepinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cabozantinib | Propafenone | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cabozantinib | Atropine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cabozantinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cabozantinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Cabozantinib | Phenylephrine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cabozantinib | Procaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C9 mediated DDI |
| Cabozantinib | Propranolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cabozantinib | Chlorpromazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cabozantinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cabozantinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cabozantinib | Benzyl benzoate | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Cabozantinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Cabozantinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Carvedilol | Chloramphenicol | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | |
| Carvedilol | Lurasidone | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | |
| Carvedilol | Miglustat | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Paliperidone | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Trametinib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Diatrizoate | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Carvedilol | Ivacaftor | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Lenvatinib | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Olaparib | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Risperidone | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Tetrabenazine | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Aminophylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Carvedilol | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Flupentixol | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Flutamide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Carvedilol | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Carvedilol | Sunitinib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Teriflunomide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Tramadol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carvedilol | Acetaminophen | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Fluoxetine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Carvedilol | Nicotinamide | 3 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Carvedilol | Praziquantel | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | |
| Carvedilol | Sertindole | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Vinpocetine | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI |
| Carvedilol | Amitriptyline | 3 | Major DDI | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Carvedilol | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cephalexin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cephalexin | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cetirizine | Chloramphenicol | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Cetirizine | Formoterol | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Cetirizine | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Cetirizine | Periciazine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Cetirizine | Flutamide | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Cetirizine | Haloperidol | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Cetirizine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Cetirizine | Chlorpromazine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cetirizine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Cetirizine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cetirizine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cetirizine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Cetirizine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Cetirizine | Mitotane | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Chloramphenicol | Drotaverine | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Chloramphenicol | Enalapril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Chloramphenicol | Levodopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Chloramphenicol | Losartan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Chloramphenicol | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Chloramphenicol | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Chloramphenicol | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Chloramphenicol | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Chloramphenicol | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Chloramphenicol | Indapamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Chloramphenicol | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Chloramphenicol | Propafenone | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Chloramphenicol | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Chloramphenicol | Captopril | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Chloramphenicol | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Chloramphenicol | Enzalutamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Chloramphenicol | Flutamide | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Chloramphenicol | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Chloramphenicol | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Chloramphenicol | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Chloramphenicol | Propranolol | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Chloramphenicol | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Chloramphenicol | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Chloramphenicol | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Chloramphenicol | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Chloramphenicol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Chloramphenicol | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Chloramphenicol | Levetiracetam | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Chloramphenicol | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Chloramphenicol | Pyrantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Chloramphenicol | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Chloramphenicol | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Chloramphenicol | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Chloramphenicol | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Chloramphenicol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Clavulanic acid | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clavulanic acid | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Crizotinib | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Crizotinib | Dobutamine | 3 | CLASS 1 (from 3); Major DDI | DDI causing tachycardia | |
| Crizotinib | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Crizotinib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Crizotinib | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Crizotinib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Crizotinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Desflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Crizotinib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Dacarbazine | Busulfan | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Dacarbazine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Dacarbazine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Dacarbazine | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Dacarbazine | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Dacarbazine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dacarbazine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Dacarbazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Dacarbazine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Dacarbazine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Dasabuvir | Fenoterol | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Dasabuvir | Formoterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Dasabuvir | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Dasabuvir | Mebeverine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Dasabuvir | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Dasabuvir | Norepinephrine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Dasabuvir | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Dasabuvir | Oxybuprocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Dasabuvir | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Dasabuvir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Dasabuvir | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Dasabuvir | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Dasabuvir | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Phenylephrine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Dasabuvir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Dasabuvir | Propranolol | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | CYP2D6 mediated DDI |
| Dasabuvir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Dasabuvir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Dasabuvir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Dasabuvir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Dasabuvir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Dasabuvir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dasabuvir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Dasabuvir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Dasabuvir | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Dexamethasone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dinoprostone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doravirine | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Doravirine | Oxacillin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doravirine | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Doravirine | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Doravirine | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Doravirine | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Doravirine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doravirine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Doravirine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Doravirine | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Doravirine | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doravirine | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Doravirine | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Doravirine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Doravirine | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doravirine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Doravirine | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Doravirine | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Doravirine | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI | |
| Doravirine | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Doravirine | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Doravirine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Doravirine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Doravirine | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Doravirine | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Doravirine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Doravirine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Doravirine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Doravirine | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Dorzolamide | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C9 mediated DDI |
| Drotaverine | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Drotaverine | Linezolid | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Drotaverine | Paliperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Drotaverine | Quetiapine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Drotaverine | Tizanidine | 3 | Major DDI | DDI causing hypotension; DDI causing tachycardia | |
| Drotaverine | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Drotaverine | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Drotaverine | Fosfomycin | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP3A4 mediated DDI |
| Drotaverine | Oseltamivir | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Drotaverine | Risperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Drotaverine | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Drotaverine | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Drotaverine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Drotaverine | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Drotaverine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Drotaverine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Drotaverine | Tramadol | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Clomipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Drotaverine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Drotaverine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Drotaverine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Drotaverine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Elsulfavirine | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Elsulfavirine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elsulfavirine | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Elsulfavirine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Elsulfavirine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Elsulfavirine | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Elsulfavirine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elsulfavirine | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Elsulfavirine | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elsulfavirine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elsulfavirine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Elsulfavirine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Elsulfavirine | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Elsulfavirine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Elsulfavirine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Emtricitabine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Emtricitabine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Emtricitabine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Enalapril | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Enalapril | Mebeverine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | |
| Enalapril | Methyldopa | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | |
| Enalapril | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Enalapril | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Enalapril | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Enalapril | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Enalapril | Sulfamethoxazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Enalapril | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Enalapril | Aminophylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Enalapril | Caffeine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Enalapril | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Enalapril | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Enalapril | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Enalapril | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Enalapril | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Enalapril | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Enalapril | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Enalapril | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Enalapril | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Enalapril | Clomipramine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | CYP2D6 mediated DDI |
| Enalapril | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Enalapril | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Enalapril | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Enalapril | Nicotinamide | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | CYP2C19 mediated DDI |
| Enalapril | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Enalapril | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Enalapril | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Enalapril | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Enalapril | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Esomeprazole | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Esomeprazole | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Fenoterol | Ibrutinib | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Fenoterol | Ipragliflozin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Fenoterol | Linezolid | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Fenoterol | Trametinib | 3 | Major DDI | DDI causing hypertension; DDI causing arrhythmia | |
| Fenoterol | Diatrizoate | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Fenoterol | Hydroxychloroquine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Fenoterol | Indapamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Fenoterol | Lenvatinib | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Fenoterol | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Fenoterol | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Fenoterol | Sulfamethoxazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Fenoterol | Baclofen | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Fenoterol | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Fenoterol | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fenoterol | Oxazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Fenoterol | Pyrazinamide | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Fenoterol | Regorafenib | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Fenoterol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fenoterol | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C9 mediated DDI |
| Fenoterol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Fenoterol | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Fenoterol | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Fenoterol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fenoterol | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Fenoterol | Oxcarbazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI |
| Fluconazole | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Talazoparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Fluconazole | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Ivacaftor | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Fluconazole | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Sotalol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Fluconazole | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Fluconazole | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fluconazole | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Fluconazole | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Fluconazole | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Fluconazole | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Fludrocortisone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Formoterol | Glyburide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Formoterol | Miglustat | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Formoterol | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Formoterol | Fosfomycin | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Formoterol | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Formoterol | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Formoterol | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Formoterol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Formoterol | Fluorescein | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Formoterol | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Formoterol | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Formoterol | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Formoterol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Formoterol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Formoterol | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Formoterol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Formoterol | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Formoterol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Vinpocetine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Formoterol | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Furosemide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Glyburide | Levodopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Nelfinavir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Glyburide | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Glyburide | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Glyburide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Glyburide | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Glyburide | Fosfomycin | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Glyburide | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Glyburide | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI | |
| Glyburide | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Glyburide | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Glyburide | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Glyburide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Glyburide | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Glyburide | Bisacodyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Glyburide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Glyburide | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Glyburide | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Glyburide | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Glyburide | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Glyburide | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Glyburide | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Glyburide | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Glyburide | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Glyburide | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Glyburide | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Glyburide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Glyburide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Glyburide | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Piracetam | 3 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Glyburide | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI | |
| Glyburide | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Glyburide | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Glyburide | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Glyburide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Glyburide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Glyburide | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Glyburide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI | |
| Glyburide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Glyburide | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydrochlorothiazide | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Hydrochlorothiazide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Hydrocortisone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ibrutinib | Atenolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Ibrutinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ibrutinib | Dobutamine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Ibrutinib | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ibrutinib | Metoprolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Ibrutinib | Norepinephrine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Ibrutinib | Sotalol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Ibrutinib | Dopamine | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Ibrutinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ibrutinib | Phenylephrine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Ibrutinib | Propranolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Ibrutinib | Clomifene | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Ibrutinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ipragliflozin | Salmeterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Ipragliflozin | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Ipragliflozin | Epinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Ipragliflozin | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Ipragliflozin | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Ipragliflozin | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Ipragliflozin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ipragliflozin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ipragliflozin | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Lamivudine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Levodopa | Linezolid | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Levodopa | Methyldopa | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing hypotension | |
| Levodopa | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Levodopa | Salmeterol | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Levodopa | Epinephrine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Levodopa | Norepinephrine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Levodopa | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Levodopa | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Levodopa | Flupentixol | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Levodopa | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Levodopa | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Levodopa | Procainamide | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia | |
| Levodopa | Salicylic acid | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Levodopa | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Levodopa | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Levodopa | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Levodopa | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Levodopa | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Levodopa | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Levodopa | Lidocaine | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing tachycardia | CYP2D6 mediated DDI |
| Levodopa | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Levodopa | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Linezolid | Mebeverine | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Linezolid | Methyldopa | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Linezolid | Repaglinide | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | CYP2C8 mediated DDI |
| Linezolid | Salmeterol | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Linezolid | Atenolol | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Linezolid | Dobutamine | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Linezolid | Epinephrine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Linezolid | Norepinephrine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Linezolid | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Linezolid | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Linezolid | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Linezolid | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Linezolid | Phenylephrine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Linezolid | Propranolol | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI |
| Linezolid | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Linezolid | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Linezolid | Agomelatine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Linezolid | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Linezolid | Clomifene | 3 | Major DDI | DDI causing hypertension; DDI causing hypotension | |
| Linezolid | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Linezolid | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Linezolid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Linezolid | Levamisole | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Linezolid | Tapentadol | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Lopinavir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Lopinavir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lopinavir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Lopinavir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lopinavir | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lopinavir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lopinavir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Lopinavir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lopinavir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lopinavir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lopinavir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lopinavir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Lopinavir | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Lopinavir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lopinavir | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Losartan | Methyldopa | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Nifedipine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Atenolol | 3 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing arrhythmia | |
| Losartan | Epinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C9 mediated DDI |
| Losartan | Ethambutol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C9 mediated DDI |
| Losartan | Fosfomycin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Losartan | Salbutamol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C9 mediated DDI |
| Losartan | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Losartan | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Losartan | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Losartan | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C9 mediated DDI |
| Losartan | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Losartan | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Losartan | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Losartan | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Lurasidone | Fosfomycin | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Lurasidone | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Lurasidone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lurasidone | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Lurasidone | Propranolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Lurasidone | Trifluoperazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP1A2 mediated DDI |
| Lurasidone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lurasidone | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Mebeverine | Paliperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Mebeverine | Hydroxychloroquine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mebeverine | Risperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Mebeverine | Cariprazine | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Chlorambucil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Mebeverine | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Mebeverine | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Mebeverine | Fluorescein | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Mebeverine | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Mebeverine | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Mebeverine | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Mebeverine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mebeverine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Mebeverine | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Mebeverine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Mebeverine | Clotrimazole | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Mebeverine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Methyldopa | Nitisinone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methyldopa | Indacaterol | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Methyldopa | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methyldopa | Metoprolol | 3 | CLASS 1 (from 3) | DDI causing hypotension; DDI causing bradycardia | |
| Methyldopa | Salbutamol | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Methyldopa | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Clonidine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Methyldopa | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methyldopa | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Methyldopa | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methyldopa | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methyldopa | Zuclopenthixol | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Methyldopa | Acetaminophen | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Methyldopa | Betahistine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Methyldopa | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Methyldopa | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Methyldopa | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Methyldopa | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Methyldopa | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methyldopa | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methyldopa | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Methyldopa | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Methyldopa | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Methyldopa | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Miglustat | Salmeterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Miglustat | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Miglustat | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Miglustat | Apalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Miglustat | Fosfomycin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Miglustat | Metoprolol | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Miglustat | Oxybuprocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Miglustat | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Miglustat | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Miglustat | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Miglustat | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Miglustat | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Miglustat | Procaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Miglustat | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Miglustat | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Miglustat | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Miglustat | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Miglustat | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Miglustat | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Miglustat | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Mycophenolic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Mycophenolic acid | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Naltrexone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Naltrexone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nelfinavir | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Nelfinavir | Dobutamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI |
| Nelfinavir | Epinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Nelfinavir | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nelfinavir | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nelfinavir | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Nelfinavir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nelfinavir | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI |
| Nelfinavir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI | |
| Nelfinavir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Nelfinavir | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nelfinavir | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Nelfinavir | Propranolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2B6 mediated DDI |
| Nelfinavir | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nelfinavir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nelfinavir | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Nelfinavir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Nelfinavir | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Nelfinavir | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nelfinavir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Nelfinavir | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Nelfinavir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Nelfinavir | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Nelfinavir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Nelfinavir | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Nelfinavir | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Nelfinavir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nelfinavir | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nelfinavir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Nifedipine | Siponimod | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Ixazomib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Nifedipine | Vemurafenib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Nifedipine | Chlorambucil | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Enzalutamide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Nifedipine | Fulvestrant | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Nifedipine | Isoniazid | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nifedipine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nifedipine | Dimethyl fumarate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Nifedipine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Nifedipine | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Nifedipine | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP3A4 mediated DDI |
| Nifedipine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Nifedipine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Sulpiride | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Nitisinone | Trametinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Nitisinone | Apalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nitisinone | Atenolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Nitisinone | Hydroxyzine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Nitisinone | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Lenvatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Nitisinone | Metoclopramide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Nitisinone | Metoprolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Nitisinone | Propafenone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Nitisinone | Risperidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Nitisinone | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nitisinone | Captopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Nitisinone | Clonidine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Nitisinone | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Nitisinone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Nitisinone | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nitisinone | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Nitisinone | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nitisinone | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Nitisinone | Procaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Nitisinone | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nitisinone | Propranolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Nitisinone | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nitisinone | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Nitisinone | Acetaminophen | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Nitisinone | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nitisinone | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Nitisinone | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Nitisinone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Nitisinone | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nitisinone | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nitisinone | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nitisinone | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nitisinone | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Nitisinone | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitisinone | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Nitisinone | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Nitisinone | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Nitisinone | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Omeprazole | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Omeprazole | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Oxacillin | Siponimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxacillin | Apalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Oxacillin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxacillin | Lenvatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Oxacillin | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxacillin | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxacillin | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Oxacillin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Oxacillin | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxacillin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxacillin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxacillin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Oxacillin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Oxacillin | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxacillin | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Oxacillin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Oxycodone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Oxycodone | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxycodone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxycodone | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paliperidone | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paliperidone | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paliperidone | Fluphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Paliperidone | Fosfomycin | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Paliperidone | Oseltamivir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Paliperidone | Oxybuprocaine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Paliperidone | Perphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Paliperidone | Sotalol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Paliperidone | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paliperidone | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paliperidone | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paliperidone | Methotrimeprazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Paliperidone | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paliperidone | Chlorpromazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Paliperidone | Clomipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Paliperidone | Imipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Paliperidone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paliperidone | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paliperidone | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paliperidone | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Perindopril | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Perindopril | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Perindopril | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Perindopril | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Perindopril | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Perindopril | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Perindopril | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Phenoxymethylpenicillin | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Phenoxymethylpenicillin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Phenoxymethylpenicillin | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Phenoxymethylpenicillin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Pomalidomide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pomalidomide | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pomalidomide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pomalidomide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pomalidomide | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pomalidomide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pomalidomide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pomalidomide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Pomalidomide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pomalidomide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pomalidomide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Quetiapine | Paroxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Quetiapine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Quetiapine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Quetiapine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Quetiapine | Procarbazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Quetiapine | Clomifene | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Quetiapine | Fluoxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Quetiapine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Quetiapine | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Quetiapine | Nicotinamide | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Quetiapine | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Quetiapine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Repaglinide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Repaglinide | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI |
| Repaglinide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Repaglinide | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Repaglinide | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Repaglinide | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Repaglinide | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Repaglinide | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Repaglinide | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Repaglinide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C8 mediated DDI |
| Repaglinide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Repaglinide | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Repaglinide | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Repaglinide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Repaglinide | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Rivaroxaban | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rivaroxaban | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rivaroxaban | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rivaroxaban | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rivaroxaban | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rivaroxaban | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rivaroxaban | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Rivaroxaban | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Rivaroxaban | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Salmeterol | Siponimod | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Salmeterol | Apalutamide | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Salmeterol | Hydroxychloroquine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Indacaterol | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Salmeterol | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Salmeterol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Salmeterol | Fluorescein | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Salmeterol | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Salmeterol | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Salmeterol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Salmeterol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Salmeterol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Salmeterol | Sertindole | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Salmeterol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Salmeterol | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Siponimod | Atenolol | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Siponimod | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Siponimod | Epinephrine | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Siponimod | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Siponimod | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Siponimod | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Siponimod | Propafenone | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Siponimod | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Siponimod | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Siponimod | Caffeine | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP1A2 mediated DDI |
| Siponimod | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Siponimod | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Siponimod | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Siponimod | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Siponimod | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Siponimod | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Siponimod | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Siponimod | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Siponimod | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Siponimod | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Siponimod | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Siponimod | Phenylephrine | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Siponimod | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Siponimod | Propranolol | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Siponimod | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Siponimod | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Siponimod | Betahistine | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Siponimod | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Siponimod | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Siponimod | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Siponimod | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Siponimod | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Siponimod | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Siponimod | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Siponimod | Rivastigmine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Siponimod | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Siponimod | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Siponimod | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Siponimod | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Siponimod | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Siponimod | Benzyl benzoate | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Siponimod | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Siponimod | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Sulbactam | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Sulpiride | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sulpiride | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sulpiride | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sulpiride | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Sulpiride | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sulpiride | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sulpiride | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sulpiride | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sulpiride | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sulpiride | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sulpiride | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Sulpiride | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Sulpiride | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sulpiride | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sulpiride | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Sulpiride | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sulpiride | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Sulpiride | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sulpiride | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Sulpiride | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Talazoparib | Voriconazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Talazoparib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Talazoparib | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Talazoparib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Talazoparib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Talazoparib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Talazoparib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Talazoparib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Talazoparib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Talazoparib | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Talazoparib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Talazoparib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Talazoparib | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Talazoparib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Talazoparib | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Talazoparib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Talazoparib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Talazoparib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Talazoparib | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Talazoparib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Telbivudine | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Telbivudine | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Telbivudine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Telbivudine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Telbivudine | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Telbivudine | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Telbivudine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Telbivudine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Telbivudine | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Telbivudine | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Telbivudine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Telbivudine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Temozolomide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Temozolomide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Temozolomide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tizanidine | Oxybuprocaine | 3 | Major DDI | DDI causing hypotension; DDI causing tachycardia | |
| Tizanidine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tizanidine | Procarbazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Tizanidine | Acetaminophen | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Tizanidine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tizanidine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tizanidine | Mitotane | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2B6 mediated DDI |
| Tofacitinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Trametinib | Atenolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Trametinib | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trametinib | Epinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing arrhythmia | |
| Trametinib | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trametinib | Norepinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing arrhythmia | |
| Trametinib | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trametinib | Propafenone | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Trametinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trametinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trametinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trametinib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trametinib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trametinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trametinib | Procainamide | 3 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Trametinib | Propranolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Trametinib | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trametinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trametinib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Trametinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trametinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trametinib | Clomifene | 3 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | |
| Trametinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trametinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Trametinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trametinib | Lidocaine | 3 | CLASS 1 (from 5); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Trametinib | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trametinib | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Trametinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trametinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Trametinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trametinib | Mitotane | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Voriconazole | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Voriconazole | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Voriconazole | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Voriconazole | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Voriconazole | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Aminosalicylic acid | Atenolol | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Aminosalicylic acid | Fluphenazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Aminosalicylic acid | Sulfamethoxazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Aminosalicylic acid | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Aminosalicylic acid | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Aminosalicylic acid | Fingolimod | 3 | CLASS 1 (from 3); Major DDI | DDI causing bradycardia | CYP2C9 mediated DDI |
| Aminosalicylic acid | Lacosamide | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Aminosalicylic acid | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Aminosalicylic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Aminosalicylic acid | Levamisole | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | |
| Aminosalicylic acid | Thioridazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypertension | |
| Aminosalicylic acid | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Aminosalicylic acid | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Aminosalicylic acid | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Anastrozole | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Anastrozole | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Anastrozole | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Anastrozole | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Anastrozole | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Apalutamide | Bedaquiline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Epinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Apalutamide | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Apalutamide | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Norepinephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Apalutamide | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apalutamide | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Apalutamide | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Apalutamide | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Apalutamide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Apalutamide | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Apalutamide | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Apalutamide | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Apalutamide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apalutamide | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Apalutamide | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Apalutamide | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apalutamide | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apalutamide | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Apalutamide | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Apalutamide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apalutamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Apalutamide | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Apalutamide | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Apalutamide | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Apalutamide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apalutamide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Apalutamide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Apalutamide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Apalutamide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Apalutamide | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Atenolol | Favipiravir | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Atenolol | Mesalazine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Atenolol | Fenofibrate | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Flutamide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Regorafenib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Teriflunomide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Atenolol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atenolol | Warfarin | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI |
| Atenolol | Diphenhydramine | 3 | CLASS 1 (from 3) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Atenolol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bedaquiline | Clonazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bedaquiline | Cobimetinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Ethambutol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bedaquiline | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Hydroxyzine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Indapamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bedaquiline | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Lenalidomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Lenvatinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Bedaquiline | Mesalazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bedaquiline | Metoclopramide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Nitrazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bedaquiline | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bedaquiline | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bedaquiline | Risperidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bedaquiline | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bedaquiline | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bedaquiline | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Bedaquiline | Acetylsalicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Bisacodyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Bedaquiline | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Bedaquiline | Diclofenac | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Bedaquiline | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Bedaquiline | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Bedaquiline | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bedaquiline | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Bedaquiline | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Bedaquiline | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Bedaquiline | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Lorazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Bedaquiline | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bedaquiline | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Oxazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bedaquiline | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bedaquiline | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Bedaquiline | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Bedaquiline | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bedaquiline | Acetaminophen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bedaquiline | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Bedaquiline | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bedaquiline | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bedaquiline | Diazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bedaquiline | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bedaquiline | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Midazolam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bedaquiline | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bedaquiline | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Bedaquiline | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bedaquiline | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bedaquiline | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Bedaquiline | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Bedaquiline | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Bedaquiline | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Bedaquiline | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bendamustine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bendamustine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Bendamustine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Benzylpenicillin | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Benzylpenicillin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Busulfan | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Busulfan | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Busulfan | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Clonazepam | Epinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Clonazepam | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Clonazepam | Sotalol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Clonazepam | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Clonazepam | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Clonazepam | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Clonazepam | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clonazepam | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clonazepam | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clonazepam | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Cobimetinib | Fluphenazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypotension | CYP2D6 mediated DDI |
| Cobimetinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cobimetinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cobimetinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobimetinib | Propranolol | 3 | Major DDI | DDI causing hypotension; DDI causing arrhythmia | CYP2D6 mediated DDI |
| Cobimetinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobimetinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobimetinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobimetinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobimetinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobimetinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobimetinib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cobimetinib | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Dapsone | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Dapsone | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Dapsone | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dapsone | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C9 mediated DDI |
| Diatrizoate | Fosfomycin | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Diatrizoate | Dopamine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Diatrizoate | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Diatrizoate | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Diatrizoate | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Diatrizoate | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Diatrizoate | Clomifene | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Diatrizoate | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Diatrizoate | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Diatrizoate | Lidocaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Diatrizoate | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Diatrizoate | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Dobutamine | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Dobutamine | Hydroxychloroquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dobutamine | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Dobutamine | Sulfamethoxazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Dobutamine | Tafluprost | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Dobutamine | Baclofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Dobutamine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Dobutamine | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Dobutamine | Fulvestrant | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Dobutamine | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Dobutamine | Lorazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Dobutamine | Oxazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Dobutamine | Phenobarbital | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Dobutamine | Tranexamic acid | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Dobutamine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dobutamine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Dobutamine | Diazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Dobutamine | Dimethyl fumarate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Dobutamine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Dobutamine | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Dobutamine | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Dobutamine | Pyrantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Dobutamine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Epinephrine | Ethambutol | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Favipiravir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Epinephrine | Hydroxychloroquine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Indapamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Epinephrine | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Epinephrine | Nitrazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Epinephrine | Sulfamethoxazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Epinephrine | Tetrabenazine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Epinephrine | Baclofen | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C8 mediated DDI |
| Epinephrine | Chlorambucil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Epinephrine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Epinephrine | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Epinephrine | Methotrimeprazine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Epinephrine | Regorafenib | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Epinephrine | Tramadol | 3 | CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Epinephrine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Epinephrine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Epinephrine | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Epinephrine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Epinephrine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Ethambutol | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ethambutol | Atropine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Ethambutol | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ethambutol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ethambutol | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ethambutol | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Ethambutol | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ethambutol | Phenylephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Ethambutol | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ethambutol | Acetaminophen | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Ethambutol | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Ethambutol | Efavirenz | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Ethambutol | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ethambutol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Ethambutol | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Ethambutol | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ethambutol | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Ethambutol | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ethambutol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ethambutol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Ethambutol | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ethambutol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Evogliptin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Evogliptin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Evogliptin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Evogliptin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Favipiravir | Fluphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Favipiravir | Indacaterol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Lenalidomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Olanzapine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Oxybuprocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Favipiravir | Pentoxifylline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Propafenone | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Favipiravir | Risperidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Captopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Favipiravir | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Enzalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Procaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Favipiravir | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Sunitinib | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Teriflunomide | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Favipiravir | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Favipiravir | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Acetaminophen | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | |
| Favipiravir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Favipiravir | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Favipiravir | Clopidogrel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Favipiravir | Diazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Favipiravir | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Favipiravir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Lidocaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | |
| Favipiravir | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Favipiravir | Phenytoin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Favipiravir | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Favipiravir | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Favipiravir | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Favipiravir | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Favipiravir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Fluphenazine | Hydroxyzine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Mesalazine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP1A2 mediated DDI |
| Fluphenazine | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Fluphenazine | Sulfamethoxazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C9 mediated DDI |
| Fluphenazine | Tafluprost | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Fluphenazine | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fluphenazine | Acetylsalicylic acid | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluphenazine | Aminocaproic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Fluphenazine | Captopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Fluphenazine | Chlorambucil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Fluphenazine | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Fluphenazine | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Fluphenazine | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Fluphenazine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fluphenazine | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Fluphenazine | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fluphenazine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fluphenazine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Fluphenazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fluphenazine | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Fluphenazine | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Fluphenazine | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fluphenazine | Rivastigmine | 3 | CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Fluphenazine | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Fluphenazine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Fluphenazine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Fluphenazine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Fluphenazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Fluphenazine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Fluphenazine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Fosfomycin | Indacaterol | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Fosfomycin | Mebendazole | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C19 mediated DDI |
| Fosfomycin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fosfomycin | Fingolimod | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Fosfomycin | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Fosfomycin | Methotrimeprazine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Fosfomycin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fosfomycin | Acetaminophen | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fosfomycin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Fosfomycin | Imipramine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Fosfomycin | Levamisole | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Fosfomycin | Lipoic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Fosfomycin | Piracetam | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Fosfomycin | Ropivacaine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP3A4 mediated DDI |
| Fosfomycin | Sertindole | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fosfomycin | Thioridazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Fosfomycin | Propofol | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Fosfomycin | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Fosfomycin | Oxaliplatin | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI |
| Galantamine | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Galantamine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Galantamine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Galantamine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Gliclazide | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C9 mediated DDI |
| Gliclazide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Gliclazide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Hydroxychloroquine | Metoclopramide | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Hydroxychloroquine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxychloroquine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxychloroquine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxychloroquine | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxychloroquine | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxychloroquine | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxychloroquine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Hydroxychloroquine | Phenylephrine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Hydroxychloroquine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxychloroquine | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Hydroxychloroquine | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Hydroxychloroquine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Hydroxychloroquine | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Hydroxychloroquine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxychloroquine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Hydroxychloroquine | Imipramine | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Hydroxychloroquine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxychloroquine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Hydroxychloroquine | Nicotinamide | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP2C9 mediated DDI |
| Hydroxychloroquine | Tamoxifen | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Hydroxychloroquine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Hydroxychloroquine | Amitriptyline | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Hydroxychloroquine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Hydroxychloroquine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxyzine | Metoclopramide | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Hydroxyzine | Periciazine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI |
| Hydroxyzine | Chlorpromazine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hydroxyzine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2B6 mediated DDI |
| Hydroxyzine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Hydroxyzine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxyzine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Hydroxyzine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Hydroxyzine | Mitotane | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Indacaterol | Ivacaftor | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indacaterol | Metoprolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Indacaterol | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indacaterol | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indacaterol | Oseltamivir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Indacaterol | Oxybuprocaine | 3 | CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Indacaterol | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Indacaterol | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Propafenone | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | |
| Indacaterol | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indacaterol | Atropine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indacaterol | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indacaterol | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Indacaterol | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indacaterol | Phenylephrine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Indacaterol | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indacaterol | Propranolol | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP1A2 mediated DDI |
| Indacaterol | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indacaterol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Indacaterol | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Indacaterol | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Indacaterol | Tamoxifen | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | |
| Indacaterol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Indacaterol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Indacaterol | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Indacaterol | Clotrimazole | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Indapamide | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Indapamide | Oseltamivir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Indapamide | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Indapamide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Indapamide | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Indapamide | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Indapamide | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Indapamide | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Indapamide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Indapamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Indapamide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Indapamide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Indapamide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Ivacaftor | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Ivacaftor | Midostaurin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Perphenazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ivacaftor | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Atropine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Ivacaftor | Cariprazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Ivacaftor | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ivacaftor | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ivacaftor | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Ivacaftor | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ivacaftor | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ivacaftor | Clomifene | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Ivacaftor | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Ivacaftor | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Ivacaftor | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ivacaftor | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ivacaftor | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ivacaftor | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ivacaftor | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Ivacaftor | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Ivacaftor | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ivacaftor | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ivacaftor | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ixazomib | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ixazomib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Ixazomib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Ixazomib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Ixazomib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Lenalidomide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenalidomide | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lenalidomide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenalidomide | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenalidomide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenalidomide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Lenalidomide | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenvatinib | Mebendazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Lenvatinib | Sotalol | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Lenvatinib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lenvatinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenvatinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenvatinib | Phenylephrine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Lenvatinib | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lenvatinib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Lenvatinib | Propranolol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Lenvatinib | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenvatinib | Agomelatine | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Lenvatinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenvatinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenvatinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lenvatinib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lenvatinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenvatinib | Lidocaine | 3 | CLASS 1 (from 3); Major DDI | DDI causing arrhythmia | |
| Lenvatinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lenvatinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lenvatinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Levothyroxine | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Levothyroxine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Levothyroxine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Maraviroc | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Maraviroc | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mebendazole | Metoclopramide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mebendazole | Metoprolol | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Olaparib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mebendazole | Salbutamol | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI |
| Mebendazole | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mebendazole | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Mebendazole | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mebendazole | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Mebendazole | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mebendazole | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mebendazole | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mebendazole | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mebendazole | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Mebendazole | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mebendazole | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Mebendazole | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Acetaminophen | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Mebendazole | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebendazole | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Mebendazole | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Mebendazole | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Mebendazole | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Mebendazole | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Mebendazole | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Mebendazole | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Mebendazole | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Melphalan | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Melphalan | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Melphalan | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Melphalan | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Melphalan | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Mesalazine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Mesalazine | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Mesalazine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Mesalazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Mesalazine | Levamisole | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | |
| Mesalazine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Mesalazine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Mesalazine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Metoclopramide | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Metoclopramide | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Metoclopramide | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Metoclopramide | Haloperidol | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Metoclopramide | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Metoclopramide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Metoclopramide | Acetaminophen | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Metoclopramide | Diphenhydramine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Metoclopramide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Metoclopramide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Metoclopramide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Metoclopramide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Metoclopramide | Amitriptyline | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Metoclopramide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Metoprolol | Sotalol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Metoprolol | Teriflunomide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Metoprolol | Warfarin | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Fluoxetine | 3 | CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Metoprolol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Metoprolol | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2D6 mediated DDI |
| Metoprolol | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Metronidazole | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Metronidazole | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Metronidazole | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Midostaurin | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Midostaurin | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Midostaurin | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Midostaurin | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Midostaurin | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Midostaurin | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Midostaurin | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Midostaurin | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Midostaurin | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Midostaurin | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Midostaurin | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Midostaurin | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Midostaurin | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Midostaurin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Midostaurin | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Midostaurin | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Midostaurin | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Midostaurin | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Midostaurin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Midostaurin | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Misoprostol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Misoprostol | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Mometasone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Morphine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Morphine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Morphine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Morphine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Nevirapine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nevirapine | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Nevirapine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Nevirapine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nevirapine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Nevirapine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitrazepam | Norepinephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Nitrazepam | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Nitrazepam | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nitrazepam | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Nitrazepam | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Nitrazepam | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Norepinephrine | Sulfamethoxazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Norepinephrine | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Norepinephrine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Norepinephrine | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Norepinephrine | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Norepinephrine | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Norepinephrine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Norepinephrine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Norepinephrine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Norepinephrine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Norepinephrine | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Norepinephrine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Norepinephrine | Praziquantel | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Norepinephrine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Olanzapine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Olanzapine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Olaparib | Paroxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Olaparib | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olaparib | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olaparib | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Olaparib | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI | |
| Olaparib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Olaparib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Olaparib | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Olaparib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Olaparib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olaparib | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olaparib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olaparib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Olaparib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olaparib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Olaparib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Olaparib | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Olaparib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Olaparib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Olaparib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Olaparib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Olaparib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Olaparib | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Olaparib | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Olaparib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Oseltamivir | Periciazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Oseltamivir | Perphenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Oseltamivir | Risperidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Oseltamivir | Amiodarone | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Oseltamivir | Atropine | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | |
| Oseltamivir | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Oseltamivir | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Oseltamivir | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Oseltamivir | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Oseltamivir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Oseltamivir | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Oseltamivir | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Oseltamivir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Oseltamivir | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Oseltamivir | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Oseltamivir | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Oseltamivir | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Oseltamivir | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Oseltamivir | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Oseltamivir | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Oseltamivir | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Oseltamivir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Oseltamivir | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Oxybuprocaine | Risperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Oxybuprocaine | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxybuprocaine | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Oxybuprocaine | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Oxybuprocaine | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI |
| Oxybuprocaine | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Oxybuprocaine | Sorafenib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Sunitinib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2C9 mediated DDI |
| Oxybuprocaine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Oxybuprocaine | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Oxybuprocaine | Acetaminophen | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Oxybuprocaine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Oxybuprocaine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Oxybuprocaine | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Oxybuprocaine | Lomustine | 3 | CLASS 1 (from 5) | DDI causing arrhythmia; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Solifenacin | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Oxybuprocaine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Oxybuprocaine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Oxybuprocaine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Propafenone | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Paroxetine | Salbutamol | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Paroxetine | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paroxetine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Paroxetine | Propranolol | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Paroxetine | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Paroxetine | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Paroxetine | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Paroxetine | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Paroxetine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Paroxetine | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Paroxetine | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Paroxetine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Paroxetine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Paroxetine | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Paroxetine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Paroxetine | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Pentoxifylline | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Pentoxifylline | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pentoxifylline | Phenylephrine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP1A2 mediated DDI |
| Pentoxifylline | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pentoxifylline | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pentoxifylline | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Pentoxifylline | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Pentoxifylline | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pentoxifylline | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Pentoxifylline | Methimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Pentoxifylline | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Periciazine | Tetrabenazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Periciazine | Vemurafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Periciazine | Captopril | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Periciazine | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2B6 mediated DDI |
| Periciazine | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Periciazine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Periciazine | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Periciazine | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2B6 mediated DDI |
| Periciazine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Periciazine | Methotrimeprazine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Periciazine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Periciazine | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Periciazine | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Periciazine | Umifenovir | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI |
| Periciazine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Periciazine | Acetaminophen | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Periciazine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Periciazine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Periciazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Periciazine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Periciazine | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Periciazine | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Periciazine | Loratadine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Periciazine | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Periciazine | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Periciazine | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Periciazine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Periciazine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Periciazine | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Periciazine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Periciazine | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Periciazine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Periciazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Periciazine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Perphenazine | Risperidone | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | |
| Perphenazine | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Perphenazine | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Perphenazine | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Perphenazine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Perphenazine | Methotrimeprazine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Perphenazine | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Perphenazine | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Perphenazine | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Perphenazine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Perphenazine | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2D6 mediated DDI |
| Perphenazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Perphenazine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Perphenazine | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Perphenazine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Perphenazine | Amitriptyline | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Perphenazine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Perphenazine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Perphenazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Perphenazine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Propafenone | Axitinib | 3 | CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Propafenone | Flutamide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Propafenone | Lacosamide | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Propafenone | Teriflunomide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Propafenone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Propafenone | Levamisole | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Sertindole | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Propofol | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propafenone | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Pyridoxine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Risperidone | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Risperidone | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Risperidone | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Risperidone | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Risperidone | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Risperidone | Chlorpromazine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Risperidone | Clomipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Risperidone | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Risperidone | Imipramine | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2D6 mediated DDI |
| Risperidone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Risperidone | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Risperidone | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Risperidone | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Risperidone | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Risperidone | Mitotane | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Salbutamol | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Salbutamol | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Salbutamol | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2B6 mediated DDI |
| Salbutamol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Salbutamol | Diphenhydramine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Salbutamol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Salbutamol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Salbutamol | Clotrimazole | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI |
| Salbutamol | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Sotalol | Ambroxol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sotalol | Caffeine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Sotalol | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Sotalol | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Sotalol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sotalol | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C9 mediated DDI |
| Sotalol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Sotalol | Praziquantel | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | |
| Sotalol | Clotrimazole | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | |
| Stavudine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Stavudine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Succinic acid | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Sulfamethoxazole | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Sulfamethoxazole | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Sulfamethoxazole | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Sulfamethoxazole | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Sulfamethoxazole | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C9 mediated DDI |
| Sulfamethoxazole | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sulfamethoxazole | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Sulfamethoxazole | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Sulfamethoxazole | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C9 mediated DDI |
| Sulfamethoxazole | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tafluprost | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tafluprost | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Tafluprost | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Tafluprost | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Tafluprost | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Tafluprost | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tafluprost | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Tafluprost | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Tafluprost | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2B6 mediated DDI |
| Tetrabenazine | Vismodegib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Acetylsalicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Tetrabenazine | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Tetrabenazine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Tetrabenazine | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Tetrabenazine | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Phenobarbital | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Tetrabenazine | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Tetrabenazine | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Tetrabenazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Phenytoin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Tetrabenazine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tetrabenazine | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Tetrabenazine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Tetrabenazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tetrabenazine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Vemurafenib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Vemurafenib | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Vemurafenib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vemurafenib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vemurafenib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Vemurafenib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Vemurafenib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vemurafenib | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vemurafenib | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Vemurafenib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vemurafenib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Vemurafenib | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Vemurafenib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vemurafenib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Vemurafenib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Vemurafenib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Vemurafenib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI; CYP3A4 mediated DDI | |
| Vemurafenib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Vemurafenib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vemurafenib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Vildagliptin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Vismodegib | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Vismodegib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Vismodegib | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Vismodegib | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Vismodegib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Vismodegib | Acetaminophen | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Vismodegib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Vismodegib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Vismodegib | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Vismodegib | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Vismodegib | Benzyl benzoate | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Vismodegib | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Vismodegib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Vismodegib | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acetylsalicylic acid | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Acetylsalicylic acid | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Acetylsalicylic acid | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Acetylsalicylic acid | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI |
| Acetylsalicylic acid | Lacosamide | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Acetylsalicylic acid | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Acetylsalicylic acid | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Acetylsalicylic acid | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Acetylsalicylic acid | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Acetylsalicylic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Acetylsalicylic acid | Levamisole | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | |
| Acetylsalicylic acid | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Acetylsalicylic acid | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Acetylsalicylic acid | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Acetylsalicylic acid | Mitotane | 3 | Major DDI | DDI causing arrhythmia; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ambroxol | Amiodarone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ambroxol | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ambroxol | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ambroxol | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ambroxol | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ambroxol | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ambroxol | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ambroxol | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ambroxol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Ambroxol | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ambroxol | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ambroxol | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ambroxol | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Aminocaproic acid | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Aminocaproic acid | Acetaminophen | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Aminocaproic acid | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Aminocaproic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Aminocaproic acid | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Aminocaproic acid | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Aminocaproic acid | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Aminocaproic acid | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Aminophylline | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Aminophylline | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Aminophylline | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Amiodarone | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Cariprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Chloropyramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Amiodarone | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Pyrazinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Amiodarone | Regorafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Amiodarone | Sorafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Amiodarone | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Amiodarone | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Amiodarone | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Betahistine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Amiodarone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Amiodarone | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Amiodarone | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Amiodarone | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Amiodarone | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Amiodarone | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Amiodarone | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI; CYP2D6 mediated DDI | |
| Amiodarone | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atropine | Axitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Atropine | Caffeine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Atropine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Atropine | Fluorescein | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Atropine | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Atropine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Atropine | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Atropine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Atropine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Atropine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Axitinib | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Axitinib | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Axitinib | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Axitinib | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Axitinib | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Axitinib | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Axitinib | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Axitinib | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Axitinib | Procaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Axitinib | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Axitinib | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Axitinib | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Axitinib | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Axitinib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Axitinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Axitinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Axitinib | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Axitinib | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Axitinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Axitinib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Axitinib | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Axitinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Axitinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Axitinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Axitinib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Axitinib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Axitinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Axitinib | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Axitinib | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Axitinib | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Axitinib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Baclofen | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Baclofen | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Baclofen | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bisacodyl | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bisacodyl | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Bisacodyl | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bisacodyl | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Bisacodyl | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Bisacodyl | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Bisacodyl | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Bisacodyl | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Bisacodyl | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Bisacodyl | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Bisacodyl | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Caffeine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Caffeine | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI |
| Caffeine | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Caffeine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Caffeine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Caffeine | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Caffeine | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Caffeine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Caffeine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Caffeine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Caffeine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Caffeine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Caffeine | Methimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Caffeine | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Captopril | Cycloserine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Captopril | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Captopril | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Captopril | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Captopril | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Captopril | Teriflunomide | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | |
| Captopril | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Captopril | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Captopril | Cinacalcet | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing hypotension | |
| Captopril | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Captopril | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Cariprazine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Cariprazine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cariprazine | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Cariprazine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cariprazine | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cariprazine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cariprazine | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Cariprazine | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Cariprazine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cariprazine | Chlorpromazine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Cariprazine | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Cariprazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cariprazine | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Cariprazine | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI |
| Cariprazine | Solifenacin | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | |
| Cariprazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Cariprazine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Cariprazine | Oxaliplatin | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Chlorambucil | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Chlorambucil | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Chlorambucil | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Chlorambucil | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Chlorambucil | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Chlorambucil | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Chlorambucil | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Chlorambucil | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Chlorambucil | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Chlorambucil | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Chlorambucil | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Chloropyramine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Chloropyramine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Chloropyramine | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Chloropyramine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Chloropyramine | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Chloropyramine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Chloropyramine | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Chloropyramine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Chloropyramine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Chloropyramine | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Chloropyramine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Chloropyramine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Chloropyramine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Chloropyramine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Chloropyramine | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Clonidine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Clonidine | Tropicamide | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Clonidine | Acetaminophen | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Clonidine | Fluoxetine | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | CYP2D6 mediated DDI |
| Clonidine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clonidine | Levamisole | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Clonidine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Clonidine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Clonidine | Amitriptyline | 3 | Major DDI | DDI causing hypertension; DDI causing tachycardia | |
| Clonidine | Propofol | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | |
| Clonidine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clonidine | Mitotane | 3 | Major DDI | DDI causing hypotension; DDI causing tachycardia | CYP2B6 mediated DDI |
| Cycloserine | Dexketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cycloserine | Diclofenac | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Cycloserine | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Cycloserine | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cycloserine | Enzalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Cycloserine | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cycloserine | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Cycloserine | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cycloserine | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Cycloserine | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Cycloserine | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cycloserine | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cycloserine | Penicillamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Cycloserine | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Cycloserine | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Cycloserine | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Cycloserine | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cycloserine | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cycloserine | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Cycloserine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Cycloserine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Cycloserine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Cycloserine | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Cycloserine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Cycloserine | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Cycloserine | Lipoic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Cycloserine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Cycloserine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Cycloserine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Cycloserine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Cycloserine | Sevelamer | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Cycloserine | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Dexketoprofen | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Dexketoprofen | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dexketoprofen | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Dexketoprofen | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Dexketoprofen | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Dexketoprofen | Ketorolac | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C8 mediated DDI |
| Dexketoprofen | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Dexketoprofen | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dexketoprofen | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Dexketoprofen | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Dexketoprofen | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Dexketoprofen | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dexketoprofen | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dexketoprofen | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Dexketoprofen | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dexketoprofen | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Dexketoprofen | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dexketoprofen | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Dexketoprofen | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dexketoprofen | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dexketoprofen | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI |
| Dexketoprofen | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Dexketoprofen | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dexketoprofen | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dexketoprofen | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dexketoprofen | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dexketoprofen | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dexketoprofen | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dexketoprofen | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Dexketoprofen | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Diclofenac | Dopamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Diclofenac | Droperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Diclofenac | Procarbazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Diclofenac | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Diclofenac | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Diclofenac | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Dopamine | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Dopamine | Fulvestrant | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Dopamine | Glycine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Dopamine | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Dopamine | Penicillamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Dopamine | Regorafenib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI |
| Dopamine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dopamine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Dopamine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Dopamine | Dydrogesterone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Dopamine | Efavirenz | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Dopamine | Finasteride | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dopamine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Dopamine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dopamine | Lipoic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Dopamine | Loratadine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dopamine | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Dopamine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Dopamine | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Dopamine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Dopamine | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Enzalutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Fenofibrate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Droperidol | Haloperidol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Droperidol | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Lorazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Droperidol | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Oxazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Droperidol | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Phenobarbital | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Pyrazinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Regorafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Sorafenib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Droperidol | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Tranexamic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Abiraterone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Betahistine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Droperidol | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Droperidol | Diazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Droperidol | Dydrogesterone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Efavirenz | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Droperidol | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Droperidol | Hydroxyurea | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Droperidol | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Droperidol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Droperidol | Loratadine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Midazolam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Droperidol | Nandrolone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Norethisterone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Oxcarbazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Droperidol | Phenytoin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Progesterone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Droperidol | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Testosterone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Droperidol | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Droperidol | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Droperidol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Droperidol | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Droperidol | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Droperidol | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Droperidol | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Enzalutamide | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Enzalutamide | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Enzalutamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Enzalutamide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Enzalutamide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Enzalutamide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Enzalutamide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Fenofibrate | Fingolimod | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Fenofibrate | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fenofibrate | Flutamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Fenofibrate | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Fenofibrate | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Fenofibrate | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Fenofibrate | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Fenofibrate | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Fenofibrate | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI |
| Fenofibrate | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C8 mediated DDI |
| Fenofibrate | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Fenofibrate | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fenofibrate | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI |
| Fenofibrate | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI |
| Fenofibrate | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Fenofibrate | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C8 mediated DDI |
| Fenofibrate | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fenofibrate | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Fingolimod | Fluorescein | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Fingolimod | Flupentixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fingolimod | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fingolimod | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fingolimod | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fingolimod | Oxazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fingolimod | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fingolimod | Phenobarbital | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Fingolimod | Pyrazinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fingolimod | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fingolimod | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Fingolimod | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fingolimod | Acetaminophen | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Fingolimod | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Fingolimod | Dimethyl fumarate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Fingolimod | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Fingolimod | Efavirenz | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Fingolimod | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI | |
| Fingolimod | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fingolimod | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Fingolimod | Loratadine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fingolimod | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Fingolimod | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fingolimod | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fingolimod | Pyrantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fingolimod | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fingolimod | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fingolimod | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fingolimod | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Fingolimod | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI | |
| Fingolimod | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Fingolimod | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fingolimod | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Fingolimod | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fluorescein | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Fluorescein | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fluorescein | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Fluorescein | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Fluorescein | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Fluorescein | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Fluorescein | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fluorescein | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Fluorescein | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Fluorescein | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Fluorescein | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Fluorescein | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluorescein | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Flupentixol | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Flupentixol | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Flupentixol | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Flupentixol | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Flupentixol | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Flupentixol | Procaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Flupentixol | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Flupentixol | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Flupentixol | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Flupentixol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Flupentixol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Flupentixol | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Flupentixol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Flupentixol | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Flupentixol | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Flupentixol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Flupentixol | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Flupentixol | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flupentixol | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Flupentixol | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Flupentixol | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Flupentixol | Methimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Flutamide | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Flutamide | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Flutamide | Methotrimeprazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Flutamide | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP3A4 mediated DDI | |
| Flutamide | Propranolol | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Flutamide | Tramadol | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Flutamide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Flutamide | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Flutamide | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Flutamide | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Flutamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Flutamide | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Flutamide | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Flutamide | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Flutamide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Flutamide | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Flutamide | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Flutamide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Flutamide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Flutamide | Ethanol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Flutamide | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Flutamide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Fulvestrant | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Fulvestrant | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fulvestrant | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Fulvestrant | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Glycine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Glycine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Haloperidol | Isoniazid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Haloperidol | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Haloperidol | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Haloperidol | Pyrazinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Haloperidol | Sunitinib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP2B6 mediated DDI |
| Haloperidol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Haloperidol | Acetaminophen | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Haloperidol | Betahistine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Haloperidol | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Haloperidol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Haloperidol | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Haloperidol | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Haloperidol | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2B6 mediated DDI |
| Haloperidol | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Haloperidol | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Haloperidol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Haloperidol | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Haloperidol | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Haloperidol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI |
| Haloperidol | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Haloperidol | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Haloperidol | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Isoniazid | Ketoprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Isoniazid | Ketorolac | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Isoniazid | Lacosamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Isoniazid | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Isoniazid | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Isoniazid | Phenylephrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Isoniazid | Propranolol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Isoniazid | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Isoniazid | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Isoniazid | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Isoniazid | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Isoniazid | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Isoniazid | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Isoniazid | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Isoniazid | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Isoniazid | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Isoniazid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Isoniazid | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Isoniazid | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Isoniazid | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Isoniazid | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Isoniazid | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ketoprofen | Ketorolac | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C8 mediated DDI |
| Ketoprofen | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Ketoprofen | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ketoprofen | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Ketoprofen | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ketoprofen | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ketoprofen | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ketoprofen | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ketoprofen | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Ketoprofen | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ketoprofen | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Ketoprofen | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ketoprofen | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Ketoprofen | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ketoprofen | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ketoprofen | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C8 mediated DDI |
| Ketoprofen | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ketoprofen | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ketoprofen | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ketoprofen | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Ketoprofen | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ketoprofen | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ketoprofen | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ketoprofen | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ketoprofen | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Ketorolac | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ketorolac | Methotrimeprazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2C19 mediated DDI |
| Ketorolac | Procarbazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | |
| Ketorolac | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ketorolac | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ketorolac | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ketorolac | Fluoxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Ketorolac | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Ketorolac | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Ketorolac | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Ketorolac | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ketorolac | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ketorolac | Cinacalcet | 3 | CLASS 1 (from 5); Major DDI | DDI causing hypertension | CYP2D6 mediated DDI |
| Lacosamide | Loperamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Lacosamide | Mefloquine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lacosamide | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Procainamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Lacosamide | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Lacosamide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lacosamide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lacosamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lacosamide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Lacosamide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Lacosamide | Tamoxifen | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Lacosamide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lacosamide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Lacosamide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Lacosamide | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Lacosamide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Lacosamide | Pirfenidone | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Lacosamide | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Lacosamide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Lacosamide | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lacosamide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Loperamide | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Loperamide | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Loperamide | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Loperamide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Loperamide | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Loperamide | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Loperamide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Loperamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Loperamide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Loperamide | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Loperamide | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI; CYP2C8 mediated DDI |
| Loperamide | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2B6 mediated DDI |
| Loperamide | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Loperamide | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI |
| Loperamide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Loperamide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Loperamide | Desflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Lorazepam | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Lorazepam | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Methotrimeprazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Mefloquine | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Perampanel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Sunitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Mefloquine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Mefloquine | Betahistine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI; CYP2D6 mediated DDI | |
| Mefloquine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Mefloquine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Mefloquine | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Mefloquine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Mefloquine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Mefloquine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Mefloquine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Mefloquine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Mefloquine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Mefloquine | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Mefloquine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Mefloquine | Methimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2D6 mediated DDI |
| Mefloquine | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Meldonium | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Methotrimeprazine | Methylergometrine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Methotrimeprazine | Phenylephrine | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Methotrimeprazine | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Methotrimeprazine | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Umifenovir | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methotrimeprazine | Zuclopenthixol | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Acetaminophen | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2C19 mediated DDI |
| Methotrimeprazine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Fluoxetine | 3 | CLASS 1 (from 5); Major DDI | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Methotrimeprazine | Tapentadol | 3 | CLASS 1 (from 5) | DDI causing hypotension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Cinacalcet | 3 | CLASS 1 (from 5) | DDI causing hypertension; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Methotrimeprazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Methotrimeprazine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Methylergometrine | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methylergometrine | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methylergometrine | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methylergometrine | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methylergometrine | Efavirenz | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Methylergometrine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methylergometrine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methylergometrine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methylergometrine | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methylergometrine | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methylergometrine | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methylergometrine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methylergometrine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Methylergometrine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Methylergometrine | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methylergometrine | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Methylergometrine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Methylergometrine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Methylergometrine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Methylergometrine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Methylergometrine | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Oxazepam | Procarbazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Oxazepam | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Oxazepam | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Perampanel | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Perampanel | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Perampanel | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Perampanel | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Perampanel | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Perampanel | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Perampanel | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Perampanel | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Perampanel | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Perampanel | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Perampanel | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Phenobarbital | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI | |
| Phenobarbital | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Phenobarbital | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C9 mediated DDI | |
| Phenylephrine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Phenylephrine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Phenylephrine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Efavirenz | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Phenylephrine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Phenylephrine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Phenylephrine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Phenylephrine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Pramipexole | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Pramipexole | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Pregabalin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Pregabalin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Procainamide | Salicylic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C8 mediated DDI | |
| Procainamide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procainamide | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Procainamide | Acetaminophen | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Procainamide | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Procainamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Procainamide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procainamide | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Procainamide | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procainamide | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Procainamide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Procainamide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Procainamide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procainamide | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procainamide | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procaine | Sorafenib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C9 mediated DDI |
| Procaine | Sunitinib | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Procaine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procaine | Betahistine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing tachycardia | |
| Procaine | Diphenhydramine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing tachycardia | |
| Procaine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Procaine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Procaine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procaine | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C9 mediated DDI |
| Procaine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Procaine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Procarbazine | Regorafenib | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Procarbazine | Sorafenib | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Procarbazine | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Procarbazine | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Procarbazine | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Procarbazine | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Procarbazine | Clopidogrel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Procarbazine | Diazepam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Procarbazine | Efavirenz | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Procarbazine | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Procarbazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Procarbazine | Loratadine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Procarbazine | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Pyrantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Procarbazine | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Procarbazine | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Procarbazine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Procarbazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Procarbazine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Procarbazine | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Propranolol | Regorafenib | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Propranolol | Teriflunomide | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Propranolol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Propranolol | Warfarin | 3 | CLASS 1 (from 3) | DDI causing arrhythmia; DDI causing bradycardia | CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Propranolol | Biperiden | 3 | CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Diphenhydramine | 3 | CLASS 1 (from 3) | DDI causing tachycardia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Propranolol | Fluoxetine | 3 | Major DDI | DDI causing tachycardia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Propranolol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Propranolol | Tamoxifen | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2D6 mediated DDI |
| Pyrazinamide | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Pyrazinamide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Pyrazinamide | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Pyrazinamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Pyrazinamide | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Pyrazinamide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Pyrazinamide | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Regorafenib | Fentanyl | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Regorafenib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Regorafenib | Lidocaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Regorafenib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Regorafenib | Mitotane | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Salicylic acid | Teriflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Salicylic acid | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Salicylic acid | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Salicylic acid | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Salicylic acid | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Salicylic acid | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Salicylic acid | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Salicylic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Salicylic acid | Levamisole | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | |
| Salicylic acid | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Salicylic acid | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Salicylic acid | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Salicylic acid | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Salicylic acid | Desflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Salicylic acid | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Salicylic acid | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Sorafenib | Trifluoperazine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Sorafenib | Tropicamide | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI |
| Sorafenib | Clomifene | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Sorafenib | Fentanyl | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | CYP2C19 mediated DDI |
| Sorafenib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Sorafenib | Lidocaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Sorafenib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Sorafenib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Sorafenib | Benzyl benzoate | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Sunitinib | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Sunitinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Sunitinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sunitinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Sunitinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sunitinib | Benzyl benzoate | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing bradycardia | |
| Sunitinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Sunitinib | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Teriflunomide | Tramadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Teriflunomide | Tropicamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Teriflunomide | Umifenovir | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Teriflunomide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Teriflunomide | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Teriflunomide | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Teriflunomide | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Teriflunomide | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Teriflunomide | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Teriflunomide | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Teriflunomide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Teriflunomide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Teriflunomide | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Teriflunomide | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Teriflunomide | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Teriflunomide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Teriflunomide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Teriflunomide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Teriflunomide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Teriflunomide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Teriflunomide | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP3A4 mediated DDI | |
| Teriflunomide | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Teriflunomide | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Teriflunomide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Teriflunomide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Teriflunomide | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tramadol | Trifluoperazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tramadol | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tramadol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Tramadol | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tramadol | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tramadol | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Tramadol | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tramadol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tramadol | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tramadol | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tramadol | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Tramadol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tramadol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Tramadol | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Tramadol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Tramadol | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Tranexamic acid | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Tranexamic acid | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tranexamic acid | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Tranexamic acid | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tranexamic acid | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Trifluoperazine | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Trifluoperazine | Betahistine | 3 | CLASS 1 (from 5) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Trifluoperazine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Trifluoperazine | Finasteride | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI |
| Trifluoperazine | Fluorouracil | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C9 mediated DDI |
| Trifluoperazine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Trifluoperazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trifluoperazine | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Trifluoperazine | Lipoic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Trifluoperazine | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Trifluoperazine | Ondansetron | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI |
| Trifluoperazine | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Trifluoperazine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Trifluoperazine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Trifluoperazine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Trifluoperazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Trifluoperazine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Trifluoperazine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Trifluoperazine | Methimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Tropicamide | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tropicamide | Zuclopenthixol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Tropicamide | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Tropicamide | Betahistine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Tropicamide | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Tropicamide | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Tropicamide | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Tropicamide | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tropicamide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Tropicamide | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Tropicamide | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Tropicamide | Loratadine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Tropicamide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Tropicamide | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Tropicamide | Clotrimazole | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Tropicamide | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Tropicamide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Umifenovir | Upadacitinib | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Umifenovir | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Umifenovir | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Umifenovir | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Umifenovir | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Umifenovir | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Umifenovir | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Umifenovir | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Umifenovir | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Umifenovir | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Umifenovir | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Umifenovir | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Upadacitinib | Warfarin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Agomelatine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Chlorpromazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Fentanyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Fluorouracil | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Upadacitinib | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Hydroxyurea | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Upadacitinib | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Imipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Upadacitinib | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Upadacitinib | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Ethionamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Upadacitinib | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Upadacitinib | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Upadacitinib | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Upadacitinib | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Warfarin | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Warfarin | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Warfarin | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Warfarin | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Warfarin | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Warfarin | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Warfarin | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Warfarin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Warfarin | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Zuclopenthixol | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Zuclopenthixol | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Zuclopenthixol | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Zuclopenthixol | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Zuclopenthixol | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Zuclopenthixol | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Zuclopenthixol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Zuclopenthixol | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Zuclopenthixol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Zuclopenthixol | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Zuclopenthixol | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Acetaminophen | Agomelatine | 3 | CLASS 1 (from 5); Major DDI | DDI causing bradycardia | |
| Acetaminophen | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Acetaminophen | Chlorpromazine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Acetaminophen | Clomipramine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP2D6 mediated DDI |
| Acetaminophen | Imipramine | 3 | Major DDI | DDI causing hypertension; DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Acetaminophen | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Acetaminophen | Levamisole | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | |
| Acetaminophen | Lidocaine | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Acetaminophen | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Acetaminophen | Amitriptyline | 3 | Major DDI | DDI causing hypertension; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Acetaminophen | Ethanol | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | CYP2D6 mediated DDI |
| Acetaminophen | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Acetaminophen | Mitotane | 3 | Major DDI | DDI causing arrhythmia; DDI causing bradycardia | |
| Agomelatine | Betahistine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Agomelatine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Agomelatine | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Agomelatine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Agomelatine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C8 mediated DDI |
| Agomelatine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Agomelatine | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP2C19 mediated DDI |
| Agomelatine | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Agomelatine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Agomelatine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Agomelatine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Agomelatine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Agomelatine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Agomelatine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Agomelatine | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Agomelatine | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Betahistine | Biperiden | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI |
| Betahistine | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Betahistine | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Betahistine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Betahistine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Betahistine | Levamisole | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | CYP2C8 mediated DDI |
| Betahistine | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Betahistine | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Betahistine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Betahistine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Betahistine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI |
| Biperiden | Bupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Clomipramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Biperiden | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI |
| Biperiden | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Biperiden | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Biperiden | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Biperiden | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI |
| Biperiden | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Biperiden | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Brivaracetam | Clomifene | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Bupivacaine | Efavirenz | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Bupivacaine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Bupivacaine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Bupivacaine | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Bupivacaine | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Bupivacaine | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Bupivacaine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Bupivacaine | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Bupivacaine | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Bupivacaine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Bupivacaine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Bupivacaine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Bupivacaine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Bupivacaine | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carmustine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP3A4 mediated DDI |
| Chlorpromazine | Diphenhydramine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Chlorpromazine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Chlorpromazine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Chlorpromazine | Loratadine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypotension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Chlorpromazine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Chlorpromazine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Chlorpromazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Chlorpromazine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Chlorpromazine | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Clomifene | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Clomifene | Levamisole | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | |
| Clomifene | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Clomifene | Loratadine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Clomifene | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Clomifene | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Clomifene | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Clomifene | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Clomifene | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Clomifene | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clomifene | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clomipramine | Diphenhydramine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing tachycardia | CYP2D6 mediated DDI |
| Clomipramine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Clomipramine | Solifenacin | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | |
| Clomipramine | Tamoxifen | 3 | CLASS 1 (from 3); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomipramine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Clomipramine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Clomipramine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Clomipramine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Clomipramine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Clomipramine | Oxaliplatin | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | |
| Clopidogrel | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Diazepam | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Diazepam | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dimethyl fumarate | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Dimethyl fumarate | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Dimethyl fumarate | Desflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Dimethyl fumarate | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Diphenhydramine | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Diphenhydramine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Diphenhydramine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Diphenhydramine | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Diphenhydramine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Diphenhydramine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2D6 mediated DDI |
| Diphenhydramine | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI |
| Diphenhydramine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Diphenhydramine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Dydrogesterone | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Dydrogesterone | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Efavirenz | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Efavirenz | Levobupivacaine | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Efavirenz | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Efavirenz | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Efavirenz | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Efavirenz | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ethosuximide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | CYP2C19 mediated DDI |
| Ethosuximide | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Fentanyl | Fluoxetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fentanyl | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Fentanyl | Ketamine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Fentanyl | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fentanyl | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Fentanyl | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fentanyl | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Fentanyl | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fentanyl | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fentanyl | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Fentanyl | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Fentanyl | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | |
| Fentanyl | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Fentanyl | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C9 mediated DDI |
| Fentanyl | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Fentanyl | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Fentanyl | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fentanyl | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Finasteride | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Finasteride | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Finasteride | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Fluorouracil | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Fluoxetine | Ibuprofen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Fluoxetine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fluoxetine | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Fluoxetine | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Fluoxetine | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Fluoxetine | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Fluoxetine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Fluoxetine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Fluoxetine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Fluoxetine | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Hydroxyurea | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP3A4 mediated DDI |
| Hydroxyurea | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP3A4 mediated DDI |
| Ibuprofen | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C8 mediated DDI | |
| Ibuprofen | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ibuprofen | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ibuprofen | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ibuprofen | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Ibuprofen | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI |
| Ibuprofen | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Imipramine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Imipramine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Imipramine | Vinpocetine | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing hypertension | CYP2D6 mediated DDI |
| Imipramine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Imipramine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Ketamine | Leflunomide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Ketamine | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI |
| Ketamine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Ketamine | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Leflunomide | Levamisole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Levetiracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Leflunomide | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI | |
| Leflunomide | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Leflunomide | Lipoic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Leflunomide | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Loratadine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Midazolam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP3A4 mediated DDI | |
| Leflunomide | Nandrolone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Leflunomide | Norethisterone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Leflunomide | Oxcarbazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Leflunomide | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Leflunomide | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Progesterone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Pyrantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Leflunomide | Rivastigmine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Leflunomide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Leflunomide | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Leflunomide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Leflunomide | Valproic acid | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI | |
| Leflunomide | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Leflunomide | Xylometazoline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C9 mediated DDI | |
| Leflunomide | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Leflunomide | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C19 mediated DDI | |
| Leflunomide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP3A4 mediated DDI | |
| Leflunomide | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Leflunomide | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2C9 mediated DDI | |
| Leflunomide | Protionamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2C8 mediated DDI | |
| Leflunomide | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI | |
| Leflunomide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Leflunomide | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Methimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Leflunomide | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Levamisole | Lomustine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Levamisole | Rivastigmine | 3 | CLASS 1 (from 3) | DDI causing hypertension; DDI causing bradycardia | |
| Levamisole | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Levamisole | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Levamisole | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Levamisole | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2D6 mediated DDI |
| Levamisole | Desflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Levamisole | Propofol | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | CYP1A2 mediated DDI |
| Levamisole | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Levetiracetam | Levobupivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Levetiracetam | Lidocaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Levetiracetam | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Levetiracetam | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Levetiracetam | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Levetiracetam | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Levetiracetam | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Levobupivacaine | Ondansetron | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Levobupivacaine | Praziquantel | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypotension | |
| Levobupivacaine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Levobupivacaine | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI | |
| Levobupivacaine | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Levobupivacaine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Levobupivacaine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Levobupivacaine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Levobupivacaine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Levobupivacaine | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Lidocaine | Nicotinamide | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Lidocaine | Piracetam | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Lidocaine | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Lidocaine | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Lidocaine | Solifenacin | 3 | CLASS 1 (from 3); Major DDI | DDI causing hypertension | |
| Lidocaine | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP1A2 mediated DDI |
| Lidocaine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Lidocaine | Pirfenidone | 3 | CLASS 1 (from 3) | DDI causing qt_interval_prolongation; DDI causing arrhythmia | CYP1A2 mediated DDI |
| Lomustine | Benzyl benzoate | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Lomustine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2D6 mediated DDI | |
| Lomustine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI |
| Lomustine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | |
| Loratadine | Ropivacaine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Midazolam | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nandrolone | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Nicotinamide | Phenytoin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Nicotinamide | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Nicotinamide | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Nicotinamide | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Nicotinamide | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Nicotinamide | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Nicotinamide | Carbamazepine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI | |
| Nicotinamide | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI |
| Nicotinamide | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Nicotinamide | Desflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP1A2 mediated DDI | |
| Norethisterone | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Ondansetron | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ondansetron | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Ondansetron | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Phenytoin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Piracetam | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Piracetam | Tamoxifen | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Piracetam | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Piracetam | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Piracetam | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Praziquantel | Sertindole | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Praziquantel | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Praziquantel | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Praziquantel | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Rivastigmine | Tapentadol | 3 | CLASS 1 (from 5) | DDI causing tachycardia; DDI causing bradycardia | |
| Rivastigmine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Ropivacaine | Solifenacin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Ropivacaine | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Ropivacaine | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Ropivacaine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Ropivacaine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Ropivacaine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Sertindole | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sertindole | Amitriptyline | 3 | CLASS 1 (from 5); Major DDI | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Sertindole | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Sertindole | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2B6 mediated DDI; CYP2C19 mediated DDI |
| Sertindole | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2B6 mediated DDI |
| Sertindole | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Sertindole | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Solifenacin | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2D6 mediated DDI | |
| Solifenacin | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Tamoxifen | Tapentadol | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tamoxifen | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tamoxifen | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Tamoxifen | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Tapentadol | Thioridazine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Tapentadol | Trihexyphenidyl | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Tapentadol | Vinpocetine | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | |
| Tapentadol | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Tapentadol | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Thioridazine | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2D6 mediated DDI |
| Thioridazine | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Thioridazine | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Thioridazine | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Tretinoin | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Trihexyphenidyl | Amitriptyline | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | |
| Trihexyphenidyl | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Trihexyphenidyl | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI; CYP3A4 mediated DDI |
| Trihexyphenidyl | Desflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2C19 mediated DDI |
| Trihexyphenidyl | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP2B6 mediated DDI |
| Trihexyphenidyl | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing tachycardia | CYP1A2 mediated DDI; CYP2B6 mediated DDI |
| Trihexyphenidyl | Sevelamer | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing bradycardia | CYP1A2 mediated DDI |
| Trihexyphenidyl | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Trihexyphenidyl | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP2C19 mediated DDI |
| Valproic acid | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI; CYP2D6 mediated DDI | |
| Vinpocetine | Cinacalcet | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Vinpocetine | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Vinpocetine | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Xylometazoline | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | |
| Amitriptyline | Clotrimazole | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Amitriptyline | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing qt_interval_prolongation | CYP1A2 mediated DDI; CYP2D6 mediated DDI |
| Amitriptyline | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Amitriptyline | Sertraline | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI; CYP2D6 mediated DDI | |
| Amitriptyline | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Benzyl benzoate | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cinacalcet | Pirfenidone | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI |
| Cinacalcet | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI |
| Cinacalcet | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2C19 mediated DDI | |
| Cinacalcet | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Cinacalcet | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Clotrimazole | Desflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP3A4 mediated DDI |
| Clotrimazole | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI |
| Clotrimazole | Mitotane | 3 | CLASS 1 (from 3); Major DDI | DDI causing tachycardia | CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI |
| Desflurane | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI |
| Ethanol | Halothane | 3 | Major DDI | DDI causing qt_interval_prolongation; DDI causing arrhythmia | |
| Pirfenidone | Propofol | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI |
| Pirfenidone | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Propofol | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing hypertension | CYP2C19 mediated DDI |
| Protionamide | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sertraline | Sevoflurane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sertraline | Carboplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sertraline | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | CYP2B6 mediated DDI | |
| Sevoflurane | Vitamin A | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sevoflurane | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Sevoflurane | Oxaliplatin | 3 | CLASS 1 (from 3); CLASS 1 (from 5) | DDI causing arrhythmia | CYP2C19 mediated DDI |
| Vitamin A | Halothane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI | ||
| Carboplatin | Mitotane | 3 | CLASS 1 (from 3); CLASS 1 (from 5); Major DDI |