Vital and Essential Drugs (ЖНВЛП)

RU:

Лекарственные препараты, находящиеся в гражданском обороте на территории Российской Федерации, делятся на 2 типа:

• - Лекарственные препараты, цены на которые регулируются государством – включены в перечень жизненно необходимых и важнейших лекарственных препаратов (далее – перечень ЖНВЛП)
• - Лекарственные препараты, цены на которые государством не регулируются, не включены в перечень ЖНВЛП

Ниже представлена таблица, в которых для двух соединений (указанных под собственным международным непатентованным названием) указываются количество предсказанных межлекарственных взаимодействий, тяжесть предсказанной нежелательной побочной реакции (в соответствии с классификацией ORCA) и типы эффектов (воздействие на сердечно-сосудистую систему и взаимодействие с специфическом изоферментом цитохрома p450)

ENG:

List of Vital and Essential Drugs (VED) published by the Ministry of Health of the Russian Federation is generally similar to list of essential medicines published by the FDA in terms of necessity and immediateness of administration and ubiquitous use of listed drugs in the context of treating life-threatening and chronic conditions.
Below is a table showing the number of predicted DDI, the severity level of the predicted adverse reactions (based on ORCA classification system), and the types of effects (cardiovascular effects and isoenzyme-specific interactions) for two drugs, listed under their generic name

Download the full list of predicted values of DDIs for VEDs (*.xls 24 mB)

Drug1	Drug2	DDI count	The severity of DDIs	Adverse effects on the cardiovascular system	Cytochromes P450 that mediate DDI
Mebeverine	Trifluoperazine	9	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Imipramine	9	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Sotalol	9	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Trifluoperazine	9	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Perphenazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Haloperidol	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Procainamide	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Trifluoperazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Bupivacaine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Chlorpromazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Clomifene	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Levobupivacaine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Nintedanib	Terizidone	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Trifluoperazine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Terizidone	Benzyl benzoate	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Carvedilol	Dopamine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Fluphenazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Perphenazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Haloperidol	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Methotrimeprazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Procainamide	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Trifluoperazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Chlorpromazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Clomipramine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Imipramine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Sulpiride	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Methotrimeprazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Chlorpromazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Clomifene	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Clomipramine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Thioridazine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Benzyl benzoate	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Dobutamine	Imipramine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Haloperidol	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Procainamide	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Fluphenazine	Oxybuprocaine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Metoprolol	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Norepinephrine	Procainamide	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Trifluoperazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Trifluoperazine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Oxybuprocaine	Imipramine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Propafenone	Chlorpromazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Perampanel	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Procainamide	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Bupivacaine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Chlorpromazine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Clomipramine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Imipramine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Levobupivacaine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Ropivacaine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Pirfenidone	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dopamine	Trifluoperazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Dopamine	Chlorpromazine	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Haloperidol	Phenylephrine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Procainamide	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI
Procarbazine	Benzyl benzoate	8	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Propranolol	Trifluoperazine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propranolol	Clomifene	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Clomifene	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Clomifene	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Clomifene	Imipramine	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Benzyl benzoate	Mitotane	8	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C9 mediated DDI
Cromoglicic acid	Dobutamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Carfilzomib	Mebeverine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Hexoprenaline	Verapamil	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Bedaquiline	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Fluphenazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Ivacaftor	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Mebendazole	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hexoprenaline	Periciazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Vismodegib	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Hexoprenaline	Amiodarone	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Procarbazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Teriflunomide	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Imipramine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hexoprenaline	Ropivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Hexoprenaline	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Imatinib	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Lisinopril	Halothane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Acalabrutinib	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Ivabradine	Dobutamine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Nimodipine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nintedanib	Dobutamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Nintedanib	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Tamsulosin	Dobutamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Terizidone	Mebeverine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Terizidone	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Terizidone	Procaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Terizidone	Chlorpromazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Halothane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Verapamil	Mebeverine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Epinephrine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Bupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Verapamil	Chlorpromazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Clomipramine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Imipramine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Levobupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Verapamil	Ropivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Verapamil	Thioridazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Mitotane	7	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cetirizine	Fenoterol	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Cetirizine	Dobutamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia
Chloramphenicol	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Drotaverine	Dobutamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Drotaverine	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Fenoterol	Hydroxyzine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Procarbazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Bupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Levobupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Thioridazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Glyburide	Dobutamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Levodopa	Halothane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Mebeverine	Dobutamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Mebeverine	Fluphenazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Metoclopramide	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Mebeverine	Oxybuprocaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Perphenazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Mebeverine	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Dopamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Mebeverine	Haloperidol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Procainamide	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Mebeverine	Tropicamide	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Bupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Levobupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Ropivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Tamoxifen	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nifedipine	Droperidol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Teriflunomide	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Atenolol	Fluphenazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Dopamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Chlorpromazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Imipramine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Fluphenazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Oxybuprocaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Propafenone	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Droperidol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Haloperidol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Methotrimeprazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Procainamide	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Procaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Procarbazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Propranolol	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Agomelatine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Bupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Chlorpromazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Clomipramine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Levobupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Ropivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Sertindole	7	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Imipramine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Fluphenazine	Metoprolol	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Norepinephrine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fluphenazine	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fluphenazine	Dopamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoclopramide	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoclopramide	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Metoprolol	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Imipramine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Norepinephrine	Perphenazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia
Norepinephrine	Haloperidol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Norepinephrine	Procarbazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Bupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Chlorpromazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Norepinephrine	Imipramine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Norepinephrine	Levobupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Thioridazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Norepinephrine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Oxybuprocaine	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Methotrimeprazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Bupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Oxybuprocaine	Chlorpromazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia
Oxybuprocaine	Clomipramine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Oxybuprocaine	Levobupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Oxybuprocaine	Tamoxifen	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Periciazine	Sotalol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Perphenazine	Dopamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia
Perphenazine	Phenylephrine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Perphenazine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propafenone	Dopamine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Mitotane	7	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Sotalol	Vismodegib	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Atropine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Bisacodyl	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Dopamine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Fingolimod	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Haloperidol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Ketorolac	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Methotrimeprazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Procaine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Tropicamide	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Agomelatine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Fentanyl	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Levamisole	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Lidocaine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Nicotinamide	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Sotalol	Sertindole	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Tapentadol	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Thioridazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Cinacalcet	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atropine	Phenylephrine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atropine	Imipramine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dopamine	Mefloquine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dopamine	Methotrimeprazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Dopamine	Procainamide	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Dopamine	Procarbazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Propranolol	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dopamine	Bupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Dopamine	Levobupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Dopamine	Ropivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Dopamine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Methotrimeprazine	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Phenylephrine	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Bupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Clomipramine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Imipramine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Levobupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Procaine	Trifluoperazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Procaine	Imipramine	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI
Procaine	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Procaine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Propranolol	Imipramine	7	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Propranolol	Thioridazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Trifluoperazine	Agomelatine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Trifluoperazine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tropicamide	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Bupivacaine	Clomifene	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Bupivacaine	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Bupivacaine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Chlorpromazine	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomifene	Levobupivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Clomifene	Ropivacaine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Clomifene	Thioridazine	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Clomifene	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Levobupivacaine	Benzyl benzoate	7	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Levobupivacaine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Lidocaine	Mitotane	7	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI
Ganirelix	Sotalol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Cromoglicic acid	Mebeverine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Oxybuprocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Cromoglicic acid	Sotalol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Cromoglicic acid	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Chlorhexidine	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Chlorhexidine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carfilzomib	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Carfilzomib	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP2D6 mediated DDI
Carfilzomib	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hexoprenaline	Carbidopa	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Nimodipine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Terizidone	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Alectinib	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Avibactam	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI
Hexoprenaline	Carvedilol	6	Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Chloramphenicol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Glyburide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Hexoprenaline	Mebeverine	6	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Hexoprenaline	Nifedipine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Nitisinone	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Hexoprenaline	Metoclopramide	6	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Atropine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Hexoprenaline	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Droperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Fingolimod	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Loperamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Perampanel	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Propranolol	6	Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Clomipramine	6	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Fentanyl	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Levamisole	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Lidocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Amitriptyline	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Hexoprenaline	Pirfenidone	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ertugliflozin	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Lisinopril	Sotalol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Selexipag	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Carbidopa	Terizidone	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Mebeverine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Carbidopa	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Carbidopa	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Carbidopa	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ivabradine	Terizidone	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Ivabradine	Nifedipine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ivabradine	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Ivabradine	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia
Ivabradine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia
Ivabradine	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nimodipine	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Nimodipine	Clomipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nimodipine	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nimodipine	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nintedanib	Fenoterol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Nintedanib	Sotalol	6	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Nintedanib	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Nintedanib	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Nintedanib	Phenylephrine	6	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Nintedanib	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nintedanib	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nintedanib	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Piribedil	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia
Tamsulosin	Fenoterol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Mebeverine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Norepinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Tamsulosin	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Verapamil	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Terizidone	Fenoterol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Terizidone	Methyldopa	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Terizidone	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Terizidone	Epinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Terizidone	Norepinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Terizidone	Propafenone	6	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Terizidone	Atropine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Methotrimeprazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Terizidone	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Terizidone	Clomipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Urapidil	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Verapamil	Salmeterol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Verapamil	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Ivacaftor	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Metoclopramide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Verapamil	Oxybuprocaine	6	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Verapamil	Fingolimod	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Verapamil	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Loperamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Methotrimeprazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Verapamil	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Procainamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Verapamil	Salicylic acid	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Verapamil	Tramadol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Verapamil	Fluoxetine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Tamoxifen	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Amitriptyline	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Verapamil	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Vilanterol	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Amlodipine	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Avibactam	Epinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI
Avibactam	Oxybuprocaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI
Avibactam	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Bisoprolol	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Fenoterol	6	Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Fluphenazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Norepinephrine	6	Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Procarbazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Chlorpromazine	6	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia
Cetirizine	Norepinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Cetirizine	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Cetirizine	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Mebendazole	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Chloramphenicol	Sotalol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Fingolimod	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Chloramphenicol	Clomipramine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia
Chloramphenicol	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2D6 mediated DDI
Chloramphenicol	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia
Drotaverine	Mebeverine	6	CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Drotaverine	Fluphenazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Oxybuprocaine	6	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Drotaverine	Periciazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Drotaverine	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Drotaverine	Procaine	6	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Drotaverine	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Drotaverine	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Enalapril	Sotalol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Fenoterol	Glyburide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Mebeverine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Nifedipine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Bedaquiline	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Ivacaftor	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Mebendazole	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fenoterol	Periciazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Propafenone	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Sotalol	6	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Vismodegib	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Amiodarone	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Atropine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Bisacodyl	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Droperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Fingolimod	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Mefloquine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Procaine	6	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Propranolol	6	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Umifenovir	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Fentanyl	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Lidocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Rivastigmine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Amitriptyline	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Fenoterol	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Oxybuprocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Sotalol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Formoterol	Atropine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Procainamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Procaine	6	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Glyburide	Norepinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Glyburide	Sotalol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Glyburide	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Glyburide	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia
Levodopa	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C8 mediated DDI
Levodopa	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C8 mediated DDI
Mebeverine	Methyldopa	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Mebeverine	Mebendazole	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Norepinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Mebeverine	Oseltamivir	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Mebeverine	Periciazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Mebeverine	Vismodegib	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Amiodarone	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Bisacodyl	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Flupentixol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Flutamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Mebeverine	Mefloquine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Procarbazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Mebeverine	Agomelatine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Fentanyl	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Mebeverine	Fluoxetine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Mebeverine	Amitriptyline	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Cinacalcet	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Methyldopa	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Sotalol	6	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Procainamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Agomelatine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Methyldopa	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Methyldopa	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Nifedipine	Salmeterol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Epinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Nifedipine	Metoclopramide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Norepinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Periciazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Nifedipine	Cariprazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Nifedipine	Procainamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Nifedipine	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP3A4 mediated DDI
Nifedipine	Clomipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Nifedipine	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nifedipine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Nicotinamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Cinacalcet	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nitisinone	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Nitisinone	Epinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Nitisinone	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Repaglinide	Dobutamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Repaglinide	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Salmeterol	Sotalol	6	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Salmeterol	Atropine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Salmeterol	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salmeterol	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salmeterol	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Sulpiride	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Atenolol	Dobutamine	6	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Atenolol	Oxybuprocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Atenolol	Tramadol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Agomelatine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Fluoxetine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Bedaquiline	Norepinephrine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Ivacaftor	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Mebendazole	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Dobutamine	Metoprolol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Oseltamivir	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Dobutamine	Periciazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Perphenazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Vismodegib	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Acetylsalicylic acid	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dobutamine	Amiodarone	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Bisacodyl	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dobutamine	Cariprazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Fingolimod	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Flutamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Dobutamine	Ketorolac	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dobutamine	Mefloquine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Umifenovir	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Fentanyl	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Fluoxetine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Levamisole	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Lidocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Rivastigmine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Tamoxifen	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Amitriptyline	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Epinephrine	Fluphenazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Atropine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Droperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Fingolimod	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Perampanel	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Epinephrine	Procarbazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Epinephrine	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Clomipramine	6	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Lidocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Fluphenazine	Procaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Fluphenazine	Propranolol	6	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fluphenazine	Nicotinamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Indacaterol	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Ivacaftor	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Mebendazole	Sotalol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Metoclopramide	Oxybuprocaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Metoclopramide	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Metoclopramide	Flutamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoclopramide	Agomelatine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Metoclopramide	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Metoprolol	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Norepinephrine	Periciazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Vismodegib	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Amiodarone	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Norepinephrine	Atropine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Bisacodyl	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Norepinephrine	Droperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Umifenovir	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Norepinephrine	Clomipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Norepinephrine	Levamisole	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Lidocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Norepinephrine	Tamoxifen	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Norepinephrine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Periciazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia
Oxybuprocaine	Amiodarone	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Oxybuprocaine	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Flupentixol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI
Oxybuprocaine	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI
Oxybuprocaine	Procarbazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Agomelatine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Oxybuprocaine	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Oxybuprocaine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Periciazine	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Periciazine	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Propranolol	6	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Perphenazine	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Propafenone	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Umifenovir	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Agomelatine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Clomifene	6	CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Salbutamol	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salbutamol	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salbutamol	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI
Sotalol	Chloropyramine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Flupentixol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Flutamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Sotalol	Loperamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Procarbazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Sotalol	Propranolol	6	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Salicylic acid	6	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Teriflunomide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Sotalol	Tramadol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Umifenovir	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Betahistine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Sotalol	Fluoxetine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Piracetam	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Tamoxifen	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Amitriptyline	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Carbamazepine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Sotalol	Propofol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Sotalol	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2D6 mediated DDI
Vismodegib	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Acetylsalicylic acid	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Amiodarone	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Amiodarone	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Amiodarone	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Atropine	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Atropine	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Atropine	Amitriptyline	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Atropine	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Dopamine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Clonidine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension
Dopamine	Fingolimod	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dopamine	Ketorolac	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dopamine	Procaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Dopamine	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Umifenovir	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Agomelatine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dopamine	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dopamine	Clomipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Dopamine	Fentanyl	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Dopamine	Levamisole	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Lidocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Dopamine	Rivastigmine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Dopamine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dopamine	Amitriptyline	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Dopamine	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Ethanol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dopamine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Droperidol	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fingolimod	Loperamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fingolimod	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Lidocaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Flutamide	Haloperidol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Flutamide	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Flutamide	Procaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Flutamide	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Haloperidol	Methotrimeprazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Procaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Haloperidol	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Lidocaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Haloperidol	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Loperamide	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Loperamide	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Methotrimeprazine	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perampanel	Phenylephrine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Perampanel	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Phenobarbital	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Phenylephrine	Procarbazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Phenylephrine	Teriflunomide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Phenylephrine	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Lidocaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Phenylephrine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Procainamide	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Procainamide	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Procainamide	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia
Procainamide	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Procaine	Procarbazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Procaine	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia
Procaine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia
Procaine	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia
Procaine	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Procaine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Procarbazine	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Procarbazine	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Procarbazine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia
Propranolol	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Chlorpromazine	6	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Clomipramine	6	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salicylic acid	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salicylic acid	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Sunitinib	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Teriflunomide	Trifluoperazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI
Teriflunomide	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Tropicamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Fluoxetine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Trifluoperazine	Nicotinamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Trifluoperazine	Cinacalcet	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Tropicamide	Bupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Tropicamide	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Tropicamide	Clomipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tropicamide	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tropicamide	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Tropicamide	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Tropicamide	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Umifenovir	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Umifenovir	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Agomelatine	Clomifene	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Agomelatine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Betahistine	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia
Bupivacaine	Chlorpromazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Bupivacaine	Imipramine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Bupivacaine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Bupivacaine	Nicotinamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI
Bupivacaine	Piracetam	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Bupivacaine	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Bupivacaine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Chlorpromazine	Fentanyl	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia
Chlorpromazine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Chlorpromazine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Clomifene	Clomipramine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomifene	Tapentadol	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Clomifene	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Clomipramine	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hydroxyurea	Leflunomide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Imipramine	Levobupivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Imipramine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Imipramine	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Levobupivacaine	Nicotinamide	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI
Levobupivacaine	Piracetam	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Levobupivacaine	Ropivacaine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Levobupivacaine	Thioridazine	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Nicotinamide	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension
Nicotinamide	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Ropivacaine	Benzyl benzoate	6	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Tapentadol	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Tapentadol	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Thioridazine	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clotrimazole	Halothane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Halothane	Mitotane	6	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Etelcalcetide	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Micafungin	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Cetrorelix	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Triptorelin	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia
Leuprolide	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Leuprolide	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia
Lanreotide	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Lanreotide	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Lanreotide	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Lanreotide	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Lanreotide	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Lanreotide	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Lanreotide	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Octreotide	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Octreotide	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Octreotide	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Octreotide	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Octreotide	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2B6 mediated DDI
Cromoglicic acid	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Methotrimeprazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cromoglicic acid	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Cromoglicic acid	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Benzyl benzoate	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Chlorhexidine	Sotalol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Chlorhexidine	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Glecaprevir	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Pasireotide	Terizidone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Pasireotide	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Pasireotide	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Pasireotide	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Pasireotide	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Iohexol	Verapamil	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ioversol	Verapamil	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ioversol	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Ioversol	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Bosutinib	Hexoprenaline	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Bosutinib	Fenoterol	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Bosutinib	Atenolol	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Dobutamine	5	Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Bosutinib	Epinephrine	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Bosutinib	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Norepinephrine	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Bosutinib	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Bosutinib	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Phenylephrine	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Propranolol	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Bosutinib	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Bosutinib	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Bosutinib	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Bosutinib	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Carfilzomib	Hexoprenaline	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Carfilzomib	Nimodipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Carfilzomib	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Carfilzomib	Formoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Carfilzomib	Levodopa	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carfilzomib	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Carfilzomib	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension	CYP2D6 mediated DDI
Carfilzomib	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Carfilzomib	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP2D6 mediated DDI
Carfilzomib	Salbutamol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI
Carfilzomib	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Carfilzomib	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Carfilzomib	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Carfilzomib	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Carfilzomib	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Carfilzomib	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Carfilzomib	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Delamanid	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI
Hexoprenaline	Atazanavir	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hexoprenaline	Imatinib	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Hexoprenaline	Acalabrutinib	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C9 mediated DDI
Hexoprenaline	Alogliptin	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Hexoprenaline	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Miglustat	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Salmeterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Ethambutol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Oseltamivir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Hexoprenaline	Paroxetine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Sotalol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Chloropyramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Hexoprenaline	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Hexoprenaline	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Hexoprenaline	Mefloquine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Methotrimeprazine	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hexoprenaline	Methylergometrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Hexoprenaline	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Regorafenib	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Umifenovir	5	CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Diphenhydramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Solifenacin	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Hexoprenaline	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Propofol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Iomeprol	Verapamil	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iomeprol	Fenoterol	5	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Dobutamine	5	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Oxybuprocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Iomeprol	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iomeprol	Levetiracetam	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Iopromide	Verapamil	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Glyburide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Iopromide	Oxybuprocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Vismodegib	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Iopromide	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iopromide	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Iopromide	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iopromide	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Iopromide	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Iopromide	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Iopromide	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Iopromide	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Iopromide	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Sulfasalazine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Apremilast	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Apremilast	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Apremilast	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atazanavir	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Benserazide	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Darunavir	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Empagliflozin	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Ertugliflozin	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Ertugliflozin	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Gefitinib	Terizidone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Verapamil	5	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Dobutamine	5	CLASS 1 (from 3); Major DDI	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Gefitinib	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Gefitinib	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Gefitinib	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Gefitinib	Procaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Gefitinib	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI
Imatinib	Fenoterol	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Imatinib	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Imatinib	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP3A4 mediated DDI
Imatinib	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Imatinib	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Imatinib	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Imatinib	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Imatinib	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Imatinib	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2D6 mediated DDI
Lapatinib	Metoprolol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Lapatinib	Propranolol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Lisinopril	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Ombitasvir	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Osimertinib	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Saquinavir	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2B6 mediated DDI
Saquinavir	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Saquinavir	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2B6 mediated DDI
Selexipag	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Selexipag	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Selexipag	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Selexipag	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Selexipag	Procaine	5	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Acalabrutinib	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Acalabrutinib	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Acalabrutinib	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Acalabrutinib	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Acalabrutinib	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Acalabrutinib	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Nimodipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Amlodipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Carbidopa	Linezolid	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension
Carbidopa	Nifedipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Bedaquiline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Carbidopa	Oxybuprocaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Carbidopa	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI
Carbidopa	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Carbidopa	Bisacodyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Carbidopa	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI
Carbidopa	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia
Carbidopa	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI
Carbidopa	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Carbidopa	Ethanol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Dapagliflozin	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dapagliflozin	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Deferasirox	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Ivabradine	Nimodipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Mebeverine	5	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Clomifene	5	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Lumacaftor	Nifedipine	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Lumacaftor	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Lumacaftor	Sotalol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Lumacaftor	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Terizidone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Nimodipine	Urapidil	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Nimodipine	Formoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Nimodipine	Glyburide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Nimodipine	Levodopa	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Nimodipine	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Methyldopa	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Nimodipine	Salmeterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Nimodipine	Metoclopramide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Oseltamivir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Nimodipine	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Nimodipine	Salbutamol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Cariprazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Nimodipine	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Nimodipine	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Nimodipine	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Nimodipine	Zuclopenthixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Nimodipine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Nimodipine	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Propofol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Nintedanib	Verapamil	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Nintedanib	Drotaverine	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Nintedanib	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nintedanib	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Nintedanib	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nintedanib	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nintedanib	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Nintedanib	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Nintedanib	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Nintedanib	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nintedanib	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nintedanib	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Nintedanib	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Olodaterol	Terizidone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Olodaterol	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Sotalol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Atropine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Olodaterol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Olodaterol	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Piribedil	Terizidone	5	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Piribedil	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C9 mediated DDI
Piribedil	Propranolol	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Piribedil	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Piribedil	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Rilpivirine	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C8 mediated DDI
Rilpivirine	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Epinephrine	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Sotalol	5	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Tamsulosin	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Tamsulosin	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Terizidone	Vilanterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Carvedilol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Dasabuvir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Terizidone	Drotaverine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Terizidone	Levodopa	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Nifedipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Terizidone	Salmeterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Oxybuprocaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Terizidone	Salbutamol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Terizidone	Tetrabenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2D6 mediated DDI
Terizidone	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Terizidone	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Terizidone	Lacosamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Terizidone	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Terizidone	Mefloquine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Propranolol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Terizidone	Umifenovir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Terizidone	Acetaminophen	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Terizidone	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Terizidone	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Terizidone	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Terizidone	Rivastigmine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Terizidone	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Sevoflurane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI
Terizidone	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Urapidil	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Nifedipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Urapidil	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Urapidil	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Urapidil	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI
Urapidil	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Verapamil	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Formoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Levodopa	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Verapamil	Methyldopa	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Verapamil	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Verapamil	Indacaterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Verapamil	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Verapamil	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Verapamil	Sotalol	5	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Vismodegib	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Verapamil	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Atropine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Verapamil	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Verapamil	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Verapamil	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Verapamil	Mefloquine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Perampanel	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP3A4 mediated DDI
Verapamil	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Propranolol	5	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Verapamil	Zuclopenthixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Verapamil	Diphenhydramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Verapamil	Rivastigmine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Sertindole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP3A4 mediated DDI
Verapamil	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Trihexyphenidyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Verapamil	Pirfenidone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Vilanterol	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Vilanterol	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vilanterol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Vilanterol	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vilanterol	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Vilanterol	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Vilanterol	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Vilanterol	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Alectinib	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Alectinib	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI
Alectinib	Nifedipine	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Alectinib	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI
Alectinib	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alectinib	Fosfomycin	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Alectinib	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alectinib	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Alectinib	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Alectinib	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Amlodipine	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Amlodipine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Amlodipine	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Amlodipine	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Amlodipine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Amlodipine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Apixaban	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Avibactam	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia
Avibactam	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Avibactam	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia
Avibactam	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Avibactam	Propranolol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension
Avibactam	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension
Avibactam	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Bicalutamide	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Bicalutamide	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Bicalutamide	Procaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Bicalutamide	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Bisoprolol	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Bisoprolol	Fingolimod	5	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Bisoprolol	Trifluoperazine	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisoprolol	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Bisoprolol	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Cabozantinib	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Cabozantinib	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cabozantinib	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Cabozantinib	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carvedilol	Salmeterol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Bedaquiline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Epinephrine	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Perphenazine	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Sotalol	5	Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Haloperidol	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Mefloquine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Methotrimeprazine	5	CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Phenylephrine	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Clomifene	5	CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Imipramine	5	CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Trihexyphenidyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Cetirizine	Nifedipine	5	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Cetirizine	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Cetirizine	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Cetirizine	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Cetirizine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Chloramphenicol	Fenoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Formoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension
Chloramphenicol	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia
Chloramphenicol	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Atropine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Chloramphenicol	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Chloramphenicol	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Drotaverine	Fenoterol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Sulpiride	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Drotaverine	Perphenazine	5	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Lacosamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Drotaverine	Methotrimeprazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Drotaverine	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2D6 mediated DDI
Drotaverine	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Drotaverine	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Benzyl benzoate	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Enalapril	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Enalapril	Atropine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Enalapril	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia
Enalapril	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Fenoterol	Formoterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Methyldopa	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Nitisinone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Salmeterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Siponimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Apalutamide	5	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Indacaterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Metoclopramide	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Oseltamivir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Fenoterol	Oxybuprocaine	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Paroxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Fenoterol	Tetrabenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Chloropyramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Fenoterol	Dexketoprofen	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Fenoterol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Fluorescein	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Ketoprofen	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Fenoterol	Ketorolac	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Methylergometrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Fenoterol	Perampanel	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Tramadol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Zuclopenthixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Fenoterol	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Sertindole	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Solifenacin	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Fenoterol	Tamoxifen	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Pirfenidone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Propofol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Sertraline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Formoterol	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Methyldopa	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Formoterol	Nifedipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Salmeterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Formoterol	Bedaquiline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Formoterol	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Metoclopramide	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Formoterol	Oseltamivir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Formoterol	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Vismodegib	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Bisacodyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Formoterol	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Formoterol	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Methotrimeprazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Perampanel	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Formoterol	Propranolol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Zuclopenthixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Glyburide	Mebeverine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Nifedipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Glyburide	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Glyburide	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Rivastigmine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Ibrutinib	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Levodopa	Mebeverine	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Levodopa	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Levodopa	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Levodopa	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension
Levodopa	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C8 mediated DDI
Levodopa	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Levodopa	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Levodopa	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia	CYP2C8 mediated DDI
Levodopa	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Levodopa	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Linezolid	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension
Losartan	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI
Losartan	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia	CYP2C9 mediated DDI
Mebeverine	Nifedipine	5	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Salmeterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Siponimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Mebeverine	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Mebeverine	Ketorolac	5	CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Mebeverine	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Propranolol	5	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Mebeverine	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Tramadol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Zuclopenthixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Mebeverine	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Nicotinamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Mebeverine	Sertindole	5	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Methyldopa	Nifedipine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Salmeterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Bedaquiline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Methyldopa	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Propafenone	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Atropine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C8 mediated DDI
Methyldopa	Bisacodyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Procaine	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension
Methyldopa	Propranolol	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Umifenovir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Chlorpromazine	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Methyldopa	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Miglustat	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Nifedipine	Bedaquiline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Nifedipine	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Nifedipine	Indacaterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Nifedipine	Tetrabenazine	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Nifedipine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nifedipine	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Tropicamide	5	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Zuclopenthixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nifedipine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nifedipine	Loratadine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Nifedipine	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nifedipine	Benzyl benzoate	5	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Propofol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Nitisinone	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Nitisinone	Salbutamol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Nitisinone	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Nitisinone	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Nitisinone	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Paliperidone	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Paliperidone	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Paliperidone	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Quetiapine	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2D6 mediated DDI
Quetiapine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI
Salmeterol	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salmeterol	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salmeterol	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Ivacaftor	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Salmeterol	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salmeterol	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salmeterol	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Salmeterol	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salmeterol	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Salmeterol	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Salmeterol	Propranolol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salmeterol	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salmeterol	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salmeterol	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salmeterol	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Salmeterol	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Siponimod	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Siponimod	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Sulpiride	Fluphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Sulpiride	Oxybuprocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Sulpiride	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Sulpiride	Methotrimeprazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Sulpiride	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Sulpiride	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Sulpiride	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Sulpiride	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Trametinib	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Aminosalicylic acid	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Aminosalicylic acid	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Aminosalicylic acid	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Aminosalicylic acid	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Apalutamide	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Apalutamide	Sotalol	5	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Apalutamide	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Atenolol	Bedaquiline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Paroxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Tetrabenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Fingolimod	5	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Mefloquine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Cinacalcet	5	CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Bedaquiline	Dobutamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Bedaquiline	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Bedaquiline	Oxybuprocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Bedaquiline	Propafenone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Bedaquiline	Salbutamol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Bedaquiline	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Bedaquiline	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Bedaquiline	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Bedaquiline	Propranolol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Bedaquiline	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Bedaquiline	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Dapsone	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia
Dobutamine	Epinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Ethambutol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Hydroxyzine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Dobutamine	Indacaterol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Metoclopramide	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Paroxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Salbutamol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Tetrabenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Atropine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Chloropyramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dobutamine	Enzalutamide	5	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dobutamine	Fluorescein	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Lacosamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia
Dobutamine	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Dobutamine	Methylergometrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Dobutamine	Perampanel	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dobutamine	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Tramadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Zuclopenthixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Loratadine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Dobutamine	Nicotinamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dobutamine	Praziquantel	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Dobutamine	Ethanol	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dobutamine	Pirfenidone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Propofol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dobutamine	Sertraline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Epinephrine	Ivacaftor	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Mebendazole	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Epinephrine	Metoclopramide	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Oseltamivir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Epinephrine	Periciazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Perphenazine	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Sotalol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Vismodegib	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Epinephrine	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Bisacodyl	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Epinephrine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Epinephrine	Mefloquine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Methylergometrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Propranolol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Umifenovir	5	CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Epinephrine	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Pirfenidone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Ethambutol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Ethambutol	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Favipiravir	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Favipiravir	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Favipiravir	Propranolol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Fluphenazine	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Fluphenazine	Propafenone	5	CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fluphenazine	Salbutamol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Fluphenazine	Tetrabenazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Fluphenazine	Vismodegib	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Fluphenazine	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Fluphenazine	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Fluphenazine	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Perampanel	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Fluphenazine	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Fluphenazine	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Fluphenazine	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Fluphenazine	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Fluphenazine	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Fluphenazine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Fosfomycin	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Fosfomycin	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Fosfomycin	Trihexyphenidyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Fosfomycin	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Hydroxychloroquine	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hydroxychloroquine	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Hydroxyzine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Hydroxyzine	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Hydroxyzine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Indacaterol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Indacaterol	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Indacaterol	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Indacaterol	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI
Ivacaftor	Norepinephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Ivacaftor	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Ivacaftor	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Ivacaftor	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Mebendazole	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mesalazine	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Mesalazine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Metoclopramide	Norepinephrine	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Metoclopramide	Sotalol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Metoclopramide	Vismodegib	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Metoclopramide	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Metoclopramide	Phenylephrine	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoclopramide	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Metoclopramide	Procaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Metoclopramide	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Metoclopramide	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Metoclopramide	Imipramine	5	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Metoclopramide	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Metoclopramide	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Metoclopramide	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Metoclopramide	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia
Metoclopramide	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Metoprolol	Oseltamivir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Metoprolol	Tetrabenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Fingolimod	5	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Phenylephrine	5	CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Biperiden	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Clomifene	5	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Trihexyphenidyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Midostaurin	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Norepinephrine	Oseltamivir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Norepinephrine	Propafenone	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Norepinephrine	Sotalol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Norepinephrine	Ketorolac	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Norepinephrine	Mefloquine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Norepinephrine	Methotrimeprazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Norepinephrine	Methylergometrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Norepinephrine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Propranolol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Norepinephrine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Norepinephrine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Norepinephrine	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Norepinephrine	Pirfenidone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Olaparib	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Oseltamivir	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Oseltamivir	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Oxybuprocaine	Perphenazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Oxybuprocaine	Propafenone	5	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Oxybuprocaine	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Oxybuprocaine	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Mefloquine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Oxybuprocaine	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Tramadol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Oxybuprocaine	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Oxybuprocaine	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Oxybuprocaine	Nicotinamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Sertindole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Oxybuprocaine	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI
Oxybuprocaine	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Sotalol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Paroxetine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Pentoxifylline	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI
Periciazine	Propafenone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Periciazine	Salbutamol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Periciazine	Cycloserine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Periciazine	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Periciazine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Periciazine	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Periciazine	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Periciazine	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Periciazine	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Periciazine	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Periciazine	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Periciazine	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Perphenazine	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Perphenazine	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Perphenazine	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Perphenazine	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Propafenone	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Atropine	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Fingolimod	5	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Methotrimeprazine	5	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propafenone	Phenylephrine	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Tramadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Nicotinamide	5	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Propafenone	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salbutamol	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salbutamol	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Salbutamol	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Salbutamol	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salbutamol	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI
Salbutamol	Propranolol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Salbutamol	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salbutamol	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salbutamol	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Salbutamol	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salbutamol	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salbutamol	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Salbutamol	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Salbutamol	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Salbutamol	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sotalol	Acetylsalicylic acid	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Amiodarone	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Axitinib	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Sotalol	Droperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Fenofibrate	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Mefloquine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Methylergometrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Sotalol	Phenylephrine	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Sotalol	Zuclopenthixol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Sotalol	Biperiden	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Solifenacin	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Sotalol	Trihexyphenidyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Sertraline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Tetrabenazine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Tetrabenazine	Propranolol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Tetrabenazine	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Tetrabenazine	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Vismodegib	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Vismodegib	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI
Vismodegib	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI
Vismodegib	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Vismodegib	Sunitinib	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Vismodegib	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Vismodegib	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP3A4 mediated DDI
Vismodegib	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Vismodegib	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vismodegib	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP3A4 mediated DDI
Vismodegib	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP3A4 mediated DDI
Vismodegib	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2D6 mediated DDI
Vismodegib	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Vismodegib	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Acetylsalicylic acid	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Aminocaproic acid	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Amiodarone	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Amiodarone	Haloperidol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Amiodarone	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Amiodarone	Propranolol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Amiodarone	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Amiodarone	Acetaminophen	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Amiodarone	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Amiodarone	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Amiodarone	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Amiodarone	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Amiodarone	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Amiodarone	Tamoxifen	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Amiodarone	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atropine	Fingolimod	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Atropine	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Atropine	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Atropine	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia
Atropine	Tramadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atropine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atropine	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Atropine	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atropine	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atropine	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Atropine	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Atropine	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia
Atropine	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atropine	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Bisacodyl	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Bisacodyl	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Bisacodyl	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Caffeine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI
Captopril	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia
Captopril	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Captopril	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia
Chloropyramine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Chloropyramine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Clonidine	Dopamine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Cycloserine	Procaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Cycloserine	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Diclofenac	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Dopamine	Flupentixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Dopamine	Flutamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Dopamine	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dopamine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Sunitinib	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Zuclopenthixol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI
Dopamine	Acetaminophen	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Dopamine	Levetiracetam	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Dopamine	Sertindole	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Dopamine	Tamoxifen	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Dopamine	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Droperidol	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Droperidol	Procaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Droperidol	Propranolol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Droperidol	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Droperidol	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Methotrimeprazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Procaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Propranolol	5	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fingolimod	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Tramadol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Umifenovir	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fingolimod	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fingolimod	Levetiracetam	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Fingolimod	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Rivastigmine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Flupentixol	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Flupentixol	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Flutamide	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Flutamide	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Flutamide	Procarbazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Flutamide	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Flutamide	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Flutamide	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Flutamide	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Flutamide	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Flutamide	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Flutamide	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Flutamide	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Flutamide	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Glycine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Haloperidol	Loperamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Haloperidol	Sorafenib	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Haloperidol	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Haloperidol	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Piracetam	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Haloperidol	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Sertindole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Haloperidol	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ketorolac	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Lacosamide	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI
Lacosamide	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Lacosamide	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Lacosamide	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Lacosamide	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Loperamide	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Loperamide	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Loperamide	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI
Mefloquine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mefloquine	Procaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia
Mefloquine	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Mefloquine	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Mefloquine	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Mefloquine	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Procainamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Methotrimeprazine	Propranolol	5	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Methotrimeprazine	Chlorpromazine	5	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methylergometrine	Phenylephrine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Perampanel	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Phenylephrine	Propranolol	5	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Umifenovir	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Phenylephrine	Levamisole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia
Phenylephrine	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Tamoxifen	5	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Phenylephrine	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Pirfenidone	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Procainamide	Sunitinib	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Procainamide	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Procainamide	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Procainamide	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Procainamide	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Procainamide	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Sertindole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Tamoxifen	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Procaine	Teriflunomide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Procaine	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Procaine	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Procaine	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Procaine	Clomifene	5	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Procaine	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Procaine	Nicotinamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI
Procaine	Tamoxifen	5	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Procaine	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procarbazine	Propranolol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Procarbazine	Salicylic acid	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing hypotension
Procarbazine	Trifluoperazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Procarbazine	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Procarbazine	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Procarbazine	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Procarbazine	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procarbazine	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Procarbazine	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Procarbazine	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Propranolol	Agomelatine	5	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Trihexyphenidyl	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia
Salicylic acid	Chlorpromazine	5	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salicylic acid	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salicylic acid	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Sunitinib	Tropicamide	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Sunitinib	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Sunitinib	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Sunitinib	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Sunitinib	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Teriflunomide	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Teriflunomide	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Tramadol	Agomelatine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Tramadol	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Tramadol	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Tramadol	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Acetaminophen	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Trifluoperazine	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Trifluoperazine	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Trifluoperazine	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Trifluoperazine	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Trifluoperazine	Praziquantel	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Trifluoperazine	Vinpocetine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Trifluoperazine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Clotrimazole	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Tropicamide	Chlorpromazine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Umifenovir	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Umifenovir	Clomifene	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Umifenovir	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Umifenovir	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Umifenovir	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Zuclopenthixol	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Acetaminophen	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Agomelatine	Bupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Agomelatine	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Agomelatine	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Agomelatine	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Agomelatine	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Agomelatine	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bupivacaine	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Bupivacaine	Rivastigmine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Chlorpromazine	Clomipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Chlorpromazine	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Chlorpromazine	Clotrimazole	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Clomifene	Fentanyl	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Clomifene	Fluoxetine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomifene	Lidocaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Clomifene	Nicotinamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Clomifene	Piracetam	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Clomifene	Sertindole	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Clomifene	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Clomifene	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Levobupivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Clomipramine	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Clomipramine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Clomipramine	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fentanyl	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Fentanyl	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia
Fluoxetine	Imipramine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Fluoxetine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Fluoxetine	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Nicotinamide	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Amitriptyline	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Imipramine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Levobupivacaine	Rivastigmine	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Lidocaine	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Lidocaine	Thioridazine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Lidocaine	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Lidocaine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nicotinamide	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Piracetam	Ropivacaine	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing arrhythmia
Piracetam	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Rivastigmine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Rivastigmine	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Ropivacaine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Ropivacaine	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Sertindole	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Solifenacin	Tapentadol	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Solifenacin	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia
Tamoxifen	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Tapentadol	Benzyl benzoate	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Thioridazine	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Vinpocetine	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Amitriptyline	Mitotane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Benzyl benzoate	Cinacalcet	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Benzyl benzoate	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Carbamazepine	Sevoflurane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing arrhythmia
Cinacalcet	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Pirfenidone	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Propofol	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Protionamide	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Sevelamer	Halothane	5	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Daptomycin	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Micafungin	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Ganirelix	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Ganirelix	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Ganirelix	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Ganirelix	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Ganirelix	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Ganirelix	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ganirelix	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Ganirelix	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ganirelix	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Sennosides	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI
Cetrorelix	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Cetrorelix	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Degarelix	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Degarelix	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Degarelix	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Degarelix	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Degarelix	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Degarelix	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Goserelin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Polymyxin B	Iopromide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Polymyxin B	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Polymyxin B	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Polymyxin B	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Terlipressin	Iohexol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Terlipressin	Iomeprol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Terlipressin	Iopromide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Terlipressin	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Terlipressin	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Terlipressin	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Terlipressin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Terlipressin	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Terlipressin	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Triptorelin	Fenoterol	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Triptorelin	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI
Triptorelin	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Triptorelin	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Triptorelin	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI
Triptorelin	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Triptorelin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Leuprolide	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI
Leuprolide	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Leuprolide	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Leuprolide	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C19 mediated DDI
Leuprolide	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Leuprolide	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Leuprolide	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Leuprolide	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C19 mediated DDI
Leuprolide	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI
Leuprolide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Leuprolide	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Desmopressin	Iomeprol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Desmopressin	Iopromide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Desmopressin	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Desmopressin	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Desmopressin	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Desmopressin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Desmopressin	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Desmopressin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Atosiban	Iopromide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Atosiban	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Atosiban	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Atosiban	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Atosiban	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Azithromycin	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Azithromycin	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Azithromycin	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Azithromycin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Azithromycin	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Azithromycin	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Azithromycin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Azithromycin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Azithromycin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Azithromycin	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Azithromycin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Alectinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Clarithromycin	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Clarithromycin	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Clarithromycin	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Clarithromycin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Clarithromycin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Clarithromycin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Clarithromycin	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Clarithromycin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Clarithromycin	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Clarithromycin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Carbetocin	Iopromide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Carbetocin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Carbetocin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Lanreotide	Iohexol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Lanreotide	Ioversol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Lanreotide	Hexoprenaline	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Lanreotide	Iomeprol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Lanreotide	Iopromide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI
Lanreotide	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Lanreotide	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Lanreotide	Formoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Lanreotide	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Lanreotide	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Lanreotide	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Lanreotide	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI
Lanreotide	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Lanreotide	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Lanreotide	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lanreotide	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Lanreotide	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lanreotide	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI
Lanreotide	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Lanreotide	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lanreotide	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lanreotide	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lanreotide	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lanreotide	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lanreotide	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Lanreotide	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Octreotide	Iohexol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Octreotide	Ioversol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Octreotide	Hexoprenaline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Octreotide	Iomeprol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Octreotide	Iopromide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Octreotide	Nintedanib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia
Octreotide	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Octreotide	Formoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Octreotide	Mebeverine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia
Octreotide	Paliperidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Octreotide	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Octreotide	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Octreotide	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Octreotide	Risperidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Octreotide	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Octreotide	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Octreotide	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Octreotide	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Octreotide	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Octreotide	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Octreotide	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Octreotide	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Octreotide	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Octreotide	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Octreotide	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Octreotide	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Octreotide	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Octreotide	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Cromoglicic acid	Gefitinib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Carbidopa	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia
Cromoglicic acid	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Cromoglicic acid	Glyburide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Sulpiride	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Metoclopramide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Cromoglicic acid	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Cromoglicic acid	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Piracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Cromoglicic acid	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Lactulose	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Ademetionine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Chlorhexidine	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Chlorhexidine	Procarbazine	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Chlorhexidine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Chlorhexidine	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Chlorhexidine	Mitotane	4	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Glecaprevir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Grazoprevir	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI
Grazoprevir	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Pasireotide	Iohexol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI
Pasireotide	Ioversol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Pasireotide	Iomeprol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Pasireotide	Iopromide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Pasireotide	Nintedanib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI
Pasireotide	Carvedilol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Pasireotide	Chloramphenicol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Pasireotide	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Pasireotide	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Pasireotide	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Pasireotide	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Pasireotide	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Pasireotide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Pasireotide	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI
Pibrentasvir	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Pibrentasvir	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Pibrentasvir	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Venetoclax	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Doxazosin	Avibactam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Fluphenazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Doxazosin	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Trifluoperazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Doxazosin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Doxazosin	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Doxazosin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iohexol	Oxybuprocaine	4	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Iohexol	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iohexol	Procaine	4	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iohexol	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Ioversol	Hexoprenaline	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Ioversol	Fenoterol	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Ioversol	Nifedipine	4	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Ioversol	Epinephrine	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Ioversol	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Ioversol	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Ioversol	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Ioversol	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Ioversol	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Ioversol	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ioversol	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Ioversol	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Macitentan	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Nelarabine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Posaconazole	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Remdesivir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Alendronic acid	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Alfuzosin	Fluphenazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Haloperidol	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Trifluoperazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Bupivacaine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Chlorpromazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Alfuzosin	Clomifene	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Imipramine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Alfuzosin	Levobupivacaine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Ropivacaine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Alfuzosin	Mitotane	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Bosutinib	Terizidone	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Bosutinib	Verapamil	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bosutinib	Carvedilol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Bosutinib	Formoterol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Mebeverine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Oxybuprocaine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bosutinib	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C8 mediated DDI
Bosutinib	Dopamine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bosutinib	Procainamide	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Bosutinib	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Bosutinib	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Carfilzomib	Verapamil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Carfilzomib	Carvedilol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carfilzomib	Drotaverine	4	CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carfilzomib	Nifedipine	4	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Carfilzomib	Salmeterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carfilzomib	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Carfilzomib	Oxybuprocaine	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Carfilzomib	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI
Carfilzomib	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Carfilzomib	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Carfilzomib	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carfilzomib	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Carfilzomib	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carfilzomib	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carfilzomib	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Carfilzomib	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Carfilzomib	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Carfilzomib	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Carfilzomib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Carfilzomib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Ceritinib	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ceritinib	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Ceritinib	Formoterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Ceritinib	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Ceritinib	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Delamanid	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Delamanid	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI
Ertapenem	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Fosamprenavir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension
Hexoprenaline	Iomeprol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Hexoprenaline	Iopromide	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Gefitinib	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Saquinavir	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Lumacaftor	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Hexoprenaline	Nilotinib	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2C9 mediated DDI
Hexoprenaline	Urapidil	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Hexoprenaline	Bicalutamide	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Cabozantinib	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Hexoprenaline	Dasabuvir	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing arrhythmia	CYP2C9 mediated DDI
Hexoprenaline	Enalapril	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Hexoprenaline	Formoterol	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Ipragliflozin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Losartan	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI
Hexoprenaline	Methyldopa	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Nelfinavir	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI
Hexoprenaline	Siponimod	4	CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Apalutamide	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Diatrizoate	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Hexoprenaline	Favipiravir	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Hexoprenaline	Hydroxychloroquine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Hexoprenaline	Nitrazepam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Norepinephrine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Tetrabenazine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Cariprazine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Chlorambucil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Hexoprenaline	Fluorescein	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Hexoprenaline	Isoniazid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Hexoprenaline	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Leflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C9 mediated DDI
Hexoprenaline	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C9 mediated DDI
Hexoprenaline	Tamoxifen	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Carbamazepine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Hexoprenaline	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C9 mediated DDI
Hexoprenaline	Sertraline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C9 mediated DDI
Inosine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iomeprol	Carvedilol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iomeprol	Chloramphenicol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Glyburide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Iomeprol	Nifedipine	4	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Iomeprol	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iomeprol	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Iomeprol	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Iomeprol	Phenylephrine	4	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing arrhythmia
Iomeprol	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Iomeprol	Procaine	4	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Iomeprol	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Iomeprol	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iomeprol	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Iomeprol	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Iomeprol	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Iomeprol	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Iomeprol	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Iomeprol	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Iopromide	Saquinavir	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iopromide	Alectinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iopromide	Bicalutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Iopromide	Chloramphenicol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Iopromide	Fenoterol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Mebeverine	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Nifedipine	4	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Iopromide	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Epinephrine	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Norepinephrine	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iopromide	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Iopromide	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Iopromide	Phenylephrine	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Procaine	4	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Iopromide	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Iopromide	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Iopromide	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iopromide	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Iopromide	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Isosorbide dinitrate	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Palbociclib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Palbociclib	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C8 mediated DDI
Palbociclib	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C8 mediated DDI
Palbociclib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Palbociclib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Riociguat	Sotalol	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Tenofovir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Abemaciclib	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Abemaciclib	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Abemaciclib	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Abemaciclib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Abemaciclib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Abemaciclib	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Abemaciclib	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Abemaciclib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Abemaciclib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Afatinib	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Afatinib	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Afatinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Afatinib	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Afatinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Apremilast	Oxybuprocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Apremilast	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Apremilast	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI
Apremilast	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Apremilast	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Apremilast	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Apremilast	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Apremilast	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Apremilast	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Apremilast	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Atazanavir	Mebeverine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Atazanavir	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Atazanavir	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Atazanavir	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Atazanavir	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Atazanavir	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Benserazide	Verapamil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Benserazide	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Benserazide	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Benserazide	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Benserazide	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Benserazide	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Cladribine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Cobicistat	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Darunavir	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Empagliflozin	Dobutamine	4	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Empagliflozin	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Erlotinib	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Erlotinib	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Erlotinib	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Erlotinib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Erlotinib	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Erlotinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Erlotinib	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Erlotinib	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Erlotinib	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Erlotinib	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Erlotinib	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Erlotinib	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Erlotinib	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Erlotinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Erlotinib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ertugliflozin	Fenoterol	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Ertugliflozin	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Ertugliflozin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Carvedilol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Gefitinib	Salmeterol	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia
Gefitinib	Atenolol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Hydroxychloroquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Gefitinib	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Metoclopramide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Gefitinib	Oxybuprocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gefitinib	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gefitinib	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Gefitinib	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Gefitinib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Phenylephrine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Gefitinib	Propranolol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Gefitinib	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gefitinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gefitinib	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Gefitinib	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Gefitinib	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gefitinib	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Gefitinib	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gefitinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gefitinib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Imatinib	Alectinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C8 mediated DDI
Imatinib	Formoterol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Imatinib	Mebeverine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Imatinib	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Imatinib	Salmeterol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Imatinib	Atenolol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Imatinib	Dobutamine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Imatinib	Epinephrine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Imatinib	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Imatinib	Metoprolol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Imatinib	Norepinephrine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Imatinib	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Imatinib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Imatinib	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Imatinib	Phenylephrine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Imatinib	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Imatinib	Propranolol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Imatinib	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Imatinib	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Imatinib	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Imatinib	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Imatinib	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Imatinib	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Imatinib	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Imatinib	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Imatinib	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Imatinib	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Imatinib	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Imatinib	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Imatinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Imatinib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Verapamil	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Mebeverine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Atenolol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Lapatinib	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Ivacaftor	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Lapatinib	Oxybuprocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C9 mediated DDI
Lapatinib	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Propafenone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Lapatinib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Lapatinib	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Lapatinib	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C9 mediated DDI
Lapatinib	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Lapatinib	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Lapatinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Lapatinib	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Lapatinib	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C8 mediated DDI
Lapatinib	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lapatinib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Levofloxacin	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Alectinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Levofloxacin	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Levofloxacin	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Leflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lisinopril	Carbidopa	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Lisinopril	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Lisinopril	Verapamil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Lisinopril	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Lisinopril	Mebeverine	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Lisinopril	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Lisinopril	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Lisinopril	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Lisinopril	Atropine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Lisinopril	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Lisinopril	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Lisinopril	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Lisinopril	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Lisinopril	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Lisinopril	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C8 mediated DDI
Lisinopril	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lisinopril	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mitomycin	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Moxifloxacin	Alectinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Bicalutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Moxifloxacin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Moxifloxacin	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Alectinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ofloxacin	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ofloxacin	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Leflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ombitasvir	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ombitasvir	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ombitasvir	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Ombitasvir	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Ombitasvir	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Ombitasvir	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ombitasvir	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ombitasvir	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Ombitasvir	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ombitasvir	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ombitasvir	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Osimertinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Osimertinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Raltegravir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ribociclib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Saquinavir	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2B6 mediated DDI
Saquinavir	Epinephrine	4	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing tachycardia
Saquinavir	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Saquinavir	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Saquinavir	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Saquinavir	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Saquinavir	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Saquinavir	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Saquinavir	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Saquinavir	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Saquinavir	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Saquinavir	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Saquinavir	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Saquinavir	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Saquinavir	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Saquinavir	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Saquinavir	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Saquinavir	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Selexipag	Norepinephrine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Selexipag	Oxybuprocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Selexipag	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Selexipag	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Selexipag	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Selexipag	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Selexipag	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Selexipag	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Tenofovir alafenamide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Timolol	Dobutamine	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Timolol	Dopamine	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Timolol	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Timolol	Fingolimod	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia
Timolol	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Trimethoprim	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Acalabrutinib	Formoterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Acalabrutinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Baricitinib	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bictegravir	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Bictegravir	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Bictegravir	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Bromocriptine	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Bromocriptine	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Bromocriptine	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Bromocriptine	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Bromocriptine	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Bromocriptine	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Capecitabine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Carbidopa	Nintedanib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI
Carbidopa	Piribedil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Carbidopa	Tamsulosin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Carbidopa	Vilanterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Carvedilol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia
Carbidopa	Enalapril	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Carbidopa	Formoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Salmeterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Indacaterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Carbidopa	Metoprolol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia
Carbidopa	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Carbidopa	Propafenone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia
Carbidopa	Atropine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Carbidopa	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Carbidopa	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Isoniazid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2C8 mediated DDI
Carbidopa	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia
Carbidopa	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI
Carbidopa	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Carbidopa	Propranolol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia
Carbidopa	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Carbidopa	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Carbidopa	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Carbidopa	Betahistine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Carbidopa	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2C8 mediated DDI
Carbidopa	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Carbidopa	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Carbidopa	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Carbidopa	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2C8 mediated DDI
Carbidopa	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Carbidopa	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Carbidopa	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Carbidopa	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Cilastatin	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Cilastatin	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Cilastatin	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Cilastatin	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ciprofloxacin	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Alectinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Fluconazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Ciprofloxacin	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ciprofloxacin	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ciprofloxacin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Leflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ciprofloxacin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Dapagliflozin	Fenoterol	4	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dapagliflozin	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C9 mediated DDI
Dapagliflozin	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Deferasirox	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Deferasirox	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Deferasirox	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Deferasirox	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Deferasirox	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Deferasirox	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Deferasirox	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Elvitegravir	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Elvitegravir	Sotalol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia
Elvitegravir	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Elvitegravir	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Elvitegravir	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Elvitegravir	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Elvitegravir	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Elvitegravir	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Elvitegravir	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Elvitegravir	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Elvitegravir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Etravirine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Gosogliptin	Periciazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Haloperidol	4	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Trifluoperazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Clomifene	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Imipenem	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Irinotecan	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ivabradine	Verapamil	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Ivabradine	Carvedilol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Fenoterol	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Favipiravir	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Ivabradine	Fluphenazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Ivabradine	Propafenone	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Ivabradine	Haloperidol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Methotrimeprazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Ivabradine	Phenylephrine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Procainamide	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Ivabradine	Propranolol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Trifluoperazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Ivabradine	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Ivabradine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Ivabradine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Lomefloxacin	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lomefloxacin	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lomefloxacin	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lomefloxacin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lomefloxacin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lomefloxacin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lomefloxacin	Leflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lomefloxacin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lumacaftor	Fenoterol	4	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing tachycardia
Lumacaftor	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Mannitol	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Meropenem	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Moxonidine	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Nilotinib	Fluconazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Nilotinib	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nilotinib	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nilotinib	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Nilotinib	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Nilotinib	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Nilotinib	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nilotinib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Nilotinib	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Nilotinib	Phenylephrine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Nilotinib	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Nilotinib	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nilotinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nilotinib	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Nilotinib	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Nilotinib	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Nilotinib	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nilotinib	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Nilotinib	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Nilotinib	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Nilotinib	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Nilotinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Nilotinib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Nimodipine	Olodaterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Alectinib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Nimodipine	Avibactam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Nimodipine	Cetirizine	4	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Nimodipine	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Nimodipine	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Nimodipine	Favipiravir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Indacaterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Tetrabenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Nimodipine	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Atropine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Fluorescein	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Nimodipine	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Nimodipine	Propranolol	4	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Nimodipine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nimodipine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nimodipine	Lomustine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Loratadine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Nimodipine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Sertindole	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Nimodipine	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nintedanib	Alectinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nintedanib	Chloramphenicol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Nintedanib	Methyldopa	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Nintedanib	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Nintedanib	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Nintedanib	Flutamide	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Nintedanib	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Nintedanib	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Nintedanib	Procainamide	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Nintedanib	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nintedanib	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nintedanib	Clomifene	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nintedanib	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Nintedanib	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nintedanib	Amitriptyline	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nintedanib	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Olodaterol	Verapamil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Olodaterol	Carvedilol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Olodaterol	Fenoterol	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI
Olodaterol	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Olodaterol	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Olodaterol	Propranolol	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Olodaterol	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI
Olodaterol	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Olodaterol	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Olodaterol	Lidocaine	4	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Olodaterol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Piribedil	Avibactam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Piribedil	Bisoprolol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Piribedil	Atenolol	4	Major DDI	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Piribedil	Propafenone	4	Major DDI	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Piribedil	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI
Piribedil	Trifluoperazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Piribedil	Bupivacaine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Piribedil	Levobupivacaine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Piribedil	Ropivacaine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Rilpivirine	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Rilpivirine	Trifluoperazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP3A4 mediated DDI
Rilpivirine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ritonavir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Tamsulosin	Terizidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Verapamil	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Methyldopa	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI
Tamsulosin	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Tamsulosin	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Tamsulosin	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Terizidone	Urapidil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Terizidone	Chloramphenicol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Terizidone	Enalapril	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2C8 mediated DDI
Terizidone	Formoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Terizidone	Losartan	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Terizidone	Siponimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Atenolol	4	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Terizidone	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Terizidone	Fosfomycin	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Terizidone	Indacaterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Terizidone	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Terizidone	Metoprolol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Terizidone	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Terizidone	Acetylsalicylic acid	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Aminophylline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Terizidone	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Terizidone	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Terizidone	Dexketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Fluorescein	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Terizidone	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Terizidone	Ketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Terizidone	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Tranexamic acid	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Terizidone	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Terizidone	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Terizidone	Pyrantel	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Terizidone	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP3A4 mediated DDI
Terizidone	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia	CYP1A2 mediated DDI
Terizidone	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Urapidil	Verapamil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP3A4 mediated DDI
Urapidil	Carvedilol	4	CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Salmeterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP1A2 mediated DDI
Urapidil	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Urapidil	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Urapidil	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vandetanib	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Vandetanib	Metoclopramide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Vandetanib	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI
Vandetanib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vandetanib	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Vandetanib	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Vandetanib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Vandetanib	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Vandetanib	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Vandetanib	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vandetanib	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Vandetanib	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Vandetanib	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Vandetanib	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Vandetanib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Vandetanib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Verapamil	Avibactam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP3A4 mediated DDI
Verapamil	Bicalutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Verapamil	Cabozantinib	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Verapamil	Chloramphenicol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Verapamil	Drotaverine	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Enalapril	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Verapamil	Glyburide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Verapamil	Siponimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Verapamil	Sulpiride	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Verapamil	Ethambutol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Verapamil	Indapamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2D6 mediated DDI
Verapamil	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Midostaurin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Verapamil	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Verapamil	Tetrabenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Verapamil	Cariprazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Verapamil	Chlorambucil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Verapamil	Dexketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI
Verapamil	Ketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI
Verapamil	Ketorolac	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Verapamil	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Sunitinib	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Verapamil	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Verapamil	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Verapamil	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Verapamil	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Loratadine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP3A4 mediated DDI
Verapamil	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Vilanterol	Fenoterol	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Vilanterol	Norepinephrine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Vilanterol	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Vilanterol	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI
Vilanterol	Sotalol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Vilanterol	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI
Vilanterol	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Vilanterol	Propranolol	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Vilanterol	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Vilanterol	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia
Vilanterol	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Vilanterol	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia
Vilanterol	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI
Vilanterol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vilanterol	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C9 mediated DDI
Alectinib	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Alectinib	Oxybuprocaine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C8 mediated DDI
Alectinib	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Alectinib	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Alectinib	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Alectinib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Alectinib	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Alectinib	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Alectinib	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Alectinib	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Alectinib	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Alectinib	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Alectinib	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Alectinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Alectinib	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Alogliptin	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Alogliptin	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Alogliptin	Sotalol	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Alogliptin	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Amlodipine	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Amlodipine	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Amlodipine	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Amlodipine	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Amlodipine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Amlodipine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Amlodipine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Amlodipine	Mitotane	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Apixaban	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Apixaban	Sotalol	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Apixaban	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Avibactam	Carvedilol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Chloramphenicol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia
Avibactam	Enalapril	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Avibactam	Formoterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Avibactam	Nifedipine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Avibactam	Salmeterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Avibactam	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Dexketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Avibactam	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Ketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Avibactam	Ketorolac	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Avibactam	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI
Avibactam	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Betahistine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Avibactam	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Avibactam	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Avibactam	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Avibactam	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Avibactam	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Avibactam	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Avibactam	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Bicalutamide	Chloramphenicol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Bicalutamide	Mebeverine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Bicalutamide	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Bicalutamide	Hydroxychloroquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Bicalutamide	Oxybuprocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Bicalutamide	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Bicalutamide	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C8 mediated DDI
Bicalutamide	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Bicalutamide	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Bicalutamide	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Bicalutamide	Phenylephrine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Bicalutamide	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Bicalutamide	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Bicalutamide	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bicalutamide	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bicalutamide	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Bisoprolol	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Bisoprolol	Sotalol	4	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Bisoprolol	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Bisoprolol	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Bisoprolol	Tropicamide	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Bisoprolol	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Bisoprolol	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Bisoprolol	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Bisoprolol	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Bisoprolol	Mitotane	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Cabozantinib	Epinephrine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Cabozantinib	Sotalol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Cabozantinib	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cabozantinib	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cabozantinib	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Cabozantinib	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cabozantinib	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Cabozantinib	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Carvedilol	Drotaverine	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Formoterol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Quetiapine	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Sulpiride	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Tizanidine	4	Major DDI	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Carvedilol	Ethambutol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Carvedilol	Favipiravir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Carvedilol	Mebendazole	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Metoclopramide	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Pentoxifylline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP1A2 mediated DDI
Carvedilol	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Salbutamol	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Carvedilol	Caffeine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP1A2 mediated DDI
Carvedilol	Procainamide	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Tropicamide	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Agomelatine	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Biperiden	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Clomipramine	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Piracetam	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Tapentadol	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Cinacalcet	4	Major DDI	DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Cetirizine	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cetirizine	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cetirizine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Chloramphenicol	Glyburide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Methyldopa	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Chloramphenicol	Salmeterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Chloramphenicol	Atenolol	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Favipiravir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Fosfomycin	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Hydroxyzine	4	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Ivacaftor	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Chloramphenicol	Metoclopramide	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Metoprolol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Chloramphenicol	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Chloramphenicol	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Chloramphenicol	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension
Chloramphenicol	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Chloramphenicol	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Chloramphenicol	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Chloramphenicol	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Chloramphenicol	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Chloramphenicol	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Chloramphenicol	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Chloramphenicol	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Chloramphenicol	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Chloramphenicol	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Chloramphenicol	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia
Dasabuvir	Atenolol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Dasabuvir	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Dasabuvir	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Dasabuvir	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Dasabuvir	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Dasabuvir	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Dasabuvir	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Dasabuvir	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Dasabuvir	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Dasabuvir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Dasabuvir	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C9 mediated DDI
Doravirine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Drotaverine	Methyldopa	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI
Drotaverine	Epinephrine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Propafenone	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Sotalol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Drotaverine	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Flutamide	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Phenylephrine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Propranolol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Zuclopenthixol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Amitriptyline	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Elsulfavirine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Emtricitabine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Enalapril	Fenoterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Enalapril	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Enalapril	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Enalapril	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Enalapril	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Enalapril	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Enalapril	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Enalapril	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Enalapril	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Enalapril	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Enalapril	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Enalapril	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Enalapril	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Enalapril	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Enalapril	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2D6 mediated DDI
Enalapril	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Enalapril	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2D6 mediated DDI
Fenoterol	Levodopa	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Fenoterol	Losartan	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI
Fenoterol	Miglustat	4	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Nelfinavir	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2B6 mediated DDI
Fenoterol	Rivaroxaban	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Fenoterol	Clonazepam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Ethambutol	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Favipiravir	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Fenoterol	Fosfomycin	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Fenoterol	Nitrazepam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Fenoterol	Acetylsalicylic acid	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Fenoterol	Axitinib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Fenoterol	Cariprazine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Chlorambucil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Fenoterol	Enzalutamide	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Fenoterol	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Sunitinib	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Fenoterol	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fenoterol	Praziquantel	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Fenoterol	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Fenoterol	Carbamazepine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Fenoterol	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Cariprazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Formoterol	Levodopa	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Formoterol	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Siponimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Epinephrine	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Formoterol	Hydroxyzine	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Ivacaftor	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Formoterol	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Chloropyramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Ketorolac	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Methylergometrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Formoterol	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Formoterol	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Formoterol	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Formoterol	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Rivastigmine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Formoterol	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Formoterol	Carbamazepine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Formoterol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Formoterol	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension
Formoterol	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Glyburide	Methyldopa	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Glyburide	Salmeterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C9 mediated DDI
Glyburide	Metoclopramide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Glyburide	Oxybuprocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Glyburide	Salbutamol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Glyburide	Atropine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C9 mediated DDI
Glyburide	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI
Glyburide	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Glyburide	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Glyburide	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Glyburide	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C9 mediated DDI
Glyburide	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Ibrutinib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Ipragliflozin	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Lamivudine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Levodopa	Nifedipine	4	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Levodopa	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Levodopa	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Levodopa	Atropine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Levodopa	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Levodopa	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C9 mediated DDI
Levodopa	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Levodopa	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI
Levodopa	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C8 mediated DDI
Levodopa	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Levodopa	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Levodopa	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Levodopa	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Levodopa	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Levodopa	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Levodopa	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Levodopa	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Levodopa	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Levodopa	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Linezolid	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Linezolid	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Linezolid	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Linezolid	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Linezolid	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2B6 mediated DDI
Lopinavir	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Lopinavir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Lopinavir	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Losartan	Mebeverine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI
Losartan	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Oxybuprocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Losartan	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Losartan	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Losartan	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Losartan	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Lurasidone	Sotalol	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Mebeverine	Miglustat	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Mebeverine	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Tizanidine	4	Major DDI	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia
Mebeverine	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Epinephrine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Mebeverine	Favipiravir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Mebeverine	Indacaterol	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Mebeverine	Ivacaftor	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Mebeverine	Paroxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Mebeverine	Axitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Mebeverine	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Mebeverine	Fenofibrate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Mebeverine	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Sunitinib	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Mebeverine	Umifenovir	4	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Mebeverine	Rivastigmine	4	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Mebeverine	Solifenacin	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Mebeverine	Vinpocetine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Mebeverine	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Mebeverine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Mebeverine	Sertraline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Methyldopa	Siponimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C8 mediated DDI
Methyldopa	Atenolol	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing bradycardia
Methyldopa	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Methyldopa	Indapamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Methyldopa	Norepinephrine	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Oxybuprocaine	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Paroxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Methyldopa	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Methyldopa	Perphenazine	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Methyldopa	Acetylsalicylic acid	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Chloropyramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Fluorescein	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Methyldopa	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Methyldopa	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Methotrimeprazine	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI
Methyldopa	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Methyldopa	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Methyldopa	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Methyldopa	Ketamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Methyldopa	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Methyldopa	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Methyldopa	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Methyldopa	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Methyldopa	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Methyldopa	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Methyldopa	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Miglustat	Nifedipine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Miglustat	Atenolol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Miglustat	Dobutamine	4	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Miglustat	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Miglustat	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Miglustat	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Nelfinavir	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Sotalol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Nelfinavir	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2B6 mediated DDI
Nelfinavir	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Nelfinavir	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Nelfinavir	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Nelfinavir	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Nitisinone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Favipiravir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Perphenazine	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing arrhythmia
Nifedipine	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Nifedipine	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Lacosamide	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI
Nifedipine	Methylergometrine	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Propranolol	4	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Nifedipine	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Salmeterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Nitisinone	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension
Nitisinone	Fosfomycin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Nitisinone	Hydroxychloroquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nitisinone	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension
Nitisinone	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Nitisinone	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Nitisinone	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Nitisinone	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nitisinone	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension
Nitisinone	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Nitisinone	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Nitisinone	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Nitisinone	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Oxycodone	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Paliperidone	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Paliperidone	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Paliperidone	Trifluoperazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Perindopril	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Perindopril	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Pomalidomide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Quetiapine	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Quetiapine	Phenylephrine	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Quetiapine	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Quetiapine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Quetiapine	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Repaglinide	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C8 mediated DDI
Repaglinide	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Repaglinide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Repaglinide	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Rivaroxaban	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Rivaroxaban	Epinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Rivaroxaban	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Rivaroxaban	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Rivaroxaban	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Salmeterol	Bedaquiline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Salmeterol	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Salmeterol	Metoclopramide	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Salmeterol	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Salmeterol	Pentoxifylline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Salmeterol	Salbutamol	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Salmeterol	Tetrabenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Salmeterol	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salmeterol	Chloropyramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Salmeterol	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI
Salmeterol	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Methotrimeprazine	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Methylergometrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salmeterol	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salmeterol	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Salmeterol	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salmeterol	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salmeterol	Zuclopenthixol	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salmeterol	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Salmeterol	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salmeterol	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Salmeterol	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Salmeterol	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Salmeterol	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Salmeterol	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Siponimod	Indacaterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Siponimod	Norepinephrine	4	CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Siponimod	Oxybuprocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Siponimod	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C8 mediated DDI
Siponimod	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI
Siponimod	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI
Siponimod	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Siponimod	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Siponimod	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C8 mediated DDI
Siponimod	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Siponimod	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Siponimod	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI
Siponimod	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI
Siponimod	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Siponimod	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Sulpiride	Hydroxychloroquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sulpiride	Metoclopramide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Sulpiride	Sotalol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Sulpiride	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sulpiride	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sulpiride	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sulpiride	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sulpiride	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sulpiride	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Sulpiride	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Sulpiride	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sulpiride	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Talazoparib	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Tizanidine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Tofacitinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Trametinib	Fosfomycin	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Trametinib	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Trametinib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Trametinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Voriconazole	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Aminosalicylic acid	Sotalol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing bradycardia
Aminosalicylic acid	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Aminosalicylic acid	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Aminosalicylic acid	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Aminosalicylic acid	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Apalutamide	Phenylephrine	4	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Atenolol	Cobimetinib	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Indacaterol	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Atenolol	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Dexketoprofen	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Atenolol	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Ketoprofen	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Atenolol	Ketorolac	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Loperamide	4	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Atenolol	Methylergometrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Atenolol	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Atenolol	Biperiden	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Levamisole	4	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing bradycardia
Atenolol	Lidocaine	4	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Sertindole	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI
Atenolol	Sertraline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Fluphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Bedaquiline	Indacaterol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Bedaquiline	Metoprolol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C9 mediated DDI
Bedaquiline	Atropine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Bedaquiline	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Bedaquiline	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Bedaquiline	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Bedaquiline	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Bedaquiline	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Bedaquiline	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Bedaquiline	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Bedaquiline	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Bedaquiline	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI
Bedaquiline	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Bedaquiline	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bedaquiline	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Clonazepam	Dobutamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Clonazepam	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Clonazepam	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Clonazepam	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Cobimetinib	Metoprolol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cobimetinib	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Cobimetinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Dapsone	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Diatrizoate	Norepinephrine	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Dobutamine	Indapamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Dobutamine	Nitrazepam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Dobutamine	Axitinib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dobutamine	Chlorambucil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Dobutamine	Fenofibrate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Dobutamine	Isoniazid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Dobutamine	Betahistine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Dobutamine	Leflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Dobutamine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Dobutamine	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Dobutamine	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Dobutamine	Carbamazepine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Dobutamine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Epinephrine	Fosfomycin	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Epinephrine	Olaparib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Paroxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Chloropyramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Epinephrine	Dexketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Epinephrine	Enzalutamide	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Epinephrine	Fluorescein	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Flutamide	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Epinephrine	Ketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Epinephrine	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Pyrazinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Epinephrine	Sunitinib	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Teriflunomide	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Epinephrine	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Leflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Epinephrine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Praziquantel	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Tamoxifen	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Carbamazepine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Epinephrine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Sertraline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Ethambutol	Norepinephrine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Ethambutol	Sotalol	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia
Ethambutol	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Ethambutol	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Ethambutol	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Ethambutol	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Favipiravir	Metoprolol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Favipiravir	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Favipiravir	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Favipiravir	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Favipiravir	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Favipiravir	Ketorolac	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Favipiravir	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Favipiravir	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Favipiravir	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Favipiravir	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Fluphenazine	Fosfomycin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Fluphenazine	Hydroxychloroquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Indacaterol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Fluphenazine	Ivacaftor	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Fluphenazine	Lenvatinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Fluphenazine	Metoclopramide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Fluphenazine	Olaparib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Fluphenazine	Oseltamivir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Fluphenazine	Paroxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Fluphenazine	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Fluphenazine	Risperidone	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Fluphenazine	Bisacodyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Fluphenazine	Cariprazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Fluphenazine	Dexketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Fluphenazine	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Fluphenazine	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Ketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Fluphenazine	Ketorolac	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Fluphenazine	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Fluphenazine	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Fluphenazine	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Fluphenazine	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2D6 mediated DDI
Fluphenazine	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Fluphenazine	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Acetaminophen	4	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Fluphenazine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Fluphenazine	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Fluphenazine	Loratadine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Praziquantel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Fluphenazine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Fluphenazine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Fluphenazine	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Fluphenazine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluphenazine	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Fosfomycin	Norepinephrine	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Fosfomycin	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Fosfomycin	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Fosfomycin	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Fosfomycin	Phenylephrine	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Fosfomycin	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Fosfomycin	Warfarin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Fosfomycin	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Fosfomycin	Biperiden	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Fosfomycin	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP3A4 mediated DDI
Fosfomycin	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP3A4 mediated DDI
Fosfomycin	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI
Fosfomycin	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Fosfomycin	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gliclazide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Hydroxychloroquine	Mebendazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Hydroxychloroquine	Oxybuprocaine	4	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Hydroxychloroquine	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Hydroxychloroquine	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Hydroxychloroquine	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Hydroxychloroquine	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Hydroxychloroquine	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Hydroxychloroquine	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Hydroxychloroquine	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hydroxychloroquine	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Hydroxychloroquine	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Hydroxychloroquine	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Hydroxychloroquine	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Hydroxychloroquine	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Hydroxychloroquine	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Hydroxychloroquine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Hydroxychloroquine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Hydroxychloroquine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Hydroxychloroquine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Hydroxychloroquine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Hydroxychloroquine	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Hydroxychloroquine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Hydroxyzine	Phenylephrine	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI
Hydroxyzine	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hydroxyzine	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Hydroxyzine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Hydroxyzine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Hydroxyzine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Indacaterol	Norepinephrine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Indacaterol	Sotalol	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Indacaterol	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Indacaterol	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Indacaterol	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Indacaterol	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Indacaterol	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Indacaterol	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Indacaterol	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Indacaterol	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Indacaterol	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Indacaterol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Indacaterol	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Indapamide	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2D6 mediated DDI
Indapamide	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Indapamide	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Indapamide	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Ivacaftor	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ivacaftor	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ivacaftor	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Ivacaftor	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Ivacaftor	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ivacaftor	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ivacaftor	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ivacaftor	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ivacaftor	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ivacaftor	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ivacaftor	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ivacaftor	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ivacaftor	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ivacaftor	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ivacaftor	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP1A2 mediated DDI
Ivacaftor	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP3A4 mediated DDI
Ixazomib	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Ixazomib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Lenalidomide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Lenvatinib	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI
Lenvatinib	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Lenvatinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lenvatinib	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C8 mediated DDI
Lenvatinib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lenvatinib	Mitotane	4	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Norepinephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Mebendazole	Oxybuprocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Mebendazole	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Mebendazole	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Propranolol	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Piracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Mebendazole	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Mebendazole	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Mesalazine	Sotalol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Mesalazine	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Mesalazine	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Mesalazine	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C9 mediated DDI
Mesalazine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C9 mediated DDI
Metoclopramide	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Metoclopramide	Propafenone	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoclopramide	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Metoclopramide	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Metoclopramide	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Metoclopramide	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Metoclopramide	Propranolol	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoclopramide	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Metoclopramide	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Metoclopramide	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Metoclopramide	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Metoclopramide	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoclopramide	Tapentadol	4	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Metoprolol	Paroxetine	4	CLASS 1 (from 5); Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Haloperidol	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Ketorolac	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Tramadol	4	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Diphenhydramine	4	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Sertindole	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Amitriptyline	4	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Nevirapine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Nitrazepam	Sotalol	4	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Nitrazepam	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Norepinephrine	Paroxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Norepinephrine	Tetrabenazine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Cariprazine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Chlorambucil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Norepinephrine	Chloropyramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Norepinephrine	Enzalutamide	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Norepinephrine	Fluorescein	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Norepinephrine	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Norepinephrine	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Norepinephrine	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Norepinephrine	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Norepinephrine	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Norepinephrine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Norepinephrine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Norepinephrine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Norepinephrine	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Norepinephrine	Carbamazepine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Norepinephrine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Norepinephrine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Norepinephrine	Sertraline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Olaparib	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Olaparib	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Olaparib	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Olaparib	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Oseltamivir	Salbutamol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Oseltamivir	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Oseltamivir	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Oseltamivir	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI
Oseltamivir	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Oseltamivir	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Oseltamivir	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Oseltamivir	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Oseltamivir	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Oseltamivir	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI
Oseltamivir	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Oseltamivir	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Oxybuprocaine	Paroxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Oxybuprocaine	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Bisacodyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Oxybuprocaine	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Oxybuprocaine	Lacosamide	4	CLASS 1 (from 5); Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Oxybuprocaine	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C8 mediated DDI
Oxybuprocaine	Betahistine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Oxybuprocaine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Oxybuprocaine	Piracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Paroxetine	Periciazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Paroxetine	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Paroxetine	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Paroxetine	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Paroxetine	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Paroxetine	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Paroxetine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Paroxetine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Paroxetine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Pentoxifylline	Sotalol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Periciazine	Perphenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Periciazine	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Periciazine	Amiodarone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Periciazine	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Periciazine	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Periciazine	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Periciazine	Ketorolac	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Periciazine	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Periciazine	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Periciazine	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Periciazine	Propranolol	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Periciazine	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Periciazine	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Periciazine	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Periciazine	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Periciazine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Periciazine	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Periciazine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Periciazine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Periciazine	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Tetrabenazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Perphenazine	Vismodegib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Perphenazine	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Perphenazine	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Perphenazine	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Perphenazine	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Perphenazine	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Perphenazine	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Perphenazine	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Perphenazine	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Perphenazine	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Perphenazine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Perphenazine	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Perphenazine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Perphenazine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Perphenazine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Perphenazine	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Tapentadol	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension; DDI causing tachycardia	CYP2D6 mediated DDI
Perphenazine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2D6 mediated DDI
Propafenone	Sotalol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Tetrabenazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Procainamide	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Fluoxetine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Benzyl benzoate	4	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Pyridoxine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Risperidone	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Risperidone	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Risperidone	Trifluoperazine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Risperidone	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Risperidone	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Risperidone	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Risperidone	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C19 mediated DDI
Salbutamol	Sotalol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing tachycardia
Salbutamol	Loperamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2B6 mediated DDI
Salbutamol	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salbutamol	Methylergometrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salbutamol	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Salbutamol	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salbutamol	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salbutamol	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salbutamol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Salbutamol	Pirfenidone	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension; DDI causing tachycardia
Salbutamol	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Sotalol	Tetrabenazine	4	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Sotalol	Cariprazine	4	CLASS 1 (from 5); Major DDI	DDI causing hypertension; DDI causing bradycardia
Sotalol	Chlorambucil	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Sotalol	Enzalutamide	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Sotalol	Fluorescein	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Isoniazid	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Sotalol	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Sunitinib	4	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Sotalol	Acetaminophen	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia
Sotalol	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Sotalol	Ketamine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Sotalol	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Sotalol	Lipoic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia
Sulfamethoxazole	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension
Tetrabenazine	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Tetrabenazine	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Tetrabenazine	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Tetrabenazine	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Tetrabenazine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Tetrabenazine	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Vemurafenib	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Vemurafenib	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP3A4 mediated DDI
Vemurafenib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Vismodegib	Atropine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Vismodegib	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Vismodegib	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Vismodegib	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Vismodegib	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vismodegib	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C9 mediated DDI
Vismodegib	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Vismodegib	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Vismodegib	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Vismodegib	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vismodegib	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vismodegib	Piracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Vismodegib	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Vismodegib	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Vismodegib	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Vismodegib	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Acetylsalicylic acid	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Acetylsalicylic acid	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Acetylsalicylic acid	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Acetylsalicylic acid	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Acetylsalicylic acid	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Acetylsalicylic acid	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Acetylsalicylic acid	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Acetylsalicylic acid	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ambroxol	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Aminocaproic acid	Cycloserine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Aminophylline	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Amiodarone	Bisacodyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Amiodarone	Captopril	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Amiodarone	Clonidine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Amiodarone	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Amiodarone	Ketorolac	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Amiodarone	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Amiodarone	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Amiodarone	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Amiodarone	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Amiodarone	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Amiodarone	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Amiodarone	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Amiodarone	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Amiodarone	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Amiodarone	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Amiodarone	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Amiodarone	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Amiodarone	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Amiodarone	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Amiodarone	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Atropine	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Atropine	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Atropine	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Atropine	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Atropine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Atropine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI
Atropine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Atropine	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Atropine	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension
Atropine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Atropine	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI
Atropine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Baclofen	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Bisacodyl	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C8 mediated DDI
Bisacodyl	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Bisacodyl	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Bisacodyl	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Captopril	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Captopril	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Captopril	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Captopril	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Captopril	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Captopril	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Captopril	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia
Captopril	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Cariprazine	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Cariprazine	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI
Cariprazine	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Cariprazine	Phenylephrine	4	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Cariprazine	Procainamide	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Cariprazine	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Cariprazine	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI
Cariprazine	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Cariprazine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI
Cariprazine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI
Cariprazine	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Cariprazine	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Chlorambucil	Dopamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI
Chloropyramine	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Chloropyramine	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Clonidine	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Clonidine	Clomifene	4	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension; DDI causing tachycardia
Clonidine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Cycloserine	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Cycloserine	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Cycloserine	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Cycloserine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Cycloserine	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI
Cycloserine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Cycloserine	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Dexketoprofen	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dexketoprofen	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Dexketoprofen	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Dexketoprofen	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C8 mediated DDI
Dexketoprofen	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Dexketoprofen	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Dopamine	Droperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Dopamine	Enzalutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C8 mediated DDI
Dopamine	Fluorescein	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Dopamine	Isoniazid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Dopamine	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Dopamine	Methylergometrine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Dopamine	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Dopamine	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Dopamine	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Dopamine	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Dopamine	Tranexamic acid	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Dopamine	Betahistine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Dopamine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Dopamine	Ketamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C9 mediated DDI
Dopamine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Dopamine	Pyrantel	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Dopamine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Dopamine	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Dopamine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Dopamine	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Dopamine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Dopamine	Sertraline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Droperidol	Fingolimod	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Droperidol	Flupentixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Droperidol	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Droperidol	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Droperidol	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Droperidol	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Droperidol	Acetaminophen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Droperidol	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Droperidol	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Droperidol	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Droperidol	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Droperidol	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Droperidol	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Droperidol	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Droperidol	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Droperidol	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Droperidol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Enzalutamide	Phenylephrine	4	Major DDI	DDI causing hypertension; DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Fenofibrate	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C8 mediated DDI
Fingolimod	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Ketoprofen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Fingolimod	Ketorolac	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fingolimod	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Fingolimod	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Fingolimod	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Betahistine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fingolimod	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Fingolimod	Piracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Fingolimod	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Fingolimod	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Fingolimod	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Fingolimod	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Fingolimod	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI
Fingolimod	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Fingolimod	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fluorescein	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Fluorescein	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Flupentixol	Flutamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Haloperidol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Flupentixol	Ketorolac	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Flupentixol	Methotrimeprazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Flupentixol	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Flupentixol	Propranolol	4	CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Flupentixol	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Flupentixol	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Flupentixol	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Flupentixol	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Flupentixol	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Flupentixol	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Flupentixol	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Flupentixol	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Flupentixol	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Flupentixol	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Flupentixol	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Flutamide	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Flutamide	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Flutamide	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Flutamide	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Flutamide	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Flutamide	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Flutamide	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flutamide	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Flutamide	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Flutamide	Lomustine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Flutamide	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flutamide	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Flutamide	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Lacosamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Haloperidol	Perampanel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Propranolol	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Haloperidol	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI
Haloperidol	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI
Haloperidol	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Haloperidol	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Haloperidol	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Haloperidol	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Haloperidol	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Isoniazid	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Isoniazid	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Isoniazid	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ketoprofen	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Ketoprofen	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Ketoprofen	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C8 mediated DDI
Ketoprofen	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Ketoprofen	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI
Ketorolac	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Ketorolac	Propranolol	4	Major DDI	DDI causing hypertension; DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ketorolac	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Ketorolac	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Ketorolac	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Ketorolac	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Ketorolac	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Ketorolac	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Ketorolac	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Lacosamide	Phenylephrine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Lacosamide	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Lacosamide	Propranolol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Lacosamide	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Lacosamide	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Loperamide	Mefloquine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Loperamide	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Loperamide	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Loperamide	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Loperamide	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Loperamide	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Loperamide	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Loperamide	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI
Loperamide	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2D6 mediated DDI
Loperamide	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Loperamide	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Loperamide	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI
Loperamide	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Loperamide	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Loperamide	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Loperamide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Lorazepam	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Mefloquine	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Mefloquine	Propranolol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Mefloquine	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Mefloquine	Acetaminophen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Mefloquine	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mefloquine	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Mefloquine	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Mefloquine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Mefloquine	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Mefloquine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mefloquine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mefloquine	Piracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Mefloquine	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Mefloquine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mefloquine	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Mefloquine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Meldonium	Desflurane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Methotrimeprazine	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Clomipramine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Imipramine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Amitriptyline	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Methotrimeprazine	Benzyl benzoate	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methylergometrine	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Methylergometrine	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Methylergometrine	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Methylergometrine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Methylergometrine	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Methylergometrine	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Methylergometrine	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Methylergometrine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Oxazepam	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Penicillamine	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Perampanel	Procainamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Perampanel	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Perampanel	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Perampanel	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Perampanel	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perampanel	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Perampanel	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perampanel	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perampanel	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perampanel	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Perampanel	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Perampanel	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Perampanel	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Perampanel	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perampanel	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Perampanel	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Perampanel	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Perampanel	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Phenobarbital	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Phenylephrine	Pyrazinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Phenylephrine	Salicylic acid	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Phenylephrine	Sunitinib	4	Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Phenylephrine	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Ketamine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Phenylephrine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Phenylephrine	Ondansetron	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Phenylephrine	Praziquantel	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Phenylephrine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Phenylephrine	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Phenylephrine	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Carbamazepine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Phenylephrine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Phenylephrine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Phenylephrine	Sertraline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Procainamide	Procaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Procarbazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Procainamide	Propranolol	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Procainamide	Teriflunomide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Procainamide	Tramadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Procainamide	Tropicamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procainamide	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Procainamide	Betahistine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI
Procainamide	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Procainamide	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Procainamide	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Procainamide	Piracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Procainamide	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Procainamide	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Procainamide	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Procainamide	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Procaine	Lidocaine	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Procaine	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Procaine	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI
Procarbazine	Sunitinib	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Procarbazine	Betahistine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI
Procarbazine	Clomipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Procarbazine	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Procarbazine	Ibuprofen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Procarbazine	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Procarbazine	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Procarbazine	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Procarbazine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Procarbazine	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Procarbazine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Procarbazine	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Procarbazine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Procarbazine	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Procarbazine	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Procarbazine	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Procarbazine	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Procarbazine	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Propranolol	Tramadol	4	Major DDI	DDI causing arrhythmia; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Levamisole	4	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing bradycardia
Propranolol	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propranolol	Piracetam	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propranolol	Sertindole	4	Major DDI	DDI causing hypotension; DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Propranolol	Amitriptyline	4	Major DDI	DDI causing hypotension; DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Propranolol	Sertraline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Regorafenib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Salicylic acid	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Salicylic acid	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Salicylic acid	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salicylic acid	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Salicylic acid	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Salicylic acid	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salicylic acid	Mitotane	4	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Sorafenib	Bupivacaine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Sorafenib	Levobupivacaine	4	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Sorafenib	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Sorafenib	Mitotane	4	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Sunitinib	Trifluoperazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Sunitinib	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Sunitinib	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Sunitinib	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Sunitinib	Mitotane	4	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Teriflunomide	Agomelatine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Teriflunomide	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Teriflunomide	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Teriflunomide	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Teriflunomide	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Teriflunomide	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2C19 mediated DDI
Teriflunomide	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Teriflunomide	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Teriflunomide	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Teriflunomide	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Teriflunomide	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Teriflunomide	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Tramadol	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Tramadol	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tramadol	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Tramadol	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Tramadol	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tramadol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Trifluoperazine	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Trifluoperazine	Zuclopenthixol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Trifluoperazine	Loratadine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Trifluoperazine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Trifluoperazine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Trifluoperazine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Trifluoperazine	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Tropicamide	Umifenovir	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Tropicamide	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tropicamide	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Tropicamide	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Tropicamide	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Tropicamide	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tropicamide	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Tropicamide	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Tropicamide	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension
Tropicamide	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tropicamide	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Tropicamide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Umifenovir	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Zuclopenthixol	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Zuclopenthixol	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Zuclopenthixol	Clomifene	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Zuclopenthixol	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Zuclopenthixol	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Zuclopenthixol	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Zuclopenthixol	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Zuclopenthixol	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Zuclopenthixol	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Acetaminophen	Bupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Acetaminophen	Clomifene	4	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Acetaminophen	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Acetaminophen	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Acetaminophen	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Acetaminophen	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Acetaminophen	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Agomelatine	Chlorpromazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Agomelatine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Agomelatine	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Agomelatine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Agomelatine	Rivastigmine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Agomelatine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Agomelatine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Agomelatine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Agomelatine	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Agomelatine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Agomelatine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Betahistine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Betahistine	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Biperiden	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Bupivacaine	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Bupivacaine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Bupivacaine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bupivacaine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Bupivacaine	Loratadine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Bupivacaine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Bupivacaine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Bupivacaine	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Bupivacaine	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Bupivacaine	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Bupivacaine	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Bupivacaine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Bupivacaine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Bupivacaine	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Chlorpromazine	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Chlorpromazine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Chlorpromazine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Piracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Chlorpromazine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Chlorpromazine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Chlorpromazine	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Tapentadol	4	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Chlorpromazine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Chlorpromazine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Clomifene	Diphenhydramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Clomifene	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Clomifene	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Clomifene	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Clomipramine	Fentanyl	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Clomipramine	Fluoxetine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Clomipramine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Clomipramine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Clomipramine	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Diazepam	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Diphenhydramine	Imipramine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Diphenhydramine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Diphenhydramine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2D6 mediated DDI
Diphenhydramine	Nicotinamide	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Diphenhydramine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Diphenhydramine	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Diphenhydramine	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Diphenhydramine	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Diphenhydramine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Diphenhydramine	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Efavirenz	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Fentanyl	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fentanyl	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fentanyl	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Fentanyl	Piracetam	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fentanyl	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fentanyl	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fentanyl	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fentanyl	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Fentanyl	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Fentanyl	Pirfenidone	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fentanyl	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI
Fluorouracil	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Fluoxetine	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Fluoxetine	Levobupivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Fluoxetine	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Fluoxetine	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Imipramine	Levamisole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Imipramine	Levetiracetam	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Imipramine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Imipramine	Praziquantel	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Imipramine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Imipramine	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Imipramine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Imipramine	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Imipramine	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ketamine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Leflunomide	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Leflunomide	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Levamisole	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension
Levamisole	Benzyl benzoate	4	CLASS 1 (from 3); Major DDI	DDI causing hypertension; DDI causing bradycardia
Levetiracetam	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Levetiracetam	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Levobupivacaine	Lidocaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Levobupivacaine	Loratadine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Levobupivacaine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Levobupivacaine	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Levobupivacaine	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Levobupivacaine	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP2C19 mediated DDI
Levobupivacaine	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Levobupivacaine	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Levobupivacaine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Levobupivacaine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Levobupivacaine	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lidocaine	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP2D6 mediated DDI
Lidocaine	Trihexyphenidyl	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia	CYP1A2 mediated DDI
Lomustine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Lomustine	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Loratadine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Loratadine	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Midazolam	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Nicotinamide	Tapentadol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Nicotinamide	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nicotinamide	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Oxcarbazepine	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Oxcarbazepine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Praziquantel	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Pyrantel	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Rivastigmine	Ropivacaine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Rivastigmine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Rivastigmine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Rivastigmine	Propofol	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Ropivacaine	Sertindole	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ropivacaine	Tamoxifen	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Ropivacaine	Thioridazine	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ropivacaine	Vinpocetine	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Ropivacaine	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Ropivacaine	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Sertindole	Solifenacin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Sertindole	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Sertindole	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Solifenacin	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Tamoxifen	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Tamoxifen	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tamoxifen	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Tapentadol	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Tapentadol	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tapentadol	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Thiopental	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Thioridazine	Amitriptyline	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing hypotension
Thioridazine	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia
Thioridazine	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Trihexyphenidyl	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Trihexyphenidyl	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Trihexyphenidyl	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI
Valproic acid	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vinpocetine	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Amitriptyline	Benzyl benzoate	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Amitriptyline	Cinacalcet	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Amitriptyline	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Carbamazepine	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Cinacalcet	Clotrimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cinacalcet	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pirfenidone	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Propofol	Mitotane	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C9 mediated DDI
Sertraline	Halothane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Sevelamer	Sevoflurane	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Sevoflurane	Methimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension; DDI causing arrhythmia
Halothane	Methimazole	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Halothane	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Mitotane	Oxaliplatin	4	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Lixisenatide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lixisenatide	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Lixisenatide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lixisenatide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lixisenatide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lixisenatide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lixisenatide	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lixisenatide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lixisenatide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Semaglutide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Semaglutide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Semaglutide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Semaglutide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Semaglutide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Semaglutide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Telavancin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Telavancin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Telavancin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Daptomycin	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Daptomycin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Daptomycin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Daptomycin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daptomycin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Vancomycin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vancomycin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vancomycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vancomycin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Etelcalcetide	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Etelcalcetide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Etelcalcetide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Etelcalcetide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Etelcalcetide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Micafungin	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Pibrentasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Micafungin	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Iopromide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Verapamil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Micafungin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Micafungin	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Micafungin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Micafungin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Micafungin	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Micafungin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Micafungin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Micafungin	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Micafungin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ganirelix	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Ticagrelor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ganirelix	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Ganirelix	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ganirelix	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Ganirelix	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Ganirelix	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ganirelix	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ganirelix	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ganirelix	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Ganirelix	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ganirelix	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ganirelix	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Ganirelix	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ganirelix	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ganirelix	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Ganirelix	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Sennosides	Dobutamine	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia
Sennosides	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sennosides	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Sennosides	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sennosides	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Sennosides	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Sennosides	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Streptomycin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Streptomycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Caspofungin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Caspofungin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Caspofungin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Caspofungin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Caspofungin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Caspofungin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Cetrorelix	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cetrorelix	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Cetrorelix	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cetrorelix	Sotalol	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Cetrorelix	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cetrorelix	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cetrorelix	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Cetrorelix	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cetrorelix	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cetrorelix	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cetrorelix	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cetrorelix	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetrorelix	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cetrorelix	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Cetrorelix	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cetrorelix	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cetrorelix	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Cetrorelix	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Cyanocobalamin	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyanocobalamin	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyanocobalamin	Fosfomycin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyanocobalamin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyanocobalamin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyanocobalamin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cyanocobalamin	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyanocobalamin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cyanocobalamin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Degarelix	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Degarelix	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Degarelix	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Degarelix	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Degarelix	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Degarelix	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Degarelix	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Degarelix	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Degarelix	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Degarelix	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Degarelix	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Degarelix	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Degarelix	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Degarelix	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Degarelix	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Degarelix	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Degarelix	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Degarelix	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Degarelix	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Degarelix	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Degarelix	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Goserelin	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Ticagrelor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Fenoterol	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Goserelin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Goserelin	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Goserelin	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Goserelin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Goserelin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Goserelin	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Goserelin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Goserelin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Clomifene	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation
Goserelin	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Goserelin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Goserelin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Goserelin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Goserelin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Goserelin	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Goserelin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Goserelin	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Polymyxin B	Pibrentasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Ioversol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Sotalol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Polymyxin B	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Polymyxin B	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Polymyxin B	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Polymyxin B	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Polymyxin B	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Polymyxin B	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Amikacin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amikacin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amikacin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amikacin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amphotericin B	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Amphotericin B	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nystatin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nystatin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Pibrentasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Terlipressin	Ioversol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Terlipressin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Terlipressin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Terlipressin	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Phenylephrine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Terlipressin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Terlipressin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Terlipressin	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Terlipressin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Terlipressin	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Terlipressin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Terlipressin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terlipressin	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Triptorelin	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Pibrentasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Triptorelin	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Iopromide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Triptorelin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Triptorelin	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Norepinephrine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing bradycardia
Triptorelin	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Triptorelin	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Triptorelin	Sotalol	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Triptorelin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Triptorelin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Triptorelin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Triptorelin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Triptorelin	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Triptorelin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Triptorelin	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Triptorelin	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Triptorelin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Triptorelin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Triptorelin	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Triptorelin	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Triptorelin	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Triptorelin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Triptorelin	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Triptorelin	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Triptorelin	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Glycyrrhizic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Glycyrrhizic acid	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Leuprolide	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Pibrentasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Leuprolide	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Iopromide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Leuprolide	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Leuprolide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Leuprolide	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Norepinephrine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing bradycardia
Leuprolide	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Leuprolide	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Leuprolide	Sotalol	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Leuprolide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Leuprolide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Leuprolide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Leuprolide	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Leuprolide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Leuprolide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Leuprolide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Leuprolide	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Leuprolide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Leuprolide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Leuprolide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leuprolide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Leuprolide	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Leuprolide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Desmopressin	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Ioversol	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Desmopressin	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Desmopressin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Desmopressin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Desmopressin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Desmopressin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Desmopressin	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Desmopressin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Desmopressin	Levamisole	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension
Desmopressin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Desmopressin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Kanamycin	Hexoprenaline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Kanamycin	Epinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Kanamycin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Kanamycin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Kanamycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Kanamycin	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Iohexol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Ioversol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Iopromide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Ribociclib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Sparfloxacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Acalabrutinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Bictegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Deferasirox	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Capreomycin	Nilotinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Trametinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Apalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Metoprolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Capreomycin	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Propranolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Capreomycin	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Capreomycin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Rifampicin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Rifampicin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Tobramycin	Iopromide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tobramycin	Bictegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tobramycin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tobramycin	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tobramycin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tobramycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tobramycin	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Iohexol	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Atosiban	Ioversol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Atosiban	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Atosiban	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Atosiban	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Atosiban	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Atosiban	Acetaminophen	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Atosiban	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Atosiban	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Atosiban	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Atosiban	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atosiban	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Atosiban	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atosiban	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Azithromycin	Ioversol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Azithromycin	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Azithromycin	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Azithromycin	Atorvastatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Azithromycin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Azithromycin	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Azithromycin	Paliperidone	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Azithromycin	Mebendazole	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Azithromycin	Paroxetine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Azithromycin	Risperidone	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Azithromycin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Azithromycin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Procarbazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Azithromycin	Sunitinib	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Azithromycin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Azithromycin	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Azithromycin	Imipramine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Azithromycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Azithromycin	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Azithromycin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Azithromycin	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Azithromycin	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Azithromycin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ceftaroline fosamil	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Clarithromycin	Ivabradine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Clarithromycin	Atorvastatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clarithromycin	Drotaverine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Paliperidone	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Clarithromycin	Mebendazole	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Paroxetine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Risperidone	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Clarithromycin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clarithromycin	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Clarithromycin	Sunitinib	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Clarithromycin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Clarithromycin	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clarithromycin	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Clarithromycin	Imipramine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Clarithromycin	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clarithromycin	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Sertindole	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Clarithromycin	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Clarithromycin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Digoxin	Iohexol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Digoxin	Ioversol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Digoxin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Digoxin	Teriflunomide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Digoxin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Everolimus	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Everolimus	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Everolimus	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Josamycin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Josamycin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Josamycin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Josamycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Josamycin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Josamycin	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Natamycin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Natamycin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Natamycin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Natamycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rifabutin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Rifabutin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Carbetocin	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Ioversol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Carbetocin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carbetocin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carbetocin	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Carbetocin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Carbetocin	Acetaminophen	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Carbetocin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Carbetocin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Carbetocin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carbetocin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbetocin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Cyclosporine	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Cyclosporine	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Cyclosporine	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Cyclosporine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyclosporine	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyclosporine	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyclosporine	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyclosporine	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Cyclosporine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cyclosporine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Cyclosporine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Cyclosporine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Doxorubicin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Doxorubicin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doxorubicin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Doxorubicin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doxorubicin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doxorubicin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doxorubicin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doxorubicin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Epirubicin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Epirubicin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Epirubicin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Epirubicin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Epirubicin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Epirubicin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Epirubicin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Epirubicin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Eribulin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Eribulin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Eribulin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Etoposide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Folic acid	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Folic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gentamicin	Octreotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gentamicin	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gentamicin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gentamicin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Grazoprevir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lanreotide	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Pibrentasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lanreotide	Posaconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Tenofovir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lanreotide	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Ombitasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Ribociclib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Acalabrutinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Bictegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Nintedanib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Lanreotide	Verapamil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Lanreotide	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lanreotide	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Carvedilol	3	CLASS 1 (from 3)	DDI causing hypotension; DDI causing bradycardia
Lanreotide	Chloramphenicol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Lanreotide	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Lanreotide	Mebeverine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Lanreotide	Salmeterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Lanreotide	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Trametinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lanreotide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Ethambutol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Lanreotide	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lanreotide	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lanreotide	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Lanreotide	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Lanreotide	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Lanreotide	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Lanreotide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Lanreotide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lanreotide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lanreotide	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Lanreotide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lanreotide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Lanreotide	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Lanreotide	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lanreotide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Lanreotide	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Lanreotide	Ethanol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Lanreotide	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Lanreotide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Lanreotide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lanreotide	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methotrexate	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Methotrexate	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Grazoprevir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Pibrentasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Posaconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Ertugliflozin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Ombitasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Ribociclib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Acalabrutinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Bictegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Mannitol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Octreotide	Verapamil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Apixaban	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Octreotide	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Carvedilol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Chloramphenicol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Salmeterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Octreotide	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Trametinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Octreotide	Apalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Ethambutol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Octreotide	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Octreotide	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Flutamide	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI
Octreotide	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Octreotide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Octreotide	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Octreotide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Octreotide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Octreotide	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Octreotide	Ethanol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Octreotide	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Octreotide	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Octreotide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Octreotide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Octreotide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Octreotide	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cromoglicic acid	Macitentan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Cromoglicic acid	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Cromoglicic acid	Iomeprol	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Isosorbide dinitrate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Cromoglicic acid	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Cromoglicic acid	Selexipag	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Cromoglicic acid	Methyldopa	3	CLASS 1 (from 3)	DDI causing hypotension; DDI causing bradycardia
Cromoglicic acid	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Cromoglicic acid	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Cromoglicic acid	Siponimod	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Cromoglicic acid	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cromoglicic acid	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Cromoglicic acid	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Cromoglicic acid	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Cromoglicic acid	Lacosamide	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia
Cromoglicic acid	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Cromoglicic acid	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Cromoglicic acid	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cromoglicic acid	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Cromoglicic acid	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Cromoglicic acid	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Cromoglicic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Cromoglicic acid	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Cromoglicic acid	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Daunorubicin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Daunorubicin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daunorubicin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Daunorubicin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daunorubicin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daunorubicin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daunorubicin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daunorubicin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lactulose	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Leucovorin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Rifamycin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Tacrolimus	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tacrolimus	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tacrolimus	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ademetionine	Procarbazine	3	Major DDI	DDI causing arrhythmia; DDI causing tachycardia
Ademetionine	Bupivacaine	3	Major DDI	DDI causing arrhythmia; DDI causing tachycardia
Ademetionine	Levobupivacaine	3	Major DDI	DDI causing arrhythmia; DDI causing tachycardia
Ademetionine	Mitotane	3	Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI
Ceftazidime	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Chlorhexidine	Iopromide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Chlorhexidine	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Chlorhexidine	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Chlorhexidine	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Chlorhexidine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Chlorhexidine	Fingolimod	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Chlorhexidine	Flutamide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Chlorhexidine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Chlorhexidine	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Chlorhexidine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Chlorhexidine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Chlorhexidine	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Chlorhexidine	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Chlorhexidine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Chlorhexidine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Citicoline	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Glecaprevir	Verapamil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Glecaprevir	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Glecaprevir	Metoprolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Glecaprevir	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Glecaprevir	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Glecaprevir	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Glecaprevir	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Glecaprevir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Glecaprevir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Glecaprevir	Propranolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Glecaprevir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Glecaprevir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Glecaprevir	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Glecaprevir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Glecaprevir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Glecaprevir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Glecaprevir	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Glecaprevir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Glecaprevir	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Glecaprevir	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Glecaprevir	Methimazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Glecaprevir	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Grazoprevir	Hexoprenaline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Grazoprevir	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Grazoprevir	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Grazoprevir	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Grazoprevir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Grazoprevir	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Grazoprevir	Epinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Grazoprevir	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Grazoprevir	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Grazoprevir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Grazoprevir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Grazoprevir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Grazoprevir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Grazoprevir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Grazoprevir	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Grazoprevir	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Grazoprevir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Grazoprevir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Grazoprevir	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Grazoprevir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Grazoprevir	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Grazoprevir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Grazoprevir	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Grazoprevir	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Grazoprevir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Grazoprevir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Grazoprevir	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Grazoprevir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Grazoprevir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Grazoprevir	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Grazoprevir	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Grazoprevir	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Grazoprevir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Grazoprevir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Grazoprevir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Grazoprevir	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Grazoprevir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Grazoprevir	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Idarubicin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Idarubicin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Idarubicin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Idarubicin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Idarubicin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Idarubicin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Idarubicin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mitoxantrone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mitoxantrone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Mitoxantrone	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Paritaprevir	Pasireotide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Posaconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Paritaprevir	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Fenoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Paritaprevir	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Paritaprevir	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Paritaprevir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paritaprevir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paritaprevir	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paritaprevir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Paritaprevir	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Pasireotide	Pibrentasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Ertapenem	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Ombitasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Acalabrutinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Bictegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Irinotecan	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Mannitol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Pasireotide	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pasireotide	Verapamil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pasireotide	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Enalapril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Pasireotide	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Pasireotide	Formoterol	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Pasireotide	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Talazoparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Trametinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pasireotide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pasireotide	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pasireotide	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Norepinephrine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Pasireotide	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pasireotide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pasireotide	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pasireotide	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pasireotide	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Pasireotide	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pasireotide	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Pasireotide	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pasireotide	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pasireotide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Pasireotide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Carfilzomib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Dolutegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Irinotecan	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Verapamil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pibrentasvir	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Chloramphenicol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Pibrentasvir	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Mebeverine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Pibrentasvir	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Pibrentasvir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pibrentasvir	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pibrentasvir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Pibrentasvir	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pibrentasvir	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Pibrentasvir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Pibrentasvir	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pimecrolimus	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pimecrolimus	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pimecrolimus	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Venetoclax	Hexoprenaline	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C9 mediated DDI
Venetoclax	Amlodipine	3	Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Venetoclax	Carvedilol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI
Venetoclax	Nifedipine	3	Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Venetoclax	Epinephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Venetoclax	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Venetoclax	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Venetoclax	Phenylephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Venetoclax	Propranolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI
Venetoclax	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Venetoclax	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bosentan	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bosentan	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Doxazosin	Ioversol	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C19 mediated DDI
Doxazosin	Iomeprol	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Iopromide	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Isosorbide dinitrate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Doxazosin	Gefitinib	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C19 mediated DDI
Doxazosin	Ivabradine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Doxazosin	Cabozantinib	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Drotaverine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Doxazosin	Sulpiride	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Doxazosin	Mebendazole	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C19 mediated DDI
Doxazosin	Metoclopramide	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Periciazine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Doxazosin	Tetrabenazine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Doxazosin	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Doxazosin	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Doxazosin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doxazosin	Fingolimod	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Haloperidol	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Doxazosin	Procainamide	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Chlorpromazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Doxazosin	Clomifene	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doxazosin	Ropivacaine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Doxazosin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Doxycycline	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doxycycline	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Alendronic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Hexoprenaline	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Imipenem	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Iohexol	Carvedilol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iohexol	Fenoterol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Iohexol	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Nifedipine	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Iohexol	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Dobutamine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Epinephrine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Fosfomycin	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Norepinephrine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iohexol	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Sotalol	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iohexol	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Fingolimod	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Iohexol	Haloperidol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Iohexol	Loperamide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iohexol	Procainamide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Propranolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Iohexol	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iohexol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iohexol	Clomifene	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Iohexol	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iohexol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iohexol	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Lidocaine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iohexol	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Iohexol	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iohexol	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iohexol	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Ioversol	Posaconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ioversol	Alendronic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Ertapenem	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Atazanavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Darunavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Gefitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ioversol	Imatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Ombitasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ioversol	Saquinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Ciprofloxacin	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation
Ioversol	Imipenem	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Irinotecan	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Meropenem	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ioversol	Carvedilol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ioversol	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Ioversol	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ioversol	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ioversol	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ioversol	Dapsone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Dobutamine	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Ioversol	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ioversol	Norepinephrine	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Ioversol	Oxybuprocaine	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Ioversol	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ioversol	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Sotalol	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ioversol	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ioversol	Captopril	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Clonidine	3	Major DDI	DDI causing hypotension; DDI causing tachycardia
Ioversol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ioversol	Fingolimod	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Ioversol	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ioversol	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ioversol	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Phenylephrine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Ioversol	Procainamide	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia
Ioversol	Procaine	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Ioversol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ioversol	Clomifene	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Ioversol	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ioversol	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ioversol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ioversol	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Lidocaine	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Ioversol	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ioversol	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ioversol	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ioversol	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Ioversol	Mitotane	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Macitentan	Gefitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Macitentan	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Macitentan	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Macitentan	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Macitentan	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Macitentan	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Macitentan	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Macitentan	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Macitentan	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pemetrexed	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pemetrexed	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pemetrexed	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pemetrexed	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pemetrexed	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pemetrexed	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pemetrexed	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Posaconazole	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Posaconazole	Iopromide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Posaconazole	Bictegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Bromocriptine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Posaconazole	Irinotecan	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Atorvastatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Posaconazole	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Posaconazole	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Sotalol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Posaconazole	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Posaconazole	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Posaconazole	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Posaconazole	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Posaconazole	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Posaconazole	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Posaconazole	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Posaconazole	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Posaconazole	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Posaconazole	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Posaconazole	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Posaconazole	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Posaconazole	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP3A4 mediated DDI
Posaconazole	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Posaconazole	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Raltitrexed	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Raltitrexed	Fenoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Raltitrexed	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Raltitrexed	Epinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Raltitrexed	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Raltitrexed	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Raltitrexed	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Raltitrexed	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Raltitrexed	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltitrexed	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Raltitrexed	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Raltitrexed	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Remdesivir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Remdesivir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Riboflavin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Tetracycline	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetracycline	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Deferasirox	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ticagrelor	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ticagrelor	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ticagrelor	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ticagrelor	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ticagrelor	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ticagrelor	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ticagrelor	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ticagrelor	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Valganciclovir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vinblastine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Vinblastine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alendronic acid	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alendronic acid	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alendronic acid	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alfuzosin	Bosutinib	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Alfuzosin	Piribedil	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Cetirizine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Drotaverine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Alfuzosin	Hydroxyzine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Alfuzosin	Oxybuprocaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Perphenazine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alfuzosin	Cariprazine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Alfuzosin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Alfuzosin	Fingolimod	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Alfuzosin	Flutamide	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Alfuzosin	Procainamide	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Alfuzosin	Teriflunomide	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension
Alfuzosin	Tropicamide	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Alfuzosin	Agomelatine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2C19 mediated DDI
Alfuzosin	Clomipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Alfuzosin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alfuzosin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alfuzosin	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Azacitidine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bosutinib	Ceritinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bosutinib	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bosutinib	Nintedanib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Bosutinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bosutinib	Chloramphenicol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Bosutinib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Paliperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Bosutinib	Aminosalicylic acid	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Bosutinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bosutinib	Mebendazole	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Bosutinib	Mesalazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Bosutinib	Perphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Bosutinib	Propafenone	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Bosutinib	Risperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Bosutinib	Sotalol	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Bosutinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bosutinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bosutinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bosutinib	Flupentixol	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bosutinib	Methotrimeprazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Procaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Bosutinib	Salicylic acid	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bosutinib	Agomelatine	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Chlorpromazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Clomipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bosutinib	Imipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bosutinib	Lidocaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Bosutinib	Cinacalcet	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bosutinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Ertapenem	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Lisinopril	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension
Carfilzomib	Piribedil	3	Major DDI	DDI causing hypotension; DDI causing tachycardia
Carfilzomib	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carfilzomib	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Carfilzomib	Chloramphenicol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Carfilzomib	Enalapril	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension
Carfilzomib	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2B6 mediated DDI
Carfilzomib	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Carfilzomib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carfilzomib	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carfilzomib	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Aminocaproic acid	3	Major DDI	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carfilzomib	Atropine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Carfilzomib	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2B6 mediated DDI
Carfilzomib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carfilzomib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Carfilzomib	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Carfilzomib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Carfilzomib	Salicylic acid	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Carfilzomib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carfilzomib	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Carfilzomib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carfilzomib	Acetaminophen	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Carfilzomib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carfilzomib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Carfilzomib	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Carfilzomib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carfilzomib	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carfilzomib	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carfilzomib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Carfilzomib	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Carfilzomib	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Carfilzomib	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Delamanid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Hexoprenaline	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C9 mediated DDI
Ceritinib	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Iopromide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Riociguat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Ceritinib	Apremilast	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Gefitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Linagliptin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ceritinib	Raltegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Saquinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Selexipag	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Acalabrutinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Bromocriptine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Irinotecan	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Ivabradine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Nilotinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Tamsulosin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ceritinib	Verapamil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ceritinib	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ceritinib	Atorvastatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Ceritinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Bisoprolol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Cabozantinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Carvedilol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI
Ceritinib	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Dorzolamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Mebeverine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI
Ceritinib	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Paliperidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Phenoxymethylpenicillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Trametinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Atenolol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Ethambutol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Lenvatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Metoclopramide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Metoprolol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Nevirapine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Oxybuprocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ceritinib	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Propafenone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI
Ceritinib	Risperidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Ceritinib	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP3A4 mediated DDI
Ceritinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ceritinib	Bisacodyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ceritinib	Caffeine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ceritinib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ceritinib	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ceritinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Fluorescein	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ceritinib	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ceritinib	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ceritinib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ceritinib	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Ceritinib	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Procaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Propranolol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Betahistine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ceritinib	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Brivaracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ceritinib	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ceritinib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ceritinib	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ceritinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Loratadine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ceritinib	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ceritinib	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ceritinib	Protionamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ceritinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ceritinib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Dabigatran etexilate	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Dabigatran etexilate	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dasatinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasatinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasatinib	Procarbazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Dasatinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Dasatinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasatinib	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Delamanid	Hexoprenaline	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Delamanid	Verapamil	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Delamanid	Fenoterol	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Delamanid	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Delamanid	Norepinephrine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Delamanid	Sotalol	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Delamanid	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Delamanid	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Delamanid	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Delamanid	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Delamanid	Procainamide	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia
Delamanid	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Delamanid	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Delamanid	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI
Delamanid	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Delamanid	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Delamanid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Delamanid	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Delamanid	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ertapenem	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Verapamil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP3A4 mediated DDI
Ertapenem	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ertapenem	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ertapenem	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Ertapenem	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ertapenem	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ertapenem	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Ertapenem	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertapenem	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Ertapenem	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Fludarabine	Halothane	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Fosamprenavir	Iomeprol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fosamprenavir	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Fosamprenavir	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Fosamprenavir	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Phenylephrine	3	CLASS 1 (from 3); Major DDI	DDI causing tachycardia
Fosamprenavir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Fosamprenavir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Fosamprenavir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fosamprenavir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Fosamprenavir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Fosamprenavir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fosamprenavir	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Hexoprenaline	Palbociclib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Hexoprenaline	Abemaciclib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2C9 mediated DDI
Hexoprenaline	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Hexoprenaline	Lisinopril	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Hexoprenaline	Ombitasvir	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Hexoprenaline	Osimertinib	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Hexoprenaline	Timolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Hexoprenaline	Bortezomib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Bromocriptine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Hexoprenaline	Vandetanib	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Ibrutinib	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Hexoprenaline	Trametinib	3	Major DDI	DDI causing hypertension; DDI causing arrhythmia
Hexoprenaline	Indapamide	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Hexoprenaline	Lenvatinib	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Hexoprenaline	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Hexoprenaline	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Hexoprenaline	Sulfamethoxazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Hexoprenaline	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Hexoprenaline	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Hexoprenaline	Dexketoprofen	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Ketoprofen	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Tramadol	3	CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Hexoprenaline	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Hexoprenaline	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C9 mediated DDI
Hexoprenaline	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iomeprol	Afatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Atazanavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Cobicistat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Darunavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Gefitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Imatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Lisinopril	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Moxifloxacin	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation
Iomeprol	Ombitasvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Raltegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Saquinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Bictegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iomeprol	Ciprofloxacin	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation
Iomeprol	Dolutegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iomeprol	Imipenem	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Irinotecan	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Ivabradine	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iomeprol	Meropenem	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Nilotinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Vandetanib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Iomeprol	Formoterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Iomeprol	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Iomeprol	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Epinephrine	3	Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP2D6 mediated DDI
Iomeprol	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Iomeprol	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iomeprol	Metoclopramide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iomeprol	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Bisacodyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iomeprol	Captopril	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iomeprol	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Lacosamide	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iomeprol	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iomeprol	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iomeprol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Lidocaine	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia
Iomeprol	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Iomeprol	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iomeprol	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Benzyl benzoate	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Iomeprol	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iomeprol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iomeprol	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Iopromide	Atazanavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iopromide	Gefitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Carbidopa	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iopromide	Imipenem	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Nimodipine	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Iopromide	Nintedanib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Iopromide	Olodaterol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Iopromide	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Iopromide	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Iopromide	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Iopromide	Formoterol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Iopromide	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iopromide	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Salmeterol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Sulpiride	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Iopromide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Iopromide	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iopromide	Indacaterol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iopromide	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Iopromide	Metoclopramide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Iopromide	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iopromide	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Iopromide	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iopromide	Caffeine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Iopromide	Captopril	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iopromide	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Iopromide	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iopromide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iopromide	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iopromide	Tramadol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Iopromide	Umifenovir	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Iopromide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iopromide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Iopromide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Iopromide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iopromide	Benzyl benzoate	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Iopromide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Iopromide	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Iopromide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Isosorbide dinitrate	Lisinopril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Drotaverine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Enalapril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Fenoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Isosorbide dinitrate	Atenolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Ethambutol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Metoprolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Propafenone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Captopril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Propranolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide dinitrate	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Isosorbide dinitrate	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Palbociclib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Palbociclib	Carvedilol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Palbociclib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Palbociclib	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Palbociclib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Palbociclib	Procarbazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Palbociclib	Propranolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Palbociclib	Trifluoperazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Palbociclib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Palbociclib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Palbociclib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Riociguat	Fenoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Riociguat	Telbivudine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Riociguat	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Riociguat	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Riociguat	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Riociguat	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Riociguat	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Riociguat	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Riociguat	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Riociguat	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Riociguat	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Riociguat	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Riociguat	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Riociguat	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Riociguat	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Riociguat	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Riociguat	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Riociguat	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Riociguat	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Sulfasalazine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Sulfasalazine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sulfasalazine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sulfasalazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Sulfasalazine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Sulfasalazine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Tenofovir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tenofovir	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tenofovir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Tenofovir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Tenofovir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tenofovir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Tenofovir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tenofovir	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Tenofovir	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Velpatasvir	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Velpatasvir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Velpatasvir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Velpatasvir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Velpatasvir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Velpatasvir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Velpatasvir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Velpatasvir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Velpatasvir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Velpatasvir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Velpatasvir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Velpatasvir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Velpatasvir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Velpatasvir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Velpatasvir	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vinorelbine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Zoledronic acid	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Abemaciclib	Bisoprolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Abemaciclib	Carvedilol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Abemaciclib	Fenoterol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Abemaciclib	Atenolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Abemaciclib	Epinephrine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Abemaciclib	Metoprolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Abemaciclib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Abemaciclib	Phenylephrine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Abemaciclib	Propranolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Abemaciclib	Teriflunomide	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Abemaciclib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Abemaciclib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Abemaciclib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Abemaciclib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acyclovir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Afatinib	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Afatinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Afatinib	Metoclopramide	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Afatinib	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Afatinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Afatinib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Afatinib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Afatinib	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Afatinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Afatinib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Afatinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Afatinib	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Tamoxifen	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Afatinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Afatinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Afatinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Afatinib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apremilast	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apremilast	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apremilast	Mebeverine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Apremilast	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apremilast	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Fosfomycin	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Apremilast	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Metoclopramide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apremilast	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Apremilast	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apremilast	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Apremilast	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Apremilast	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apremilast	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apremilast	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apremilast	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Apremilast	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apremilast	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Apremilast	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apremilast	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Irinotecan	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Atazanavir	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Atorvastatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Atazanavir	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Formoterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Atazanavir	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Atazanavir	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atazanavir	Salmeterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atazanavir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atazanavir	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Atropine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Atazanavir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atazanavir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Atazanavir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Methotrimeprazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atazanavir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atazanavir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atazanavir	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atazanavir	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Atazanavir	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atazanavir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atazanavir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Atazanavir	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atazanavir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Atazanavir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atazanavir	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Benserazide	Nimodipine	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Benserazide	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Benserazide	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Benserazide	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Benserazide	Atropine	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing tachycardia
Benserazide	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Benserazide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Benserazide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Benserazide	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Benserazide	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Benserazide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Benserazide	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Benserazide	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Benserazide	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Benserazide	Clomipramine	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Benserazide	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Benserazide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Benserazide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Benserazide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Benserazide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Benserazide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Benserazide	Amitriptyline	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Benserazide	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Benserazide	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Cladribine	Oxybuprocaine	3	Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI
Cladribine	Dopamine	3	Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2C9 mediated DDI
Cladribine	Propranolol	3	Major DDI	DDI causing arrhythmia; DDI causing tachycardia
Cobicistat	Irinotecan	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Cobicistat	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Cobicistat	Atorvastatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Fenoterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Cobicistat	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Cobicistat	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cobicistat	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cobicistat	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobicistat	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cobicistat	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cobicistat	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Cobicistat	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cobicistat	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cobicistat	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Cobicistat	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cobicistat	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Cobicistat	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cobicistat	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cobicistat	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cobicistat	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Cobicistat	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cobicistat	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cobicistat	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobicistat	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cobicistat	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Cobicistat	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cobicistat	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cobicistat	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Cobicistat	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Cytarabine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Darunavir	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Darunavir	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Darunavir	Atorvastatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Darunavir	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Darunavir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Darunavir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Darunavir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Darunavir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Darunavir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Darunavir	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Darunavir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Darunavir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Darunavir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Darunavir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Darunavir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Elbasvir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Elbasvir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elbasvir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Elbasvir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Elbasvir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Elbasvir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Elbasvir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elbasvir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Elbasvir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elbasvir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Elbasvir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elbasvir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Elbasvir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Elbasvir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Elbasvir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Elbasvir	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Empagliflozin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Empagliflozin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI
Empagliflozin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Empagliflozin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Empagliflozin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Empagliflozin	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Empagliflozin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Empagliflozin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Erlotinib	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Erlotinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Erlotinib	Metoclopramide	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Erlotinib	Oxybuprocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Erlotinib	Periciazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Erlotinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Erlotinib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Erlotinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Erlotinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Erlotinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Erlotinib	Methotrimeprazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Erlotinib	Procaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Erlotinib	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Erlotinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Erlotinib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Erlotinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Erlotinib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Erlotinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Erlotinib	Ropivacaine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Erlotinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Erlotinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ertugliflozin	Methyldopa	3	CLASS 1 (from 3)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI
Ertugliflozin	Ethambutol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Ertugliflozin	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ertugliflozin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Ertugliflozin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Ertugliflozin	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ertugliflozin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ertugliflozin	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Ertugliflozin	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Ertugliflozin	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ertugliflozin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Ertugliflozin	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ertugliflozin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ertugliflozin	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Ertugliflozin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Lapatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Vandetanib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Alectinib	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C8 mediated DDI
Gefitinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gefitinib	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gefitinib	Drotaverine	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Gefitinib	Fenoterol	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Gefitinib	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Formoterol	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI
Gefitinib	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Gefitinib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gefitinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gefitinib	Sulpiride	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gefitinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Epinephrine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI
Gefitinib	Norepinephrine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Gefitinib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gefitinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gefitinib	Cariprazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Gefitinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gefitinib	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Gefitinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gefitinib	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gefitinib	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gefitinib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gefitinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Gefitinib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gefitinib	Sunitinib	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gefitinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gefitinib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Gefitinib	Zuclopenthixol	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Gefitinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gefitinib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gefitinib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gefitinib	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gefitinib	Benzyl benzoate	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Gefitinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Gefitinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imatinib	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Imatinib	Verapamil	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP3A4 mediated DDI
Imatinib	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Imatinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imatinib	Bisoprolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Imatinib	Carvedilol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Imatinib	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Imatinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Imatinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Imatinib	Oxybuprocaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Imatinib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Imatinib	Propafenone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Imatinib	Risperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Imatinib	Salbutamol	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Imatinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imatinib	Cariprazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Imatinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Imatinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Imatinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imatinib	Procaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C9 mediated DDI
Imatinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imatinib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Imatinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imatinib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Imatinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imatinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Imatinib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imatinib	Lidocaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Imatinib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Imatinib	Benzyl benzoate	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Imatinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Imatinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Deferasirox	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Irinotecan	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Ivabradine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Nilotinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Tamsulosin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lapatinib	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Vandetanib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Lapatinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Cabozantinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Carvedilol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lapatinib	Crizotinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Drotaverine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lapatinib	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Salmeterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Lapatinib	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Trametinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Epinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Lapatinib	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Lenvatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Metoclopramide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lapatinib	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lapatinib	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Lapatinib	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Aminocaproic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Lapatinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Lapatinib	Chlorambucil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Lapatinib	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Lapatinib	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lapatinib	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Salicylic acid	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Lapatinib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Lapatinib	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Lapatinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lapatinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lapatinib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lapatinib	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C9 mediated DDI
Lapatinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lapatinib	Pirfenidone	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Lapatinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Levofloxacin	Raltegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Levofloxacin	Urapidil	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Levofloxacin	Atenolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Levofloxacin	Mebendazole	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Levofloxacin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Levofloxacin	Fluoxetine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Ropivacaine	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Levofloxacin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Linagliptin	Ribociclib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Linagliptin	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Linagliptin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Linagliptin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Linagliptin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Lisinopril	Isosorbide mononitrate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Lisinopril	Chloramphenicol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Lisinopril	Formoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Lisinopril	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Lisinopril	Methyldopa	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension
Lisinopril	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Lisinopril	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lisinopril	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Lisinopril	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Lisinopril	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Lisinopril	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Lisinopril	Caffeine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Lisinopril	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Lisinopril	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lisinopril	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lisinopril	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Lisinopril	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Lisinopril	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Lisinopril	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Lisinopril	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Lisinopril	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Lisinopril	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Lisinopril	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Lisinopril	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lisinopril	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lisinopril	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Lisinopril	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Lisinopril	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lisinopril	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Lisinopril	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Lisinopril	Nicotinamide	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Lisinopril	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Lisinopril	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Lisinopril	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Lisinopril	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Lisinopril	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Lisinopril	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Lisinopril	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Mitomycin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mitomycin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mitomycin	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Moxifloxacin	Raltegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Moxifloxacin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxifloxacin	Fluconazole	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Moxifloxacin	Glyburide	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Moxifloxacin	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxifloxacin	Paroxetine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Moxifloxacin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxifloxacin	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxifloxacin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxifloxacin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxifloxacin	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Moxifloxacin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxifloxacin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxifloxacin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ofloxacin	Raltegravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ofloxacin	Urapidil	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ofloxacin	Atenolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Ofloxacin	Mebendazole	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ofloxacin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ofloxacin	Fluoxetine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Ropivacaine	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ofloxacin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ombitasvir	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ombitasvir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ombitasvir	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ombitasvir	Fenoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Ombitasvir	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Ombitasvir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ombitasvir	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ombitasvir	Epinephrine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Ombitasvir	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ombitasvir	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ombitasvir	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Ombitasvir	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ombitasvir	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ombitasvir	Sotalol	3	Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ombitasvir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ombitasvir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Ombitasvir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ombitasvir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ombitasvir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Ombitasvir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ombitasvir	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ombitasvir	Perampanel	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Ombitasvir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ombitasvir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ombitasvir	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ombitasvir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ombitasvir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ombitasvir	Chlorpromazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Ombitasvir	Clomipramine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ombitasvir	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Ombitasvir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ombitasvir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ombitasvir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Ombitasvir	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Ombitasvir	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ombitasvir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ombitasvir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ombitasvir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ombitasvir	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Ombitasvir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Osimertinib	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Osimertinib	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Fenoterol	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Osimertinib	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Osimertinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Osimertinib	Dobutamine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Osimertinib	Epinephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Osimertinib	Ethambutol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Fluphenazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Osimertinib	Norepinephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Osimertinib	Salbutamol	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Osimertinib	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Osimertinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Osimertinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Osimertinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Osimertinib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Phenylephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Osimertinib	Procainamide	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Osimertinib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Osimertinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Osimertinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Osimertinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Osimertinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Osimertinib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Pazopanib	Atenolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Pazopanib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pazopanib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Pazopanib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pazopanib	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Raltegravir	Ribociclib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltegravir	Ciprofloxacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Raltegravir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Raltegravir	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Raltegravir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Raltegravir	Epinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Raltegravir	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Raltegravir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Raltegravir	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Raltegravir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Raltegravir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Raltegravir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ribociclib	Carbidopa	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ribociclib	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ribociclib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ribociclib	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Ribociclib	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ribociclib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ribociclib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ribociclib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ribociclib	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ribociclib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Ribociclib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ribociclib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ribociclib	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Ribociclib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ribociclib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Sapropterin	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Saquinavir	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Saquinavir	Verapamil	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Saquinavir	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Atorvastatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Saquinavir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Saquinavir	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Saquinavir	Carvedilol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP3A4 mediated DDI
Saquinavir	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Saquinavir	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Saquinavir	Salmeterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Saquinavir	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Saquinavir	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Saquinavir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Saquinavir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Saquinavir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Saquinavir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Saquinavir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Saquinavir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Saquinavir	Propranolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2B6 mediated DDI
Saquinavir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Saquinavir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Zuclopenthixol	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Saquinavir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Saquinavir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Saquinavir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Saquinavir	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Saquinavir	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Saquinavir	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Saquinavir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Saquinavir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Saquinavir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Saquinavir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Selexipag	Formoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Selexipag	Salmeterol	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Selexipag	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Selexipag	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Selexipag	Epinephrine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Selexipag	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Selexipag	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Selexipag	Flutamide	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Selexipag	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI
Selexipag	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Selexipag	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Selexipag	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Selexipag	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Selexipag	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Selexipag	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Selexipag	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Selexipag	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Selexipag	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Selexipag	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Selexipag	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Selexipag	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Selexipag	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Selexipag	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Sparfloxacin	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sparfloxacin	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Sparfloxacin	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sparfloxacin	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sparfloxacin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sparfloxacin	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sparfloxacin	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sparfloxacin	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sparfloxacin	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sparfloxacin	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sparfloxacin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sparfloxacin	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Tazobactam	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tedizolid	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tedizolid	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tedizolid	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Tedizolid	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tedizolid	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Tedizolid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tedizolid	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tedizolid	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tenofovir alafenamide	Sotalol	3	CLASS 1 (from 3); Major DDI	DDI causing tachycardia
Tenofovir alafenamide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tenofovir alafenamide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir alafenamide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir alafenamide	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir alafenamide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tenofovir alafenamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Tenofovir alafenamide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Timolol	Carbidopa	3	Major DDI	DDI causing hypotension; DDI causing bradycardia
Timolol	Vilanterol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Timolol	Fenoterol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Timolol	Methyldopa	3	Major DDI	DDI causing hypotension; DDI causing bradycardia
Timolol	Epinephrine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Timolol	Phenylephrine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Timolol	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Trimethoprim	Fluphenazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Trimethoprim	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Trimethoprim	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Trimethoprim	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Trimethoprim	Trifluoperazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Trimethoprim	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Trimethoprim	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Trimethoprim	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Trimethoprim	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Trimethoprim	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Carbidopa	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Acalabrutinib	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Acalabrutinib	Verapamil	3	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Acalabrutinib	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Acalabrutinib	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Carvedilol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Acalabrutinib	Chloramphenicol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Acalabrutinib	Mebeverine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Methyldopa	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Acalabrutinib	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Acalabrutinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Acalabrutinib	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Acalabrutinib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Acalabrutinib	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Acalabrutinib	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Acalabrutinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Acalabrutinib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Acalabrutinib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Acalabrutinib	Propranolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI
Acalabrutinib	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Acalabrutinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Acalabrutinib	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Acalabrutinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Acalabrutinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Lidocaine	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia
Acalabrutinib	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Acalabrutinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Acalabrutinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acalabrutinib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Acalabrutinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Acalabrutinib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ambrisentan	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Ambrisentan	Mebeverine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ambrisentan	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Ambrisentan	Oseltamivir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ambrisentan	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ambrisentan	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ambrisentan	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Ambrisentan	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ambrisentan	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ambrisentan	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ambrisentan	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Ambrisentan	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ambrisentan	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ambrisentan	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Azathioprine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Azathioprine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Baricitinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Baricitinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Baricitinib	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Baricitinib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bictegravir	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Bictegravir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bictegravir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bictegravir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bictegravir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bictegravir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Bictegravir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bictegravir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bictegravir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Bictegravir	Chlorpromazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Bictegravir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bictegravir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bictegravir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Bictegravir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bictegravir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bictegravir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Bortezomib	Fenoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Bortezomib	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Bortezomib	Epinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Bortezomib	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Bortezomib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bortezomib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bortezomib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Bortezomib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bortezomib	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Bortezomib	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bortezomib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bortezomib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bortezomib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bortezomib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bortezomib	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Bortezomib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Bromocriptine	Levodopa	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Bromocriptine	Linezolid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bromocriptine	Rivaroxaban	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bromocriptine	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bromocriptine	Atenolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Bromocriptine	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bromocriptine	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Bromocriptine	Metoprolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Bromocriptine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bromocriptine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bromocriptine	Efavirenz	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Bromocriptine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bromocriptine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bromocriptine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Bromocriptine	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bromocriptine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bromocriptine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Bromocriptine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Bromocriptine	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Capecitabine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Capecitabine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Carbidopa	Ivabradine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Carbidopa	Lumacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Carbidopa	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Verapamil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Carbidopa	Cetirizine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Drotaverine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C8 mediated DDI
Carbidopa	Levodopa	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Carbidopa	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Carbidopa	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Carbidopa	Rivaroxaban	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbidopa	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Carbidopa	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Carbidopa	Atenolol	3	CLASS 1 (from 3)	DDI causing hypotension; DDI causing bradycardia	CYP2C8 mediated DDI
Carbidopa	Ethambutol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Carbidopa	Hydroxyzine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Carbidopa	Metoclopramide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Carbidopa	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Carbidopa	Salbutamol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Carbidopa	Acetylsalicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Carbidopa	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Carbidopa	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Clonidine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Carbidopa	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Carbidopa	Diclofenac	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Carbidopa	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Carbidopa	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Carbidopa	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Carbidopa	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Carbidopa	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Carbidopa	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Carbidopa	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Carbidopa	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Carbidopa	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Carbidopa	Tranexamic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbidopa	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Carbidopa	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carbidopa	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Carbidopa	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carbidopa	Efavirenz	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Carbidopa	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Carbidopa	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Carbidopa	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Carbidopa	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Carbidopa	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Carbidopa	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Carbidopa	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Carbidopa	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Carbidopa	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cilastatin	Formoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cilastatin	Salmeterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cilastatin	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cilastatin	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cilastatin	Atropine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Cilastatin	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cilastatin	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Cilastatin	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cilastatin	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Cilastatin	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cilastatin	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cilastatin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Cilastatin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Cilastatin	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Ciprofloxacin	Urapidil	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Alogliptin	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ciprofloxacin	Bicalutamide	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ciprofloxacin	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ciprofloxacin	Mebendazole	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Ciprofloxacin	Paroxetine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Ciprofloxacin	Dopamine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Procainamide	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Procarbazine	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation
Ciprofloxacin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ciprofloxacin	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Ropivacaine	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Ciprofloxacin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Dabrafenib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dabrafenib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Daclatasvir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Daclatasvir	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Daclatasvir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Daclatasvir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Daclatasvir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Daclatasvir	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Daclatasvir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Daclatasvir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Daclatasvir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Daclatasvir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Daclatasvir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Daclatasvir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Daclatasvir	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Dapagliflozin	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Dapagliflozin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Dapagliflozin	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Dapagliflozin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dapagliflozin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Dapagliflozin	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Dapagliflozin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Deferasirox	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Deferasirox	Fenoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Deferasirox	Formoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Deferasirox	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Deferasirox	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Deferasirox	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Deferasirox	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Deferasirox	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Deferasirox	Sulfamethoxazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Deferasirox	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Deferasirox	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Deferasirox	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Deferasirox	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Deferasirox	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Deferasirox	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Deferasirox	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Deferasirox	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Deferasirox	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Deferasirox	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Deferasirox	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Deferasirox	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Deferasirox	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Deferasirox	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Deferasirox	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Deferasirox	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Dolutegravir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Dolutegravir	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dolutegravir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dolutegravir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Dolutegravir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dolutegravir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dolutegravir	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dolutegravir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Dolutegravir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Dolutegravir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dolutegravir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dolutegravir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Elvitegravir	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Elvitegravir	Verapamil	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Elvitegravir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Elvitegravir	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Elvitegravir	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elvitegravir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Elvitegravir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Elvitegravir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Elvitegravir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elvitegravir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Elvitegravir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elvitegravir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Elvitegravir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elvitegravir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Elvitegravir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elvitegravir	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Elvitegravir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Elvitegravir	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Elvitegravir	Mitotane	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Etravirine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Etravirine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Etravirine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Etravirine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gemcitabine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Gosogliptin	Nintedanib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Quetiapine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Atenolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia
Gosogliptin	Fluphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Metoclopramide	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Gosogliptin	Oxybuprocaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Perphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gosogliptin	Procainamide	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Gosogliptin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gosogliptin	Chlorpromazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Clomipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Imipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Gosogliptin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Gosogliptin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gosogliptin	Mitotane	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP3A4 mediated DDI
Imipenem	Rivaroxaban	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imipenem	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imipenem	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Imipenem	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Irinotecan	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Irinotecan	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Irinotecan	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Irinotecan	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Irinotecan	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Irinotecan	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Irinotecan	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Irinotecan	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Isosorbide mononitrate	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide mononitrate	Drotaverine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide mononitrate	Enalapril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide mononitrate	Fenoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Isosorbide mononitrate	Atenolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide mononitrate	Metoprolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide mononitrate	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide mononitrate	Propranolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Isosorbide mononitrate	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Ivabradine	Nintedanib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Alogliptin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Cabozantinib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Chloramphenicol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Ivabradine	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ivabradine	Atenolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Oseltamivir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Ivabradine	Oxybuprocaine	3	Major DDI	DDI causing arrhythmia; DDI causing tachycardia
Ivabradine	Periciazine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Ivabradine	Perphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Ivabradine	Sotalol	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Flutamide	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Ivabradine	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ivabradine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ivabradine	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Chlorpromazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Ivabradine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Ivabradine	Lidocaine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Ivabradine	Tamoxifen	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivabradine	Benzyl benzoate	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Ivabradine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Ivabradine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ixabepilone	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Levosimendan	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Levosimendan	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Levosimendan	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Levosimendan	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Levosimendan	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Levosimendan	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Levosimendan	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Levosimendan	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Levosimendan	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Levosimendan	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Lomefloxacin	Atenolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Lomefloxacin	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lomefloxacin	Dopamine	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Lomefloxacin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lomefloxacin	Loperamide	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lomefloxacin	Propranolol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP1A2 mediated DDI
Lomefloxacin	Teriflunomide	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation
Lomefloxacin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lomefloxacin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lomefloxacin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lomefloxacin	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lomefloxacin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Lomefloxacin	Mitotane	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Lumacaftor	Nimodipine	3	Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP2C9 mediated DDI
Lumacaftor	Amlodipine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Lumacaftor	Carvedilol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Lumacaftor	Formoterol	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Lumacaftor	Methyldopa	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Lumacaftor	Epinephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Lumacaftor	Fluphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Lumacaftor	Norepinephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Lumacaftor	Perphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Lumacaftor	Propafenone	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Lumacaftor	Clonidine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Lumacaftor	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lumacaftor	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lumacaftor	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Lumacaftor	Phenylephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Lumacaftor	Propranolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Lumacaftor	Trifluoperazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Lumacaftor	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Lumacaftor	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Mannitol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Mannitol	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Mannitol	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Mannitol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Mannitol	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Meropenem	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Meropenem	Rivaroxaban	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Meropenem	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Meropenem	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Meropenem	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Meropenem	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Meropenem	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Meropenem	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Meropenem	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Meropenem	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Moxonidine	Tizanidine	3	Major DDI	DDI causing hypotension; DDI causing tachycardia
Moxonidine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxonidine	Clomifene	3	CLASS 1 (from 3)	DDI causing hypotension; DDI causing tachycardia
Moxonidine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Moxonidine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Moxonidine	Mitotane	3	Major DDI	DDI causing hypotension; DDI causing tachycardia
Mycophenolate mofetil	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mycophenolate mofetil	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nilotinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Nilotinib	Fenoterol	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Nilotinib	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nilotinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nilotinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nilotinib	Epinephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Nilotinib	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nilotinib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Nilotinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nilotinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nilotinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nilotinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nilotinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nilotinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nilotinib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Nilotinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nilotinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Nilotinib	Nicotinamide	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Nilotinib	Tapentadol	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Nilotinib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C8 mediated DDI
Nilotinib	Amitriptyline	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Nilotinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Nilotinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nimodipine	Bicalutamide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Chloramphenicol	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia
Nimodipine	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Nimodipine	Siponimod	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Nimodipine	Risperidone	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension
Nimodipine	Vemurafenib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Nimodipine	Axitinib	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Chlorambucil	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nimodipine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Nimodipine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Nimodipine	Fulvestrant	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Nimodipine	Lacosamide	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Regorafenib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Umifenovir	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP2C19 mediated DDI
Nimodipine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nimodipine	Betahistine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Nimodipine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nimodipine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nimodipine	Pyrantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Nimodipine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Nintedanib	Rilpivirine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C8 mediated DDI; CYP3A4 mediated DDI
Nintedanib	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Nintedanib	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C9 mediated DDI
Nintedanib	Paliperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Nintedanib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nintedanib	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Nintedanib	Indacaterol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI
Nintedanib	Ivacaftor	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nintedanib	Mebendazole	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nintedanib	Metoclopramide	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Nintedanib	Oseltamivir	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia
Nintedanib	Perphenazine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Nintedanib	Risperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Nintedanib	Vismodegib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP3A4 mediated DDI
Nintedanib	Caffeine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Nintedanib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nintedanib	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Nintedanib	Sunitinib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Nintedanib	Teriflunomide	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nintedanib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Nintedanib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Nintedanib	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Nintedanib	Clomipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Nintedanib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Nintedanib	Levamisole	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia
Nintedanib	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Nintedanib	Piracetam	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Nintedanib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Nintedanib	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nintedanib	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Nintedanib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olodaterol	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olodaterol	Chloramphenicol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Olodaterol	Mebeverine	3	CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Methyldopa	3	CLASS 1 (from 3)	DDI causing tachycardia; DDI causing bradycardia
Olodaterol	Salmeterol	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Olodaterol	Siponimod	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C8 mediated DDI
Olodaterol	Oseltamivir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Olodaterol	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Olodaterol	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Olodaterol	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Olodaterol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olodaterol	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Olodaterol	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Olodaterol	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Olodaterol	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Olodaterol	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olodaterol	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Olodaterol	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Olodaterol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Olodaterol	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Olodaterol	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Olodaterol	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Olodaterol	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Olodaterol	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Olodaterol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olodaterol	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Olodaterol	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Olodaterol	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Olodaterol	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Olodaterol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Olodaterol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Olodaterol	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Olodaterol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Piribedil	Verapamil	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Piribedil	Carvedilol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Piribedil	Sulpiride	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Piribedil	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Piribedil	Fluphenazine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Piribedil	Periciazine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Piribedil	Sotalol	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Piribedil	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Piribedil	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Piribedil	Flupentixol	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Piribedil	Haloperidol	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Piribedil	Perampanel	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP3A4 mediated DDI
Piribedil	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Piribedil	Acetaminophen	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Piribedil	Agomelatine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Piribedil	Clomifene	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Piribedil	Clomipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Piribedil	Fluoxetine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Piribedil	Imipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Piribedil	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Piribedil	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Piribedil	Amitriptyline	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Piribedil	Cinacalcet	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Rilpivirine	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rilpivirine	Fluphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP3A4 mediated DDI
Rilpivirine	Oxybuprocaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Rilpivirine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rilpivirine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Rilpivirine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Rilpivirine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Rilpivirine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Rilpivirine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Rilpivirine	Benzyl benzoate	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Rilpivirine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Rilpivirine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Risdiplam	Fosfomycin	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Risdiplam	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Risdiplam	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Ritonavir	Terizidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Urapidil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Ritonavir	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ritonavir	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ritonavir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Ritonavir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ritonavir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Ritonavir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ritonavir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Procainamide	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ritonavir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Ritonavir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Ritonavir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ritonavir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ritonavir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Ritonavir	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Sofosbuvir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sofosbuvir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sofosbuvir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sofosbuvir	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Tamsulosin	Chloramphenicol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Tamsulosin	Levodopa	3	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Tamsulosin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tamsulosin	Oseltamivir	3	CLASS 1 (from 3)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tamsulosin	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Tamsulosin	Atropine	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Tamsulosin	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Tamsulosin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tamsulosin	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Tamsulosin	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Tamsulosin	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tamsulosin	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Tamsulosin	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Tamsulosin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Tamsulosin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Tamsulosin	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Tamsulosin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Tamsulosin	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Tamsulosin	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Tamsulosin	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Terizidone	Vandetanib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Terizidone	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Terizidone	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Terizidone	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Terizidone	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Linezolid	3	Major DDI	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Terizidone	Lopinavir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Terizidone	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Terizidone	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Terizidone	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Terizidone	Lenvatinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Metoclopramide	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Terizidone	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Terizidone	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Terizidone	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Terizidone	Tafluprost	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C8 mediated DDI
Terizidone	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Terizidone	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Terizidone	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Terizidone	Caffeine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Terizidone	Captopril	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension
Terizidone	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Terizidone	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Terizidone	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Terizidone	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Terizidone	Betahistine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Terizidone	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Terizidone	Dimethyl fumarate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Terizidone	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Terizidone	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Terizidone	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Terizidone	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Terizidone	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C8 mediated DDI
Terizidone	Desflurane	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Terizidone	Ethanol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Terizidone	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Terizidone	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Terizidone	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Urapidil	Alectinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Bisoprolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Urapidil	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Enalapril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Urapidil	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Urapidil	Formoterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Urapidil	Mebeverine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Methyldopa	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Urapidil	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Urapidil	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Urapidil	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Urapidil	Atenolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Epinephrine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Urapidil	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Lenvatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Urapidil	Metoprolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Urapidil	Oxybuprocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Urapidil	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Urapidil	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Urapidil	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Urapidil	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Urapidil	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Urapidil	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Urapidil	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Urapidil	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Urapidil	Phenylephrine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Urapidil	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Propranolol	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Urapidil	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Urapidil	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Urapidil	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Urapidil	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Urapidil	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Urapidil	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Urapidil	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Urapidil	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Urapidil	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Urapidil	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Urapidil	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Urapidil	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Urapidil	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Urapidil	Oxaliplatin	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Vandetanib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Vandetanib	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Fenoterol	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Vandetanib	Mebeverine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Vandetanib	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Vandetanib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vandetanib	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Vandetanib	Norepinephrine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Vandetanib	Oxybuprocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vandetanib	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Vandetanib	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vandetanib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vandetanib	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vandetanib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Vandetanib	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vandetanib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vandetanib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Vandetanib	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Vandetanib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Vandetanib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Vandetanib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vandetanib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Vandetanib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Vandetanib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Verapamil	Apixaban	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia	CYP3A4 mediated DDI
Verapamil	Atorvastatin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP3A4 mediated DDI
Verapamil	Lopinavir	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Verapamil	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C9 mediated DDI
Verapamil	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP3A4 mediated DDI
Verapamil	Nelfinavir	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Verapamil	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Verapamil	Hydroxychloroquine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2D6 mediated DDI
Verapamil	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Verapamil	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Verapamil	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Verapamil	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI
Verapamil	Fenofibrate	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP3A4 mediated DDI
Verapamil	Fluorescein	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Verapamil	Fulvestrant	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Verapamil	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Verapamil	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Verapamil	Regorafenib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Verapamil	Sorafenib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Verapamil	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Verapamil	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Verapamil	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C9 mediated DDI
Verapamil	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Verapamil	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Verapamil	Lipoic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Verapamil	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Verapamil	Piracetam	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Verapamil	Pyrantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Verapamil	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Verapamil	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP3A4 mediated DDI
Verapamil	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Verapamil	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vilanterol	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Vilanterol	Carvedilol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Vilanterol	Chloramphenicol	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing bradycardia
Vilanterol	Methyldopa	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Vilanterol	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Vilanterol	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Vilanterol	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Vilanterol	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vilanterol	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Vilanterol	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Vilanterol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Vilanterol	Diphenhydramine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vilanterol	Fluoxetine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vilanterol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vilanterol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Vilanterol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Vilanterol	Amitriptyline	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Zidovudine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Zidovudine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Zopiclone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Zopiclone	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Zopiclone	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Alectinib	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alectinib	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Carvedilol	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI
Alectinib	Chloramphenicol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Doravirine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Alectinib	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Alectinib	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Alectinib	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Alectinib	Talazoparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Alectinib	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Alectinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Alectinib	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alectinib	Lenalidomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alectinib	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Alectinib	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alectinib	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP3A4 mediated DDI
Alectinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Alectinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Alectinib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Alectinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Alectinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Alectinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Alectinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Alectinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Alectinib	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Alectinib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C8 mediated DDI
Alectinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alectinib	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Alectinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Alectinib	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alogliptin	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alogliptin	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Alogliptin	Salmeterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Alogliptin	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alogliptin	Apalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Alogliptin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Alogliptin	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Alogliptin	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Alogliptin	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Alogliptin	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Alogliptin	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Alogliptin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alogliptin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Alogliptin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alogliptin	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alogliptin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alogliptin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alogliptin	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alogliptin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alogliptin	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Alogliptin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alogliptin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Alogliptin	Efavirenz	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Alogliptin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Alogliptin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Alogliptin	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Alogliptin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Alogliptin	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Alprostadil	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Alprostadil	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amlodipine	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Amlodipine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Amlodipine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Amlodipine	Isoniazid	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Amlodipine	Teriflunomide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Amlodipine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amlodipine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Amlodipine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Amlodipine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Amlodipine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Amlodipine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Amlodipine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Apixaban	Avibactam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Apixaban	Fluphenazine	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apixaban	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apixaban	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apixaban	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apixaban	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apixaban	Phenylephrine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Apixaban	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apixaban	Trifluoperazine	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Apixaban	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Apixaban	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apixaban	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apixaban	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apixaban	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apixaban	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Apixaban	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apixaban	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apixaban	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apixaban	Cinacalcet	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apixaban	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Apixaban	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Ascorbic acid	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ascorbic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atorvastatin	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Atorvastatin	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Atorvastatin	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atorvastatin	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Atorvastatin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atorvastatin	Fosfomycin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Atorvastatin	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI; CYP3A4 mediated DDI
Atorvastatin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Atorvastatin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI
Atorvastatin	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Atorvastatin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Atorvastatin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atorvastatin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atorvastatin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atorvastatin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Avibactam	Bicalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Cabozantinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Drotaverine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Elsulfavirine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Avibactam	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Ibrutinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Linezolid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Avibactam	Methyldopa	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Avibactam	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Perindopril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Avibactam	Pomalidomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Rivaroxaban	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Telbivudine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Trametinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Avibactam	Apalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Atenolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Lenalidomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Lenvatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Metoclopramide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Metoprolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Avibactam	Propafenone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Risperidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Avibactam	Salbutamol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Avibactam	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Acetylsalicylic acid	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Avibactam	Atropine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Avibactam	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Bisacodyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Avibactam	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Enzalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Avibactam	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Phenobarbital	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Avibactam	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Avibactam	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Clopidogrel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Avibactam	Dimethyl fumarate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Avibactam	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Avibactam	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Avibactam	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Avibactam	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Avibactam	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Avibactam	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Avibactam	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Avibactam	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Avibactam	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Avibactam	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Avibactam	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Beclomethasone dipropionate	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Betamethasone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Dasabuvir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Bicalutamide	Fenoterol	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Bicalutamide	Fluconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Bicalutamide	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Talazoparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Telbivudine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Bicalutamide	Trametinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Bicalutamide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Fosfomycin	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bicalutamide	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Lenalidomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Bicalutamide	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Norepinephrine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Bicalutamide	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Oseltamivir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Bicalutamide	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bicalutamide	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bicalutamide	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Stavudine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Bicalutamide	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bicalutamide	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bicalutamide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bicalutamide	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Bicalutamide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Bicalutamide	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Bicalutamide	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bicalutamide	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Bicalutamide	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bicalutamide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bicalutamide	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bicalutamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bicalutamide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bicalutamide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bicalutamide	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Bicalutamide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bicalutamide	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Bicalutamide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Bicalutamide	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Bicalutamide	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bisoprolol	Miglustat	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia
Bisoprolol	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisoprolol	Favipiravir	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Bisoprolol	Teriflunomide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisoprolol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bisoprolol	Fluoxetine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisoprolol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Buprenorphine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Buprenorphine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Buprenorphine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Buprenorphine	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Buprenorphine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Buprenorphine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Buprenorphine	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Cabozantinib	Carvedilol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Fenoterol	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cabozantinib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cabozantinib	Atenolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cabozantinib	Metoprolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Norepinephrine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cabozantinib	Propafenone	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cabozantinib	Atropine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cabozantinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cabozantinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Phenylephrine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cabozantinib	Procaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C9 mediated DDI
Cabozantinib	Propranolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cabozantinib	Chlorpromazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cabozantinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cabozantinib	Benzyl benzoate	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Cabozantinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cabozantinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Carvedilol	Chloramphenicol	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia
Carvedilol	Lurasidone	3	Major DDI	DDI causing hypotension; DDI causing bradycardia
Carvedilol	Miglustat	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Paliperidone	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Trametinib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Diatrizoate	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Carvedilol	Ivacaftor	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Lenvatinib	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Olaparib	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Risperidone	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Tetrabenazine	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Aminophylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Carvedilol	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Flupentixol	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Flutamide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Carvedilol	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Carvedilol	Sunitinib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Teriflunomide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Tramadol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carvedilol	Acetaminophen	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Fluoxetine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Carvedilol	Nicotinamide	3	CLASS 1 (from 3)	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Carvedilol	Praziquantel	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia
Carvedilol	Sertindole	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Vinpocetine	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI
Carvedilol	Amitriptyline	3	Major DDI	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Carvedilol	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cephalexin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cephalexin	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cetirizine	Chloramphenicol	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Cetirizine	Formoterol	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Cetirizine	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Cetirizine	Periciazine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Cetirizine	Flutamide	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Cetirizine	Haloperidol	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Cetirizine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Cetirizine	Chlorpromazine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cetirizine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Cetirizine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cetirizine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cetirizine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Cetirizine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Cetirizine	Mitotane	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Chloramphenicol	Drotaverine	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Chloramphenicol	Enalapril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Chloramphenicol	Levodopa	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Chloramphenicol	Losartan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Chloramphenicol	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Chloramphenicol	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Chloramphenicol	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Chloramphenicol	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Chloramphenicol	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Chloramphenicol	Indapamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Chloramphenicol	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Chloramphenicol	Propafenone	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Chloramphenicol	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Chloramphenicol	Captopril	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing arrhythmia	CYP2C19 mediated DDI
Chloramphenicol	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Chloramphenicol	Enzalutamide	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Chloramphenicol	Flutamide	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Chloramphenicol	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Chloramphenicol	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Chloramphenicol	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Chloramphenicol	Propranolol	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Chloramphenicol	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Chloramphenicol	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Chloramphenicol	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Chloramphenicol	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Chloramphenicol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Chloramphenicol	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Chloramphenicol	Levetiracetam	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Chloramphenicol	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Chloramphenicol	Pyrantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Chloramphenicol	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Chloramphenicol	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Chloramphenicol	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Chloramphenicol	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Chloramphenicol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Clavulanic acid	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clavulanic acid	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Crizotinib	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Crizotinib	Dobutamine	3	CLASS 1 (from 3); Major DDI	DDI causing tachycardia
Crizotinib	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Crizotinib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Crizotinib	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Crizotinib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Crizotinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Desflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Crizotinib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Dacarbazine	Busulfan	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Dacarbazine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Dacarbazine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Dacarbazine	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Dacarbazine	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Dacarbazine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dacarbazine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Dacarbazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Dacarbazine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Dacarbazine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Dasabuvir	Fenoterol	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Dasabuvir	Formoterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Dasabuvir	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Dasabuvir	Mebeverine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Dasabuvir	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Dasabuvir	Norepinephrine	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Dasabuvir	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Dasabuvir	Oxybuprocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Dasabuvir	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Dasabuvir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Dasabuvir	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Dasabuvir	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Dasabuvir	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Phenylephrine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Dasabuvir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Dasabuvir	Propranolol	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia	CYP2D6 mediated DDI
Dasabuvir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Dasabuvir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Dasabuvir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Dasabuvir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Dasabuvir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Dasabuvir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dasabuvir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Dasabuvir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Dasabuvir	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Dexamethasone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dinoprostone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doravirine	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Doravirine	Oxacillin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doravirine	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Doravirine	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Doravirine	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Doravirine	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Doravirine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doravirine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Doravirine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Doravirine	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Doravirine	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doravirine	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Doravirine	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Doravirine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Doravirine	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doravirine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Doravirine	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Doravirine	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Doravirine	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI
Doravirine	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Doravirine	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Doravirine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Doravirine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Doravirine	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Doravirine	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Doravirine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Doravirine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Doravirine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Doravirine	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Dorzolamide	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C9 mediated DDI
Drotaverine	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2D6 mediated DDI
Drotaverine	Linezolid	3	Major DDI	DDI causing hypertension; DDI causing hypotension
Drotaverine	Paliperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Drotaverine	Quetiapine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Drotaverine	Tizanidine	3	Major DDI	DDI causing hypotension; DDI causing tachycardia
Drotaverine	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Drotaverine	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Drotaverine	Fosfomycin	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP3A4 mediated DDI
Drotaverine	Oseltamivir	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Drotaverine	Risperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Drotaverine	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Drotaverine	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2D6 mediated DDI
Drotaverine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Drotaverine	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Drotaverine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Drotaverine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Drotaverine	Tramadol	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Clomipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Drotaverine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Drotaverine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Drotaverine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Drotaverine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Elsulfavirine	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Elsulfavirine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elsulfavirine	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Elsulfavirine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Elsulfavirine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Elsulfavirine	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Elsulfavirine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elsulfavirine	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Elsulfavirine	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elsulfavirine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elsulfavirine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Elsulfavirine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Elsulfavirine	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Elsulfavirine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Elsulfavirine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Emtricitabine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Emtricitabine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Emtricitabine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Enalapril	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Enalapril	Mebeverine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension
Enalapril	Methyldopa	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension
Enalapril	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Enalapril	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Enalapril	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Enalapril	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Enalapril	Sulfamethoxazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Enalapril	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Enalapril	Aminophylline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Enalapril	Caffeine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Enalapril	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Enalapril	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Enalapril	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Enalapril	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Enalapril	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Enalapril	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Enalapril	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Enalapril	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Enalapril	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Enalapril	Clomipramine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension	CYP2D6 mediated DDI
Enalapril	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Enalapril	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Enalapril	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Enalapril	Nicotinamide	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension	CYP2C19 mediated DDI
Enalapril	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Enalapril	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Enalapril	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Enalapril	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Enalapril	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Esomeprazole	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Esomeprazole	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fenoterol	Ibrutinib	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Fenoterol	Ipragliflozin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Fenoterol	Linezolid	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Fenoterol	Trametinib	3	Major DDI	DDI causing hypertension; DDI causing arrhythmia
Fenoterol	Diatrizoate	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Fenoterol	Hydroxychloroquine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Fenoterol	Indapamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Fenoterol	Lenvatinib	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Fenoterol	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Fenoterol	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Fenoterol	Sulfamethoxazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Fenoterol	Baclofen	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Fenoterol	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Fenoterol	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fenoterol	Oxazepam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Fenoterol	Pyrazinamide	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Fenoterol	Regorafenib	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Fenoterol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fenoterol	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C9 mediated DDI
Fenoterol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Fenoterol	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Fenoterol	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Fenoterol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fenoterol	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Fenoterol	Oxcarbazepine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI
Fluconazole	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Talazoparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fluconazole	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Ivacaftor	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fluconazole	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Sotalol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fluconazole	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fluconazole	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fluconazole	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fluconazole	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fluconazole	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Fludrocortisone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Formoterol	Glyburide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Formoterol	Miglustat	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Formoterol	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Formoterol	Fosfomycin	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Formoterol	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Formoterol	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Formoterol	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Formoterol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Formoterol	Fluorescein	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Formoterol	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Formoterol	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Formoterol	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Formoterol	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Formoterol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Formoterol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Formoterol	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Formoterol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Formoterol	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Formoterol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Vinpocetine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Formoterol	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Furosemide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Levodopa	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Glyburide	Nelfinavir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2C9 mediated DDI
Glyburide	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Glyburide	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Fosfomycin	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C9 mediated DDI
Glyburide	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Glyburide	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI
Glyburide	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Glyburide	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Glyburide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Glyburide	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Glyburide	Bisacodyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Glyburide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Glyburide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Glyburide	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Glyburide	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Glyburide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Glyburide	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Glyburide	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Glyburide	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Glyburide	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Glyburide	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Glyburide	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Glyburide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Glyburide	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Glyburide	Piracetam	3	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Glyburide	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI
Glyburide	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Glyburide	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Glyburide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Glyburide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Glyburide	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Glyburide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI
Glyburide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Glyburide	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydrochlorothiazide	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Hydrochlorothiazide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Hydrocortisone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ibrutinib	Atenolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Ibrutinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ibrutinib	Dobutamine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Ibrutinib	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ibrutinib	Metoprolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Ibrutinib	Norepinephrine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Ibrutinib	Sotalol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Ibrutinib	Dopamine	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Ibrutinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ibrutinib	Phenylephrine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Ibrutinib	Propranolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Ibrutinib	Clomifene	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Ibrutinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ipragliflozin	Salmeterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Ipragliflozin	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Ipragliflozin	Epinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Ipragliflozin	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Ipragliflozin	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Ipragliflozin	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Ipragliflozin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ipragliflozin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ipragliflozin	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Lamivudine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Levodopa	Linezolid	3	Major DDI	DDI causing hypertension; DDI causing hypotension
Levodopa	Methyldopa	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing hypotension
Levodopa	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Levodopa	Salmeterol	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Levodopa	Epinephrine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Levodopa	Norepinephrine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Levodopa	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Levodopa	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Levodopa	Flupentixol	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Levodopa	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Levodopa	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Levodopa	Procainamide	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia
Levodopa	Salicylic acid	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Levodopa	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Levodopa	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Levodopa	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Levodopa	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Levodopa	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Levodopa	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Levodopa	Lidocaine	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing tachycardia	CYP2D6 mediated DDI
Levodopa	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Levodopa	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Linezolid	Mebeverine	3	Major DDI	DDI causing hypertension; DDI causing hypotension
Linezolid	Methyldopa	3	Major DDI	DDI causing hypertension; DDI causing hypotension
Linezolid	Repaglinide	3	Major DDI	DDI causing hypertension; DDI causing hypotension	CYP2C8 mediated DDI
Linezolid	Salmeterol	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Linezolid	Atenolol	3	Major DDI	DDI causing hypertension; DDI causing hypotension
Linezolid	Dobutamine	3	Major DDI	DDI causing hypertension; DDI causing hypotension
Linezolid	Epinephrine	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Linezolid	Norepinephrine	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Linezolid	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Linezolid	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Linezolid	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Linezolid	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Linezolid	Phenylephrine	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Linezolid	Propranolol	3	Major DDI	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI
Linezolid	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Linezolid	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Linezolid	Agomelatine	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Linezolid	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Linezolid	Clomifene	3	Major DDI	DDI causing hypertension; DDI causing hypotension
Linezolid	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Linezolid	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Linezolid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Linezolid	Levamisole	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Linezolid	Tapentadol	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Lopinavir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Lopinavir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lopinavir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Lopinavir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lopinavir	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lopinavir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lopinavir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Lopinavir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lopinavir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lopinavir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lopinavir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lopinavir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Lopinavir	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Lopinavir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lopinavir	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Losartan	Methyldopa	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Losartan	Nifedipine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Atenolol	3	CLASS 1 (from 3)	DDI causing hypotension; DDI causing arrhythmia
Losartan	Epinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C9 mediated DDI
Losartan	Ethambutol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C9 mediated DDI
Losartan	Fosfomycin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Losartan	Salbutamol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C9 mediated DDI
Losartan	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Losartan	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Losartan	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Losartan	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Losartan	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C9 mediated DDI
Losartan	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Losartan	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Losartan	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Losartan	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Losartan	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Lurasidone	Fosfomycin	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Lurasidone	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Lurasidone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lurasidone	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Lurasidone	Propranolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Lurasidone	Trifluoperazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP1A2 mediated DDI
Lurasidone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lurasidone	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Mebeverine	Paliperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Mebeverine	Hydroxychloroquine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mebeverine	Risperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Mebeverine	Cariprazine	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Chlorambucil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Mebeverine	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Mebeverine	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Mebeverine	Fluorescein	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Mebeverine	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Mebeverine	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Mebeverine	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Mebeverine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mebeverine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Mebeverine	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Mebeverine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Mebeverine	Clotrimazole	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Mebeverine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Methyldopa	Nitisinone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methyldopa	Indacaterol	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Methyldopa	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methyldopa	Metoprolol	3	CLASS 1 (from 3)	DDI causing hypotension; DDI causing bradycardia
Methyldopa	Salbutamol	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Methyldopa	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Clonidine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Methyldopa	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methyldopa	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Methyldopa	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methyldopa	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methyldopa	Zuclopenthixol	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI
Methyldopa	Acetaminophen	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Methyldopa	Betahistine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Methyldopa	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Methyldopa	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Methyldopa	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Methyldopa	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Methyldopa	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methyldopa	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methyldopa	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Methyldopa	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Methyldopa	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Methyldopa	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Miglustat	Salmeterol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Miglustat	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Miglustat	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Miglustat	Apalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Miglustat	Fosfomycin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Miglustat	Metoprolol	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Miglustat	Oxybuprocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Miglustat	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Miglustat	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Miglustat	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Miglustat	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Miglustat	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Miglustat	Procaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Miglustat	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Miglustat	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Miglustat	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Miglustat	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Miglustat	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Miglustat	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Miglustat	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Mycophenolic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Mycophenolic acid	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Naltrexone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Naltrexone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nelfinavir	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Nelfinavir	Dobutamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI
Nelfinavir	Epinephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Nelfinavir	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nelfinavir	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nelfinavir	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Nelfinavir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nelfinavir	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI
Nelfinavir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI
Nelfinavir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Nelfinavir	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nelfinavir	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Nelfinavir	Propranolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2B6 mediated DDI
Nelfinavir	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nelfinavir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nelfinavir	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Nelfinavir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Nelfinavir	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Nelfinavir	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nelfinavir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nelfinavir	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Nelfinavir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Nelfinavir	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Nelfinavir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Nelfinavir	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Nelfinavir	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Nelfinavir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nelfinavir	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nelfinavir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Nifedipine	Siponimod	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Ixazomib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Nifedipine	Vemurafenib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Nifedipine	Chlorambucil	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Enzalutamide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Nifedipine	Fulvestrant	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Nifedipine	Isoniazid	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nifedipine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nifedipine	Dimethyl fumarate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Nifedipine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Nifedipine	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP3A4 mediated DDI
Nifedipine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Nifedipine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Sulpiride	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Nitisinone	Trametinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Nitisinone	Apalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nitisinone	Atenolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Nitisinone	Hydroxyzine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Nitisinone	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Lenvatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nitisinone	Metoclopramide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Nitisinone	Metoprolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Nitisinone	Propafenone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Nitisinone	Risperidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Nitisinone	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nitisinone	Captopril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Nitisinone	Clonidine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Nitisinone	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Nitisinone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Nitisinone	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nitisinone	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Nitisinone	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nitisinone	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Nitisinone	Procaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Nitisinone	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nitisinone	Propranolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Nitisinone	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nitisinone	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Nitisinone	Acetaminophen	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Nitisinone	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nitisinone	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Nitisinone	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Nitisinone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Nitisinone	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nitisinone	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nitisinone	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nitisinone	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nitisinone	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Nitisinone	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitisinone	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Nitisinone	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Nitisinone	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP3A4 mediated DDI
Nitisinone	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Omeprazole	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Omeprazole	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Oxacillin	Siponimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxacillin	Apalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Oxacillin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxacillin	Lenvatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Oxacillin	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxacillin	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxacillin	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Oxacillin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Oxacillin	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxacillin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxacillin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxacillin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Oxacillin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Oxacillin	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxacillin	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Oxacillin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Oxycodone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Oxycodone	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxycodone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxycodone	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paliperidone	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paliperidone	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paliperidone	Fluphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Paliperidone	Fosfomycin	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Paliperidone	Oseltamivir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Paliperidone	Oxybuprocaine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Paliperidone	Perphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Paliperidone	Sotalol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Paliperidone	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paliperidone	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paliperidone	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paliperidone	Methotrimeprazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paliperidone	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paliperidone	Chlorpromazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Paliperidone	Clomipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Paliperidone	Imipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Paliperidone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paliperidone	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paliperidone	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paliperidone	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Perindopril	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Perindopril	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Perindopril	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Perindopril	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Perindopril	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Perindopril	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Perindopril	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Phenoxymethylpenicillin	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Phenoxymethylpenicillin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Phenoxymethylpenicillin	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Phenoxymethylpenicillin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Pomalidomide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pomalidomide	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pomalidomide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pomalidomide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pomalidomide	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pomalidomide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pomalidomide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pomalidomide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Pomalidomide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pomalidomide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pomalidomide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Quetiapine	Paroxetine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Quetiapine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Quetiapine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Quetiapine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Quetiapine	Procarbazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Quetiapine	Clomifene	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Quetiapine	Fluoxetine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Quetiapine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Quetiapine	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Quetiapine	Nicotinamide	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Quetiapine	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Quetiapine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Repaglinide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Repaglinide	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI
Repaglinide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Repaglinide	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Repaglinide	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Repaglinide	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Repaglinide	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Repaglinide	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Repaglinide	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Repaglinide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C8 mediated DDI
Repaglinide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Repaglinide	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Repaglinide	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Repaglinide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Repaglinide	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Rivaroxaban	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rivaroxaban	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rivaroxaban	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rivaroxaban	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rivaroxaban	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rivaroxaban	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rivaroxaban	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Rivaroxaban	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Rivaroxaban	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Salmeterol	Siponimod	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Salmeterol	Apalutamide	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Salmeterol	Hydroxychloroquine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Indacaterol	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salmeterol	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Salmeterol	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Salmeterol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Salmeterol	Fluorescein	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Salmeterol	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Salmeterol	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Salmeterol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Salmeterol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Salmeterol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Salmeterol	Sertindole	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Salmeterol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Salmeterol	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Siponimod	Atenolol	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Siponimod	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Siponimod	Epinephrine	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Siponimod	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Siponimod	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Siponimod	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Siponimod	Propafenone	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Siponimod	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Siponimod	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Siponimod	Caffeine	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP1A2 mediated DDI
Siponimod	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Siponimod	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Siponimod	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Siponimod	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Siponimod	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Siponimod	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Siponimod	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Siponimod	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Siponimod	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Siponimod	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Siponimod	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Siponimod	Phenylephrine	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Siponimod	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Siponimod	Propranolol	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Siponimod	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Siponimod	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Siponimod	Betahistine	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Siponimod	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Siponimod	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Siponimod	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Siponimod	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Siponimod	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Siponimod	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Siponimod	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Siponimod	Rivastigmine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Siponimod	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Siponimod	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Siponimod	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Siponimod	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Siponimod	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Siponimod	Benzyl benzoate	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Siponimod	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Siponimod	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Sulbactam	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Sulpiride	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sulpiride	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sulpiride	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sulpiride	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sulpiride	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sulpiride	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sulpiride	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sulpiride	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sulpiride	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sulpiride	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Sulpiride	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sulpiride	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sulpiride	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sulpiride	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sulpiride	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Sulpiride	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sulpiride	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Sulpiride	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Talazoparib	Voriconazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Talazoparib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Talazoparib	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Talazoparib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Talazoparib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Talazoparib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Talazoparib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Talazoparib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Talazoparib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Talazoparib	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Talazoparib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Talazoparib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Talazoparib	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Talazoparib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Talazoparib	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Talazoparib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Talazoparib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Talazoparib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Talazoparib	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Talazoparib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Telbivudine	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Telbivudine	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Telbivudine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Telbivudine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Telbivudine	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Telbivudine	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Telbivudine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Telbivudine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Telbivudine	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Telbivudine	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Telbivudine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Telbivudine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Temozolomide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Temozolomide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Temozolomide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tizanidine	Oxybuprocaine	3	Major DDI	DDI causing hypotension; DDI causing tachycardia
Tizanidine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tizanidine	Procarbazine	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Tizanidine	Acetaminophen	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Tizanidine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tizanidine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tizanidine	Mitotane	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2B6 mediated DDI
Tofacitinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Trametinib	Atenolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Trametinib	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trametinib	Epinephrine	3	Major DDI	DDI causing hypertension; DDI causing arrhythmia
Trametinib	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trametinib	Norepinephrine	3	Major DDI	DDI causing hypertension; DDI causing arrhythmia
Trametinib	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trametinib	Propafenone	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Trametinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trametinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trametinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trametinib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trametinib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trametinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trametinib	Procainamide	3	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Trametinib	Propranolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Trametinib	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trametinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trametinib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Trametinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trametinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trametinib	Clomifene	3	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia
Trametinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trametinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Trametinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trametinib	Lidocaine	3	CLASS 1 (from 5); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Trametinib	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trametinib	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Trametinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trametinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Trametinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trametinib	Mitotane	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Voriconazole	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Voriconazole	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Voriconazole	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Voriconazole	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Voriconazole	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Aminosalicylic acid	Atenolol	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Aminosalicylic acid	Fluphenazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Aminosalicylic acid	Sulfamethoxazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Aminosalicylic acid	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Aminosalicylic acid	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Aminosalicylic acid	Fingolimod	3	CLASS 1 (from 3); Major DDI	DDI causing bradycardia	CYP2C9 mediated DDI
Aminosalicylic acid	Lacosamide	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Aminosalicylic acid	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Aminosalicylic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Aminosalicylic acid	Levamisole	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension
Aminosalicylic acid	Thioridazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypertension
Aminosalicylic acid	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Aminosalicylic acid	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Aminosalicylic acid	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Anastrozole	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Anastrozole	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Anastrozole	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Anastrozole	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Anastrozole	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Apalutamide	Bedaquiline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Epinephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Apalutamide	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Apalutamide	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Norepinephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Apalutamide	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apalutamide	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Apalutamide	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Apalutamide	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Apalutamide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Apalutamide	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Apalutamide	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Apalutamide	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Apalutamide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apalutamide	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Apalutamide	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Apalutamide	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apalutamide	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apalutamide	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Apalutamide	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Apalutamide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apalutamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Apalutamide	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Apalutamide	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Apalutamide	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Apalutamide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apalutamide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Apalutamide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Apalutamide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Apalutamide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Apalutamide	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Atenolol	Favipiravir	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Atenolol	Mesalazine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Atenolol	Fenofibrate	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Atenolol	Flutamide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Regorafenib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Teriflunomide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Atenolol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atenolol	Warfarin	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI
Atenolol	Diphenhydramine	3	CLASS 1 (from 3)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Atenolol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Clonazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bedaquiline	Cobimetinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Ethambutol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bedaquiline	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Hydroxyzine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Indapamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bedaquiline	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Lenalidomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Lenvatinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Bedaquiline	Mesalazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bedaquiline	Metoclopramide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Nitrazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bedaquiline	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bedaquiline	Risperidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bedaquiline	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bedaquiline	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bedaquiline	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Bedaquiline	Acetylsalicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Bisacodyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Bedaquiline	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Bedaquiline	Diclofenac	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Bedaquiline	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Bedaquiline	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bedaquiline	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Bedaquiline	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Bedaquiline	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Bedaquiline	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Lorazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Bedaquiline	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Oxazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bedaquiline	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bedaquiline	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Bedaquiline	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Bedaquiline	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bedaquiline	Acetaminophen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bedaquiline	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Bedaquiline	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bedaquiline	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Diazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bedaquiline	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Midazolam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bedaquiline	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bedaquiline	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bedaquiline	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bedaquiline	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Bedaquiline	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Bedaquiline	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bedaquiline	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Bedaquiline	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bendamustine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bendamustine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Bendamustine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Benzylpenicillin	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Benzylpenicillin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Busulfan	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Busulfan	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Busulfan	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Clonazepam	Epinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Clonazepam	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Clonazepam	Sotalol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Clonazepam	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Clonazepam	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI
Clonazepam	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Clonazepam	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clonazepam	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clonazepam	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clonazepam	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Cobimetinib	Fluphenazine	3	CLASS 1 (from 5); Major DDI	DDI causing hypotension	CYP2D6 mediated DDI
Cobimetinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cobimetinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cobimetinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobimetinib	Propranolol	3	Major DDI	DDI causing hypotension; DDI causing arrhythmia	CYP2D6 mediated DDI
Cobimetinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobimetinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobimetinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobimetinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobimetinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobimetinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobimetinib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cobimetinib	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Dapsone	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Dapsone	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Dapsone	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dapsone	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C9 mediated DDI
Diatrizoate	Fosfomycin	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Diatrizoate	Dopamine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Diatrizoate	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Diatrizoate	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Diatrizoate	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Diatrizoate	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Diatrizoate	Clomifene	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Diatrizoate	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Diatrizoate	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Diatrizoate	Lidocaine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Diatrizoate	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Diatrizoate	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Dobutamine	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Dobutamine	Hydroxychloroquine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dobutamine	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Dobutamine	Sulfamethoxazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Dobutamine	Tafluprost	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Dobutamine	Baclofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Dobutamine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Dobutamine	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Dobutamine	Fulvestrant	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Dobutamine	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Dobutamine	Lorazepam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Dobutamine	Oxazepam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Dobutamine	Phenobarbital	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Dobutamine	Tranexamic acid	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Dobutamine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dobutamine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Dobutamine	Diazepam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Dobutamine	Dimethyl fumarate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Dobutamine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Dobutamine	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Dobutamine	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Dobutamine	Pyrantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Dobutamine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Epinephrine	Ethambutol	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Favipiravir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Epinephrine	Hydroxychloroquine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Indapamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Epinephrine	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Epinephrine	Nitrazepam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Epinephrine	Sulfamethoxazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Epinephrine	Tetrabenazine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Epinephrine	Baclofen	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C8 mediated DDI
Epinephrine	Chlorambucil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Epinephrine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Epinephrine	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Epinephrine	Methotrimeprazine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Epinephrine	Regorafenib	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Epinephrine	Tramadol	3	CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Epinephrine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Epinephrine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Epinephrine	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Epinephrine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Epinephrine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Ethambutol	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ethambutol	Atropine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Ethambutol	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ethambutol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ethambutol	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ethambutol	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Ethambutol	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ethambutol	Phenylephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Ethambutol	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ethambutol	Acetaminophen	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Ethambutol	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Ethambutol	Efavirenz	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Ethambutol	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ethambutol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Ethambutol	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Ethambutol	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ethambutol	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Ethambutol	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ethambutol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ethambutol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Ethambutol	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ethambutol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Evogliptin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Evogliptin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Evogliptin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Evogliptin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Favipiravir	Fluphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Favipiravir	Indacaterol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Lenalidomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Olanzapine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Oxybuprocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Favipiravir	Pentoxifylline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Propafenone	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI
Favipiravir	Risperidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Captopril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Favipiravir	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Enzalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Procaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Favipiravir	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Sunitinib	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Teriflunomide	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Favipiravir	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Favipiravir	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Acetaminophen	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia
Favipiravir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Favipiravir	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Favipiravir	Clopidogrel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Favipiravir	Diazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Favipiravir	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Favipiravir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Lidocaine	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia
Favipiravir	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Favipiravir	Phenytoin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Favipiravir	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Favipiravir	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Favipiravir	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Favipiravir	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Favipiravir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Hydroxyzine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Mesalazine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP1A2 mediated DDI
Fluphenazine	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Fluphenazine	Sulfamethoxazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C9 mediated DDI
Fluphenazine	Tafluprost	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Fluphenazine	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fluphenazine	Acetylsalicylic acid	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Aminocaproic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Fluphenazine	Captopril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Fluphenazine	Chlorambucil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Fluphenazine	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Fluphenazine	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Fluphenazine	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fluphenazine	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Fluphenazine	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fluphenazine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fluphenazine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Fluphenazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fluphenazine	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Fluphenazine	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Fluphenazine	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fluphenazine	Rivastigmine	3	CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Fluphenazine	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Fluphenazine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Fluphenazine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Fluphenazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Fluphenazine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Fluphenazine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Fosfomycin	Indacaterol	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Fosfomycin	Mebendazole	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C19 mediated DDI
Fosfomycin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fosfomycin	Fingolimod	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Fosfomycin	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI
Fosfomycin	Methotrimeprazine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Fosfomycin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fosfomycin	Acetaminophen	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fosfomycin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Fosfomycin	Imipramine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Fosfomycin	Levamisole	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Fosfomycin	Lipoic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Fosfomycin	Piracetam	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Fosfomycin	Ropivacaine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP3A4 mediated DDI
Fosfomycin	Sertindole	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fosfomycin	Thioridazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Fosfomycin	Propofol	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Fosfomycin	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Fosfomycin	Oxaliplatin	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI
Galantamine	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Galantamine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Galantamine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Galantamine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Gliclazide	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C9 mediated DDI
Gliclazide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Gliclazide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Hydroxychloroquine	Metoclopramide	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation
Hydroxychloroquine	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Hydroxychloroquine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxychloroquine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Hydroxychloroquine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxychloroquine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxychloroquine	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxychloroquine	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxychloroquine	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxychloroquine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Hydroxychloroquine	Phenylephrine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Hydroxychloroquine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxychloroquine	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Hydroxychloroquine	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Hydroxychloroquine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Hydroxychloroquine	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Hydroxychloroquine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxychloroquine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Hydroxychloroquine	Imipramine	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Hydroxychloroquine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxychloroquine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Hydroxychloroquine	Nicotinamide	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP2C9 mediated DDI
Hydroxychloroquine	Tamoxifen	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Hydroxychloroquine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Hydroxychloroquine	Amitriptyline	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Hydroxychloroquine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Hydroxychloroquine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxyzine	Metoclopramide	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Hydroxyzine	Periciazine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI
Hydroxyzine	Chlorpromazine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hydroxyzine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2B6 mediated DDI
Hydroxyzine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Hydroxyzine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxyzine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Hydroxyzine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Hydroxyzine	Mitotane	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Indacaterol	Ivacaftor	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indacaterol	Metoprolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Indacaterol	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indacaterol	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indacaterol	Oseltamivir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Indacaterol	Oxybuprocaine	3	CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Indacaterol	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Indacaterol	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Propafenone	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia
Indacaterol	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indacaterol	Atropine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indacaterol	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indacaterol	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Indacaterol	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indacaterol	Phenylephrine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Indacaterol	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indacaterol	Propranolol	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP1A2 mediated DDI
Indacaterol	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indacaterol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Indacaterol	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Indacaterol	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Indacaterol	Tamoxifen	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia
Indacaterol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Indacaterol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Indacaterol	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Indacaterol	Clotrimazole	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Indapamide	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Indapamide	Oseltamivir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Indapamide	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Indapamide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Indapamide	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Indapamide	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Indapamide	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Indapamide	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Indapamide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Indapamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Indapamide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Indapamide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Indapamide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Ivacaftor	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Ivacaftor	Midostaurin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Perphenazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ivacaftor	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Atropine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Ivacaftor	Cariprazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Ivacaftor	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ivacaftor	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ivacaftor	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Ivacaftor	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ivacaftor	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ivacaftor	Clomifene	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Ivacaftor	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Ivacaftor	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Ivacaftor	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ivacaftor	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ivacaftor	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ivacaftor	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ivacaftor	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Ivacaftor	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Ivacaftor	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ivacaftor	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ivacaftor	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ixazomib	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ixazomib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Ixazomib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Ixazomib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Ixazomib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Lenalidomide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenalidomide	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lenalidomide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenalidomide	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenalidomide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenalidomide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Lenalidomide	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenvatinib	Mebendazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Lenvatinib	Sotalol	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Lenvatinib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lenvatinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenvatinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenvatinib	Phenylephrine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Lenvatinib	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lenvatinib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Lenvatinib	Propranolol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Lenvatinib	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenvatinib	Agomelatine	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Lenvatinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenvatinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenvatinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lenvatinib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lenvatinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenvatinib	Lidocaine	3	CLASS 1 (from 3); Major DDI	DDI causing arrhythmia
Lenvatinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lenvatinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lenvatinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Levothyroxine	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Levothyroxine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Levothyroxine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Maraviroc	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Maraviroc	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mebendazole	Metoclopramide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mebendazole	Metoprolol	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Olaparib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mebendazole	Salbutamol	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI
Mebendazole	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mebendazole	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Mebendazole	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mebendazole	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Mebendazole	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mebendazole	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mebendazole	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mebendazole	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mebendazole	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mebendazole	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Mebendazole	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Acetaminophen	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mebendazole	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Mebendazole	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Mebendazole	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Mebendazole	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Mebendazole	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Mebendazole	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Mebendazole	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Mebendazole	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Melphalan	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Melphalan	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Melphalan	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Melphalan	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Melphalan	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Mesalazine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Mesalazine	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Mesalazine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Mesalazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Mesalazine	Levamisole	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension
Mesalazine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Mesalazine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Mesalazine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Metoclopramide	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Metoclopramide	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Metoclopramide	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Metoclopramide	Haloperidol	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Metoclopramide	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Metoclopramide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Metoclopramide	Acetaminophen	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Metoclopramide	Diphenhydramine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Metoclopramide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Metoclopramide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Metoclopramide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Metoclopramide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Metoclopramide	Amitriptyline	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Metoclopramide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Metoprolol	Sotalol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Metoprolol	Teriflunomide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Metoprolol	Warfarin	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Fluoxetine	3	CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Metoprolol	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2D6 mediated DDI
Metoprolol	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Metronidazole	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Metronidazole	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Metronidazole	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Midostaurin	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Midostaurin	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Midostaurin	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Midostaurin	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Midostaurin	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Midostaurin	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Midostaurin	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Midostaurin	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Midostaurin	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Midostaurin	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Midostaurin	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Midostaurin	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Midostaurin	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Midostaurin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Midostaurin	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Midostaurin	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Midostaurin	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Midostaurin	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Midostaurin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Midostaurin	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Misoprostol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Misoprostol	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Mometasone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Morphine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Morphine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Morphine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Morphine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Nevirapine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nevirapine	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Nevirapine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Nevirapine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nevirapine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Nevirapine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitrazepam	Norepinephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Nitrazepam	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Nitrazepam	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nitrazepam	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Nitrazepam	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Nitrazepam	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Norepinephrine	Sulfamethoxazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Norepinephrine	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Norepinephrine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Norepinephrine	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Norepinephrine	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Norepinephrine	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Norepinephrine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Norepinephrine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Norepinephrine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Norepinephrine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Norepinephrine	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Norepinephrine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Norepinephrine	Praziquantel	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Norepinephrine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Olanzapine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Olanzapine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Olaparib	Paroxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Olaparib	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olaparib	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olaparib	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Olaparib	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI
Olaparib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Olaparib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Olaparib	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Olaparib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Olaparib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olaparib	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olaparib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olaparib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Olaparib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olaparib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Olaparib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Olaparib	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Olaparib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Olaparib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Olaparib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Olaparib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Olaparib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Olaparib	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Olaparib	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Olaparib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Oseltamivir	Periciazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Oseltamivir	Perphenazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Oseltamivir	Risperidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Oseltamivir	Amiodarone	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Oseltamivir	Atropine	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia
Oseltamivir	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Oseltamivir	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Oseltamivir	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Oseltamivir	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Oseltamivir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Oseltamivir	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Oseltamivir	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Oseltamivir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Oseltamivir	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Oseltamivir	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Oseltamivir	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Oseltamivir	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Oseltamivir	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Oseltamivir	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Oseltamivir	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Oseltamivir	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Oseltamivir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Oseltamivir	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Oxybuprocaine	Risperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Oxybuprocaine	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxybuprocaine	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Oxybuprocaine	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Oxybuprocaine	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI
Oxybuprocaine	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Oxybuprocaine	Sorafenib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Sunitinib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2C9 mediated DDI
Oxybuprocaine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Oxybuprocaine	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Oxybuprocaine	Acetaminophen	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Oxybuprocaine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Oxybuprocaine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Oxybuprocaine	Lomustine	3	CLASS 1 (from 5)	DDI causing arrhythmia; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Solifenacin	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Oxybuprocaine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Oxybuprocaine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Oxybuprocaine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Propafenone	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Paroxetine	Salbutamol	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Paroxetine	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paroxetine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Paroxetine	Propranolol	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Paroxetine	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Paroxetine	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Paroxetine	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Paroxetine	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Paroxetine	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Paroxetine	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Paroxetine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Paroxetine	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Paroxetine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Paroxetine	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Pentoxifylline	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Pentoxifylline	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pentoxifylline	Phenylephrine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP1A2 mediated DDI
Pentoxifylline	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pentoxifylline	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pentoxifylline	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Pentoxifylline	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Pentoxifylline	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pentoxifylline	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Pentoxifylline	Methimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Pentoxifylline	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Periciazine	Tetrabenazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Periciazine	Vemurafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Periciazine	Captopril	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Periciazine	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2B6 mediated DDI
Periciazine	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Periciazine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Periciazine	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Periciazine	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2B6 mediated DDI
Periciazine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Periciazine	Methotrimeprazine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Periciazine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Periciazine	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Periciazine	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Periciazine	Umifenovir	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI
Periciazine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Periciazine	Acetaminophen	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Periciazine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Periciazine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Periciazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Periciazine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Periciazine	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Periciazine	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Periciazine	Loratadine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Periciazine	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Periciazine	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Periciazine	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Periciazine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Periciazine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Periciazine	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Periciazine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Periciazine	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Periciazine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Periciazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Periciazine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Perphenazine	Risperidone	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension
Perphenazine	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Perphenazine	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Perphenazine	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Perphenazine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Perphenazine	Methotrimeprazine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Perphenazine	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Perphenazine	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Perphenazine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Perphenazine	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2D6 mediated DDI
Perphenazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Perphenazine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Perphenazine	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Perphenazine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Perphenazine	Amitriptyline	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Perphenazine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Perphenazine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Perphenazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Perphenazine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Propafenone	Axitinib	3	CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Propafenone	Flutamide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propafenone	Lacosamide	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Propafenone	Teriflunomide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Propafenone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Propafenone	Levamisole	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Sertindole	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Propofol	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Propafenone	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Pyridoxine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Risperidone	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Risperidone	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Risperidone	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Risperidone	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Risperidone	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Risperidone	Chlorpromazine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Risperidone	Clomipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Risperidone	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Risperidone	Imipramine	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2D6 mediated DDI
Risperidone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Risperidone	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Risperidone	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Risperidone	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Risperidone	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Risperidone	Mitotane	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Salbutamol	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Salbutamol	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Salbutamol	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2B6 mediated DDI
Salbutamol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Salbutamol	Diphenhydramine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Salbutamol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Salbutamol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Salbutamol	Clotrimazole	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI
Salbutamol	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Sotalol	Ambroxol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sotalol	Caffeine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Sotalol	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Sotalol	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Sotalol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sotalol	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C9 mediated DDI
Sotalol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sotalol	Praziquantel	3	Major DDI	DDI causing hypertension; DDI causing bradycardia
Sotalol	Clotrimazole	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia
Stavudine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Stavudine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Succinic acid	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Sulfamethoxazole	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Sulfamethoxazole	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Sulfamethoxazole	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Sulfamethoxazole	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Sulfamethoxazole	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C9 mediated DDI
Sulfamethoxazole	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sulfamethoxazole	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Sulfamethoxazole	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Sulfamethoxazole	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C9 mediated DDI
Sulfamethoxazole	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tafluprost	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tafluprost	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Tafluprost	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Tafluprost	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Tafluprost	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Tafluprost	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tafluprost	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Tafluprost	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Tafluprost	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2B6 mediated DDI
Tetrabenazine	Vismodegib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Acetylsalicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Tetrabenazine	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Tetrabenazine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Tetrabenazine	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Tetrabenazine	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Phenobarbital	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Tetrabenazine	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Tetrabenazine	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Tetrabenazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Phenytoin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Tetrabenazine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tetrabenazine	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Tetrabenazine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Tetrabenazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tetrabenazine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Vemurafenib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Vemurafenib	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Vemurafenib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vemurafenib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vemurafenib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Vemurafenib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Vemurafenib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vemurafenib	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vemurafenib	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Vemurafenib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vemurafenib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Vemurafenib	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Vemurafenib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vemurafenib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Vemurafenib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Vemurafenib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Vemurafenib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI; CYP3A4 mediated DDI
Vemurafenib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Vemurafenib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vemurafenib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Vildagliptin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Vismodegib	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Vismodegib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Vismodegib	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Vismodegib	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Vismodegib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Vismodegib	Acetaminophen	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Vismodegib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Vismodegib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Vismodegib	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Vismodegib	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Vismodegib	Benzyl benzoate	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Vismodegib	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Vismodegib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Vismodegib	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acetylsalicylic acid	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Acetylsalicylic acid	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Acetylsalicylic acid	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Acetylsalicylic acid	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP3A4 mediated DDI
Acetylsalicylic acid	Lacosamide	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI
Acetylsalicylic acid	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Acetylsalicylic acid	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Acetylsalicylic acid	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Acetylsalicylic acid	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Acetylsalicylic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Acetylsalicylic acid	Levamisole	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension
Acetylsalicylic acid	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Acetylsalicylic acid	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Acetylsalicylic acid	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Acetylsalicylic acid	Mitotane	3	Major DDI	DDI causing arrhythmia; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ambroxol	Amiodarone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ambroxol	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ambroxol	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ambroxol	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ambroxol	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ambroxol	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ambroxol	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ambroxol	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ambroxol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Ambroxol	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ambroxol	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ambroxol	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ambroxol	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Aminocaproic acid	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Aminocaproic acid	Acetaminophen	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Aminocaproic acid	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Aminocaproic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Aminocaproic acid	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Aminocaproic acid	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Aminocaproic acid	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Aminocaproic acid	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Aminophylline	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Aminophylline	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Aminophylline	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Amiodarone	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Cariprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Chloropyramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Amiodarone	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Pyrazinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Amiodarone	Regorafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Amiodarone	Sorafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Amiodarone	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Amiodarone	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Amiodarone	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Betahistine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Amiodarone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Amiodarone	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Amiodarone	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Amiodarone	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Amiodarone	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Amiodarone	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Amiodarone	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI; CYP2D6 mediated DDI
Amiodarone	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atropine	Axitinib	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Atropine	Caffeine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Atropine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Atropine	Fluorescein	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Atropine	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Atropine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Atropine	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Atropine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Atropine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Atropine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Axitinib	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Axitinib	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Axitinib	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Axitinib	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Axitinib	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Axitinib	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Axitinib	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Axitinib	Procaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Axitinib	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Axitinib	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Axitinib	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Axitinib	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Axitinib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Axitinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Axitinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Axitinib	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Axitinib	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Axitinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Axitinib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Axitinib	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Axitinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Axitinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Axitinib	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Axitinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Axitinib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Axitinib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Axitinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Axitinib	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Axitinib	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Axitinib	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Axitinib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Baclofen	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Baclofen	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Baclofen	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bisacodyl	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Bisacodyl	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bisacodyl	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Bisacodyl	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Bisacodyl	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Bisacodyl	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Bisacodyl	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Bisacodyl	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Bisacodyl	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Caffeine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Caffeine	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI
Caffeine	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Caffeine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Caffeine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Caffeine	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Caffeine	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Caffeine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Caffeine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Caffeine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Caffeine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Caffeine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Caffeine	Methimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Caffeine	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Captopril	Cycloserine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Captopril	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Captopril	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Captopril	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Captopril	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Captopril	Teriflunomide	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension
Captopril	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Captopril	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Captopril	Cinacalcet	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing hypotension
Captopril	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Captopril	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Cariprazine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cariprazine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cariprazine	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Cariprazine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cariprazine	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cariprazine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cariprazine	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Cariprazine	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Cariprazine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cariprazine	Chlorpromazine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Cariprazine	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Cariprazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cariprazine	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Cariprazine	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI
Cariprazine	Solifenacin	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation
Cariprazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Cariprazine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Cariprazine	Oxaliplatin	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Chlorambucil	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Chlorambucil	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Chlorambucil	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Chlorambucil	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Chlorambucil	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Chlorambucil	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Chlorambucil	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Chlorambucil	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Chlorambucil	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Chlorambucil	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Chlorambucil	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Chloropyramine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Chloropyramine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Chloropyramine	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Chloropyramine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Chloropyramine	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Chloropyramine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Chloropyramine	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Chloropyramine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Chloropyramine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Chloropyramine	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Chloropyramine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Chloropyramine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Chloropyramine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Chloropyramine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Chloropyramine	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Clonidine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Clonidine	Tropicamide	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Clonidine	Acetaminophen	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Clonidine	Fluoxetine	3	Major DDI	DDI causing hypertension; DDI causing tachycardia	CYP2D6 mediated DDI
Clonidine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clonidine	Levamisole	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Clonidine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Clonidine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Clonidine	Amitriptyline	3	Major DDI	DDI causing hypertension; DDI causing tachycardia
Clonidine	Propofol	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia
Clonidine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clonidine	Mitotane	3	Major DDI	DDI causing hypotension; DDI causing tachycardia	CYP2B6 mediated DDI
Cycloserine	Dexketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cycloserine	Diclofenac	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Cycloserine	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Cycloserine	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cycloserine	Enzalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Cycloserine	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cycloserine	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Cycloserine	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cycloserine	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Cycloserine	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Cycloserine	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cycloserine	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cycloserine	Penicillamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Cycloserine	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Cycloserine	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Cycloserine	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Cycloserine	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cycloserine	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cycloserine	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Cycloserine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Cycloserine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Cycloserine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Cycloserine	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Cycloserine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Cycloserine	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Cycloserine	Lipoic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Cycloserine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cycloserine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Cycloserine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Cycloserine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Cycloserine	Sevelamer	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Cycloserine	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Dexketoprofen	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Dexketoprofen	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dexketoprofen	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Dexketoprofen	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Dexketoprofen	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Dexketoprofen	Ketorolac	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C8 mediated DDI
Dexketoprofen	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Dexketoprofen	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dexketoprofen	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Dexketoprofen	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Dexketoprofen	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Dexketoprofen	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dexketoprofen	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dexketoprofen	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Dexketoprofen	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dexketoprofen	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Dexketoprofen	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dexketoprofen	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Dexketoprofen	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dexketoprofen	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dexketoprofen	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI
Dexketoprofen	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Dexketoprofen	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dexketoprofen	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dexketoprofen	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dexketoprofen	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dexketoprofen	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dexketoprofen	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dexketoprofen	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Dexketoprofen	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Diclofenac	Dopamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Diclofenac	Droperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Diclofenac	Procarbazine	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Diclofenac	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Diclofenac	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Diclofenac	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Dopamine	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Dopamine	Fulvestrant	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Dopamine	Glycine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Dopamine	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Dopamine	Penicillamine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Dopamine	Regorafenib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI
Dopamine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dopamine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Dopamine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Dopamine	Dydrogesterone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Dopamine	Efavirenz	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Dopamine	Finasteride	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dopamine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI; CYP2C9 mediated DDI
Dopamine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dopamine	Lipoic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Dopamine	Loratadine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dopamine	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Dopamine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Dopamine	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Dopamine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Dopamine	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Enzalutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Fenofibrate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Droperidol	Haloperidol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Droperidol	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Lorazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Droperidol	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Oxazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Droperidol	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Phenobarbital	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Pyrazinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Regorafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Sorafenib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Droperidol	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Tranexamic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Abiraterone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Betahistine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Droperidol	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Droperidol	Diazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Droperidol	Dydrogesterone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Efavirenz	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Droperidol	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Droperidol	Hydroxyurea	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Droperidol	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Droperidol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Droperidol	Loratadine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Midazolam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Droperidol	Nandrolone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Norethisterone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Oxcarbazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Droperidol	Phenytoin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Progesterone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Droperidol	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Testosterone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Droperidol	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Droperidol	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Droperidol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Droperidol	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Droperidol	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Droperidol	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Droperidol	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Enzalutamide	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Enzalutamide	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Enzalutamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Enzalutamide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Enzalutamide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Enzalutamide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Enzalutamide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Fenofibrate	Fingolimod	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Fenofibrate	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fenofibrate	Flutamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Fenofibrate	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Fenofibrate	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2D6 mediated DDI
Fenofibrate	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Fenofibrate	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Fenofibrate	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Fenofibrate	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI
Fenofibrate	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C8 mediated DDI
Fenofibrate	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fenofibrate	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fenofibrate	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI
Fenofibrate	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI
Fenofibrate	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Fenofibrate	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C8 mediated DDI
Fenofibrate	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fenofibrate	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Fingolimod	Fluorescein	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Fingolimod	Flupentixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fingolimod	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fingolimod	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fingolimod	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fingolimod	Oxazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fingolimod	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fingolimod	Phenobarbital	3	CLASS 1 (from 3); Major DDI	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Fingolimod	Pyrazinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fingolimod	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fingolimod	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Fingolimod	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fingolimod	Acetaminophen	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Fingolimod	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Fingolimod	Dimethyl fumarate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Fingolimod	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Fingolimod	Efavirenz	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fingolimod	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI
Fingolimod	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fingolimod	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Fingolimod	Loratadine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fingolimod	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Fingolimod	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fingolimod	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fingolimod	Pyrantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fingolimod	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fingolimod	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fingolimod	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Fingolimod	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI
Fingolimod	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fingolimod	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fingolimod	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fluorescein	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Fluorescein	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fluorescein	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Fluorescein	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Fluorescein	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Fluorescein	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Fluorescein	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fluorescein	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Fluorescein	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Fluorescein	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Fluorescein	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Fluorescein	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluorescein	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Flupentixol	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Flupentixol	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Flupentixol	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Flupentixol	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Flupentixol	Procaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Flupentixol	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Flupentixol	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Flupentixol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Flupentixol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Flupentixol	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Flupentixol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Flupentixol	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Flupentixol	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Flupentixol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Flupentixol	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Flupentixol	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Flupentixol	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Flupentixol	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Flupentixol	Methimazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flutamide	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Flutamide	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Flutamide	Methotrimeprazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Flutamide	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP3A4 mediated DDI
Flutamide	Propranolol	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Flutamide	Tramadol	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Flutamide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Flutamide	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flutamide	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Flutamide	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Flutamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Flutamide	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Flutamide	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Flutamide	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Flutamide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Flutamide	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Flutamide	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Flutamide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Flutamide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Flutamide	Ethanol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Flutamide	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Flutamide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Fulvestrant	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Fulvestrant	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fulvestrant	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Fulvestrant	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Glycine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Glycine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Haloperidol	Isoniazid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Haloperidol	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Haloperidol	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Haloperidol	Pyrazinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Haloperidol	Sunitinib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP2B6 mediated DDI
Haloperidol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Acetaminophen	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Haloperidol	Betahistine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Haloperidol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Haloperidol	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Haloperidol	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Haloperidol	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2B6 mediated DDI
Haloperidol	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Haloperidol	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Haloperidol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI
Haloperidol	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Haloperidol	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Haloperidol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI
Haloperidol	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Haloperidol	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Haloperidol	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Isoniazid	Ketoprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Isoniazid	Ketorolac	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Isoniazid	Lacosamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Isoniazid	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Isoniazid	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Isoniazid	Phenylephrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Isoniazid	Propranolol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Isoniazid	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Isoniazid	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Isoniazid	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Isoniazid	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Isoniazid	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Isoniazid	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Isoniazid	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Isoniazid	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Isoniazid	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Isoniazid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Isoniazid	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Isoniazid	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Isoniazid	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Isoniazid	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Isoniazid	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ketoprofen	Ketorolac	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C8 mediated DDI
Ketoprofen	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Ketoprofen	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ketoprofen	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Ketoprofen	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ketoprofen	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ketoprofen	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ketoprofen	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ketoprofen	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Ketoprofen	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ketoprofen	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Ketoprofen	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ketoprofen	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Ketoprofen	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ketoprofen	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ketoprofen	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C8 mediated DDI
Ketoprofen	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ketoprofen	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ketoprofen	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ketoprofen	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ketoprofen	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ketoprofen	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ketoprofen	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ketoprofen	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ketoprofen	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ketorolac	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ketorolac	Methotrimeprazine	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2C19 mediated DDI
Ketorolac	Procarbazine	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension
Ketorolac	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ketorolac	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ketorolac	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ketorolac	Fluoxetine	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Ketorolac	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Ketorolac	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Ketorolac	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Ketorolac	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ketorolac	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ketorolac	Cinacalcet	3	CLASS 1 (from 5); Major DDI	DDI causing hypertension	CYP2D6 mediated DDI
Lacosamide	Loperamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Lacosamide	Mefloquine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lacosamide	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Procainamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Lacosamide	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Lacosamide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lacosamide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Lacosamide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Lacosamide	Tamoxifen	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lacosamide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Lacosamide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Lacosamide	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Lacosamide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Lacosamide	Pirfenidone	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Lacosamide	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Lacosamide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Lacosamide	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lacosamide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Loperamide	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Loperamide	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Loperamide	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Loperamide	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Loperamide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Loperamide	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Loperamide	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Loperamide	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Loperamide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Loperamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Loperamide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Loperamide	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Loperamide	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI; CYP2C8 mediated DDI
Loperamide	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2B6 mediated DDI
Loperamide	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Loperamide	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI
Loperamide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Loperamide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Loperamide	Desflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Lorazepam	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Lorazepam	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Methotrimeprazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Mefloquine	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Perampanel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Sunitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Mefloquine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Mefloquine	Betahistine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI; CYP2D6 mediated DDI
Mefloquine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Mefloquine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Mefloquine	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Mefloquine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Mefloquine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Mefloquine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Mefloquine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Mefloquine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Mefloquine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Mefloquine	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Mefloquine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Mefloquine	Methimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2D6 mediated DDI
Mefloquine	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Meldonium	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Methotrimeprazine	Methylergometrine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Methotrimeprazine	Phenylephrine	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Methotrimeprazine	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Umifenovir	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methotrimeprazine	Zuclopenthixol	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Acetaminophen	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2C19 mediated DDI
Methotrimeprazine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Fluoxetine	3	CLASS 1 (from 5); Major DDI	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Tapentadol	3	CLASS 1 (from 5)	DDI causing hypotension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Cinacalcet	3	CLASS 1 (from 5)	DDI causing hypertension; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Methotrimeprazine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Methylergometrine	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methylergometrine	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methylergometrine	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methylergometrine	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methylergometrine	Efavirenz	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Methylergometrine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methylergometrine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methylergometrine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methylergometrine	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methylergometrine	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methylergometrine	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methylergometrine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methylergometrine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Methylergometrine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Methylergometrine	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methylergometrine	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Methylergometrine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Methylergometrine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Methylergometrine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Methylergometrine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Methylergometrine	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Oxazepam	Procarbazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Oxazepam	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Oxazepam	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Perampanel	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Perampanel	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Perampanel	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Perampanel	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Perampanel	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Perampanel	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Perampanel	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Perampanel	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Perampanel	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Perampanel	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Perampanel	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Phenobarbital	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Phenobarbital	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Phenobarbital	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C9 mediated DDI
Phenylephrine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Phenylephrine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Phenylephrine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Efavirenz	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Phenylephrine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Phenylephrine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Phenylephrine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Phenylephrine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Pramipexole	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Pramipexole	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Pregabalin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Pregabalin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Procainamide	Salicylic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C8 mediated DDI
Procainamide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procainamide	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Procainamide	Acetaminophen	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Procainamide	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Procainamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Procainamide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procainamide	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Procainamide	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procainamide	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Procainamide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Procainamide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Procainamide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procainamide	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procainamide	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procaine	Sorafenib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C9 mediated DDI
Procaine	Sunitinib	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Procaine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procaine	Betahistine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing tachycardia
Procaine	Diphenhydramine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing tachycardia
Procaine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Procaine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Procaine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procaine	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C9 mediated DDI
Procaine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Procaine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Procarbazine	Regorafenib	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Procarbazine	Sorafenib	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Procarbazine	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Procarbazine	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Procarbazine	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Procarbazine	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Procarbazine	Clopidogrel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Procarbazine	Diazepam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Procarbazine	Efavirenz	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Procarbazine	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Procarbazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Procarbazine	Loratadine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Procarbazine	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Pyrantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Procarbazine	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Procarbazine	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Procarbazine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Procarbazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Procarbazine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Procarbazine	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Propranolol	Regorafenib	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propranolol	Teriflunomide	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propranolol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Propranolol	Warfarin	3	CLASS 1 (from 3)	DDI causing arrhythmia; DDI causing bradycardia	CYP2C9 mediated DDI; CYP2D6 mediated DDI
Propranolol	Biperiden	3	CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Diphenhydramine	3	CLASS 1 (from 3)	DDI causing tachycardia; DDI causing bradycardia	CYP2D6 mediated DDI
Propranolol	Fluoxetine	3	Major DDI	DDI causing tachycardia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propranolol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Propranolol	Tamoxifen	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2D6 mediated DDI
Pyrazinamide	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pyrazinamide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Pyrazinamide	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Pyrazinamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Pyrazinamide	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP3A4 mediated DDI
Pyrazinamide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Pyrazinamide	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Regorafenib	Fentanyl	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Regorafenib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Regorafenib	Lidocaine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Regorafenib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Regorafenib	Mitotane	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Salicylic acid	Teriflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Salicylic acid	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Salicylic acid	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Salicylic acid	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Salicylic acid	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Salicylic acid	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Salicylic acid	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Salicylic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Salicylic acid	Levamisole	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension
Salicylic acid	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Salicylic acid	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Salicylic acid	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Salicylic acid	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Salicylic acid	Desflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Salicylic acid	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Salicylic acid	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Sorafenib	Trifluoperazine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Sorafenib	Tropicamide	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI
Sorafenib	Clomifene	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Sorafenib	Fentanyl	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia	CYP2C19 mediated DDI
Sorafenib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Sorafenib	Lidocaine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Sorafenib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sorafenib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI
Sorafenib	Benzyl benzoate	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia	CYP2C19 mediated DDI; CYP2C9 mediated DDI
Sunitinib	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Sunitinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Sunitinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sunitinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Sunitinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sunitinib	Benzyl benzoate	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing bradycardia
Sunitinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Sunitinib	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Teriflunomide	Tramadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Teriflunomide	Tropicamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Teriflunomide	Umifenovir	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Teriflunomide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Teriflunomide	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Teriflunomide	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Teriflunomide	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Teriflunomide	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Teriflunomide	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Teriflunomide	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Teriflunomide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Teriflunomide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Teriflunomide	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Teriflunomide	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Teriflunomide	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Teriflunomide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Teriflunomide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Teriflunomide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Teriflunomide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Teriflunomide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Teriflunomide	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP3A4 mediated DDI
Teriflunomide	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Teriflunomide	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Teriflunomide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Teriflunomide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Teriflunomide	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tramadol	Trifluoperazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tramadol	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tramadol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Tramadol	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tramadol	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tramadol	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Tramadol	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tramadol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tramadol	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tramadol	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tramadol	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tramadol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tramadol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Tramadol	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Tramadol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Tramadol	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Tranexamic acid	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Tranexamic acid	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tranexamic acid	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Tranexamic acid	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tranexamic acid	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Trifluoperazine	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Trifluoperazine	Betahistine	3	CLASS 1 (from 5)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Trifluoperazine	Finasteride	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI
Trifluoperazine	Fluorouracil	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C9 mediated DDI
Trifluoperazine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Trifluoperazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trifluoperazine	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Trifluoperazine	Lipoic acid	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Trifluoperazine	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Trifluoperazine	Ondansetron	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI
Trifluoperazine	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Trifluoperazine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Trifluoperazine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Trifluoperazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Trifluoperazine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Trifluoperazine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Trifluoperazine	Methimazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Tropicamide	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tropicamide	Zuclopenthixol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Tropicamide	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Tropicamide	Betahistine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Tropicamide	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Tropicamide	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Tropicamide	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Tropicamide	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tropicamide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Tropicamide	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Tropicamide	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Tropicamide	Loratadine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Tropicamide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Tropicamide	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Tropicamide	Clotrimazole	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Tropicamide	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Tropicamide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Umifenovir	Upadacitinib	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Umifenovir	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Umifenovir	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Umifenovir	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Umifenovir	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Umifenovir	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Umifenovir	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Umifenovir	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Umifenovir	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Umifenovir	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Umifenovir	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Umifenovir	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Upadacitinib	Warfarin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Agomelatine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Chlorpromazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Fentanyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Fluorouracil	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Upadacitinib	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Hydroxyurea	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Upadacitinib	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Imipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Upadacitinib	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Upadacitinib	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Ethionamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Upadacitinib	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Upadacitinib	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Upadacitinib	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Upadacitinib	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Warfarin	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Warfarin	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Warfarin	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C9 mediated DDI
Warfarin	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Warfarin	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Warfarin	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Warfarin	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Warfarin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Warfarin	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Zuclopenthixol	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Zuclopenthixol	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Zuclopenthixol	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Zuclopenthixol	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Zuclopenthixol	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Zuclopenthixol	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Zuclopenthixol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Zuclopenthixol	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Zuclopenthixol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Zuclopenthixol	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Zuclopenthixol	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Acetaminophen	Agomelatine	3	CLASS 1 (from 5); Major DDI	DDI causing bradycardia
Acetaminophen	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Acetaminophen	Chlorpromazine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Acetaminophen	Clomipramine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP2D6 mediated DDI
Acetaminophen	Imipramine	3	Major DDI	DDI causing hypertension; DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Acetaminophen	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Acetaminophen	Levamisole	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension
Acetaminophen	Lidocaine	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Acetaminophen	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Acetaminophen	Amitriptyline	3	Major DDI	DDI causing hypertension; DDI causing arrhythmia	CYP1A2 mediated DDI
Acetaminophen	Ethanol	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia	CYP2D6 mediated DDI
Acetaminophen	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Acetaminophen	Mitotane	3	Major DDI	DDI causing arrhythmia; DDI causing bradycardia
Agomelatine	Betahistine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Agomelatine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Agomelatine	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Agomelatine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Agomelatine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C8 mediated DDI
Agomelatine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Agomelatine	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP2C19 mediated DDI
Agomelatine	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Agomelatine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Agomelatine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Agomelatine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Agomelatine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Agomelatine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Agomelatine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Agomelatine	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Agomelatine	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Betahistine	Biperiden	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI
Betahistine	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Betahistine	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Betahistine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Betahistine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Betahistine	Levamisole	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension	CYP2C8 mediated DDI
Betahistine	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Betahistine	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Betahistine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Betahistine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C8 mediated DDI; CYP2D6 mediated DDI
Betahistine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2D6 mediated DDI
Biperiden	Bupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Clomipramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Biperiden	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI
Biperiden	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Biperiden	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Biperiden	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Biperiden	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI
Biperiden	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Biperiden	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Brivaracetam	Clomifene	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Bupivacaine	Efavirenz	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Bupivacaine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Bupivacaine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Bupivacaine	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Bupivacaine	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Bupivacaine	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Bupivacaine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Bupivacaine	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Bupivacaine	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Bupivacaine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Bupivacaine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Bupivacaine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Bupivacaine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Bupivacaine	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carmustine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP3A4 mediated DDI
Chlorpromazine	Diphenhydramine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Chlorpromazine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Chlorpromazine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Chlorpromazine	Loratadine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypotension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Chlorpromazine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Chlorpromazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Chlorpromazine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Chlorpromazine	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Clomifene	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Clomifene	Levamisole	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension
Clomifene	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Clomifene	Loratadine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Clomifene	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomifene	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Clomifene	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Clomifene	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Clomifene	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomifene	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clomifene	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clomipramine	Diphenhydramine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing tachycardia	CYP2D6 mediated DDI
Clomipramine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Solifenacin	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation
Clomipramine	Tamoxifen	3	CLASS 1 (from 3); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Clomipramine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Clomipramine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Clomipramine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Clomipramine	Oxaliplatin	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation
Clopidogrel	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Diazepam	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Diazepam	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dimethyl fumarate	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dimethyl fumarate	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Dimethyl fumarate	Desflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Dimethyl fumarate	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Diphenhydramine	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Diphenhydramine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Diphenhydramine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Diphenhydramine	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Diphenhydramine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Diphenhydramine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2D6 mediated DDI
Diphenhydramine	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI; CYP3A4 mediated DDI
Diphenhydramine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2D6 mediated DDI
Diphenhydramine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Dydrogesterone	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Dydrogesterone	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Efavirenz	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Efavirenz	Levobupivacaine	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Efavirenz	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Efavirenz	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Efavirenz	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Efavirenz	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ethosuximide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension	CYP2C19 mediated DDI
Ethosuximide	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Fentanyl	Fluoxetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fentanyl	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Fentanyl	Ketamine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Fentanyl	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fentanyl	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Fentanyl	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fentanyl	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Fentanyl	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fentanyl	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fentanyl	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Fentanyl	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Fentanyl	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia
Fentanyl	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Fentanyl	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C9 mediated DDI
Fentanyl	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Fentanyl	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Fentanyl	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fentanyl	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Finasteride	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Finasteride	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Finasteride	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Fluorouracil	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Fluoxetine	Ibuprofen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Fluoxetine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fluoxetine	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Fluoxetine	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Fluoxetine	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Hydroxyurea	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP3A4 mediated DDI
Hydroxyurea	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP3A4 mediated DDI
Ibuprofen	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C8 mediated DDI
Ibuprofen	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ibuprofen	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ibuprofen	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ibuprofen	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Ibuprofen	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Ibuprofen	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP3A4 mediated DDI
Imipramine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Imipramine	Vinpocetine	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing hypertension	CYP2D6 mediated DDI
Imipramine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Imipramine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Ketamine	Leflunomide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Ketamine	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI
Ketamine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Ketamine	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Leflunomide	Levamisole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Levetiracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Leflunomide	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Leflunomide	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Leflunomide	Lipoic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Leflunomide	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Loratadine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Midazolam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP3A4 mediated DDI
Leflunomide	Nandrolone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Leflunomide	Norethisterone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Leflunomide	Oxcarbazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Leflunomide	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Leflunomide	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Progesterone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Pyrantel	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Leflunomide	Rivastigmine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Leflunomide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Leflunomide	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Leflunomide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Leflunomide	Valproic acid	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI
Leflunomide	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Leflunomide	Xylometazoline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C9 mediated DDI
Leflunomide	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Leflunomide	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C19 mediated DDI
Leflunomide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP3A4 mediated DDI
Leflunomide	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Leflunomide	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2C9 mediated DDI
Leflunomide	Protionamide	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2C8 mediated DDI
Leflunomide	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI
Leflunomide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Leflunomide	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Methimazole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Leflunomide	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2C19 mediated DDI
Levamisole	Lomustine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Levamisole	Rivastigmine	3	CLASS 1 (from 3)	DDI causing hypertension; DDI causing bradycardia
Levamisole	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Levamisole	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Levamisole	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Levamisole	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2D6 mediated DDI
Levamisole	Desflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Levamisole	Propofol	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension	CYP1A2 mediated DDI
Levamisole	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Levetiracetam	Levobupivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Levetiracetam	Lidocaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Levetiracetam	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Levetiracetam	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Levetiracetam	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Levetiracetam	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Levetiracetam	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Levobupivacaine	Ondansetron	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Levobupivacaine	Praziquantel	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypotension
Levobupivacaine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Levobupivacaine	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI
Levobupivacaine	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Levobupivacaine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Levobupivacaine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Levobupivacaine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Levobupivacaine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Levobupivacaine	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Lidocaine	Nicotinamide	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Lidocaine	Piracetam	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Lidocaine	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Lidocaine	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Lidocaine	Solifenacin	3	CLASS 1 (from 3); Major DDI	DDI causing hypertension
Lidocaine	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP1A2 mediated DDI
Lidocaine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Lidocaine	Pirfenidone	3	CLASS 1 (from 3)	DDI causing qt_interval_prolongation; DDI causing arrhythmia	CYP1A2 mediated DDI
Lomustine	Benzyl benzoate	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Lomustine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2D6 mediated DDI
Lomustine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2D6 mediated DDI
Lomustine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia
Loratadine	Ropivacaine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Midazolam	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nandrolone	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Nicotinamide	Phenytoin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Nicotinamide	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Nicotinamide	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nicotinamide	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Nicotinamide	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Nicotinamide	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Nicotinamide	Carbamazepine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Nicotinamide	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C8 mediated DDI
Nicotinamide	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI; CYP2C8 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Nicotinamide	Desflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP1A2 mediated DDI
Norethisterone	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Ondansetron	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ondansetron	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Ondansetron	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Phenytoin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Piracetam	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Piracetam	Tamoxifen	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Piracetam	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Piracetam	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Piracetam	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Praziquantel	Sertindole	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Praziquantel	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Praziquantel	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Praziquantel	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Rivastigmine	Tapentadol	3	CLASS 1 (from 5)	DDI causing tachycardia; DDI causing bradycardia
Rivastigmine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Ropivacaine	Solifenacin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Ropivacaine	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Ropivacaine	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Ropivacaine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Ropivacaine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Ropivacaine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Sertindole	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sertindole	Amitriptyline	3	CLASS 1 (from 5); Major DDI	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Sertindole	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Sertindole	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2B6 mediated DDI; CYP2C19 mediated DDI
Sertindole	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2B6 mediated DDI
Sertindole	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Sertindole	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Solifenacin	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2D6 mediated DDI
Solifenacin	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Tamoxifen	Tapentadol	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tamoxifen	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tamoxifen	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Tamoxifen	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Tapentadol	Thioridazine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Tapentadol	Trihexyphenidyl	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Tapentadol	Vinpocetine	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension
Tapentadol	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Tapentadol	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Thioridazine	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2D6 mediated DDI
Thioridazine	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Thioridazine	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Thioridazine	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Tretinoin	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Trihexyphenidyl	Amitriptyline	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia
Trihexyphenidyl	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Trihexyphenidyl	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI; CYP3A4 mediated DDI
Trihexyphenidyl	Desflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2C19 mediated DDI
Trihexyphenidyl	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP2B6 mediated DDI
Trihexyphenidyl	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing tachycardia	CYP1A2 mediated DDI; CYP2B6 mediated DDI
Trihexyphenidyl	Sevelamer	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing bradycardia	CYP1A2 mediated DDI
Trihexyphenidyl	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Trihexyphenidyl	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP2C19 mediated DDI
Valproic acid	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI; CYP2D6 mediated DDI
Vinpocetine	Cinacalcet	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Vinpocetine	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Vinpocetine	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Xylometazoline	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation
Amitriptyline	Clotrimazole	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Amitriptyline	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing qt_interval_prolongation	CYP1A2 mediated DDI; CYP2D6 mediated DDI
Amitriptyline	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Amitriptyline	Sertraline	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI; CYP2D6 mediated DDI
Amitriptyline	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Benzyl benzoate	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cinacalcet	Pirfenidone	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2D6 mediated DDI
Cinacalcet	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C9 mediated DDI; CYP2D6 mediated DDI
Cinacalcet	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2C19 mediated DDI
Cinacalcet	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Cinacalcet	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Clotrimazole	Desflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP3A4 mediated DDI
Clotrimazole	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI; CYP3A4 mediated DDI
Clotrimazole	Mitotane	3	CLASS 1 (from 3); Major DDI	DDI causing tachycardia	CYP2B6 mediated DDI; CYP2C19 mediated DDI; CYP3A4 mediated DDI
Desflurane	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI
Ethanol	Halothane	3	Major DDI	DDI causing qt_interval_prolongation; DDI causing arrhythmia
Pirfenidone	Propofol	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP1A2 mediated DDI; CYP2C19 mediated DDI; CYP2C9 mediated DDI
Pirfenidone	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Propofol	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing hypertension	CYP2C19 mediated DDI
Protionamide	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sertraline	Sevoflurane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sertraline	Carboplatin	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sertraline	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI		CYP2B6 mediated DDI
Sevoflurane	Vitamin A	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sevoflurane	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Sevoflurane	Oxaliplatin	3	CLASS 1 (from 3); CLASS 1 (from 5)	DDI causing arrhythmia	CYP2C19 mediated DDI
Vitamin A	Halothane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI
Carboplatin	Mitotane	3	CLASS 1 (from 3); CLASS 1 (from 5); Major DDI